EKS-MUM-00122

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00122

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	439.6	8.9E-132	159	433	275

Status

Reviewed

Ensembl Protein

ENSMUSP00000114938

UniProt Accession

Q3UHC2; Q3U476; Q66JQ4; Q6GQR9; Q6NZF5; Q6ZPI4; Q8BKP3; Q8BU93; Q8BUY0; Q8BVV2; Q8R085;

Protein Name

Leucine-rich repeat serine/threonine-protein kinase 1

Protein Synonyms/Alias

Gene Name

Lrrk1

Gene Synonyms/Alias

Lrrk1; Kiaa1790;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000015133	ENSMUSP00000015277	ENSMUST00000015277
ENSMUSG00000015133	ENSMUSP00000114938	ENSMUST00000145954

Organism

Mus musculus

Functional Description

Protein Length

508

Protein Sequence
(FASTA)

WQEGLLVTFD GGYLSVESSD VNWKKKKSGG IKIICQSEMR DFSAMAFITD HVNSLIDQWF 60

PALTATESDG TPLMEQYVPC PVCEASWAQH ADPNERSESV QYFDMEDCVL TAIERDFISC 120

PRHPDLPVPL QELVPELFMT DFPARLFLEN SKLEHTEGEN SILGQGGSGT VIYQARYQGQ 180

PVAVKRFHIK KFKNSANAPA DTMLRHLRAM DAMKNFSDFR QEASMLHALQ HPCIVSLIGI 240

SIHPLCFALE LAPLGSLNTV LSENAKDSSF MPLGHMLTQK IAYQIASGLA YLHKKNIIFC 300

DLKSDNILVW SLSAKEHINI KLSDYGISRQ SFHEGALGVE GTPGYQAPEI RPRIVYDEKV 360

DMFSYGMVLY ELLSGQRPAL GHHQLQIVKK LSKGIRPVLG QPEEVQFHRL QALMMECWDT 420

KPEKRPLALS VVSQMKDPTF ATFMYMLPCG KQSAFFSSQS QEYTVVFWDG KEESSLFWFQ 480

LFFIEKWQEV RMGNEISEKK REGPKWSP 508

Nucleotide Sequence
(FASTA)

TGGCAGGAAG GGCTGCTGGT CACTTTCGAT GGGGGCTACC TCAGTGTGGA ATCCTCAGAT 60

GTGAACTGGA AAAAGAAAAA AAGCGGAGGA ATTAAAATCA TCTGCCAGTC AGAGATGAGG 120

GACTTCTCGG CAATGGCTTT TATCACAGAC CATGTCAACT CCCTGATTGA CCAGTGGTTC 180

CCTGCCCTGA CGGCCACAGA AAGTGACGGG ACCCCACTGA TGGAGCAGTA CGTACCCTGC 240

CCTGTCTGTG AAGCATCCTG GGCCCAGCAT GCAGATCCAA ACGAGAGGTC AGAGAGCGTG 300

CAGTACTTTG ATATGGAAGA CTGTGTGCTC ACAGCCATCG AACGGGACTT CATCTCCTGC 360

CCCAGACACC CAGACCTCCC AGTACCACTT CAGGAGCTTG TACCAGAGCT GTTCATGACT 420

GACTTCCCAG CCAGGCTCTT CCTGGAGAAC AGCAAGCTGG AGCACACGGA GGGTGAGAAC 480

AGCATTCTGG GCCAAGGTGG CAGTGGCACA GTCATCTACC AGGCCCGGTA CCAGGGCCAG 540

CCTGTGGCTG TGAAGAGGTT CCATATCAAG AAGTTCAAGA ATTCTGCTAA TGCCCCAGCA 600

GACACCATGC TGCGGCACCT GAGAGCCATG GATGCCATGA AGAACTTCTC AGATTTCCGT 660

CAGGAGGCCA GCATGCTGCA TGCCTTGCAG CATCCTTGCA TCGTGTCACT CATCGGCATC 720

AGCATCCACC CGCTCTGCTT CGCCTTGGAG CTGGCCCCGC TGGGCAGTCT CAACACCGTG 780

CTATCTGAGA ATGCCAAAGA TTCTTCCTTT ATGCCCCTGG GACACATGCT CACCCAAAAG 840

ATAGCCTACC AGATTGCCTC GGGCCTGGCC TACCTGCACA AGAAAAACAT CATCTTCTGT 900

GACCTCAAGT CGGACAACAT CCTAGTGTGG TCGCTGAGCG CCAAGGAGCA TATCAACATC 960

AAACTGTCAG ACTACGGCAT CTCCAGGCAG TCCTTTCACG AGGGGGCCCT GGGTGTGGAG 1020

GGCACCCCAG GTTACCAGGC CCCAGAGATC AGGCCTCGCA TCGTGTATGA CGAGAAGGTA 1080

GATATGTTCT CCTACGGCAT GGTGCTATAC GAGCTGCTGT CAGGACAGCG TCCTGCACTG 1140

GGCCACCACC AACTTCAGAT TGTCAAGAAG TTGTCCAAGG GCATCCGCCC AGTTCTGGGG 1200

CAGCCGGAGG AAGTTCAGTT CCATCGGCTG CAGGCGCTCA TGATGGAGTG CTGGGACACA 1260

AAGCCGGAGA AGCGCCCCCT GGCCTTGTCC GTGGTGAGCC AGATGAAAGA CCCAACCTTT 1320

GCCACCTTCA TGTACATGCT GCCCTGTGGG AAGCAGTCGG CCTTCTTCTC ATCCCAGAGC 1380

CAGGAGTACA CTGTGGTGTT CTGGGATGGG AAGGAGGAGT CCAGTCTCTT CTGGTTTCAG 1440

CTCTTTTTCA TAGAAAAGTG GCAGGAAGTG AGAATGGGGA ATGAGATATC TGAGAAGAAA 1500

AGAGAAGGTC CAAAATGGTC ACCATGA 1527

Domain Profile

S: 3     kgsllGrGafGsv.yraavkGeevavkafki..........aadklkrdslelalkayse  51

         ++s+lG+G++G+v y+a+++G++vavk+f+i          a+++l+++++++a+k++s+

Q: 159   ENSILGQGGSGTViYQARYQGQPVAVKRFHIkkfknsanapADTMLRHLRAMDAMKNFSD  218

         799*********************************************************

S: 52    lrqelsvLlalkhPsivsLvgisikPlalvleLaplgsLdrlLsedkksss..klgrtlt  109

         +rqe+s+L+al+hP+ivsL+gisi+Pl+++leLaplgsL+++Lse++k+ss  +lg++lt

Q: 219   FRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSfmPLGHMLT  278

         **************************************************9999******

S: 110   kkialqvargleyLhkkkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakg  169

         +kia+q+a+gl+yLhkk+ii++dLks+n+Lvwsls+ke+i+ikl+dyGisrqs+++Ga+g

Q: 279   QKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQSFHEGALG  338

         ************************************************************

S: 170   veGteGfraPeivrgevvydekvdvfsfGlllyellsgkrpvegeeqlkivekllkGkrP  229

         veGt+G++aPei r+++vydekvd+fs+G++lyellsg+rp++g++ql+iv+kl+kG+rP

Q: 339   VEGTPGYQAPEI-RPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRP  397

         ************.***********************************************

S: 230   vlvkeeevlptplldLlveCwkekPekrPtasqvvs  265

         vl+++eev++++l++L++eCw++kPekrP+a++vvs

Q: 398   VLGQPEEVQFHRLQALMMECWDTKPEKRPLALSVVS  433

         **********************************97

Domain Sequence
(FASTA)

ENSILGQGGS GTVIYQARYQ GQPVAVKRFH IKKFKNSANA PADTMLRHLR AMDAMKNFSD 60

FRQEASMLHA LQHPCIVSLI GISIHPLCFA LELAPLGSLN TVLSENAKDS SFMPLGHMLT 120

QKIAYQIASG LAYLHKKNII FCDLKSDNIL VWSLSAKEHI NIKLSDYGIS RQSFHEGALG 180

VEGTPGYQAP EIRPRIVYDE KVDMFSYGMV LYELLSGQRP ALGHHQLQIV KKLSKGIRPV 240

LGQPEEVQFH RLQALMMECW DTKPEKRPLA LSVVS 275

Keyword

Alternative splicing; ANK repeat; ATP-binding; Complete proteome; Cytoplasm; GTP-binding; Kinase; Leucine-rich repeat; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007264	; P:small GTPase mediated signal transduction

KEGG

mmu:233328

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR020859	; ROC_GTPase.

Pfam

PF12796	; Ank_2; 1.
PF00560	; LRR_1; 2.
PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 4.
SM00369	; LRR_TYP; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; FALSE_NEG.
PS51450	; LRR; 11.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.
PS51424	; ROC; 1.

Prints

Created Date

20-Feb-2013