EKS-MUM-00201

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00201

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	514.8	1.4E-154	4	284	281

Status

Reviewed

Ensembl Protein

ENSMUSP00000113655

UniProt Accession

Q9JKV2; Q8K138;

Protein Name

Serine/threonine-protein kinase ICK

Protein Synonyms/Alias

Intestinal cell kinase; mICK; MAK-related kinase; MRK;

Gene Name

Ick

Gene Synonyms/Alias

Ick;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000009828	ENSMUSP00000115522	ENSMUST00000125615
ENSMUSG00000009828	ENSMUSP00000113655	ENSMUST00000117330
ENSMUSG00000009828	ENSMUSP00000048234	ENSMUST00000044551
ENSMUSG00000009828	ENSMUSP00000112961	ENSMUST00000118869
ENSMUSG00000009828	ENSMUSP00000009972	ENSMUST00000009972

Organism

Mus musculus

Functional Description

May play a role in cardiac development (By similarity).

Protein Length

539

Protein Sequence
(FASTA)

MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 60

NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG 120

FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP 180

IDIWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFLWPQ 240

CIPNNLKTLI PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GIISKDSGKP 300

QREVQDKTGP PPYIKPAPPA QAPAKAYTLI SSRPSQASQP PQHSVHPYKG DVSRTEQLSH 360

VQEGKPSPPF FPSLHNKNLQ PKILASLEQK NGEIKPKSRR RWGLISRSTK GSDDWADLDD 420

LDFSPSLTRI DVKNKKRQSD DTLCRFESVL DLKPSESVGT GTTVSTQASS QRRDTPTLQS 480

SAKQHYLKHS RYLPGINIRN GVLPNPGKDF LPSNSWSSSG LSGKSSGTVS VVSKITSGK 539

Nucleotide Sequence
(FASTA)

ATGAATAGAT ACACAACGAT CAAGCAGCTT GGGGATGGGA CCTACGGCTC TGTCCTGCTG 60

GGGAGAAGCA TTGAGTCTGG AGAACTGATT GCCATTAAAA AAATGAAAAG AAAGTTTTAC 120

TCCTGGGAAG AATGCATGAA CCTTCGGGAG GTTAAGTCTT TAAAGAAGCT TAATCATGCC 180

AATATCGTAA AGTTAAAAGA GGTTATCAGG GAAAACGACC ATCTTTACTT TATCTTCGAG 240

TACATGAAGG AAAACCTTTA CCAGCTCATT AAAGAAAGAA ATAAGTTGTT TCCAGAGTCT 300

GCTATAAGGA ATATAATGTA CCAGATATTG CAAGGACTGG CATTCATTCA CAAACACGGT 360

TTCTTCCACC GGGACTTAAA ACCCGAGAAC CTCCTCTGCA TGGGACCAGA ACTTGTGAAA 420

ATCGCCGACT TTGGATTGGC TCGAGAAATC CGATCAAGAC CTCCGTACAC AGACTATGTG 480

TCTACTAGAT GGTACAGGGC TCCAGAGGTA CTGCTGAGAT CCACCAACTA CAGCTCCCCC 540

ATTGACATCT GGGCGGTAGG CTGCATCATG GCGGAGGTGT ACACGCTCCG GCCCCTTTTC 600

CCTGGGGCCA GTGAAATTGA CACAATTTTC AAAATTTGCC AAGTGTTGGG AACACCAAAG 660

AAGACTGACT GGCCTGAAGG CTACCAGCTG TCAAGTGCTA TGAATTTCCT CTGGCCCCAG 720

TGCATACCCA ATAACTTAAA GACTCTAATC CCAAATGCTA GCAGCGAAGC CATTCAGCTC 780

CTGAGAGACT TGCTTCAGTG GGATCCCAAG AAACGACCAA CCGCTAGTCA GGCTCTTCGA 840

TATCCTTACT TCCAGATCGG ACACCCACTG GGCATCATCA GCAAGGACTC AGGAAAACCA 900

CAGAGAGAGG TCCAGGACAA GACAGGCCCT CCTCCTTACA TCAAGCCAGC CCCTCCTGCC 960

CAGGCCCCGG CCAAGGCATA TACGCTGATT TCTTCACGAC CAAGCCAAGC CAGTCAGCCC 1020

CCTCAGCATT CTGTGCACCC CTACAAAGGC GATGTCTCTA GGACTGAGCA GCTGAGCCAT 1080

GTTCAGGAGG GCAAGCCAAG CCCTCCATTC TTCCCATCCC TCCACAATAA GAATCTTCAG 1140

CCAAAAATCC TAGCCAGCCT GGAACAGAAA AATGGTGAAA TCAAGCCAAA GAGCAGGAGA 1200

AGATGGGGTC TCATCTCCAG GTCGACAAAG GGTTCTGACG ACTGGGCCGA CTTGGATGAC 1260

TTAGACTTCA GTCCCTCTCT CACCAGGATA GATGTAAAAA ACAAGAAGAG ACAGAGTGAT 1320

GACACCCTCT GCAGGTTTGA AAGTGTTCTG GACCTGAAGC CATCTGAGTC AGTGGGTACA 1380

GGAACCACTG TCTCCACGCA GGCTTCCTCG CAGAGGAGAG ACACGCCGAC CCTGCAGTCC 1440

TCAGCAAAGC AGCACTACTT GAAGCACTCT CGCTACTTGC CTGGAATAAA TATAAGAAAT 1500

GGCGTGCTCC CAAATCCAGG CAAGGACTTT CTTCCATCAA ATTCATGGTC CAGTTCCGGC 1560

TTGTCTGGAA AATCTTCAGG AACAGTATCA GTAGTGAGCA AAATAACTTC AGGCAAGTAA 1620

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         y++ik+lGdGt+g+vll++s+++gel+aikkmkrkf+s+ee++nlrevkslkkln h+ni

Q: 4     YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANI  62

         99*****************************************************.****

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         +klkevi  rend+ly+++e+m+enlyqlik+r+kl++es++++i+yqil+glafihkhg

Q: 63    VKLKEVI--RENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG  120

         *******..***************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         ffhrdlkPen+l++g+elvk+adfGlare+rs++PytdyvstrwyraPevllrs++yssp

Q: 121   FFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSP  180

         ************************************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +d+wavGc++aev++lrplfPGaseid+ifki++vlGtPkk++w+e+y+l+sa+n+ +pq

Q: 181   IDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFLWPQ  240

         ************************************************************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         +++++lktl++nas+ea++ll+dll++dP++r+ta+qal+ypyf

Q: 241   CIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYF  284

         *******************************************9

Domain Sequence
(FASTA)

YTTIKQLGDG TYGSVLLGRS IESGELIAIK KMKRKFYSWE ECMNLREVKS LKKLNHANIV 60

KLKEVIREND HLYFIFEYMK ENLYQLIKER NKLFPESAIR NIMYQILQGL AFIHKHGFFH 120

RDLKPENLLC MGPELVKIAD FGLAREIRSR PPYTDYVSTR WYRAPEVLLR STNYSSPIDI 180

WAVGCIMAEV YTLRPLFPGA SEIDTIFKIC QVLGTPKKTD WPEGYQLSSA MNFLWPQCIP 240

NNLKTLIPNA SSEAIQLLRD LLQWDPKKRP TASQALRYPY F 281

Keyword

ATP-binding; Complete proteome; Cytoplasm; Developmental protein; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043231	; C:intracellular membrane-bounded organelle
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007049	; P:cell cycle
GO:0007243	; P:intracellular protein kinase cascade
GO:0007275	; P:multicellular organismal development

KEGG

mmu:56542

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013