| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00234 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| STE/STE7 | 382.8 | 2.1E-114 | 64 | 325 | 262 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000019076 |
| UniProt Accession | O09110; P97293; Q91VX1; |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 3 |
| Protein Synonyms/Alias | MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3; |
| Gene Name | Map2k3 |
| Gene Synonyms/Alias | Map2k3; Mkk3, Prkmk3; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Dual specificity kinase. Is activated by cytokines andenvironmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38 (By similarity). |
| Protein Length | 347 |
Protein Sequence
(FASTA) | | MESPAASPPA SLPQTKGKSK RKKDLRISCV SKPPVSNPTP PRNLDSRTFI TIGDRNFEVE 60 | | ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN TQEQKRLLMD LDINMRTVDC 120 | | FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLEKNMK IPEDILGEIA VSIVRALEHL 180 | | HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 240 | | NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD 300 | | FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS 347 |
|
Nucleotide Sequence
(FASTA) | | ATGGAGTCGC CCGCCGCGAG CCCGCCGGCC AGCTTGCCTC AGACCAAAGG AAAATCCAAA 60 | | AGGAAAAAGG ACTTACGGAT ATCCTGCGTG TCCAAGCCAC CTGTGTCCAA CCCCACACCC 120 | | CCCCGGAACC TGGACTCCCG GACCTTCATC ACTATCGGAG ACAGAAACTT CGAAGTGGAG 180 | | GCTGATGACT TGGTGACCAT CTCAGAGCTG GGTCGTGGAG CCTATGGGGT GGTAGAGAAA 240 | | GTGCGGCATG CTCAGAGTGG TACCATCATG GCTGTCAAGC GCATCCGGGC CACAGTGAAC 300 | | ACACAGGAGC AGAAACGTCT GCTTATGGAC CTAGACATCA ACATGCGCAC GGTCGACTGC 360 | | TTCTACACTG TCACCTTCTA TGGTGCCCTC TTCAGAGAGG GGGATGTATG GATCTGCATG 420 | | GAGCTCATGG ACACTTCCCT GGATAAGTTC TACCGGAAGG TGCTGGAGAA GAACATGAAA 480 | | ATTCCGGAAG ACATCCTGGG GGAGATCGCT GTGTCTATCG TGCGGGCCCT GGAGCACCTG 540 | | CATAGCAAGC TGTCTGTGAT CCACAGAGAT GTGAAGCCAT CCAATGTCCT CATCAACAAG 600 | | GAAGGGCATG TGAAGATGTG CGACTTTGGC ATCAGTGGCT ACCTGGTGGA CTCTGTGGCA 660 | | AAGACAATGG ATGCTGGCTG CAAGCCTTAC ATGGCCCCTG AGAGGATCAA CCCTGAACTG 720 | | AATCAGAAGG GCTACAATGT CAAGTCTGAT GTCTGGAGCC TCGGCATCAC CATGATCGAG 780 | | ATGGCCATTC TGCGATTCCC TTATGAGTCT TGGGGCACAC CGTTCCAGCA GCTGAAGCAG 840 | | GTGGTGGAGG AGCCATCCCC ACAGCTCCCA GCGGACCAGT TCTCCCCTGA GTTTGTGGAC 900 | | TTCACTAGCC AGTGCCTAAG GAAGAACCCT GCAGAGCGCA TGAGCTACCT GGAGCTGATG 960 | | GAACACCCAT TCTTCACCTT GCACAAAACT AAGAAGACAG ACATTGCTGC CTTTGTGAAG 1020 | | GAGATCCTGG GAGAGGATTC ATAG 1044 |
|
| Domain Profile | S: 1 lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi 60 | l +++elG+G++gvVekv+h +sg+i+avK+ir++++++eqk++l++l++ +++ ++ y+ | Q: 64 LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYT 123 | 56899******************************************************* |
| S: 61 vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke 120 | v+fyGa+++egdv+icmelmd tsldk+++kvlek+ +ipe++lg+iav++v+ale+l++ | Q: 124 VTFYGALFREGDVWICMELMD-TSLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHS 182 | *********************.************************************** |
| S: 121 klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k 176 | kl++iHRDvKPsN+L+n++G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++ + | Q: 183 KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMdAGCKPYMAPERINPelnQ 242 | ********************************************************9999 |
| S: 177 kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv 236 | k Y+vksdvWslG+t++e+a+ r+pye++ +++++lk++v+e++p+lp+++fs+ef++f | Q: 243 KGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFT 302 | 9*********************************************************** |
| S: 237 skClkkdekeRpklkellkhafi 259 | s+Cl+k+++eR+++ el++h+f+ | Q: 303 SQCLRKNPAERMSYLELMEHPFF 325 | *********************96 |
|
Domain Sequence
(FASTA) | | LVTISELGRG AYGVVEKVRH AQSGTIMAVK RIRATVNTQE QKRLLMDLDI NMRTVDCFYT 60 | | VTFYGALFRE GDVWICMELM DTSLDKFYRK VLEKNMKIPE DILGEIAVSI VRALEHLHSK 120 | | LSVIHRDVKP SNVLINKEGH VKMCDFGISG YLVDSVAKTM DAGCKPYMAP ERINPELNQK 180 | | GYNVKSDVWS LGITMIEMAI LRFPYESWGT PFQQLKQVVE EPSPQLPADQ FSPEFVDFTS 240 | | QCLRKNPAER MSYLELMEHP FF 262 |
|
| Keyword | 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |