EKS-MUM-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	450.8	2.5E-135	193	436	244

Status

Reviewed

Ensembl Protein

ENSMUSP00000100965

UniProt Accession

P41242; Q6LE90;

Protein Name

Megakaryocyte-associated tyrosine-protein kinase

Protein Synonyms/Alias

Protein kinase NTK; Tyrosine-protein kinase CTK;

Gene Name

Matk

Gene Synonyms/Alias

Matk; Ctk, Ntk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000004933	ENSMUSP00000113043	ENSMUST00000121205
ENSMUSG00000004933	ENSMUSP00000113221	ENSMUST00000117488
ENSMUSG00000004933	ENSMUSP00000113576	ENSMUST00000119547
ENSMUSG00000004933	ENSMUSP00000113666	ENSMUST00000120265
ENSMUSG00000004933	ENSMUSP00000122445	ENSMUST00000128576
ENSMUSG00000004933	ENSMUSP00000114233	ENSMUST00000130282
ENSMUSG00000004933	ENSMUSP00000100965	ENSMUST00000105328

Organism

Mus musculus

Functional Description

Could play a significant role in the signal transductionof hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Protein Length

465

Protein Sequence
(FASTA)

MPTRWAPGTQ CMTKCENSRP KPGELAFRKG DMVTILEACE DKSWYRAKHH GSGQEGLLAA 60

AALRQREALS TDPKLSLMPW FHGKISGQEA IQQLQPPEDG LFLVRESARH PGDYVLCVSF 120

GRDVIHYRVL HRDGHLTIDE AVCFCNLMDM VEHYTKDKGA ICTKLVKPRR KQGAKSAEEE 180

LAKAGWLLDL QHLTLGAQIG EGEFGAVLQG EYLGQKVAVK NIKCDVTAQA FLDETAVMTK 240

LQHRNLVRLL GVILHHGLYI VMEHVSKGNL VNFLRTRGRA LVSTSQLLQF ALHVAEGMEY 300

LESKKLVHRD LAARNILVSE DLVAKVSDFG LAKAERKGLD SSRLPVKWTA PEALKNGRFS 360

SKSDVWSFGV LLWEVFSYGR APYPKMSLKE VSEAVEKGYR MEPPDGCPGS VHTLMGSCWE 420

AEPARRPPFR KIVEKLGREL RSVGVSAPAG GQEAEGSAPT RSQDP 465

Nucleotide Sequence
(FASTA)

ATGCCAACGC GCTGGGCCCC TGGGACTCAA TGCATGACCA AGTGTGAGAA CTCTCGCCCC 60

AAGCCCGGTG AGCTAGCCTT TCGAAAGGGT GACATGGTGA CCATCTTGGA GGCCTGTGAG 120

GACAAGAGCT GGTACCGAGC CAAGCACCAT GGCAGTGGGC AGGAAGGGCT GCTGGCGGCC 180

GCTGCTCTGC GACAGCGGGA GGCCCTCTCC ACAGACCCCA AGCTCAGCCT CATGCCATGG 240

TTTCATGGCA AGATCTCCGG CCAGGAAGCC ATACAGCAGC TGCAGCCACC CGAGGACGGG 300

CTGTTCCTTG TGAGGGAATC AGCTCGTCAC CCTGGAGACT ATGTCTTGTG TGTCAGTTTC 360

GGCCGTGACG TCATCCACTA CCGTGTTTTG CATCGAGATG GGCACCTCAC CATCGATGAG 420

GCCGTGTGTT TCTGTAACCT GATGGACATG GTGGAGCACT ACACCAAGGA CAAGGGGGCC 480

ATCTGCACCA AGCTGGTGAA GCCAAGGAGG AAACAGGGCG CAAAGTCTGC AGAGGAGGAG 540

CTCGCCAAGG CTGGCTGGCT ACTCGACCTG CAGCATCTGA CTCTGGGAGC ACAGATTGGA 600

GAGGGGGAGT TTGGAGCCGT CCTACAGGGT GAGTACCTGG GACAGAAGGT GGCTGTGAAG 660

AATATCAAGT GTGATGTGAC AGCCCAGGCC TTCCTGGATG AGACGGCTGT GATGACGAAG 720

CTGCAGCACA GGAACCTAGT GCGACTCCTG GGTGTGATCC TGCACCACGG CTTGTACATT 780

GTCATGGAGC ACGTGAGCAA GGGCAACCTG GTGAACTTCC TGCGCACGCG GGGCCGTGCT 840

CTTGTGAGCA CCTCTCAGCT TCTGCAGTTT GCTCTTCATG TTGCTGAAGG CATGGAATAC 900

CTGGAGAGCA AGAAGCTGGT GCACCGGGAC CTGGCTGCTC GGAACATCCT GGTCTCTGAG 960

GACTTGGTGG CCAAGGTCAG TGACTTTGGC TTAGCCAAGG CAGAGCGCAA GGGGCTGGAC 1020

TCAAGCCGGC TGCCAGTCAA GTGGACGGCA CCTGAGGCTC TCAAAAACGG GCGGTTCTCC 1080

AGCAAGTCGG ATGTCTGGAG TTTTGGGGTG CTGTTGTGGG AAGTCTTCTC TTATGGAAGA 1140

GCCCCATACC CCAAGATGTC GCTAAAGGAG GTTTCAGAGG CTGTGGAGAA GGGTTACCGC 1200

ATGGAGCCCC CCGATGGCTG CCCAGGCTCT GTGCACACCC TCATGGGTAG CTGCTGGGAG 1260

GCAGAGCCTG CGCGCCGACC ACCCTTCCGC AAAATAGTGG AGAAGCTGGG CCGTGAGCTC 1320

CGCAGTGTGG GTGTCTCGGC CCCCGCTGGG GGACAGGAGG CTGAGGGCTC AGCTCCCACA 1380

CGGAGCCAGG ACCCCTGA 1398

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lg++ig+gefg+vl+gey g+kvavk+ik+d+taqaflde++vmtkl+h+nlv+llgv

Q: 193   LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGV  252

         6899********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+v+e+v+kg+lv++lr+rgral++++qll+fal+vaegmeyleskklvhrdl

Q: 253   ILHH-GLYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDL  311

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+lvsedlvakvsdfglak+e+k+lds++lpvkwtapealk+++fs+ksdvwsfg+l

Q: 312   AARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVL  371

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lwe+fs+gr+pyp+++lk+v++avekgy+me+p+gcp++v++lm ++we+e+a+rp+f+k

Q: 372   LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPDGCPGSVHTLMGSCWEAEPARRPPFRK  431

         ************************************************************

S: 241   lkekl  245

         ++ekl

Q: 432   IVEKL  436

         **997

Domain Sequence
(FASTA)

LTLGAQIGEG EFGAVLQGEY LGQKVAVKNI KCDVTAQAFL DETAVMTKLQ HRNLVRLLGV 60

ILHHGLYIVM EHVSKGNLVN FLRTRGRALV STSQLLQFAL HVAEGMEYLE SKKLVHRDLA 120

ARNILVSEDL VAKVSDFGLA KAERKGLDSS RLPVKWTAPE ALKNGRFSSK SDVWSFGVLL 180

WEVFSYGRAP YPKMSLKEVS EAVEKGYRME PPDGCPGSVH TLMGSCWEAE PARRPPFRKI 240

VEKL 244

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

mmu:17179

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013