EKS-MUM-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	523.5	2.2E-157	979	1246	268

Status

Reviewed

Ensembl Protein

ENSMUSP00000029711

UniProt Accession

Q9WTL4; B2RQC5;

Protein Name

Insulin receptor-related protein beta chain

Protein Synonyms/Alias

IRR; IR-related receptor;

Gene Name

Insrr

Gene Synonyms/Alias

Insrr; Irr;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000005640	ENSMUSP00000103208	ENSMUST00000107582
ENSMUSG00000005640	ENSMUSP00000029711	ENSMUST00000029711

Organism

Mus musculus

Functional Description

Receptor with tyrosine-protein kinase activity.Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Protein Length

1300

Protein Sequence
(FASTA)

MAVPALWPWG VHLLMSLLSL GSGLDTLEVC PSLDIRSEVT ELRRLENCSV VEGHLQILLM 60

FAATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LTVIRGTRLF LGYALIIFEM 120

PHLRDVGLPS LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGTNHIVGN KLGEECADVC 180

PGVLGAAGEP CSRTTFSGRT DYRCWTSSHC QKVCPCPRGM ACTAGGDCCH SECLGGCSQP 240

EDPRACVACR HLYFQGVCLR ACPPGTYQYE SWRCVTAELC AHLREVPGLA TTFGIYEGSC 300

LAQCPPGFTR NGSSIFCHKC EGLCPKECKV GTKTIDSVQA TQDLVGCTHV EGNLILNLRQ 360

GYNLEPELQR NLGLVETITG FLKIKHSFAL VTLGFFKNLK LIRGDSMVDG NYTLYVLDNQ 420

NLQQLGSWVT AGLTIPVGKI YFAFNPRLCL EHIYQLEEVT GTRGRQSKAE INPRTNGDRA 480

ACQTRTLRFV FNLTEEDRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT 540

QSWNLLDVEL PLSRTQEPGV TLAPLKPWTQ YAVFVRAITL TTAEDSPHQG AQSPIVYLRT 600

LPAAPTVPQD VISTSNSSSH LLVRWKPPVQ RNGNITYYLV LWQRLAEDGD LYINDYCHRG 660

LRLPTSSHDT RFDREDPALE AEPEQGCCPC QHSPPGQALP ALEAQEVTFQ KKFENFLHHA 720

ITIPKAPWKV TSINKNPQRD SERHRREAGL LRLGKNNSDF EIQEDKVPRE RAILSGLRHF 780

TEYRIDIHAC NHAAHTVGCS AATFVFARTM PHREADGIPG KVAWKAAGKS SVTLHWLEPP 840

DPNGLILKYE IKYRRLGEEA TVLCVSRLRY AKVGGVHLAL LPPGNYSAKV RATSLAGNGS 900

WTDGVTFYIT DLEEEDTGGM RIFLTVTPVG FMLLVTLAAL GFFYSRKRNS TLYTSVNPEY 960

FSASHMYVPD EWEVPREQIA IIRELGQGSF GMVYEGLARG LEAGEESTPV ALKTVNELAS 1020

ARERVEFLKE ASVMKAFKCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSH LRSLRPEAEN 1080

NPGLPQPALS DMIQMAGEIA DGMAYLAAKK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 1140

YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIVTLAE QPYQGLSNEQ 1200

VLKFVMDGGV LEELENCPIQ LQELMRLCWQ HSPRLRPTFV HILDRIQDEL RPSFRLCSFY 1260

YSPECQRGQA SLLPTEAEPD SPPTLNGASD YSAPNGGPGH 1300

Nucleotide Sequence
(FASTA)

