EKS-MUM-00487

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00487

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	467.5	2.6E-140	46	308	263

Status

Reviewed

Ensembl Protein

ENSMUSP00000082560

UniProt Accession

Q8BVP5;

Protein Name

Casein kinase I isoform gamma-2

Protein Synonyms/Alias

CKI-gamma 2;

Gene Name

Csnk1g2

Gene Synonyms/Alias

Csnk1g2; Ck1g2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000003345	ENSMUSP00000082560	ENSMUST00000085435
ENSMUSG00000003345	ENSMUSP00000078706	ENSMUST00000079773

Organism

Mus musculus

Functional Description

Serine/threonine-protein kinase. Casein kinases areoperationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.

Protein Length

415

Protein Sequence
(FASTA)

MDFDKKGGKG ELEEGRRMSK TGTSRSNHGV RSSGTSSGVL MVGPNFRVGK KIGCGNFGEL 60

RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSTTE GVPQVYYFGP CGKYNAMVLE 120

LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI TRMEYVHTKS LIYRDVKPEN FLVGRPGSKR 180

QHSIHIIDFG LAKEYIDPET KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH 240

MFMYFLRGSL PWQGLKADTL KERYQKIGDT KRATPIEVLC ESFPEEMATY LRYVRRLDFF 300

EKPDYDYLRK LFTDLFDRSG YVFDYEYDWA GKPLPTPIGT VHPDVPSQPP HRDKAQLHTK 360

NQALNSTNGE LNTDDPTAGH SNAPIAAPAE VEVADETKCC CFFKRRKRKS LQRHK 415

Nucleotide Sequence
(FASTA)

ATGGATTTTG ACAAGAAAGG AGGGAAGGGG GAGTTGGAGG AGGGCAGGAG AATGTCCAAA 60

ACCGGCACGA GTCGGAGCAA CCACGGCGTC CGCAGTTCGG GGACCAGCTC AGGGGTCCTG 120

ATGGTGGGCC CAAACTTCCG AGTCGGCAAG AAGATAGGCT GTGGGAACTT CGGGGAGCTT 180

CGCCTAGGAA AGAATCTGTA TACAAATGAG TACGTGGCTA TCAAGCTGGA GCCCATCAAG 240

TCCCGGGCCC CACAGCTGCA CCTGGAGTAC CGCTTTTACA AGCAGCTCAG CACGACAGAG 300

GGCGTCCCTC AGGTCTACTA CTTCGGCCCT TGTGGGAAGT ACAACGCCAT GGTGCTGGAG 360

CTGCTGGGGC CCAGCCTGGA GGACCTTTTC GACCTGTGCG ACCGCACCTT CACGCTGAAG 420

ACGGTGCTGA TGATCGCCAT CCAGCTGATC ACGCGCATGG AGTACGTGCA CACCAAGAGC 480

CTCATCTACC GTGACGTGAA GCCCGAGAAC TTCCTGGTTG GGCGGCCGGG CAGCAAGCGG 540

CAGCACTCCA TCCACATCAT CGACTTTGGG CTGGCCAAGG AGTACATCGA CCCTGAGACT 600

AAGAAGCACA TCCCATATCG CGAGCACAAG AGCCTGACAG GCACTGCGCG CTACATGAGC 660

ATCAACACGC ACTTGGGCAA AGAGCAGAGC CGCCGGGATG ACCTGGAGGC GCTGGGACAC 720

ATGTTCATGT ACTTCCTGCG CGGCAGTCTG CCCTGGCAGG GGCTCAAGGC AGACACGCTG 780

AAGGAGCGCT ACCAGAAGAT TGGAGACACC AAGCGTGCCA CACCAATCGA GGTGCTGTGT 840

GAGAGCTTCC CGGAGGAGAT GGCCACCTAT TTGCGCTATG TGCGGCGCCT AGACTTTTTT 900

GAGAAGCCAG ACTACGACTA CCTGAGGAAG CTCTTCACTG ACCTCTTTGA CCGCAGCGGC 960

TACGTGTTTG ACTACGAGTA TGACTGGGCC GGCAAGCCCC TGCCGACACC CATCGGCACC 1020

GTCCACCCTG ACGTGCCCTC CCAGCCACCA CATCGCGACA AAGCTCAGCT CCACACCAAG 1080

AACCAGGCGC TCAACTCCAC TAATGGAGAG CTGAACACAG ACGACCCCAC CGCGGGCCAC 1140

TCCAACGCCC CCATCGCGGC CCCCGCAGAA GTAGAGGTGG CAGATGAAAC AAAGTGCTGC 1200

TGCTTCTTCA AGAGGAGAAA GAGAAAATCG CTGCAGCGAC ATAAGTGA 1248

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         +rv+kkiG+G+fG+++lgknl+++e+vaikle++ks+apql+le+r+yk+l++++g+P+v

Q: 46    FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEGVPQV  105

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +yfg+++kyn++vl+llGpsledlfdlc+r+f+lktvl++a+qli+r+eyvh+k+liyrd

Q: 106   YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRD  165

         ************************************************************

S: 121   ikPdnfllgigrkgkk....vylidfGlakkyrdaktkkhipyreeksltGtaryasint  176

         +kP+nfl+g  r g+k    +++idfGlak+y+d++tkkhipyre+ksltGtary+sint

Q: 166   VKPENFLVG--RPGSKrqhsIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT  223

         *******66..444444445****************************************

S: 177   hlgkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegf  236

         hlgkeqsrrddle+lg++++yflrgslPWqglka+t k++y+ki+++k++t+ievlce+f

Q: 224   HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCESF  283

         ************************************************************

S: 237   PeefatylkyvrklkfeekPdyeyl  261

         Pee+atyl+yvr+l+f+ekPdy+yl

Q: 284   PEEMATYLRYVRRLDFFEKPDYDYL  308

         ***********************97

Domain Sequence
(FASTA)

FRVGKKIGCG NFGELRLGKN LYTNEYVAIK LEPIKSRAPQ LHLEYRFYKQ LSTTEGVPQV 60

YYFGPCGKYN AMVLELLGPS LEDLFDLCDR TFTLKTVLMI AIQLITRMEY VHTKSLIYRD 120

VKPENFLVGR PGSKRQHSIH IIDFGLAKEY IDPETKKHIP YREHKSLTGT ARYMSINTHL 180

GKEQSRRDDL EALGHMFMYF LRGSLPWQGL KADTLKERYQ KIGDTKRATP IEVLCESFPE 240

EMATYLRYVR RLDFFEKPDY DYL 263

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

mmu:103236

;

InterPros

IPR022247	; Casein_kinase-1_gamma_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12605	; CK1gamma_C; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013