EKS-MUM-00535
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00535
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/BCRN/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinENSMUSP00000126377
UniProt AccessionQ6PAJ1; E9PZL3; Q61339; Q6ZPE5; Q99LW5;
Protein NameBreakpoint cluster region protein
Protein Synonyms/Alias
Gene NameBcr
Gene Synonyms/Alias Bcr; Kiaa3017;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000009681ENSMUSP00000126377ENSMUST00000164107
OrganismMus musculus
Functional DescriptionGTPase-activating protein for RAC1 and CDC42. Promotesthe exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (By similarity).
Protein Length1270
Protein Sequence
(FASTA)
MVDSVGFAEA WRAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ 60
TLLAKEKKSY DRQRWGFRRA AQPPDGAAEP RASAPRPPPA PADGADPAPV EESEARPDGE 120
GSPSKGRSAS ARRPAAAASA DRDDRGPPTS VAALRSNFEK IRKGPAQPGS ADAEKPFYVN 180
VEFHHERGLV KVNDKEVSDR ISSLGSQAMQ MERKKSQQSA GQGLGEAPRP HYRGRSSESS 240
CGLDGDYEDA ELNPRFLKDN LINANGGNRP PWPPLEYQPY QSIYVGGMMV EGEGKSPLLR 300
SQSTSEQEKR LTWPRRSYSP RSFEDSGGGY TPDCSSNENL TSSEEDFSSG QSSRVSPSPT 360
TYRMFRDKSR SPSQNSQQSF DSSSPPTPQC QKRHRQCQVV VSEATIVGVR KTGQIWPSDG 420
DSTFQGEADS SFGTPPGYGC AADQAEEQRR HQDGLPYIDD SPSSSPHLSS KGRGSLASGA 480
LDPTKVSELD LEKGLEMRKW VLSGILASEE TYLSHLEALL LPMKPLKAAA TTSQPVLTSQ 540
QIETIFFKVP ELYEIHKEFY DGLFPRVQQW SHQQRVGDLF QKLASQLGVY RAFVDNYGVA 600
METAEKCCQA NAQFAEISEN LRARSNKDVK DSTTKNSLET LLYKPVDRVT RSTLVLHDLL 660
KHTPSSHPDH SLLQDALRIS QNFLSSINEE ITPRRQSMTV KKGEHRQLLK DSFMVELVEG 720
ARKLRHIFLF TDLLLCTKLK KQSGGKTQQY DCKWYIPLTD LSFQMVDELE ALPNIPLVPD 780
EELDALKIKI SQIKSDIQRE KRANKGSKVM ERLRKKLSEQ ESLLLLMSPS MAFRVHSRNG 840
KSYTFLISSD YERAEWRESI REQQKKCFKS FSLTSVELQM LTNSCVKLQT VHHIPLTINK 900
EDDESPGLYG FLHVIVHSAT GFKQSSNLYC TLEVDSFGYF VNKAKTRVYR DTTEPNWNEE 960
FEIELEGSQT LRILCYEKCY NKMKMTKEDG ESADKLMGKG QVQLDPQTLQ DRDWQRTVID 1020
MNGIEVKLSV KFTSREFSLK RMPSRKQTGV FGVKIAVVTK RERSKVPYIV RQCVEEIERR 1080
GMEEVGIYRV SGVATDIQAL KAAFDVNNKD VSVMMSEMDV NAIAGTLKLY FRELPEPLFT 1140
DEFYPNFAEG IALSDPVAKE SCMLNLLLSL PEANLLTFLF LLDHLKRVAE KETVNKMSLH 1200
NLATVFGPTL LRPSEKESKL PANPSQPITM TDSWSLEVMS QVQVLLYFLQ LEAIPAPDSK 1260
RQSILFSTEV 1270
Nucleotide Sequence
(FASTA)
ATGGTGGACT CGGTGGGCTT CGCCGAGGCG TGGAGGGCGC AGTTCCCGGA CTCGGAGCCG 60
CCGCGCATGG AGCTGCGCTC GGTGGGTGAC ATCGAGCAGG AGCTGGAGCG CTGCAAGGCC 120
TCCATTAGGC GCTTGGAGCA GGAGGTGAAC CAGGAGCGCT TCCGCATGAT CTACCTGCAG 180
ACGCTGCTGG CCAAGGAGAA GAAGAGCTAC GATCGGCAGC GCTGGGGCTT CCGCCGTGCA 240
GCGCAGCCCC CCGACGGCGC CGCCGAGCCC CGAGCGTCCG CCCCGCGCCC GCCGCCCGCG 300
CCCGCCGACG GCGCAGACCC GGCGCCCGTC GAGGAGTCCG AGGCGCGGCC GGACGGAGAG 360
GGGTCACCGA GTAAGGGGCG GTCAGCGTCC GCCCGCAGGC CAGCGGCTGC TGCATCGGCG 420
GACCGGGACG ACCGAGGGCC CCCCACCAGC GTGGCGGCGC TCAGATCCAA CTTCGAGAAG 480
ATCCGCAAGG GACCTGCCCA GCCCGGCTCT GCCGACGCCG AGAAGCCCTT CTACGTGAAC 540
GTCGAGTTCC ACCACGAGCG CGGCCTGGTG AAGGTCAACG ACAAAGAGGT GTCCGACCGA 600
ATCAGTTCCC TGGGCAGCCA GGCCATGCAA ATGGAGCGCA AGAAGTCCCA GCAGAGCGCC 660
GGGCAGGGCC TGGGGGAAGC ACCCAGACCC CATTACCGTG GGCGCTCCTC GGAAAGCAGT 720
TGCGGCCTTG ACGGTGACTA TGAGGATGCA GAGTTGAATC CCCGCTTCCT GAAGGACAAC 780
CTAATAAATG CCAACGGCGG CAACAGGCCC CCTTGGCCGC CCCTGGAGTA CCAACCCTAC 840
CAGAGCATCT ATGTCGGAGG CATGATGGTG GAAGGGGAGG GCAAGAGCCC TCTCCTGCGA 900
AGCCAGAGCA CTTCAGAGCA GGAGAAACGC CTAACCTGGC CTCGCAGGTC CTACTCGCCT 960
CGGAGTTTCG AGGACAGCGG AGGTGGCTAC ACGCCGGACT GCAGCTCCAA CGAGAACCTC 1020
ACCTCCAGCG AGGAGGACTT TTCCTCTGGC CAGTCCAGCC GCGTGTCACC AAGCCCCACC 1080
ACCTACCGCA TGTTCCGGGA CAAGAGCCGC TCACCCTCGC AGAATTCGCA GCAGTCCTTT 1140
GACAGCAGCA GCCCCCCGAC GCCACAGTGC CAGAAGCGGC ACCGGCAGTG CCAGGTTGTG 1200
GTGTCTGAGG CTACCATCGT GGGTGTCCGC AAGACTGGGC AGATCTGGCC CAGTGATGGG 1260
GACAGCACCT TTCAAGGGGA AGCAGATTCC TCGTTTGGAA CACCACCTGG ATATGGCTGT 1320
GCCGCAGACC AGGCTGAGGA ACAGCGCCGG CACCAGGACG GGCTGCCCTA CATCGATGAT 1380
TCACCTTCTT CCTCGCCACA CCTCAGCAGC AAAGGCAGAG GCAGCCTGGC CTCAGGCGCC 1440
CTGGATCCCA CCAAAGTGAG TGAGCTGGAT CTGGAAAAGG GCCTGGAGAT GAGAAAGTGG 1500
GTTTTGTCCG GAATCCTGGC CAGCGAGGAG ACGTACCTGA GCCATCTGGA GGCCCTGCTG 1560
CTGCCCATGA AGCCTCTGAA AGCCGCTGCC ACCACCTCTC AGCCTGTGCT GACCAGCCAG 1620
CAGATTGAGA CCATTTTCTT CAAAGTGCCT GAGCTCTACG AGATCCACAA GGAGTTCTAC 1680
GATGGGCTGT TCCCCCGAGT GCAGCAGTGG AGCCACCAGC AGCGTGTAGG GGACCTCTTC 1740
CAGAAGCTGG CCAGCCAGCT GGGTGTGTAC CGAGCCTTTG TGGATAACTA CGGAGTGGCC 1800
ATGGAAACTG CAGAGAAGTG CTGTCAGGCC AACGCTCAGT TTGCAGAAAT CTCTGAGAAC 1860
