EKS-MUM-00076

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00076

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Sev	572.4	3.3E-172	1938	2208	271

Status

Reviewed

Ensembl Protein

ENSMUSP00000020045

UniProt Accession

Q78DX7; Q60705;

Protein Name

Proto-oncogene tyrosine-protein kinase ROS

Protein Synonyms/Alias

Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase;

Gene Name

Ros1

Gene Synonyms/Alias

Ros1; Ros, Ros-1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000019893	ENSMUSP00000134905	ENSMUST00000177378
ENSMUSG00000019893	ENSMUSP00000112873	ENSMUST00000117992
ENSMUSG00000019893	ENSMUSP00000020045	ENSMUST00000020045
ENSMUSG00000019893	ENSMUSP00000135235	ENSMUST00000175892

Organism

Mus musculus

Functional Description

Orphan receptor tyrosine kinase (RTK) that plays a rolein epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2.

Protein Length

2340

Protein Sequence
(FASTA)

MKNICWLTLK LVKFVVLGCI IWISVAQSTV LSSCLTSCVT NLGRQLDSGT RYNLSEACIH 60

GCQFWNSVDQ ETCALKCNDT YATICERESC EVGCSNAEGS YEEEVLESTE LPTAPFASSI 120

GSHGVTLRWN PANISGVKYI IQWKYAQLPG SWTFTETVSK LSYTVEPLHP FTEYIFRVVW 180

IFTAQLHLYS PPSPSYRTHP YGVPETAPLI LNMESWSPDT VEVSWAPPHF PGGPILGYNL 240

RLISKNQKLD SGTQRTSFQF YSTLPNTTYR FSIAAVNEVG EGPEAESTVT TPSPSVQEEE 300

QWLFLSRKTS LRKRSLKYLV DEAHCLWSDA IHHNITGISV YAQQQVVYFS EGTVIWMKGA 360

ANMSDVSDLR IFYQGSGLVS SISIDWLYQR MYFIMDKLVY VCELKNCSNL EEITPFSLIA 420

PQKVVVDSYN GYLFYLLRDG IYRVNLPLPS GRDTKAVRIV ESGTLKDFAV KPQSKRIIYF 480

NDTMQLFMST FLDGSAFHRV LPWVPLVTVK SFACENNDFL ITDGKAIFQQ DSLSFNEFIV 540

GCDLSHIEEF GFGNLVIFGS SVQSYPLPGH PQEVSVLFGS REALIQWTPP ALAIGASPSA 600

WQNWTYEVKV YSQDILEITQ VFSNISGTML NVPELQSSTK YTVSVRASSP KGPGPWSAPS 660

VGTTLVPATE PPFIMAVKED GLWSKPLCSF GPGEFLSSDV GNVSDMDWYN NSLYYSDTKG 720

NVYVRPLNGM DISENYHIPS IVGAGALAFE WLGHFLYWAG KTYVIQRQSV LTGHTDIVTH 780

VKLLVNDMAV DSVGGYLYWT TLYSVESTRL NGESSLVLQA QPWLSGKKVI ALTLDLSDGL 840

LYWLVQDNQC IHLYTAVLRG WSGGDATITE FAAWSTSEIS QNALMYYSGR LFWINGFRII 900

TAQEIGQRTS VSVSEPAKFN QFTIIQTSLK PLPGNFSSTP KVIPDPVQES SFRIEGHTSS 960

FQILWNEPPA VDWGIVFYSV EFSTHSKFLI IEQQSLPIFT VEGLEPYTLF NLSVTPYTYW 1020

GKGQKTSLSF RAPESVPSAP ENPRIFILSS GRYTKKNEVV VEFRWNKPKH ENGVLTKFEI 1080

FYHISKQSGT NRSTEDWMSA SVIPPVMSFQ LEAVSPEYTV AFQVRVFTSK GPGPFSDIVM 1140

SKTSEIKPCP YLISLLGNKI VFLDMDQNQV LWTFSLEGDV STVGYTTDDE MGYFAQGDTL 1200

FLLNLRNHSS SKLFQDALVS DIRVIAVDWI ARHLYFALKA SQNGTQIFNV DLEHKVKSPR 1260

EVKTCKAHTT IISFSIYPLL SRLYWTEVSD LGHQMFYCNI SNHTSQHVLQ PKASNQHGRS 1320

QCSCNVTESE LSGAMTVDTS DPDRPWIYFT KRQEIWAMDL EGCQCWKVIM VPTIPGKRII 1380

SLTVDGEFIY WIMKTKDDAQ IYQAKKGSGA ILSQVKASRS KHILAYSSAL QPFPDKAYLS 1440

LASDMVEATI LYATNTSLTL KLPPVKTNLT WHGITHPTST YLIYYMEANR ANSSDRRHKM 1500

LESQENVARI EGLQPFSMYM IQIAVKNYYS EPLEHLPLGK EIQGQTKSGV PGAVCHINAT 1560

VLSDTSLHVF WTESHKPNGP KESVRYQLVM SYLAPIPETP LRQGEFPSAK LSLLITKLSG 1620

GQLYVMKVLA CHPEEMWCTE SHPVSVNMFD TPEKPSALVP ENTSLQLDWK ARSNVNLTGF 1680

WFELQKWKYN EFYHVKASCS QGPVYVCNIT DLQPYTSYNI RVVVVYTTGE NSSSIPESFK 1740

TKAGVPSKPG IPKLLEGSKN SIQWEKAEDN GSRLMYYTLE VRKGISNDSQ NQSSRWKVVF 1800

NGSCSSICTW RSKNLKGTFQ FRAVAANEIG LGEYSEISED ITLVEDGVWI TETSFILTII 1860

VGIFLVATVP LTFVWHRSLK SHKASKEGLS VLNDNDKELA ELRGLAAGVG LANACYAVHT 1920

VPTQEEIENL PAFPREKLSL RLLLGSGAFG EVYEGTAIDI LGVGSGEIKV AVKTLKKGST 1980

DQEKIEFLKE AHLMSKFNHP NILKQLGVCL LGEPQYIILE LMEGGDLLSY LRKARGTTFH 2040

GPSLTLLDLV ELCVDISKGC VYLEQMHFIH RDLAARNCLV SVKDYTSPRV VKIGDFGLAR 2100

EIYKNDYYRK RGEGLLPVRW MAPENLMDGI FTSQSDVWSF GILVWEILTL GHQPYPAHSN 2160

LDVLNYVQAG GRLEPPRNCP DDLWNLMSQC WAQEPDQRPT FHNIQNQLQL FRNVFLNNVS 2220

HCGEAAPTGG VINKGFEGED DEMVTLNSDD TMPVALMETK NQEGLNYMVL ATKCSQGEGS 2280

YEGPLGPKEL GSCDLKKDKK QPQADKDFCQ EPQVAYGSPG LSEGLNYACL AHSEHGDVSE 2340

Nucleotide Sequence
(FASTA)

ATGAAGAACA TCTGCTGGCT CACCCTGAAA CTTGTGAAGT TTGTGGTCCT TGGGTGCATC 60

ATATGGATTT CTGTGGCACA GAGTACAGTT CTGAGCAGCT GCCTAACGTC CTGTGTAACT 120

AACCTGGGCA GGCAGCTTGA CAGTGGCACA CGGTACAATC TGAGTGAGGC GTGCATCCAT 180

GGATGTCAGT TTTGGAACTC TGTAGATCAG GAAACGTGTG CTTTAAAGTG TAATGACACC 240

TACGCCACCA TTTGTGAGAG GGAGTCCTGT GAGGTCGGCT GCAGCAATGC GGAGGGTAGC 300

TACGAAGAGG AAGTGCTGGA AAGCACAGAA CTTCCTACAG CACCCTTTGC ATCTTCCATT 360

GGAAGTCATG GTGTGACATT ACGCTGGAAC CCTGCCAACA TCTCTGGAGT CAAATACATA 420

ATTCAATGGA AATATGCCCA ACTTCCAGGA AGCTGGACTT TCACGGAGAC CGTGTCCAAG 480

CTCTCATACA CGGTGGAACC CCTGCATCCA TTCACAGAAT ATATTTTTCG AGTGGTTTGG 540

ATCTTCACAG CCCAACTGCA TCTTTATTCC CCACCAAGTC CCAGTTACAG GACTCATCCT 600

TATGGAGTTC CAGAAACTGC ACCTCTCATC CTGAACATGG AAAGCTGGAG CCCTGATACT 660

GTGGAGGTCA GCTGGGCTCC ACCTCATTTC CCAGGTGGAC CTATTTTGGG TTATAATTTA 720

AGGCTCATCA GTAAAAATCA AAAATTAGAT TCAGGGACAC AGAGAACCAG TTTCCAGTTT 780

TATTCTACTC TACCAAACAC CACCTACAGG TTTTCTATCG CAGCAGTCAA TGAAGTTGGT 840

GAGGGGCCAG AAGCAGAATC TACAGTTACC ACTCCATCCC CATCAGTTCA AGAAGAAGAA 900

CAATGGCTCT TTTTATCCAG AAAAACTTCT CTAAGAAAGA GGTCTTTGAA GTACTTAGTA 960

GATGAAGCAC ATTGCCTTTG GTCAGATGCT ATACACCATA ATATTACAGG AATATCAGTC 1020

TATGCTCAGC AGCAAGTGGT TTATTTTTCA GAAGGAACTG TCATCTGGAT GAAGGGGGCT 1080

GCCAACATGT CTGATGTGTC TGACCTGAGA ATTTTTTACC AAGGCTCAGG TCTAGTGTCT 1140

TCTATCTCCA TAGACTGGCT GTACCAAAGG ATGTATTTCA TCATGGATAA ACTGGTATAT 1200

GTCTGTGAAT TAAAGAATTG CTCAAATTTA GAGGAAATCA CTCCCTTCTC TCTTATTGCA 1260

CCTCAGAAAG TTGTGGTTGA CTCCTACAAT GGGTACCTCT TTTATCTCCT GAGAGACGGC 1320

ATCTACAGAG TCAATCTCCC TTTGCCATCT GGCAGGGACA CCAAAGCTGT GCGTATTGTG 1380

GAGAGTGGCA CATTAAAGGA CTTTGCAGTA AAGCCCCAAT CCAAGCGAAT CATTTACTTC 1440

AATGACACCA TGCAACTCTT CATGTCAACG TTTCTGGATG GCTCTGCCTT CCACCGGGTC 1500

CTGCCTTGGG TCCCCCTTGT GACTGTGAAG AGCTTTGCTT GTGAAAACAA TGACTTCCTC 1560

ATCACAGATG GCAAGGCCAT TTTTCAGCAG GACTCCCTGT CTTTCAATGA ATTCATCGTG 1620

GGATGTGACC TGAGTCACAT AGAAGAGTTT GGGTTTGGTA ACTTGGTCAT CTTTGGCTCC 1680

TCTGTCCAGT CATACCCTCT GCCAGGACAT CCACAGGAGG TCTCAGTGCT GTTTGGTTCT 1740

CGAGAGGCCC TTATTCAGTG GACGCCTCCT GCTCTCGCCA TAGGAGCCAG TCCTTCCGCC 1800

TGGCAGAACT GGACTTATGA AGTCAAAGTT TATTCCCAGG ACATCCTTGA AATCACTCAA 1860

GTTTTCTCGA ACATAAGCGG GACCATGCTT AATGTACCCG AACTGCAGAG TTCTACAAAG 1920

TACACTGTCT CTGTGAGAGC AAGTTCTCCT AAAGGCCCAG GCCCCTGGTC AGCACCATCA 1980

GTGGGTACCA CCTTGGTACC AGCTACTGAA CCACCATTCA TCATGGCTGT GAAAGAAGAT 2040

GGGCTCTGGA GCAAACCACT CTGTAGTTTT GGTCCAGGAG AATTCCTGTC CTCTGATGTA 2100

GGAAACGTGT CAGATATGGA TTGGTACAAC AACAGCCTCT ACTACAGTGA CACAAAAGGC 2160

AACGTTTATG TGCGGCCTCT GAATGGGATG GATATCTCAG AGAATTATCA CATACCCAGC 2220

ATTGTAGGAG CTGGGGCTTT GGCCTTTGAA TGGCTGGGTC ACTTTCTCTA CTGGGCTGGG 2280

AAGACATATG TGATCCAAAG GCAGTCTGTG TTGACGGGAC ACACGGACAT TGTGACTCAT 2340

GTGAAGCTGT TGGTGAATGA CATGGCTGTG GATTCAGTTG GTGGCTATCT CTATTGGACA 2400

ACACTCTACT CAGTTGAAAG CACCAGACTC AATGGAGAAA GTTCTCTTGT ACTACAGGCT 2460

CAGCCCTGGC TCTCTGGAAA AAAGGTTATT GCTCTAACAC TAGACCTCAG TGATGGGCTC 2520

CTGTATTGGC TGGTGCAGGA CAATCAGTGT ATTCATCTGT ACACAGCTGT TCTTCGAGGA 2580

TGGAGTGGTG GGGATGCTAC CATCACAGAG TTTGCAGCCT GGAGTACTTC TGAAATCTCC 2640

CAGAATGCAC TGATGTACTA CAGTGGTAGA CTCTTCTGGA TCAATGGATT TAGGATCATT 2700

ACAGCACAGG AAATAGGTCA GAGAACCAGT GTGTCTGTTT CGGAGCCAGC GAAATTCAAT 2760

CAGTTCACAA TTATACAGAC ATCTCTCAAG CCTCTGCCAG GAAACTTTTC CTCTACTCCC 2820

AAGGTTATCC CAGATCCTGT TCAGGAGTCT TCATTTCGAA TTGAAGGACA CACTTCAAGT 2880

TTCCAAATCC TGTGGAATGA GCCCCCTGCG GTGGACTGGG GCATCGTTTT CTACAGTGTG 2940

GAATTTAGCA CTCATTCCAA GTTCCTGATT ATTGAACAAC AGTCTTTACC TATTTTTACT 3000

GTGGAAGGAC TGGAGCCCTA TACCTTATTT AATCTTTCTG TCACTCCTTA TACCTACTGG 3060

GGAAAGGGCC AAAAAACATC TCTATCATTT CGTGCACCTG AATCAGTTCC ATCAGCACCA 3120

GAAAACCCCA GAATATTTAT ATTGTCAAGC GGAAGATACA CCAAGAAGAA TGAAGTTGTG 3180

GTAGAGTTCA GGTGGAATAA ACCTAAGCAT GAAAATGGAG TGCTAACCAA ATTTGAAATC 3240

TTCTATCACA TATCTAAACA AAGTGGCACA AATAGATCAA CTGAAGACTG GATGTCTGCC 3300

AGTGTTATAC CCCCAGTGAT GTCTTTTCAA CTTGAGGCTG TGAGTCCTGA GTATACTGTT 3360

GCCTTCCAGG TTAGAGTCTT CACATCCAAA GGGCCAGGGC CATTTTCTGA TATAGTGATG 3420

TCTAAAACAT CAGAAATCAA GCCATGTCCG TATCTCATAT CTCTTCTCGG CAATAAGATC 3480

GTGTTTCTAG ACATGGATCA AAATCAAGTT TTGTGGACAT TTTCCCTGGA GGGAGACGTC 3540

AGCACAGTGG GGTACACAAC AGACGATGAA ATGGGGTATT TCGCTCAAGG AGACACGCTC 3600

TTCCTTCTGA ATTTGCGTAA TCATTCCAGT TCCAAGCTTT TCCAGGATGC ACTGGTTTCT 3660

GACATTAGAG TTATTGCTGT TGATTGGATT GCAAGGCACC TCTACTTTGC TCTGAAAGCA 3720

TCACAAAACG GAACACAGAT ATTCAATGTT GACCTTGAAC ACAAGGTGAA ATCCCCCAGG 3780

GAGGTGAAGA CTTGCAAAGC ACATACAACA ATAATTTCTT TCTCTATATA TCCCCTCTTG 3840

AGTCGCTTGT ATTGGACAGA AGTTTCAGAT CTGGGCCATC AGATGTTCTA CTGCAATATT 3900

AGCAATCACA CCTCGCAACA TGTTCTACAA CCCAAGGCTT CAAACCAACA TGGAAGGAGT 3960

CAATGTTCTT GTAATGTGAC AGAATCTGAG TTAAGTGGGG CAATGACTGT GGATACCTCT 4020

GACCCAGACA GACCATGGAT ATACTTTACC AAAAGGCAAG AGATCTGGGC CATGGATCTG 4080

GAAGGATGTC AGTGTTGGAA AGTCATCATG GTACCTACTA TCCCTGGAAA AAGAATCATT 4140

AGCTTAACAG TGGATGGGGA GTTTATATAT TGGATCATGA AAACAAAGGA TGATGCCCAA 4200

ATTTATCAAG CAAAGAAGGG AAGCGGGGCC ATCCTTTCCC AAGTGAAGGC CTCCAGGAGT 4260

AAGCATATCT TGGCTTACAG TTCTGCTCTG CAGCCTTTTC CAGATAAAGC ATATCTGTCT 4320

CTAGCTTCAG ATATGGTAGA AGCAACTATA TTATATGCCA CCAACACCAG CCTCACACTC 4380

AAATTACCTC CAGTCAAGAC AAACCTCACG TGGCATGGTA TTACCCACCC CACGTCAACA 4440

TACCTGATTT ACTATATGGA AGCTAATAGG GCAAACAGCT CTGACAGGAG ACACAAAATG 4500

CTGGAATCAC AGGAGAATGT AGCCCGGATT GAAGGTCTGC AGCCATTTTC AATGTACATG 4560

ATTCAGATAG CTGTGAAGAA CTATTATTCA GAGCCTTTAG AACATTTACC TCTTGGAAAA 4620

GAGATTCAAG GACAAACTAA AAGTGGAGTG CCTGGGGCAG TTTGTCATAT CAACGCAACT 4680

GTGTTGTCGG ACACCAGTCT CCATGTATTC TGGACAGAAT CCCATAAGCC AAACGGACCA 4740

AAAGAGTCAG TCCGCTATCA GCTGGTTATG TCATACCTGG CTCCCATTCC TGAGACTCCT 4800

CTAAGACAGG GTGAATTTCC AAGTGCCAAG CTTTCTCTGC TCATCACTAA ACTATCTGGT 4860

GGACAGCTCT ATGTGATGAA GGTTCTGGCG TGCCACCCTG AGGAAATGTG GTGTACTGAG 4920

AGTCATCCTG TCAGTGTCAA CATGTTTGAC ACACCAGAGA AACCCTCTGC CTTGGTTCCA 4980

GAGAACACTA GTCTGCAGTT AGATTGGAAG GCTCGATCAA ACGTTAACCT CACCGGATTT 5040

TGGTTTGAAC TCCAGAAGTG GAAATATAAT GAGTTTTACC ATGTCAAAGC TTCATGCAGC 5100

CAAGGTCCAG TTTATGTCTG TAACATCACA GATCTACAAC CTTACACCTC CTATAACATT 5160

CGAGTGGTGG TGGTCTATAC GACAGGAGAA AATAGCTCCT CCATTCCAGA GAGTTTCAAG 5220

ACAAAAGCCG GAGTCCCAAG CAAACCAGGT ATTCCTAAAT TACTAGAAGG GAGTAAAAAT 5280

TCCATCCAGT GGGAAAAAGC TGAAGATAAT GGGAGCAGAT TGATGTACTA CACCCTTGAG 5340

GTCAGAAAAG GCATTTCAAA TGACTCACAG AACCAGAGTT CAAGGTGGAA GGTGGTGTTT 5400

AATGGGTCCT GCAGTAGCAT TTGCACATGG AGATCAAAAA ACCTAAAAGG AACATTTCAG 5460

TTCAGAGCAG TTGCTGCAAA TGAAATTGGA CTTGGAGAAT ATAGTGAAAT CAGTGAAGAC 5520

ATTACATTAG TGGAAGATGG TGTTTGGATA ACAGAAACAA GTTTTATACT TACTATCATA 5580

GTTGGGATAT TTCTGGTTGC TACAGTCCCA CTGACCTTTG TCTGGCATAG AAGCTTGAAA 5640

AGTCACAAAG CTTCCAAGGA AGGCCTCTCG GTTCTCAACG ACAACGACAA AGAGTTGGCT 5700

GAGCTTCGAG GTCTGGCGGC TGGAGTGGGA CTGGCCAATG CCTGCTACGC AGTACATACT 5760

GTTCCAACCC AAGAAGAGAT TGAAAATCTT CCTGCCTTCC CTCGGGAGAA GCTGAGCCTG 5820

CGTCTTTTGT TGGGAAGTGG AGCTTTTGGA GAAGTGTATG AAGGCACAGC TATAGACATC 5880

CTAGGCGTGG GAAGTGGAGA AATCAAAGTG GCAGTGAAGA CCTTGAAGAA AGGTTCAACA 5940

GACCAGGAGA AGATTGAGTT CCTGAAGGAG GCGCACCTGA TGAGCAAGTT TAATCACCCC 6000

AACATTCTGA AGCAGCTGGG AGTCTGTCTG TTAGGCGAAC CCCAGTACAT TATTCTGGAA 6060

CTGATGGAAG GGGGAGACCT TCTAAGCTAT CTGCGCAAAG CTCGGGGGAC AACGTTTCAT 6120

GGTCCTTCAC TCACCTTGCT TGACCTTGTA GAGCTGTGTG TAGATATTTC AAAAGGCTGC 6180

GTCTACTTGG AGCAGATGCA CTTCATTCAC AGGGATCTGG CAGCTCGGAA TTGCCTTGTA 6240

TCAGTGAAAG ACTACACCAG TCCTCGGGTA GTCAAGATTG GTGACTTTGG ATTGGCAAGA 6300

GAAATCTATA AAAATGATTA TTATAGAAAG AGAGGGGAAG GCCTGCTTCC TGTTCGGTGG 6360

ATGGCTCCTG AAAACTTGAT GGACGGAATC TTCACTTCTC AGTCTGATGT ATGGTCCTTT 6420

GGAATTTTGG TGTGGGAGAT TTTAACTCTC GGTCATCAAC CTTATCCAGC GCATTCCAAC 6480

CTTGATGTTT TAAACTATGT GCAAGCAGGA GGGAGACTGG AGCCACCAAG AAATTGTCCT 6540

GATGATCTGT GGAATTTAAT GTCCCAATGC TGGGCTCAAG AACCTGACCA AAGACCCACT 6600

TTCCATAACA TTCAAAACCA GCTTCAGTTA TTCAGAAATG TTTTCTTAAA CAATGTTTCT 6660

CATTGTGGAG AAGCAGCTCC CACCGGTGGA GTCATCAACA AAGGCTTTGA AGGTGAAGAT 6720

GATGAAATGG TCACTTTGAA CTCAGATGAC ACGATGCCAG TTGCCTTGAT GGAAACCAAG 6780

AACCAAGAAG GATTAAATTA TATGGTGCTT GCCACAAAAT GTAGCCAAGG TGAAGGAAGT 6840

TATGAGGGTC CTCTAGGCCC TAAGGAACTT GGGTCATGTG ATCTGAAGAA AGACAAGAAG 6900

CAACCACAGG CAGACAAAGA TTTCTGCCAG GAACCACAGG TGGCTTATGG CTCTCCTGGC 6960

CTGTCTGAAG GCCTGAATTA TGCCTGTCTT GCTCACAGTG AACATGGAGA TGTGTCTGAA 7020

TAA 7023

Domain Profile

S: 1     lklrlllgsgafgevyegtavdilkvesgeikvavktlkkgstdqekiellkeaqlmskf  60

         l+lrlllgsgafgevyegta+dil+v+sgeikvavktlkkgstdqekie+lkea+lmskf

Q: 1938  LSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKF  1997

         78**********************************************************

S: 61    khenilkllgvclltesqylilelmeagdllsylrkarattfqepsltlvdlvelcvdis  120

         +h+nilk+lgvcll+e+qy+ilelme+gdllsylrkar+ttf++psltl+dlvelcvdis

Q: 1998  NHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCVDIS  2057

         ************************************************************

S: 121   kgcvyledmhfihrdlaarnclvsvkdytsrrvvkigdfglardiykndyyrkrgegllp  180

         kgcvyle+mhfihrdlaarnclvsvkdyts+rvvkigdfglar+iykndyyrkrgegllp

Q: 2058  KGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKNDYYRKRGEGLLP  2117

         ************************************************************

S: 181   vrwmapeslvdglfttqsdvwsfgilvweiltlgqqpyaarsnldvlayvkeggrleqpr  240

         vrwmape+l+dg+ft+qsdvwsfgilvweiltlg+qpy+a+snldvl+yv++ggrle+pr

Q: 2118  VRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPR  2177

         ************************************************************

S: 241   nctddlynllllcwaqepderptfrriqnql  271

         nc+ddl+nl+++cwaqepd+rptf++iqnql

Q: 2178  NCPDDLWNLMSQCWAQEPDQRPTFHNIQNQL  2208

         *****************************97

Domain Sequence
(FASTA)

LSLRLLLGSG AFGEVYEGTA IDILGVGSGE IKVAVKTLKK GSTDQEKIEF LKEAHLMSKF 60

NHPNILKQLG VCLLGEPQYI ILELMEGGDL LSYLRKARGT TFHGPSLTLL DLVELCVDIS 120

KGCVYLEQMH FIHRDLAARN CLVSVKDYTS PRVVKIGDFG LAREIYKNDY YRKRGEGLLP 180

VRWMAPENLM DGIFTSQSDV WSFGILVWEI LTLGHQPYPA HSNLDVLNYV QAGGRLEPPR 240

NCPDDLWNLM SQCWAQEPDQ RPTFHNIQNQ L 271

Keyword

ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0016049	; P:cell growth
GO:0008283	; P:cell proliferation
GO:0002066	; P:columnar/cuboidal epithelial cell development
GO:0010629	; P:negative regulation of gene expression
GO:0070372	; P:regulation of ERK1 and ERK2 cascade
GO:0010966	; P:regulation of phosphate transport
GO:0032006	; P:regulation of TOR signaling cascade
GO:0007283	; P:spermatogenesis

KEGG

mmu:19886

;

InterPros

IPR011042	; 6-blade_b-propeller_TolB-like.
IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000033	; LDLR_classB_rpt.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 4.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 9.
SM00135	; LY; 3.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 9.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013