EKS-MUM-00124

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00124

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	482.8	6.0E-145	1076	1336	261

Status

Unreviewed

Ensembl Protein

ENSMUSP00000079324

UniProt Accession

F8VQL0;

Protein Name

Protein Synonyms/Alias

Hepatocyte growth factor receptor;

Gene Name

Met

Gene Synonyms/Alias

Met;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000009376	ENSMUSP00000118755	ENSMUST00000152802
ENSMUSG00000009376	ENSMUSP00000079324	ENSMUST00000080469
ENSMUSG00000009376	ENSMUSP00000111102	ENSMUST00000115442
ENSMUSG00000009376	ENSMUSP00000121923	ENSMUST00000148903
ENSMUSG00000009376	ENSMUSP00000117856	ENSMUST00000140070
ENSMUSG00000009376	ENSMUSP00000111103	ENSMUST00000115443

Organism

Mus musculus

Functional Description

Protein Length

1379

Protein Sequence
(FASTA)

MKAPTVLAPG ILVLLLSLVQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIQNVVLHGH 60

HIYLGATNYI YVLNDKDLQK VSEFKTGPVL EHPDCLPCRD CSSKANSSGG VWKDNINMAL 120

LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN SADIQSEVHC MFSPEEESGQ CPDCVVSALG 180

AKVLLSEKDR FINFFVGNTI NSSYPPGYSL HSISVRRLKE TQDGFKFLTD QSYIDVLPEF 240

QDSYPIKYIH AFESNHFIYF LTVQKETLDA QTFHTRIIRF CSVDSGLHSY MEMPLECILT 300

EKRRKRSTRE EVFNILQAAY VSKPGANLAK QIGASPSDDI LFGVFAQSKP DSAEPVNRSA 360

VCAFPIKYVN DFFNKIVNKN NVRCLQHFYG PNHEHCFNRT LLRNSSGCEA RSDEYRTEFT 420

TALQRVDLFM GRLNQVLLTS ISTFIKGDLT IANLGTSEGR FMQVVLSRTA HLTPHVNFLL 480

DSHPVSPEVI VEHPSNQNGY TLVVTGKKIT KIPLNGLGCG HFQSCSQCLS APYFIQCGWC 540

HNQCVRFDEC PSGTWTQEIC LPAVYKVFPT SAPLEGGTVL TICGWDFGFR KNNKFDLRKT 600

KVLLGNESCT LTLSESTTNT LKCTVGPAMS EHFNVSVIIS NSRETTQYSA FSYVDPVITS 660

ISPRYGPQAG GTLLTLTGKY LNSGNSRHIS IGGKTCTLKS VSDSILECYT PAQTTSDEFP 720

VKLKIDLANR ETSSFSYRED PVVYEIHPTK SFISGGSTIT GIGKTLNSVS LPKLVIDVHE 780

VGVNYTVACQ HRSNSEIICC TTPSLKQLGL QLPLKTKAFF LLDGILSKHF DLTYVHNPVF 840

EPFEKPVMIS IGNENVVEIK GNNIDPEAVK GEVLKVGNQS CESLHWHSGA VLCTVPSDLL 900

KLNSELNIEW KQAVSSTVLG KVIVQPDQNF AGLIIGAVSI SVVVLLLSGL FLWMRKRKHK 960

DLGSELVRYD ARVHTPHLDR LVSARSVSPT TEMVSNESVD YRATFPEDQF PNSSQNGACR 1020

QVQYPLTDLS PILTSGDSDI SSPLLQNTVH IDLSALNPEL VQAVQHVVIG PSSLIVHFNE 1080

VIGRGHFGCV YHGTLLDNDG KKIHCAVKSL NRITDIEEVS QFLTEGIIMK DFSHPNVLSL 1140

LGICLRSEGS PLVVLPYMKH GDLRNFIRNE THNPTVKDLI GFGLQVAKGM KYLASKKFVH 1200

RDLAARNCML DEKFTVKVAD FGLARDMYDK EYYSVHNKTG AKLPVKWMAL ESLQTQKFTT 1260

KSDVWSFGVL LWELMTRGAP PYPDVNTFDI TIYLLQGRRL LQPEYCPDAL YEVMLKCWHP 1320

KAEMRPSFSE LVSRISSIFS TFIGEHYVHV NATYVNVKCV APYPSLLPSQ DNIDGEGNT 1379

Nucleotide Sequence
(FASTA)

