| Tag | Content |
|---|
| EKPD ID | EPS-MUM-00007 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 158.2 | 3.1E-46 | 31 | 177 | 147 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000003612 |
| UniProt Accession | Q9D7X3; |
| Protein Name | Dual specificity protein phosphatase 3 |
| Protein Synonyms/Alias | T-DSP11; Vaccinia H1-related phosphatase; VHR; |
| Gene Name | Dusp3 |
| Gene Synonyms/Alias | Dusp3; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Shows activity both for tyrosine-protein phosphate andserine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity). |
| Protein Length | 185 |
Protein Sequence
(FASTA) | | MSSSFELSVQ DLNDLLSDGS GCYSLPSQPC NEVVPRVYVG NASVAQDITQ LQKLGITHVL 60 | | NAAEGRSFMH VNTSASFYED SGITYLGIKA NDTQEFNLSA YFERATDFID QALAHKNGRV 120 | | LVHCREGYSR SPTLVIAYLM MRQKMDVKSA LSTVRQNREI GPNDGFLAQL CQLNDRLAKE 180 | | GKVKL 185 |
|
Nucleotide Sequence
(FASTA) | | ATGTCCAGCT CGTTCGAACT CTCGGTGCAA GATCTCAACG ACCTGCTCTC GGATGGCAGC 60 | | GGCTGCTACA GCCTGCCGAG CCAGCCCTGC AACGAGGTCG TCCCGAGGGT CTACGTGGGC 120 | | AACGCGTCTG TGGCTCAGGA CATCACCCAG CTGCAGAAAC TGGGCATCAC CCACGTCCTG 180 | | AATGCTGCCG AGGGCAGGTC CTTCATGCAC GTCAACACCA GTGCTAGCTT CTACGAGGAT 240 | | TCTGGCATCA CCTACTTGGG CATCAAGGCC AATGATACGC AGGAGTTCAA CCTCAGTGCT 300 | | TACTTTGAAA GGGCCACAGA TTTCATTGAC CAGGCGCTGG CCCATAAAAA TGGCCGGGTG 360 | | CTTGTCCATT GCCGCGAGGG CTACAGCCGC TCCCCAACGC TAGTTATCGC CTACCTCATG 420 | | ATGCGGCAGA AGATGGACGT CAAGTCTGCT CTGAGTACTG TGAGGCAGAA TCGTGAGATC 480 | | GGCCCCAACG ATGGCTTCCT GGCCCAACTC TGCCAGCTCA ATGACAGACT AGCCAAGGAG 540 | | GGCAAGGTGA AACTCTAG 558 |
|
| Domain Profile | S: 3 teilpglylgdqataldrreLsklgitvvinaslsv..ikvqviPeylikkgityknipv 60 | +e++p++y+g++ +a d ++L+klgit+v+na+ ++ ++v++ ++++++gity++i++ | Q: 31 NEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRsfMHVNTSASFYEDSGITYLGIKA 90 | 79******************************9754227889999*************** |
| S: 61 dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA 119 | +D+++++l+ yf++a++fid+a +k+g+vlvHC+ G+sRS+tlv+aYLm+++++ +++A | Q: 91 NDTQEFNLSAYFERATDFIDQAlAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSA 150 | **********************999*********************************** |
| S: 120 ieavkrkrpsiepnegfleQLlelekkl 147 | +++v+++r +i pn+gfl+QL++l+ +l | Q: 151 LSTVRQNR-EIGPNDGFLAQLCQLNDRL 177 | ********.***************9876 |
|
Domain Sequence
(FASTA) | | NEVVPRVYVG NASVAQDITQ LQKLGITHVL NAAEGRSFMH VNTSASFYED SGITYLGIKA 60 | | NDTQEFNLSA YFERATDFID QALAHKNGRV LVHCREGYSR SPTLVIAYLM MRQKMDVKSA 120 | | LSTVRQNREI GPNDGFLAQL CQLNDRL 147 |
|
| Keyword | Complete proteome; Direct protein sequencing; Hydrolase; Nucleus; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |