EKS-MUM-00331

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00331

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	458.2	1.8E-137	707	963	257

Status

Reviewed

Ensembl Protein

ENSMUSP00000080716

UniProt Accession

Q61526; Q3KQR1; Q68J64; Q810U8; Q8K317;

Protein Name

Receptor tyrosine-protein kinase erbB-3

Protein Synonyms/Alias

Glial growth factor receptor; Proto-oncogene-like protein c-ErbB-3;

Gene Name

Erbb3

Gene Synonyms/Alias

Erbb3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000018166	ENSMUSP00000080716	ENSMUST00000082059

Organism

Mus musculus

Functional Description

Binds and is activated by neuregulins and NTAK. May alsobe activated by CSPG5 (By similarity).

Protein Length

1339

Protein Sequence
(FASTA)

MSAIGTLQVL GFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY KLYEKCEVVM 60

GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP NLRVVRGTQV YDGKFAIFVM 120

LNYNTNSSHA LRQLRFTQLT EILLGGVYIE KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG 180

GNCPPCHEVC KGRCWGPGPE DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD 240

TDCFACRHFN DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF 300

CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN 360

LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420

RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRVYISANQ QLCYHHSLNW TRLLRGPAEE 480

RLDIKYNRPL GECVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP 540

REFVHEAHCF SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 600

YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP HLVIAVTVGL TVIFLILGGS 660

FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR IFKETELRKL KVLGSGVFGT 720

VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS 780

LQLVTQYLPL GSLLDHVRQH RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML 840

KSPSQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900

ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 960

NEFTRMARDP PRYLVIKRAS GPGIPPAAEP SALSTKELQD AELEPDLDLD LDVEVEEEGL 1020

ATTLGSALSL PTGTLTRPRG SQSLLSPSSG YMPMNQSNLG EACLDSAVLG GREQFSRPIS 1080

LHPIPRGRQT SESSEGHVTG SEAELQERVS MCRSRSRSRS PRPRGDSAYH SQRHSLLTPV 1140

TPLSPPGLEE EDGNGYVMPD THLRGTSSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 1200

RRGSPARPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG TTPDEDYEYM 1260

NRRRGAGGSG GDYAAMGACP AAEQGYEEMR AFQGPGHQAP HVRYARLKTL RSLEATDSAF 1320

DNPDYWHSRL FPKANAQRI 1339

Nucleotide Sequence
(FASTA)

ATGAGTGCGA TTGGGACTCT GCAGGTGCTG GGTTTCCTTC TCAGCCTGGC CCGGGGTTCC 60

GAGATGGGCA ACTCTCAGGC AGTATGTCCT GGGACTCTAA ACGGGCTGAG TGTGACCGGC 120

GATGCTGACA ACCAGTACCA GACACTGTAC AAACTCTATG AGAAGTGTGA GGTGGTCATG 180

GGTAACCTGG AGATTGTGCT TACGGGACAC AATGCTGATC TTTCCTTCCT GCAATGGATC 240

CGAGAAGTGA CAGGCTATGT ACTGGTGGCC ATGAATGAAT TCTCTGTACT GCCCTTACCT 300

AACCTCCGAG TGGTCCGGGG AACCCAGGTC TACGATGGGA AGTTTGCCAT CTTTGTCATG 360

TTGAACTACA ATACCAACTC CAGCCATGCT CTGCGCCAGC TCCGGTTCAC TCAGCTTACT 420

GAGATTCTGT TAGGGGGCGT TTACATTGAG AAGAATGACA AACTTTGCCA CATGGATACA 480

ATTGACTGGA GGGACATCGT GAGGGTTCCA GACGCTGAGA TAGTGGTGAA GAACAACGGG 540

GGGAACTGTC CACCCTGTCA CGAAGTCTGC AAGGGGCGAT GCTGGGGGCC TGGACCAGAA 600

GACTGCCAGA TATTGACCAA GACCATCTGT GCCCCTCAGT GTAACGGTCG CTGCTTCGGG 660

CCCAATCCTA ACCAGTGCTG CCACGATGAA TGTGCAGGTG GCTGCTCTGG ACCCCAGGAC 720

ACAGATTGCT TCGCCTGCCG ACACTTCAAT GACAGTGGTG CCTGTGTGCC CAGGTGTCCA 780

GCGCCCCTTG TGTACAACAA GCTAACGTTC CAGCTTGAGC CCAACCCCCA TATCAAGTAT 840

CAGTACGGAG GAGTCTGTGT TGCCAGTTGT CCCCATAACT TTGTGGTGGA TCAGACATTT 900

TGTGTCAGGG CTTGTCCTGC TGACAAGATG GAAGTAGATA AGAATGGACT CAAGATGTGT 960

GAGCCTTGCA GAGGGCTGTG CCCAAAAGCC TGTGAGGGGA CGGGCTCTGG AAGCCGCTAC 1020

CAGACCGTGG ACTCTAGCAA TATCGATGGG TTCGTGAACT GTACCAAGAT CCTGGGCAAC 1080

CTGGACTTCC TCATCACTGG CCTCAATGGT GACCCCTGGC ACAAGATCCC TGCACTGGAC 1140

CCGGAAAAGC TCAATGTTTT CAGGACAGTC CGGGAGATTA CAGGCTACCT AAACATCCAG 1200

TCCTGGCCCC CTCACATGCA CAACTTCAGT GTTTTTTCCA ACCTGACGAC CATCGGGGGC 1260

AGAAGCCTCT ACAATCGGGG CTTCTCCTTG TTGATCATGA AGAACTTGAA TGTCACGTCT 1320

CTGGGCTTCC GGTCCCTGAA GGAAATTAGT GCTGGGCGTG TCTACATAAG TGCCAATCAG 1380

CAACTTTGTT ACCACCACTC TCTGAACTGG ACCAGACTTC TGCGGGGGCC CGCAGAGGAG 1440

AGACTTGACA TCAAGTACAA CCGGCCTCTG GGAGAATGCG TGGCAGAGGG CAAAGTGTGT 1500

GATCCACTGT GCTCCTCTGG GGGATGCTGG GGCCCAGGCC CTGGTCAGTG CTTGTCTTGT 1560

CGAAACTACA GCCGGGAAGG TGTCTGTGTG ACTCACTGCA ACGTTCTGCA AGGGGAACCC 1620

CGAGAGTTTG TTCATGAGGC TCATTGCTTC TCCTGCCATC CAGAATGCCA GCCCATGGAG 1680

GGCACCAGCA CGTGCAATGG CTCGGGCTCC GACGCTTGTG CTCGATGCGC CCATTTTCGT 1740

GATGGGCCCC ACTGTGTGAA CAGCTGCCCC CATGGAATCC TAGGTGCCAA AGGTCCAATC 1800

TACAAATATC CAGATGCTCA GAATGAGTGC CGGCCCTGCC ACGAGAACTG CACCCAAGGG 1860

TGTAAGGGAC CAGAACTACA AGACTGTTTA GGCCAAGCAG AGGTATTAAT GAGCAAACCA 1920

CACCTGGTCA TAGCGGTGAC AGTAGGACTG ACTGTGATCT TCCTGATTCT GGGAGGCTCT 1980

TTTCTCTATT GGCGTGGACG CAGGATTCAG AATAAAAGGG CTATGAGACG CTACTTGGAG 2040

CGGGGTGAGA GCATCGAGCC TCTGGACCCA AGCGAGAAGG CAAACAAAGT CTTGGCTAGA 2100

ATCTTCAAAG AGACAGAGCT GAGGAAACTT AAGGTGCTTG GCTCTGGTGT CTTTGGAACT 2160

GTACACAAGG GGATTTGGAT TCCCGAGGGT GAATCCATCA AGATTCCAGT CTGCATTAAA 2220

GTCATCGAGG ACAAGAGTGG GCGGCAGAGT TTTCAGGCTG TGACTGATCA CATGCTGGCC 2280

GTCGGCAGCC TGGACCATGC CCACATTGTA CGGCTGCTGG GACTGTGCCC AGGGTCATCT 2340

CTGCAGCTTG TCACTCAGTA CTTGCCTCTG GGCTCTCTCC TTGATCATGT AAGACAGCAC 2400

CGTGAGACAC TGGGACCACA GCTGCTGCTC AACTGGGGAG TACAAATTGC CAAGGGTATG 2460

TATTACCTCG AGGAACACAG CATGGTGCAT AGGGACCTTG CGCTCCGGAA TGTGATGCTT 2520

AAGTCACCGA GTCAAGTCCA GGTGGCAGAT TTTGGTGTGG CTGACTTGCT GCCGCCAGAT 2580

GACAAGCAGT TACTACACAG TGAGGCCAAG ACTCCAATTA AATGGATGGC CCTTGAGAGT 2640

ATCCACTTTG GGAAATACAC ACACCAGAGT GATGTCTGGA GTTACGGTGT AACCGTTTGG 2700

GAGTTGATGA CCTTCGGGGC AGAGCCCTAC GCAGGGCTAC GACTGGCTGA AATACCAGAC 2760

CTGCTGGAGA AGGGAGAGCG GTTAGCACAG CCCCAGATCT GCACCATTGA CGTCTACATG 2820

GTCATGGTCA AGTGTTGGAT GATTGACGAG AATATTCGCC CAACCTTTAA AGAACTGGCC 2880

AATGAGTTTA CCAGGATGGC CCGGGACCCA CCAAGGTATC TGGTCATCAA GAGAGCGAGT 2940

GGGCCTGGAA TACCTCCTGC AGCAGAGCCA TCTGCTCTGA GCACCAAAGA GTTGCAGGAT 3000

GCAGAGCTGG AGCCAGACCT GGACCTCGAC CTAGACGTGG AGGTAGAAGA GGAGGGCCTG 3060

GCGACCACAC TGGGTTCTGC CCTCAGCTTG CCTACAGGAA CGCTTACCCG GCCACGTGGG 3120

AGCCAGAGTC TTTTAAGTCC TTCGTCTGGA TACATGCCCA TGAACCAGAG CAACCTTGGG 3180

GAGGCTTGTC TGGATTCTGC GGTTTTGGGG GGTCGCGAAC AGTTCTCCCG TCCCATCTCT 3240

CTGCACCCGA TCCCACGGGG GCGTCAAACG TCAGAGTCAT CAGAGGGCCA TGTGACGGGC 3300

TCTGAGGCTG AACTCCAAGA GAGAGTATCA ATGTGTAGGA GCCGGAGCCG GAGCCGGAGC 3360

CCACGGCCAC GTGGGGACAG TGCCTACCAT TCGCAGCGAC ACAGCCTGCT TACTCCCGTC 3420

ACCCCGCTCT CCCCACCAGG GTTAGAGGAA GAGGATGGCA ATGGTTATGT CATGCCAGAT 3480

ACGCACCTCA GAGGTACATC CTCTTCCCGG GAAGGCACCC TTTCGTCAGT AGGTCTCAGT 3540

TCTGTGCTGG GTACCGAAGA GGAAGATGAA GATGAGGAGT ATGAATACAT GAACCGGAAG 3600

AGGAGGGGTA GCCCGGCTCG GCCCCCCAGA CCTGGTTCCC TGGAAGAGCT GGGCTATGAG 3660

TACATGGATG TGGGTTCAGA CCTCAGTGCT TCTCTGGGCA GTACGCAGAG TTGCCCACTC 3720

CATCCCATGG CCATCGTGCC CTCTGCTGGC ACGACTCCAG ATGAGGACTA TGAATACATG 3780

AACCGCAGGC GTGGTGCGGG CGGTTCCGGA GGGGATTATG CAGCTATGGG GGCCTGCCCA 3840

GCAGCTGAAC AAGGGTATGA GGAAATGCGA GCTTTCCAGG GGCCTGGACA TCAAGCCCCC 3900

CATGTTCGTT ATGCCCGCCT CAAAACTCTG CGTAGTTTAG AAGCCACTGA CTCCGCCTTT 3960

GACAACCCCG ATTACTGGCA TAGCAGGCTT TTCCCTAAGG CTAACGCCCA GAGAATTTGA 4020

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+klkvlGsG+fGtv+kGiwipege++kipv+ikv+e+k+g++++++++d++l+++sldh

Q: 707   LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDH  766

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+

Q: 767   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEH  826

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         ++vhrdla rnv++ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky

Q: 827   SMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  886

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGa+py+g++++eipdllekGerlaqp+ictidvymv+vkcw

Q: 887   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCW  946

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 947   MIDENIRPTFKELANEF  963

         ****************9

Domain Sequence
(FASTA)

LRKLKVLGSG VFGTVHKGIW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAVGSLDH 60

AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRETLGP QLLLNWGVQI AKGMYYLEEH 120

SMVHRDLALR NVMLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180

THQSDVWSYG VTVWELMTFG AEPYAGLRLA EIPDLLEKGE RLAQPQICTI DVYMVMVKCW 240

MIDENIRPTF KELANEF 257

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0016323	; C:basolateral plasma membrane
GO:0005615	; C:extracellular space
GO:0016021	; C:integral to membrane
GO:0016328	; C:lateral plasma membrane
GO:0005634	; C:nucleus
GO:0045211	; C:postsynaptic membrane
GO:0005524	; F:ATP binding
GO:0030296	; F:protein tyrosine kinase activator activity
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007409	; P:axonogenesis
GO:0032869	; P:cellular response to insulin stimulus
GO:0007623	; P:circadian rhythm
GO:0021545	; P:cranial nerve development
GO:0003197	; P:endocardial cushion development
GO:0060056	; P:mammary gland involution
GO:0007162	; P:negative regulation of cell adhesion
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0051048	; P:negative regulation of secretion
GO:0009968	; P:negative regulation of signal transduction
GO:0051402	; P:neuron apoptotic process
GO:0042476	; P:odontogenesis
GO:0014065	; P:phosphatidylinositol 3-kinase cascade
GO:0046326	; P:positive regulation of glucose import
GO:0042127	; P:regulation of cell proliferation
GO:0042493	; P:response to drug
GO:0009611	; P:response to wounding
GO:0014037	; P:Schwann cell differentiation
GO:0023014	; P:signal transduction by phosphorylation
GO:0007519	; P:skeletal muscle tissue development
GO:0043586	; P:tongue development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mmu:13867

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013