EKS-MUM-00480
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00480
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PDHK216.62.4E-64243367125
StatusReviewed
Ensembl ProteinENSMUSP00000019721
UniProt AccessionO70571;
Protein Name[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
Protein Synonyms/Alias Pyruvate dehydrogenase kinase isoform 4;
Gene NamePdk4
Gene Synonyms/Alias Pdk4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000019577ENSMUSP00000019721ENSMUST00000019721
OrganismMus musculus
Functional DescriptionInhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity).
Protein Length412
Protein Sequence
(FASTA)
MKAARFVMRS ASSLSSASLV PREVELFSRY SPSPLSMKQL LDFGSENACE RTSFAFLRQE 60
LPVRLANILK EIDILPDRLV NTPSVQLVKS WYIQSLMDLV EFHEKSPEDQ KALSEFVDTL 120
VKVRNRHHNV VPTMAQGILE YKDTCTVDPV TNQNLQYFLD RFYMNRISTR MLMNQHILIF 180
SDSKTGNPSH IGSIDPNCDV VAVVQDAFEC AKMLCDQYYL TSPELNLTQV NGKFPGQPIH 240
IVYVPSHLHH MLFELFKNAM RATVEHQENR PSLTPVEATV VLGKEDLTIK ISDRGGGVPL 300
RITDRLFSYT YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLNL YSMSGYGTDA 360
IIYLKALSSE SVEKLPVFNK SAFKHYQMSS EADDWCIPSR EPKNLAKEKL AV 412
Nucleotide Sequence
(FASTA)
ATGAAGGCAG CCCGCTTCGT GATGCGCAGC GCCAGCTCGC TGAGCAGCGC CAGCCTGGTC 60
CCCAGGGAGG TCGAGCTGTT CTCCCGCTAC AGCCCGTCCC CGCTGTCCAT GAAGCAGCTG 120
CTGGACTTTG GTTCAGAAAA TGCCTGTGAA AGAACGTCCT TTGCTTTTCT GCGGCAAGAG 180
CTGCCCGTCC GCCTGGCCAA TATCCTGAAG GAGATTGACA TCCTGCCTGA CCGCTTAGTG 240
AACACTCCTT CGGTGCAGCT GGTGAAGAGC TGGTATATCC AGAGCCTGAT GGATTTGGTG 300
GAGTTCCATG AGAAGAGCCC AGAAGACCAG AAAGCCCTGT CAGAGTTTGT AGACACGCTG 360
GTCAAAGTTC GAAACAGACA TCATAATGTG GTCCCTACAA TGGCTCAAGG CATCCTGGAG 420
TATAAAGACA CCTGCACAGT GGACCCCGTT ACCAATCAAA ATCTTCAGTA TTTTTTAGAC 480
CGGTTTTACA TGAACCGCAT TTCTACTCGG ATGCTCATGA ATCAGCACAT CCTCATATTC 540
AGTGACTCAA AGACGGGAAA CCCAAGCCAC ATTGGAAGTA TCGACCCAAA CTGTGATGTG 600
GTAGCAGTAG TCCAAGATGC CTTTGAGTGT GCAAAGATGC TCTGCGACCA GTATTATCTA 660
ACATCGCCAG AATTAAACCT CACACAAGTC AATGGAAAAT TTCCAGGCCA ACCAATCCAC 720
ATTGTGTACG TTCCTTCACA CCTTCACCAC ATGCTCTTCG AACTCTTCAA GAATGCCATG 780
AGGGCCACGG TCGAGCATCA AGAAAACCGT CCTTCCTTGA CCCCAGTAGA GGCCACTGTC 840
GTCTTGGGAA AAGAAGACCT TACAATCAAG ATTTCTGACC GAGGAGGCGG TGTTCCTCTG 900
AGGATTACTG ACCGCCTCTT TAGTTACACG TACTCCACTG CTCCAACACC TGTGATGGAC 960
AATTCCCGGA ATGCCCCTTT GGCTGGTTTT GGTTATGGCT TGCCAATTTC TCGTCTCTAC 1020
GCCAAGTATT TTCAAGGAGA TCTGAATCTC TACTCTATGT CAGGTTATGG GACAGACGCT 1080
ATCATCTACT TAAAGGCTTT ATCTTCTGAG TCTGTAGAAA AGCTCCCAGT CTTTAACAAG 1140
TCAGCCTTCA AACATTATCA GATGAGCTCC GAAGCTGATG ACTGGTGTAT CCCAAGCAGG 1200
GAACCGAAGA ACCTGGCGAA GGAGAAGCTG GCAGTGTGA 1239
Domain Profile
S: 1     yvpshlyyllfellknamratveshedkkvlpdvkvlvalgkedliikisdrGGGvplrk  60
         yvpshl+++lfel+knamratve++e++++l++v+ +v+lgkedl+ikisdrGGGvplr 
Q: 243   YVPSHLHHMLFELFKNAMRATVEHQENRPSLTPVEATVVLGKEDLTIKISDRGGGVPLRI  302
         9***********************************************************
S: 61    idrlldymystapapskddaraaplaGfGyGlpisrlyakylqGdlkllsleGiGtdavi  120
         +drl++y+ystap+p +d++r+aplaGfGyGlpisrlyaky+qGdl+l+s++G+Gtda+i
Q: 303   TDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAII  362
         ************************************************************
S: 121   ylkal  125
         ylkal
Q: 363   YLKAL  367
         ***85
Domain Sequence
(FASTA)
YVPSHLHHML FELFKNAMRA TVEHQENRPS LTPVEATVVL GKEDLTIKIS DRGGGVPLRI 60
TDRLFSYTYS TAPTPVMDNS RNAPLAGFGY GLPISRLYAK YFQGDLNLYS MSGYGTDAII 120
YLKAL 125
KeywordATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00417
EKS-ANC-00436
EKS-BOT-00449
EKS-CAJ-00452
EKS-CAF-00446
EKS-CAP-00480
EKS-CHH-00030
EKS-EQC-00437
EKS-FEC-00428
EKS-GAG-00378
EKS-GOG-00439
EKS-HOS-00454
EKS-ICT-00429
EKS-LOA-00456
EKS-MAM-00445
EKS-MAE-00061
EKS-MEG-00369
EKS-MOD-00436
EKS-MUP-00440
EKS-MYL-00440
EKS-NOL-00406
EKS-ORC-00420
EKS-OTG-00450
EKS-PAT-00422
EKS-PES-00395
EKS-POA-00436
EKS-PRC-00053
EKS-PTV-00155
EKS-RAN-00461
EKS-SAH-00413
EKS-SUS-00396
EKS-TAG-00514
EKS-TUB-00042
EKS-TUT-00160
EKS-VIP-00081
Gene Ontology
GO:0005743; C:mitochondrial inner membrane
GO:0005759; C:mitochondrial matrix
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate
GO:0006006; P:glucose metabolic process
KEGG
mmu:27273;
InterPros
IPR003594; ATPase-like_ATP-bd.
IPR018955; BCDHK/PDK_N.
IPR005467; Sig_transdc_His_kinase_core.
Pfam
PF10436; BCDHK_Adom3; 1.
PF02518; HATPase_c; 1.
SMARTs
SM00387; HATPase_c; 1.
Prosites
PS50109; HIS_KIN; 1.
Prints
Created Date20-Feb-2013