ATGGCAGTGC CTGCTCTGTG GCCCTGGGGA GTACACTTGC TTATGAGCCT GCTGTCCTTG 60

GGATCTGGCC TGGACACACT AGAGGTGTGC CCCAGCCTGG ATATCCGCTC GGAGGTGACC 120

GAGCTCCGTC GGCTGGAGAA CTGCAGTGTG GTGGAGGGTC ACCTGCAGAT CCTTCTTATG 180

TTTGCTGCCA CTGGAGAGGA TTTCCGAGGC CTCAGCTTTC CTCGCCTTAC CCAGGTGACT 240

GACTACCTGC TGTTGTTCCG AGTCTATGGC CTGGAGAGCC TTCGAGACCT CTTCCCCAAC 300

CTCACTGTGA TCCGAGGCAC CCGGCTCTTC CTGGGCTACG CACTCATTAT CTTTGAGATG 360

CCCCACCTAC GGGACGTCGG GCTGCCGTCG CTTGGGGCCG TGCTGCGTGG GGCCGTGCGT 420

GTGGAGAAGA ACCAGGAACT TTGCCATCTC TCCACCATTG ACTGGGGTCT GCTGCAGCCT 480

GCACCTGGTA CCAACCACAT TGTAGGAAAC AAGCTGGGCG AGGAGTGTGC AGACGTGTGC 540

CCCGGTGTGC TGGGAGCTGC TGGTGAGCCC TGTTCGAGAA CCACCTTCAG CGGGCGCACT 600

GACTACAGGT GCTGGACGTC CAGCCACTGT CAGAAAGTGT GTCCCTGCCC CCGAGGGATG 660

GCCTGCACAG CAGGCGGTGA TTGCTGCCAC AGTGAGTGTC TGGGGGGCTG CAGCCAGCCT 720

GAAGACCCTC GAGCCTGTGT AGCTTGCCGC CACCTCTACT TCCAAGGAGT CTGCCTCCGA 780

GCCTGCCCTC CGGGCACCTA CCAATATGAG TCCTGGCGCT GTGTCACCGC GGAGCTCTGC 840

GCTCATCTGC GTGAGGTTCC TGGACTTGCC ACCACCTTCG GCATCTACGA GGGCAGCTGC 900

CTAGCTCAGT GCCCTCCAGG CTTCACCCGC AATGGCAGCA GCATTTTCTG CCATAAGTGT 960

GAGGGCCTGT GCCCCAAAGA GTGCAAGGTT GGGACAAAGA CCATCGACTC TGTCCAAGCC 1020

ACACAGGACC TGGTGGGCTG CACCCACGTG GAGGGAAACC TCATCCTCAA CCTTCGCCAA 1080

GGCTACAATC TGGAGCCAGA GCTTCAACGC AACCTGGGTC TGGTGGAGAC CATCACTGGC 1140

TTCCTCAAAA TCAAGCACTC TTTTGCACTC GTGACCCTGG GCTTTTTCAA GAACCTCAAA 1200

CTAATCCGGG GAGATTCCAT GGTGGATGGG AATTACACTC TCTACGTATT GGACAACCAG 1260

AACCTGCAAC AGTTGGGATC CTGGGTGACC GCGGGGCTCA CCATTCCCGT GGGCAAAATA 1320

TACTTCGCCT TCAACCCACG CCTCTGCTTG GAGCACATAT ACCAACTGGA GGAGGTGACG 1380

GGAACCAGAG GTCGGCAGAG CAAGGCTGAA ATCAACCCCC GGACCAATGG AGATCGGGCT 1440

GCCTGTCAGA CTCGCACTCT ACGTTTTGTG TTCAACCTGA CGGAGGAAGA CCGCATCCTC 1500

CTGCGCTGGG AGCGCTATGA GCCACTGGAG GCCCGTGACC TGCTCAGCTT CATTGTCTAT 1560

TACAAGGAGT CCCCATTTCA GAATGCCACA GAACACGTGG GTCCAGATGC CTGTGGAACC 1620

CAGAGCTGGA ACCTGTTGGA TGTGGAACTA CCCCTCAGCC GCACCCAGGA ACCAGGGGTA 1680

ACCCTGGCCC CCCTTAAGCC CTGGACACAG TATGCTGTGT TTGTGCGGGC CATCACACTG 1740

ACCACCGCTG AGGACAGTCC CCATCAGGGA GCCCAGAGCC CCATTGTCTA CCTGCGAACA 1800

TTGCCTGCTG CACCCACGGT GCCCCAAGAT GTCATCTCCA CCTCCAACTC CTCTTCCCAC 1860

CTCCTGGTGC GCTGGAAGCC ACCGGTCCAG CGCAATGGAA ACATCACCTA CTACCTGGTG 1920

CTGTGGCAGC GCCTGGCGGA GGACGGTGAC CTCTACATCA ATGACTACTG CCACCGCGGT 1980

CTGCGGCTGC CCACCAGCAG CCACGACACA CGCTTCGACC GTGAAGACCC GGCGCTGGAG 2040

GCTGAGCCGG AACAAGGCTG CTGTCCTTGC CAACACTCAC CTCCTGGGCA GGCCCTGCCT 2100

GCACTGGAGG CTCAAGAGGT CACCTTCCAG AAAAAATTTG AAAACTTCCT ACACCATGCC 2160

ATCACCATCC CCAAGGCTCC ATGGAAAGTG ACATCCATCA ACAAGAACCC CCAAAGGGAT 2220

TCGGAGAGGC ACCGCAGGGA AGCTGGACTT CTCAGACTAG GGAAAAACAA CTCGGATTTT 2280

GAGATTCAAG AGGACAAGGT TCCCCGGGAG CGAGCGATAT TGAGCGGCTT ACGGCACTTC 2340

ACAGAGTACA GGATTGACAT CCATGCCTGC AACCACGCTG CGCACACTGT GGGCTGCAGC 2400

GCCGCCACCT TCGTCTTTGC ACGCACCATG CCACATAGAG AGGCCGATGG CATCCCGGGG 2460

