EKS-MUM-00137

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00137

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/ABC1	372.2	5.5E-111	212	513	302

Status

Reviewed

Ensembl Protein

ENSMUSP00000003860

UniProt Accession

Q566J8; Q5XJH7; Q91WT5;

Protein Name

Uncharacterized aarF domain-containing protein kinase 4

Protein Synonyms/Alias

Gene Name

Adck4

Gene Synonyms/Alias

Adck4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000003762	ENSMUSP00000123309	ENSMUST00000128090
ENSMUSG00000003762	ENSMUSP00000104015	ENSMUST00000108378
ENSMUSG00000003762	ENSMUSP00000003860	ENSMUST00000003860

Organism

Mus musculus

Functional Description

The function of this protein is not yet clear. It is notknown if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Protein Length

533

Protein Sequence
(FASTA)

MWLELGAMLR RTCGPLGRAV RLPCGGALGP RPHWWGPCRS CLAQSVHQDQ PGRGLSEDDI 60

RRAREARLRK APRPQLSDRS RERKVPASRI SRLASFGGLA VGLGLGALAE VTKKSLPGGS 120

LQHEGVSGLG SSPFLSEANA ERIVQTLCTV RGAALKIGQM LSIQDNSFIS PQLQRIFERV 180

RQSADFMPRW QMMRVLEEEL GKDWQDKVAS LEEVPFAAAS IGQVHQGLLK DGTEVAVKIQ 240

YPGVAQSIQS DVENLLALLK MSVGLPEGLF AEQSLQTLQQ ELAWECDYCR EAACAQTFRK 300

LLADDPFFRV PAVVQELCTT RVLGMELAGG IPLDQCQGLS QDIRNQICFQ LLRLCLRELF 360

EFRFMQTDPN WANFLYDASS HQVTLLDFGA SRAFGTEFTD HYIEVVKAAA DGDRDRVLQK 420

SQDLKFLTGF ETKAFSDAHV EAVMILGEPF AASGPYDFGA GETARRIQGL IPVLLRHRLR 480

PPPEETYALH RKLAGAFLAC ARLHAHIACR DLFQDTYHRY WASRQTLPLP AAS 533

Nucleotide Sequence
(FASTA)