CTGCGAGCCA GAAGCAACAA GGATGTCAAG GACTCAACTA CCAAGAACTC TTTGGAAACT 1920
CTGCTCTACA AACCTGTGGA CCGGGTGACG AGGAGCACGC TAGTCCTTCA CGACTTGCTA 1980
AAACACACCC CGTCCAGCCA TCCCGACCAT TCCCTGCTGC AAGACGCCCT CCGAATCTCT 2040
CAGAACTTCC TGTCCAGCAT CAACGAGGAG ATCACGCCCC GCCGACAGTC CATGACGGTG 2100
AAAAAAGGAG AGCACCGGCA GCTGCTGAAG GACAGCTTTA TGGTAGAGCT GGTGGAGGGG 2160
GCCCGCAAGC TGCGTCACAT CTTCCTGTTC ACTGACCTGC TCCTCTGCAC CAAGCTGAAG 2220
AAGCAAAGTG GAGGCAAAAC CCAGCAATAT GACTGTAAAT GGTACATTCC GCTCACGGAC 2280
CTCAGCTTCC AGATGGTGGA TGAATTGGAG GCACTACCCA ACATCCCTCT GGTGCCAGAT 2340
GAGGAACTGG ATGCCTTGAA GATCAAAATC TCCCAAATCA AGAGCGACAT CCAACGAGAG 2400
AAGAGAGCAA ATAAGGGCAG CAAGGTCATG GAGAGGCTGA GGAAGAAGCT GTCAGAGCAG 2460
GAGTCACTGC TGCTGTTAAT GTCTCCCAGC ATGGCCTTCC GCGTTCACAG TCGCAACGGC 2520
AAGAGTTACA CGTTCCTTAT TTCCTCTGAC TATGAGCGAG CCGAGTGGAG AGAAAGCATC 2580
CGAGAGCAGC AGAAGAAATG TTTCAAAAGT TTCTCTCTGA CATCTGTGGA GCTACAAATG 2640
CTGACCAACT CATGTGTAAA ACTTCAGACG GTTCACCACA TTCCACTGAC CATCAACAAA 2700
GAAGATGACG AGTCTCCTGG ACTCTACGGC TTCCTGCATG TCATCGTCCA CTCAGCCACC 2760
GGCTTTAAGC AGAGCTCAAA TCTCTACTGC ACCCTGGAGG TGGATTCCTT TGGATATTTT 2820
GTGAATAAAG CAAAGACTCG AGTCTACAGG GACACAACTG AGCCAAACTG GAATGAGGAG 2880
TTTGAGATAG AGCTAGAAGG CTCCCAGACC CTGCGGATAC TATGTTATGA AAAGTGTTAC 2940
AACAAAATGA AGATGACGAA GGAAGATGGT GAGAGCGCAG ACAAGCTCAT GGGGAAAGGC 3000
CAGGTCCAGC TGGACCCCCA AACCCTACAG GACAGAGACT GGCAGCGGAC TGTCATCGAC 3060
ATGAATGGAA TTGAAGTGAA ACTCTCCGTC AAGTTCACGA GCAGGGAGTT CAGCCTGAAG 3120
AGAATGCCCT CCCGCAAACA GACAGGGGTC TTCGGTGTCA AGATTGCTGT AGTCACAAAG 3180
AGAGAGAGGT CCAAGGTACC TTACATTGTG CGCCAGTGTG TGGAAGAGAT CGAGCGCCGG 3240
GGTATGGAGG AGGTGGGCAT CTACCGAGTG TCTGGAGTGG CCACAGACAT CCAGGCACTG 3300
AAGGCAGCCT TTGATGTCAA TAACAAGGAT GTGTCCGTGA TGATGAGCGA GATGGACGTG 3360
AACGCCATTG CCGGCACGCT GAAGCTCTAC TTCCGTGAGC TGCCCGAGCC CCTCTTCACG 3420
GATGAGTTCT ACCCTAACTT CGCAGAAGGC ATTGCTCTTT CAGACCCCGT CGCAAAGGAG 3480
AGCTGCATGC TGAACCTGCT GCTGTCCCTC CCAGAAGCCA ACCTGCTCAC CTTCCTCTTC 3540
CTCCTGGACC ACCTGAAAAG GGTAGCTGAA AAGGAGACGG TGAACAAGAT GTCCCTGCAC 3600
AACCTCGCCA CGGTCTTTGG CCCCACACTG CTTCGGCCCT CAGAGAAGGA AAGCAAGCTC 3660
CCTGCTAACC CCAGCCAGCC CATCACCATG ACTGACAGCT GGTCCCTGGA GGTCATGTCC 3720