ATGAAGGCTC CCACCGTGCT GGCACCTGGC ATTCTGGTGC TGCTGTTGTC CTTGGTGCAG 60

AGGAGCCATG GGGAGTGCAA GGAGGCCCTA GTGAAGTCTG AGATGAACGT GAACATGAAG 120

TATCAGCTCC CCAACTTCAC GGCAGAAACC CCCATCCAGA ATGTCGTCCT ACACGGCCAT 180

CATATTTATC TCGGAGCCAC AAACTACATT TATGTTTTAA ATGACAAAGA CCTTCAGAAG 240

GTATCCGAAT TCAAGACCGG GCCCGTGTTG GAACACCCAG ATTGTTTACC TTGTCGGGAC 300

TGCAGCAGCA AAGCCAATTC ATCAGGAGGG GTTTGGAAAG ACAACATCAA CATGGCTCTG 360

CTTGTTGACA CATACTATGA TGATCAACTC ATTAGCTGTG GCAGTGTCAA CAGAGGGACT 420

TGCCAGCGGC ATGTCCTTCC TCCTGACAAT TCTGCTGACA TCCAGTCTGA GGTCCACTGC 480

ATGTTCTCCC CAGAAGAGGA GTCAGGGCAG TGTCCTGACT GTGTAGTGAG TGCCCTCGGA 540

GCCAAAGTCC TCCTGTCGGA AAAGGACCGG TTCATCAATT TCTTTGTGGG GAATACGATC 600

AATTCCTCCT ATCCTCCTGG TTATTCACTG CATTCGATAT CGGTGAGACG GCTGAAGGAA 660

ACCCAAGATG GTTTTAAGTT TTTGACAGAC CAGTCCTATA TTGATGTCTT ACCAGAATTC 720

CAAGATTCCT ACCCCATAAA GTACATACAT GCCTTCGAAA GCAACCATTT TATTTACTTT 780

CTGACTGTCC AAAAGGAAAC TCTAGATGCT CAGACTTTTC ATACAAGAAT AATCAGGTTC 840

TGTTCCGTAG ACTCTGGGTT GCACTCCTAC ATGGAAATGC CCCTGGAATG CATCCTGACA 900

GAAAAAAGAA GGAAGAGATC CACAAGGGAA GAAGTGTTTA ATATCCTCCA AGCCGCGTAT 960

GTCAGTAAAC CAGGGGCCAA TCTTGCTAAG CAAATAGGAG CTAGCCCTTC TGATGACATT 1020

CTCTTCGGGG TGTTTGCACA AAGCAAGCCA GATTCTGCTG AACCTGTGAA TCGATCAGCA 1080

GTCTGTGCAT TCCCCATCAA ATATGTCAAT GACTTCTTCA ACAAGATTGT CAACAAAAAC 1140

AACGTGAGAT GTCTCCAGCA TTTTTACGGA CCCAACCATG AGCACTGTTT CAATAGGACC 1200

CTGCTGAGAA ACTCTTCCGG CTGTGAAGCG CGCAGTGACG AGTATCGGAC AGAGTTTACC 1260

ACGGCTTTGC AGCGCGTCGA CTTATTCATG GGCCGGCTTA ACCAAGTGCT CCTGACATCC 1320

ATCTCCACCT TCATCAAAGG TGACCTCACC ATTGCTAATC TAGGGACGTC AGAAGGTCGC 1380

TTCATGCAGG TGGTGCTCTC TCGAACAGCA CACCTCACTC CTCATGTGAA CTTCCTCCTG 1440

GACTCCCATC CTGTATCTCC AGAAGTTATT GTTGAGCATC CATCAAATCA AAATGGCTAT 1500

ACATTGGTTG TCACAGGAAA GAAGATCACC AAGATTCCAT TGAATGGCCT GGGCTGTGGA 1560

CATTTCCAAT CCTGCAGTCA GTGCCTCTCT GCCCCTTACT TTATACAGTG TGGCTGGTGC 1620

CACAATCAAT GTGTGCGTTT TGATGAATGC CCCAGCGGTA CATGGACTCA AGAGATCTGT 1680

CTGCCGGCGG TTTATAAGGT GTTCCCCACC AGCGCGCCCC TTGAAGGAGG AACAGTGTTG 1740

ACCATATGTG GCTGGGACTT TGGATTCAGG AAGAATAATA AATTTGATTT AAGGAAAACC 1800

AAAGTTCTGC TTGGCAACGA GAGCTGTACC TTGACCTTAA GCGAGAGCAC GACAAATACG 1860

TTGAAATGCA CAGTTGGTCC CGCGATGAGT GAGCACTTCA ATGTGTCTGT AATTATCTCA 1920

AACAGTCGAG AGACGACGCA ATACAGTGCA TTCTCCTATG TAGATCCTGT AATAACAAGC 1980

ATTTCTCCGA GGTACGGCCC TCAGGCTGGA GGCACCTTAC TCACTCTTAC TGGGAAATAC 2040

CTCAACAGTG GCAATTCTAG ACACATTTCA ATTGGAGGGA AAACATGTAC TTTAAAAAGT 2100

GTATCAGATA GTATTCTTGA ATGCTACACC CCAGCCCAAA CTACCTCTGA TGAGTTTCCT 2160

GTGAAATTGA AGATTGACTT GGCTAACCGA GAGACCAGCA GCTTCAGTTA CCGGGAAGAC 2220

CCCGTTGTCT ATGAAATCCA CCCGACCAAA TCTTTTATTA GTGGTGGAAG CACAATAACG 2280

GGTATTGGGA AGACCCTGAA CTCGGTTAGC CTCCCAAAGC TGGTAATAGA TGTGCATGAA 2340

GTGGGTGTGA ACTACACAGT GGCATGTCAG CATCGCTCAA ATTCAGAGAT CATCTGCTGC 2400

ACTACTCCTT CACTGAAACA GCTGGGCCTG CAACTCCCCC TGAAGACCAA AGCCTTCTTC 2460

CTGTTAGACG GGATTCTTTC CAAACACTTT GATCTCACTT ATGTGCATAA TCCTGTGTTT 2520

GAGCCTTTTG AAAAGCCAGT AATGATCTCA ATAGGCAATG AAAATGTAGT GGAAATTAAG 2580

GGAAACAATA TTGACCCTGA AGCAGTTAAA GGTGAAGTGT TAAAAGTTGG AAATCAGAGC 2640

TGCGAGAGTC TCCACTGGCA CTCTGGAGCT GTGTTGTGTA CAGTCCCCAG TGACCTGCTC 2700

AAACTGAACA GCGAGCTAAA TATAGAGTGG AAGCAAGCAG TCTCTTCAAC TGTTCTTGGA 2760

AAAGTGATCG TTCAACCGGA TCAGAATTTT GCAGGATTGA TCATTGGTGC GGTCTCAATA 2820

TCAGTAGTAG TTTTGTTATT ATCCGGGCTC TTCCTGTGGA TGAGAAAGAG AAAGCATAAA 2880

GATCTGGGCA GTGAATTAGT TCGCTATGAC GCAAGAGTAC ACACTCCTCA TTTGGATAGG 2940

CTTGTAAGTG CCCGAAGTGT AAGTCCAACT ACAGAGATGG TTTCAAATGA GTCTGTAGAC 3000

TACAGAGCTA CTTTTCCAGA AGACCAGTTT CCCAACTCCT CTCAGAATGG AGCATGCAGA 3060

CAAGTGCAAT ACCCTCTGAC AGACCTGTCC CCTATCCTGA CAAGTGGAGA CTCTGATATA 3120

TCCAGCCCAT TACTACAAAA TACTGTTCAC ATTGACCTCA GTGCTCTAAA TCCAGAGCTG 3180

GTCCAAGCAG TTCAGCACGT AGTGATTGGA CCCAGCAGCC TGATTGTGCA TTTCAATGAA 3240

GTCATAGGAA GAGGGCATTT TGGCTGTGTC TATCATGGGA CTTTGCTGGA CAATGACGGA 3300

AAGAAAATTC ACTGTGCTGT GAAATCCTTA AATAGAATCA CAGATATAGA AGAGGTCTCC 3360

CAGTTTCTGA CTGAGGGAAT CATCATGAAA GACTTCAGCC ATCCCAATGT TCTCTCACTC 3420

TTGGGAATCT GCCTGAGGAG TGAAGGGTCT CCTCTGGTGG TCCTGCCCTA TATGAAGCAT 3480

GGAGATCTGC GAAATTTCAT TCGAAACGAG ACTCATAATC CAACTGTGAA AGATCTTATA 3540

GGATTTGGCC TTCAAGTAGC CAAAGGCATG AAATATCTTG CCAGCAAAAA GTTTGTCCAC 3600

AGAGACTTAG CTGCAAGAAA CTGCATGTTG GATGAAAAAT TCACTGTCAA GGTTGCTGAT 3660

TTCGGTCTTG CCAGAGACAT GTACGATAAA GAGTACTATA GTGTCCACAA CAAGACGGGT 3720

GCCAAGCTAC CAGTAAAGTG GATGGCTTTA GAGAGTCTGC AAACGCAGAA GTTCACCACC 3780

AAGTCAGATG TGTGGTCCTT TGGTGTGCTC CTCTGGGAGC TCATGACGAG AGGAGCCCCT 3840

CCTTATCCCG ACGTGAACAC ATTTGATATC ACTATCTACC TGTTGCAAGG CAGAAGACTC 3900

TTGCAACCAG AATACTGTCC AGACGCCTTG TACGAAGTGA TGCTAAAATG CTGGCACCCC 3960

AAAGCGGAAA TGCGCCCGTC CTTTTCCGAA CTGGTCTCCA GGATATCCTC AATCTTCTCC 4020

ACGTTCATTG GGGAACACTA CGTCCACGTG AACGCTACTT ATGTGAATGT AAAATGTGTT 4080

GCTCCATATC CTTCTCTGTT GCCATCCCAA GACAACATTG ATGGCGAGGG GAACACATGA 4140

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdie+v++fl+eg++mk+++hp

Q: 1076  VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHP  1135

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1136  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1195

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1196  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1255

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd+ly+vm

Q: 1256  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVM  1314

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1315  LKCWHPKAEMRPSFSELVSRIS  1336

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IEEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITIYLL QGRRLLQPEY CPDALYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0005737	; C:cytoplasm
GO:0060076	; C:excitatory synapse
GO:0005615	; C:extracellular space
GO:0019861	; C:flagellum
GO:0016021	; C:integral to membrane
GO:0043025	; C:neuronal cell body
GO:0014069	; C:postsynaptic density
GO:0045211	; C:postsynaptic membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0007569	; P:cell aging
GO:0071243	; P:cellular response to arsenic-containing substance
GO:0071333	; P:cellular response to glucose stimulus
GO:0071363	; P:cellular response to growth factor stimulus
GO:0071354	; P:cellular response to interleukin-6
GO:0071375	; P:cellular response to peptide hormone stimulus
GO:0021953	; P:central nervous system neuron differentiation
GO:0042593	; P:glucose homeostasis
GO:0007595	; P:lactation
GO:0001889	; P:liver development
GO:0008584	; P:male gonad development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0010801	; P:negative regulation of peptidyl-threonine phosphorylation
GO:0001764	; P:neuron migration
GO:0014003	; P:oligodendrocyte development
GO:0031016	; P:pancreas development
GO:0001890	; P:placenta development
GO:0050775	; P:positive regulation of dendrite morphogenesis
GO:0045740	; P:positive regulation of DNA replication
GO:0010628	; P:positive regulation of gene expression
GO:0010828	; P:positive regulation of glucose transport
GO:0045840	; P:positive regulation of mitosis
GO:0010976	; P:positive regulation of neuron projection development
GO:0033138	; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0001101	; P:response to acid
GO:0042493	; P:response to drug
GO:0014070	; P:response to organic cyclic compound
GO:0009611	; P:response to wounding
GO:0030317	; P:sperm motility

KEGG

mmu:17295

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013