ATGTGGCTGG AGCTAGGTGC CATGCTGCGC AGGACCTGTG GACCGCTGGG CAGGGCTGTT 60

CGTCTGCCCT GTGGGGGGGC CCTAGGACCT AGGCCCCACT GGTGGGGGCC ATGTAGGAGT 120

TGCTTGGCCC AAAGTGTTCA TCAAGACCAG CCTGGAAGAG GCCTCAGTGA AGATGACATT 180

CGCAGGGCAC GGGAGGCCCG GCTCAGGAAG GCACCCCGGC CCCAGCTGAG TGATCGCTCT 240

CGTGAACGCA AGGTGCCTGC CTCCCGCATC AGTCGCTTGG CCAGCTTTGG GGGGCTGGCT 300

GTGGGCTTGG GCCTGGGAGC GCTGGCTGAG GTGACTAAGA AGTCCTTGCC AGGTGGAAGT 360

CTGCAGCATG AGGGCGTCTC TGGATTGGGC TCCAGTCCTT TCCTCTCCGA GGCCAATGCT 420

GAGAGGATCG TGCAGACCTT ATGTACAGTC CGGGGGGCTG CCCTCAAGAT CGGCCAAATG 480

CTCAGTATCC AGGACAACAG CTTTATCAGC CCCCAGCTTC AGCGAATCTT TGAGAGGGTC 540

CGACAGAGTG CCGACTTTAT GCCCCGCTGG CAAATGATGA GAGTTCTAGA AGAGGAGCTA 600

GGCAAGGACT GGCAAGACAA GGTGGCCTCC CTCGAGGAAG TGCCCTTTGC TGCTGCCTCC 660

ATTGGGCAGG TACACCAAGG CTTGCTAAAG GATGGGACTG AGGTGGCTGT GAAGATCCAG 720

TACCCAGGTG TTGCCCAGAG CATCCAGAGT GACGTGGAGA ACCTGCTGGC CCTGCTCAAG 780

ATGAGTGTGG GCCTGCCAGA GGGCCTGTTT GCTGAGCAGA GCCTGCAGAC CTTGCAGCAG 840

GAGCTGGCTT GGGAATGTGA CTACTGCAGA GAAGCGGCCT GTGCCCAGAC CTTCAGGAAG 900

CTCTTAGCTG ACGACCCCTT CTTCCGAGTG CCAGCTGTGG TGCAGGAGCT ATGCACTACA 960

CGGGTGCTGG GCATGGAGCT GGCTGGGGGA ATCCCTCTAG ACCAGTGCCA GGGCCTGAGC 1020

CAAGACATCC GGAATCAGAT CTGCTTTCAG CTCCTGAGGT TGTGTCTGCG GGAACTGTTT 1080

GAGTTCAGAT TCATGCAGAC TGATCCCAAC TGGGCCAACT TCCTGTATGA TGCCTCCAGC 1140

CACCAGGTGA CTCTACTGGA TTTTGGTGCA AGCCGGGCGT TTGGGACAGA GTTCACGGAC 1200

CATTACATTG AGGTGGTGAA GGCTGCAGCA GATGGAGACA GAGATCGAGT TCTACAGAAA 1260

TCCCAGGACC TCAAGTTCCT TACAGGCTTT GAAACCAAGG CATTCTCTGA CGCCCACGTC 1320

GAGGCAGTGA TGATCCTGGG GGAGCCCTTT GCTGCCTCAG GCCCCTACGA CTTTGGGGCT 1380

GGAGAGACTG CTCGCCGAAT ACAGGGCCTC ATCCCGGTAT TGCTTCGGCA CCGGCTGCGC 1440

CCACCGCCTG AGGAGACCTA TGCTCTACAC CGCAAGCTAG CTGGGGCTTT CTTAGCCTGT 1500

GCCCGTCTCC ACGCCCACAT CGCCTGCCGG GACCTCTTCC AAGATACCTA CCACCGCTAC 1560

TGGGCCAGTC GCCAGACACT GCCGCTGCCA GCAGCCTCCT GA 1602

Domain Profile

S: 1     eekPlaaASlaqvhkArLkdGeeVAVKvqypgvkesidsDlktlelllkvlevlfkdlkl  60

         ee P+aaAS++qvh++ LkdG+eVAVK+qypgv++si+sD+++l +llk++  l+++l+

Q: 212   EEVPFAAASIGQVHQGLLKDGTEVAVKIQYPGVAQSIQSDVENLLALLKMSVGLPEGLFA  271

         689*********************************************************

S: 61    ewlvdelkkeLaleldferEarnaekfrkllkkfkalkvPkvleelstkrvLtmelvegv  120

         e+ ++ l++eLa+e+d+ rEa++a+ frkll+++++++vP+v++el+t+rvL mel++g

Q: 272   EQSLQTLQQELAWECDYCREAACAQTFRKLLADDPFFRVPAVVQELCTTRVLGMELAGGI  331

         ************************************************************

S: 121   pvddleyiessqilrneiaekliklllkeifvdnfvhtDphpgNvlvqksskegklelvL  180

         p+d+++  + sq++rn+i+ +l++l+l+e+f+++f++tDp+++N+l+++ss+    +++L

Q: 332   PLDQCQ--GLSQDIRNQICFQLLRLCLRELFEFRFMQTDPNWANFLYDASSH----QVTL  385

         ******..********************************************....****

S: 181   LDfGlsrelsekfrrlyikllkavvdrDrkkvkkksqrlaeltgeeaklladalvervlt  240

         LDfG+sr+++++f+++yi+++ka++d Dr++v +ksq+l++ltg e+k+++da+ve+v++

Q: 386   LDFGASRAFGTEFTDHYIEVVKAAADGDRDRVLQKSQDLKFLTGFETKAFSDAHVEAVMI  445

         ************************************************************

S: 241   lgeafasqarkeveeleklaverlessllkllmevlvklprevllilktidllrgieeaL  300

         lge+fa +   +++++  ++++r+++++++ll+++l+++p+e++++++++++++  ++ L

Q: 446   LGEPFAAS--GPYDFGAGETARRIQGLIPVLLRHRLRPPPEETYALHRKLAGAFLACARL  503

         ******99..**************************************************

S: 301   kakldilell  310

         +a++++++l+

Q: 504   HAHIACRDLF  513

         ******9875

Domain Sequence
(FASTA)

EEVPFAAASI GQVHQGLLKD GTEVAVKIQY PGVAQSIQSD VENLLALLKM SVGLPEGLFA 60

EQSLQTLQQE LAWECDYCRE AACAQTFRKL LADDPFFRVP AVVQELCTTR VLGMELAGGI 120

PLDQCQGLSQ DIRNQICFQL LRLCLRELFE FRFMQTDPNW ANFLYDASSH QVTLLDFGAS 180

RAFGTEFTDH YIEVVKAAAD GDRDRVLQKS QDLKFLTGFE TKAFSDAHVE AVMILGEPFA 240

ASGPYDFGAG ETARRIQGLI PVLLRHRLRP PPEETYALHR KLAGAFLACA RLHAHIACRD 300

LF 302

Keyword

Complete proteome; Kinase; Membrane; Reference proteome; Serine/threonine-protein kinase; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>