CAGGTCCAAG TGTTGCTGTA CTTCCTGCAG CTGGAGGCCA TCCCTGCCCC TGACAGCAAG 3780
AGACAGAGCA TCCTGTTTTC CACTGAAGTC TAA 3813
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
KeywordATP-binding; Complete proteome; GTPase activation; Guanine-nucleotide releasing factor; Kinase; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00465
EKS-ANC-00489
EKS-CAJ-00506
EKS-CAF-00502
EKS-CAP-00532
EKS-CII-00278
EKS-CIS-00251
EKS-DAR-00925
EKS-EQC-00486
EKS-FEC-00480
EKS-GAG-00414
EKS-GAA-00603
EKS-GOG-00487
EKS-HOS-00512
EKS-LAC-00512
EKS-LOA-00503
EKS-MAM-00499
EKS-MEG-00403
EKS-MUP-00493
EKS-NOL-00455
EKS-ORN-00633
EKS-ORA-00440
EKS-ORC-00469
EKS-ORL-00583
EKS-OTG-00512
EKS-PAT-00472
EKS-PES-00435
EKS-PEM-00273
EKS-POA-00482
EKS-PTV-00195
EKS-RAN-00512
EKS-SUS-00442
EKS-TAG-00561
EKS-TAR-00619
EKS-TEN-00630
EKS-XET-00653
EKS-XIM-00627
Gene Ontology
GO:0005829; C:cytosol
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030675; F:Rac GTPase activator activity
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity
GO:0030036; P:actin cytoskeleton organization
GO:0007420; P:brain development
GO:0042472; P:inner ear morphogenesis
GO:0035556; P:intracellular signal transduction
GO:0030336; P:negative regulation of cell migration
GO:0050728; P:negative regulation of inflammatory response
GO:0043314; P:negative regulation of neutrophil degranulation
GO:0050885; P:neuromuscular process controlling balance
GO:0050766; P:positive regulation of phagocytosis
GO:0051726; P:regulation of cell cycle
GO:0032496; P:response to lipopolysaccharide
KEGG
mmu:110279;
InterPros
IPR015123; Bcr-Abl_oncoprot_oligo.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR018029; C2_membr_targeting.
IPR000219; DH-domain.
IPR001331; GDS_CDC24_CS.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR008936; Rho_GTPase_activation_prot.
IPR000198; RhoGAP_dom.
Pfam
PF09036; Bcr-Abl_Oligo; 1.
PF00168; C2; 1.
PF00169; PH; 1.
PF00620; RhoGAP; 1.
PF00621; RhoGEF; 1.
SMARTs
SM00239; C2; 1.
SM00233; PH; 1.
SM00324; RhoGAP; 1.
SM00325; RhoGEF; 1.
Prosites
PS50004; C2; 1.
PS00741; DH_1; 1.
PS50010; DH_2; 1.
PS50003; PH_DOMAIN; 1.
PS50238; RHOGAP; 1.
Prints
Created Date20-Feb-2013