AAAGTGGCCT GGAAGGCAGC TGGCAAGAGC AGTGTCACCT TGCATTGGCT TGAACCACCT 2520

GACCCCAATG GGCTCATTCT CAAGTATGAA ATCAAGTACC GACGTCTGGG AGAGGAGGCC 2580

ACAGTGCTTT GTGTGTCCCG TCTTCGATAT GCCAAAGTCG GTGGAGTCCA CCTGGCTCTG 2640

CTGCCCCCTG GAAACTACTC TGCTAAAGTT CGGGCCACCT CGTTGGCTGG CAATGGTTCC 2700

TGGACTGACG GTGTTACCTT CTACATCACC GATCTAGAGG AAGAGGATAC CGGGGGGATG 2760

CGCATCTTCC TCACTGTCAC CCCTGTGGGG TTCATGCTGC TCGTGACACT TGCTGCCCTC 2820

GGTTTCTTCT ACAGCAGAAA GAGAAACAGC ACGCTGTACA CATCCGTGAA CCCCGAGTAT 2880

TTCAGTGCAT CCCACATGTA TGTCCCCGAC GAGTGGGAGG TGCCTCGGGA GCAGATAGCC 2940

ATCATCCGGG AGCTGGGCCA AGGCTCTTTT GGGATGGTCT ATGAGGGACT GGCCCGAGGA 3000

CTTGAGGCTG GAGAGGAGTC CACGCCTGTA GCCCTGAAGA CAGTTAATGA GCTGGCCAGC 3060

GCTCGGGAAC GCGTTGAATT CCTCAAGGAA GCATCTGTCA TGAAGGCATT CAAGTGTCAC 3120

CATGTGGTTC GTCTCCTGGG TGTGGTGTCT CAGGGCCAGC CAACTCTGGT CATCATGGAG 3180

TTAATGACCC GTGGGGACCT CAAGAGCCAT CTCCGATCTC TGAGACCTGA GGCAGAGAAC 3240

AACCCCGGCC TCCCGCAGCC TGCACTCAGT GACATGATTC AGATGGCAGG GGAAATTGCA 3300

GATGGCATGG CCTACCTTGC TGCCAAGAAG TTTGTGCACC GGGACCTGGC GGCCCGCAAC 3360

TGCATGGTGT CCCAGGATTT CACAGTCAAA ATTGGTGACT TTGGAATGAC TCGGGATGTG 3420

TATGAGACAG ACTATTACCG CAAGGGTGGA AAAGGGTTAC TGCCAGTGCG CTGGATGGCC 3480

CCCGAGTCCC TCAAAGATGG AATCTTCACC ACTCACTCAG ATGTCTGGTC CTTCGGTGTG 3540

GTGCTCTGGG AGATTGTGAC CCTGGCCGAA CAACCATACC AGGGTCTATC AAATGAGCAG 3600

GTGCTGAAAT TTGTCATGGA TGGTGGAGTT CTAGAGGAGC TGGAGAACTG TCCGATTCAG 3660

CTACAAGAGC TGATGAGACT CTGCTGGCAG CATAGTCCAC GCCTGCGCCC GACTTTCGTC 3720

CACATCCTGG ATCGCATACA GGATGAGCTT CGGCCCTCTT TCCGGCTCTG CTCCTTCTAC 3780

TACAGCCCAG AGTGCCAGCG GGGTCAGGCC TCCTTGCTGC CTACTGAGGC AGAACCTGAT 3840

TCCCCACCAA CCTTAAATGG AGCTTCAGAC TATAGTGCCC CAAATGGGGG CCCAGGACAC 3900

TGA 3903

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as+rer+eflkeasvmk+fk

Q: 979   IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFK  1038

         6899********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e

Q: 1039  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALSDMIQMAGE  1098

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1099  IADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1158

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle++encp

Q: 1159  MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCP  1218

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l+elmrlcwq++p+lrp+f++i++++

Q: 1219  IQLQELMRLCWQHSPRLRPTFVHILDRI  1246

         ************************9975

Domain Sequence
(FASTA)

IAIIRELGQG SFGMVYEGLA RGLEAGEEST PVALKTVNEL ASARERVEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPQPA LSDMIQMAGE 120

IADGMAYLAA KKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELENCP 240

IQLQELMRLC WQHSPRLRPT FVHILDRI 268

Keyword

ATP-binding; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0071469	; P:cellular response to alkalinity
GO:0030238	; P:male sex determination
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mmu:23920

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013