| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00186 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| AGC/PKA | 483.3 | 3.6E-145 | 31 | 285 | 255 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000101743 |
| UniProt Accession | P68181; P05206; Q3TQH5; Q3UDD0; Q3UTH5; |
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
| Protein Synonyms/Alias | PKA C-beta; |
| Gene Name | Prkacb |
| Gene Synonyms/Alias | Prkacb; Pkacb; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Mediates cAMP-dependent signaling triggered by receptorbinding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). |
| Protein Length | 338 |
Protein Sequence
(FASTA) | | MNVKEFLAKA KEDFLRKWEN PPPSNAGLED FERKKTLGTG SFGRVMLVKH KATEQYYAMK 60 | | ILDKQKVVKL KQIEHTLNEK RILQAVEFPF LVRLEYSFKD NSNLYMVMEY VPGGEMFSHL 120 | | RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL IYRDLKPENL LIDHQGYIQV TDFGFAKRVK 180 | | GRTWTLCGTP EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS 240 | | GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG NLKNGVSDIK THKWFATTDW IAIYQRKVEA 300 | | PFIPKFRGSG DTSNFDDYEE EEIRVSITEK CGKEFCEF 338 |
|
Nucleotide Sequence
(FASTA) | | ATGAATGTGA AAGAGTTTCT AGCCAAAGCC AAAGAAGACT TTCTGAGGAA ATGGGAGAAC 60 | | CCTCCCCCGA GTAATGCTGG GCTTGAGGAT TTTGAGAGGA AGAAAACCCT CGGGACGGGT 120 | | TCCTTTGGAA GAGTCATGTT GGTGAAGCAT AAAGCCACTG AGCAGTACTA CGCCATGAAG 180 | | ATCTTAGACA AGCAGAAGGT TGTTAAGCTG AAGCAAATAG AGCACACTCT GAATGAGAAG 240 | | AGAATCCTGC AGGCCGTGGA GTTCCCGTTC CTTGTGCGGC TGGAGTACTC TTTTAAGGAT 300 | | AATTCTAATT TATACATGGT TATGGAATAC GTCCCTGGGG GAGAGATGTT CTCACATCTG 360 | | AGAAGAATTG GAAGGTTCAG TGAGCCCCAC GCCCGTTTCT ATGCAGCCCA GATTGTGCTA 420 | | ACATTTGAGT ACCTTCATTC CCTCGACCTC ATCTACAGAG ATCTCAAGCC GGAAAACCTC 480 | | TTAATTGACC ACCAGGGTTA CATCCAGGTC ACAGATTTCG GGTTCGCCAA AAGAGTCAAG 540 | | GGCAGGACAT GGACATTGTG TGGCACCCCA GAGTACCTGG CCCCGGAGAT CATCCTCAGC 600 | | AAGGGTTACA ATAAGGCGGT GGACTGGTGG GCACTGGGCG TGCTGATCTA TGAGATGGCT 660 | | GCTGGCTACC CTCCATTCTT TGCTGACCAG CCAATTCAGA TCTATGAGAA GATTGTCTCT 720 | | GGAAAGGTCC GGTTCCCATC ACACTTCAGC TCCGATCTCA AGGACCTTCT GCGGAACCTG 780 | | CTGCAGGTGG ATCTGACAAA GCGATTCGGG AACCTGAAGA ACGGCGTGAG TGACATAAAG 840 | | ACCCACAAGT GGTTTGCCAC AACTGACTGG ATTGCTATTT ATCAGAGAAA GGTTGAGGCT 900 | | CCATTCATAC CAAAGTTCAG AGGCTCTGGC GATACCAGCA ACTTCGATGA CTATGAAGAA 960 | | GAAGAAATCC GTGTGTCTAT AACAGAAAAA TGTGGAAAGG AATTTTGTGA ATTTTAG 1017 |
|
| Domain Profile | S: 1 ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf 60 | fer+ktlGtGsfGrv+lv++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+avefpf | Q: 31 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPF 90 | 799********************************************************* |
| S: 61 lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl 120 | lv+l++sfkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl | Q: 91 LVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 150 | ************************************************************ |
| S: 121 iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww 180 | iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww | Q: 151 IYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW 210 | ************************************************************ |
| S: 181 alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg 240 | alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g | Q: 211 ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG 270 | ************************************************************ |
| S: 241 nlkngvedikehkwf 255 | nlkngv+dik+hkwf | Q: 271 NLKNGVSDIKTHKWF 285 | **************9 |
|
Domain Sequence
(FASTA) | | FERKKTLGTG SFGRVMLVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVEFPF 60 | | LVRLEYSFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120 | | IYRDLKPENL LIDHQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180 | | ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG 240 | | NLKNGVSDIK THKWF 255 |
|
| Keyword | Acetylation; Alternative splicing; ATP-binding; cAMP; Cell membrane; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |