| Tag | Content |
|---|
| EKPD ID | EPS-MUM-00072 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPP/PP2A | 419.5 | 4.0E-126 | 51 | 243 | 193 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000020608 |
| UniProt Accession | P63330; O88591; P13353; Q5SNY5; |
| Protein Name | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| Protein Synonyms/Alias | PP2A-alpha; |
| Gene Name | Ppp2ca |
| Gene Synonyms/Alias | Ppp2ca; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | PP2A is the major phosphatase for microtubule-associatedproteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). |
| Protein Length | 309 |
Protein Sequence
(FASTA) | | MDEKLFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60 | | QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120 | | RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180 | | RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240 | | HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300 | | TRRTPDYFL 309 |
|
Nucleotide Sequence
(FASTA) | | ATGGACGAGA AGTTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC 60 | | AAGCAGCTCT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA 120 | | AAAGAATCCA ACGTTCAAGA GGTTCGATGT CCAGTCACTG TGTGTGGAGA TGTACATGGG 180 | | CAATTTCATG ATCTCATGGA ACTCTTTAGA ATTGGTGGTA AATCACCAGA TACAAATTAC 240 | | CTGTTTATGG GAGACTATGT GGACAGAGGA TATTACTCTG TTGAAACAGT TACACTGCTT 300 | | GTAGCTCTTA AGGTTCGTTA CCGAGAGCGC ATCACCATAC TCCGAGGGAA TCACGAGAGC 360 | | AGACAGATCA CACAGGTTTA TGGGTTCTAC GACGAGTGTT TAAGGAAATA CGGAAATGCA 420 | | AATGTTTGGA AATACTTCAC AGACCTTTTT GACTATCTTC CTCTCACTGC CTTGGTGGAT 480 | | GGGCAGATCT TCTGTCTACA CGGTGGTCTG TCACCATCCA TAGACACACT GGATCACATC 540 | | CGAGCACTCG ATCGCCTACA GGAAGTTCCT CATGAGGGTC CAATGTGTGA CTTGCTGTGG 600 | | TCAGATCCAG ATGACCGTGG TGGCTGGGGG ATATCTCCTC GGGGAGCTGG TTATACCTTT 660 | | GGCCAAGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCCAGAGCT 720 | | CACCAGCTGG TGATGGAGGG ATATAACTGG TGCCATGACC GGAACGTAGT AACAATTTTC 780 | | AGTGCTCCAA ACTATTGCTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGACGAC 840 | | ACTCTTAAGT ATTCTTTCTT GCAGTTTGAC CCAGCACCTC GTAGAGGCGA GCCACATGTC 900 | | ACTCGTCGTA CCCCAGACTA CTTCCTGTAA 930 |
|
| Domain Profile | S: 1 pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer 60 | pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvryrer | Q: 51 PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRER 110 | 9*********************************************************** |
| S: 61 itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl 120 | itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl | Q: 111 ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL 170 | ************************************************************ |
| S: 121 spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh 180 | spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh | Q: 171 SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH 230 | ************************************************************ |
| S: 181 angleliarahql 193 | angl+l++rahql | Q: 231 ANGLTLVSRAHQL 243 | ************8 |
|
Domain Sequence
(FASTA) | | PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER 60 | | ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120 | | SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180 | | ANGLTLVSRA HQL 193 |
|
| Keyword | Acetylation; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Hydrolase; Iron; Manganese; Meiosis; Metal-binding; Methylation; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |