| Tag | Content |
|---|
| EKPD ID | EPS-MUM-00064 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Asp-Based PTP/FCP | 170.6 | 6.1E-50 | 62 | 231 | 170 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000104234 |
| UniProt Accession | Q3TP92; Q5NCW4; Q8VEL4; |
| Protein Name | CTD nuclear envelope phosphatase 1 |
| Protein Synonyms/Alias | Serine/threonine-protein phosphatase dullard; |
| Gene Name | Ctdnep1 |
| Gene Synonyms/Alias | Ctdnep1; Dullard; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Serine/threonine protein phosphatase forming withCNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity). |
| Protein Length | 244 |
Protein Sequence
(FASTA) | | MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP LSRNRLAQVK 60 | | RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV 120 | | VSQWYELVVF TASMEIYGSA VADKLDNSRS ILKRRYYRQH CTLELGSYIK DLSVVHSDLS 180 | | SIVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ 240 | | HRLW 244 |
|
Nucleotide Sequence
(FASTA) | | ATGATGCGGA CGCAGTGTCT GCTGGGGCTG CGCACGTTCG TGGCCTTCGC CGCCAAGCTC 60 | | TGGAGCTTCT TTATTTACCT TTTGCGGAGG CAGATCCGCA CGGTAATTCA GTATCAGACT 120 | | GTTCGATATG ATATCCTGCC CTTATCTCCT TTGTCCCGGA ATCGCCTAGC CCAGGTGAAG 180 | | AGGAAGATCC TGGTGCTGGA TCTGGACGAA ACCCTGATTC ACTCTCACCA CGATGGGGTG 240 | | CTGAGGCCTA CAGTGAGACC TGGGACACCT CCCGACTTCA TCCTCAAGGT GGTAATAGAC 300 | | AAACACCCAG TCCGGTTTTT TGTACATAAG AGGCCCCATG TGGATTTCTT CTTAGAAGTG 360 | | GTAAGCCAGT GGTATGAGCT TGTGGTGTTC ACAGCAAGCA TGGAAATTTA TGGCTCTGCT 420 | | GTGGCAGATA AACTGGACAA CAGCAGAAGC ATTCTTAAGA GGAGATACTA CAGACAGCAC 480 | | TGCACTTTGG AGTTGGGCAG CTACATCAAA GACCTCTCCG TGGTCCACAG CGACCTGTCC 540 | | AGCATCGTGA TCCTGGACAA CTCCCCCGGG GCTTACAGGA GCCACCCAGA CAATGCCATC 600 | | CCCATCAAAT CCTGGTTCAG TGACCCCAGT GACACAGCCC TTCTCAACCT TCTCCCAATG 660 | | CTGGATGCCC TCAGGTTCAC TGCTGATGTC CGATCGGTGC TGAGCCGAAA CCTTCACCAA 720 | | CATAGGCTCT GGTGA 735 |
|
| Domain Profile | S: 1 ktLVLDLDetLvhsksekdee.................e.ektkasvkkRPgldeFLkel 42 | k+LVLDLDetL+hs ++ + + ++ v+kRP++d FL+ + | Q: 62 KILVLDLDETLIHSHHDGVLRptvrpgtppdfilkvviDkHPVRFFVHKRPHVDFFLEVV 121 | 78*************5444423566777777877765526999***************** |
| S: 43 skayevviftasskeyadavldkldpkkklfkkrlyresctlengkyvKdLsllgrdlsk 102 | s++ye+v+ftas++ y av dkld ++ ++k+r+yr++ctle g+y+KdLs++++dls+ | Q: 122 SQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSS 181 | **************************99999***************************** |
| S: 103 vvivDdsprsfelqpdnlipiepfygdsdkdtellkllpflealeksddvr 153 | +vi+D+sp +++++pdn+ipi+++++d ++dt+ll+llp+l+al++ dvr | Q: 182 IVILDNSPGAYRSHPDNAIPIKSWFSD-PSDTALLNLLPMLDALRFTADVR 231 | ***************************.*****************999997 |
|
Domain Sequence
(FASTA) | | KILVLDLDET LIHSHHDGVL RPTVRPGTPP DFILKVVIDK HPVRFFVHKR PHVDFFLEVV 60 | | SQWYELVVFT ASMEIYGSAV ADKLDNSRSI LKRRYYRQHC TLELGSYIKD LSVVHSDLSS 120 | | IVILDNSPGA YRSHPDNAIP IKSWFSDPSD TALLNLLPML DALRFTADVR 170 |
|
| Keyword | Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Nucleus; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |