EKS-MUM-00405
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00405
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src421.03.8E-126241494254
StatusReviewed
Ensembl ProteinENSMUSP00000019913
UniProt AccessionQ922K9; Q61364; Q61745;
Protein NameTyrosine-protein kinase FRK
Protein Synonyms/Alias Beta-cell Src-homology tyrosine kinase; BSK; FYN-related kinase; Intestine tyrosine kinase;
Gene NameFrk
Gene Synonyms/Alias Frk; Bsk, Iyk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000019779ENSMUSP00000019913ENSMUST00000019913
ENSMUSG00000019779ENSMUSP00000130289ENSMUST00000170771
OrganismMus musculus
Functional DescriptionNon-receptor tyrosine-protein kinase that negativelyregulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Protein Length512
Protein Sequence
(FASTA)
MGSVCVRLWA YLQPFLPCWS QEADKSVVIE NPGAFCPPEA PRSQEPERSH GQYFVALFDY 60
QARTAEDLSF RAGDKLQVLD TSHEGWWLAR HLEKKGTGLG QQLQGYIPSN YVAEDRSLQA 120
EPWFFGAIKR ADAEKQLLYS ENQTGAFLIR ESESQKGDFS LSVLDEGVVK HYRIRRLDEG 180
GFFLTRRKVF STLNEFVNYY TTTSDGLCVK LEKPCLKIQV PTPFDLSYKT ADQWEIDRNS 240
IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY 300
AVCTLEDPIY IITELMRHGS LQEYLQNDGG SKIHLIQQVD MAAQVASGMA YLESQNYIHR 360
DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 420
SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLSQNYRLP QPSNCPQQFY SIMLECWNVE 480
PKQRPTFETL HWKLEDYFET DCSYSDTNNF IN 512
Nucleotide Sequence
(FASTA)
ATGGGCAGCG TCTGTGTGAG ACTCTGGGCA TACCTGCAGC CTTTTCTCCC GTGCTGGTCT 60
CAAGAGGCAG ACAAGTCAGT AGTAATTGAG AATCCAGGGG CCTTCTGTCC CCCAGAGGCT 120
CCCAGGTCAC AAGAGCCCGA GAGAAGCCAT GGCCAGTATT TTGTGGCTCT GTTTGATTAC 180
CAAGCACGTA CTGCAGAGGA CCTGAGCTTC CGTGCCGGCG ACAAACTCCA AGTCTTGGAC 240
ACTTCGCATG AGGGCTGGTG GTTGGCCAGA CATTTGGAGA AGAAGGGAAC CGGCTTAGGT 300
CAGCAGCTAC AGGGCTACAT TCCTTCCAAT TACGTGGCGG AGGACCGGAG TCTCCAGGCA 360
GAGCCGTGGT TTTTTGGAGC AATCAAAAGA GCAGATGCAG AAAAACAACT TCTGTATTCA 420
GAAAACCAGA CGGGCGCCTT TCTAATCAGA GAGAGTGAGA GCCAGAAGGG TGACTTTTCC 480
CTCTCAGTTT TAGATGAAGG TGTTGTAAAA CACTACAGAA TAAGAAGGTT GGATGAAGGT 540
GGCTTCTTCC TCACCAGGAG GAAAGTCTTT TCAACCCTGA ATGAATTCGT GAACTACTAC 600
ACCACAACAA GTGACGGGCT GTGTGTCAAG CTGGAGAAGC CATGCTTAAA GATCCAGGTA 660
CCAACCCCTT TTGATTTGTC ATATAAAACT GCAGACCAGT GGGAGATAGA CCGCAACTCC 720
ATACAGCTTT TGAAGCGACT GGGATCTGGT CAGTTTGGAG AAGTTTGGGA AGGTCTGTGG 780
AATAATACCA CTCCAGTGGC CGTAAAAACG TTAAAACCAG GTTCAATGGA TCCAAATGAC 840
TTCCTGAGGG AGGCACAGAT AATGAAGAGC CTAAGACACC CAAAACTCAT CCAGCTCTAT 900
GCTGTTTGCA CTTTAGAAGA TCCCATTTAT ATTATTACAG AGTTGATGAG ACATGGAAGC 960
CTGCAAGAAT ATCTCCAAAA TGATGGTGGG TCAAAAATCC ATTTGATTCA ACAGGTAGAC 1020
ATGGCGGCAC AGGTGGCTTC TGGAATGGCC TATCTTGAGT CGCAGAACTA TATTCACAGA 1080
GATCTGGCTG CAAGAAATGT CCTTGTTGGT GAACATAATA TCTACAAAGT AGCAGATTTT 1140
GGACTTGCAA GAGTTTTTAA GGTAGATAAT GAAGACATCT ATGAATCTAA ACACGAAATA 1200
AAGCTGCCAG TGAAGTGGAC TGCACCCGAA GCCATTCGTA CTAATAAATT CAGCATTAAG 1260
TCTGATGTGT GGTCTTTTGG AATCCTGCTC TATGAAATCA TTACTTATGG CAAAATGCCT 1320
TACAGTGGTA TGACAGGTGC TCAAGTAATT CAAATGTTGA GTCAAAACTA CAGACTTCCA 1380
CAGCCATCTA ACTGCCCACA GCAATTCTAC AGCATCATGC TAGAGTGCTG GAATGTTGAG 1440
CCTAAGCAAC GGCCAACATT TGAGACCCTG CATTGGAAAC TTGAAGACTA CTTTGAAACA 1500
GACTGTTCCT ATTCAGATAC AAATAACTTC ATAAACTAA 1539
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly
Q: 241   IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLY  300
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         av++ e+Piyi+telm++Gsl+++l+++ g+k++l ++vd+aaqva+Gmayle++n+ihr
Q: 301   AVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVDMAAQVASGMAYLESQNYIHR  360
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177
         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik
Q: 361   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRTNKFSIK  420
         ************************998878999***************************
S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237
         sdvWsfGill+ei+t+Gk+Py+Gmt ++v+++++++yrlp+p++cp+++y+++lecw+ +
Q: 421   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVE  480
         ************************************************************
S: 238   peerPtfetlqevl  251
         p++rPtfetl+++l
Q: 481   PKQRPTFETLHWKL  494
         **********9986
Domain Sequence
(FASTA)
IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY 60
AVCTLEDPIY IITELMRHGS LQEYLQNDGG SKIHLIQQVD MAAQVASGMA YLESQNYIHR 120
DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 180
SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLSQNYRLP QPSNCPQQFY SIMLECWNVE 240
PKQRPTFETL HWKL 254
Keyword3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tumor suppressor; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00346
EKS-ANC-00361
EKS-BOT-00373
EKS-CAJ-00375
EKS-CAF-00374
EKS-CAP-00406
EKS-CII-00205
EKS-CIS-00120
EKS-DAR-00752
EKS-DAN-00036
EKS-DIO-00056
EKS-DRM-00174
EKS-EQC-00364
EKS-FEC-00360
EKS-GAM-00224
EKS-GAG-00315
EKS-GAA-00454
EKS-GOG-00362
EKS-HOS-00378
EKS-ICT-00352
EKS-LAC-00387
EKS-LOA-00380
EKS-MAM-00371
EKS-MEG-00305
EKS-MOD-00362
EKS-MUP-00367
EKS-MYL-00370
EKS-NOL-00340
EKS-ORN-00481
EKS-ORC-00350
EKS-ORL-00442
EKS-OTG-00376
EKS-PAT-00351
EKS-PES-00330
EKS-PEM-00197
EKS-POA-00362
EKS-RAN-00387
EKS-SAH-00343
EKS-SUS-00326
EKS-TAG-00444
EKS-TAR-00477
EKS-TAS-00041
EKS-TEN-00468
EKS-TUT-00100
EKS-XET-00486
EKS-XIM-00470
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030154; P:cell differentiation
KEGG
mmu:14302;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013