EKS-MUM-00212

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00212

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	486.0	6.7E-146	4	286	283

Status

Reviewed

Ensembl Protein

ENSMUSP00000104704

UniProt Accession

Q8BLF2; A2ACR7; A2ACR8; A2ACR9; A2ACS0; A2ACS1; Q5M6W2; Q8BKR2; Q8BL49; Q8BLN9; Q8BVE0; Q8K134;

Protein Name

Cyclin-dependent kinase-like 3

Protein Synonyms/Alias

Gene Name

Cdkl3

Gene Synonyms/Alias

Cdkl3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000020389	ENSMUSP00000104707	ENSMUST00000109079
ENSMUSG00000020389	ENSMUSP00000104708	ENSMUST00000109080
ENSMUSG00000020389	ENSMUSP00000123279	ENSMUST00000143228
ENSMUSG00000020389	ENSMUSP00000104705	ENSMUST00000109077
ENSMUSG00000020389	ENSMUSP00000117315	ENSMUST00000136021
ENSMUSG00000020389	ENSMUSP00000104706	ENSMUST00000109078
ENSMUSG00000020389	ENSMUSP00000113303	ENSMUST00000120374
ENSMUSG00000020389	ENSMUSP00000104709	ENSMUST00000109081
ENSMUSG00000020389	ENSMUSP00000119505	ENSMUST00000147874
ENSMUSG00000020389	ENSMUSP00000104704	ENSMUST00000109076
ENSMUSG00000020389	ENSMUSP00000121945	ENSMUST00000128853
ENSMUSG00000020389	ENSMUSP00000118607	ENSMUST00000150736
ENSMUSG00000020389	ENSMUSP00000112477	ENSMUST00000121591
ENSMUSG00000020389	ENSMUSP00000065128	ENSMUST00000063321
ENSMUSG00000020389	ENSMUSP00000117983	ENSMUST00000135076
ENSMUSG00000020389	ENSMUSP00000116009	ENSMUST00000154701
ENSMUSG00000020389	ENSMUSP00000064315	ENSMUST00000063303

Organism

Mus musculus

Functional Description

Protein Length

353

Protein Sequence
(FASTA)

MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE IKFLKQFRHE 60

NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIEYLHNNN 120

IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDVYTDY VATRWYRAPE LVLKDTSYGK 180

PVDIWALGCM IIEMATGHPF LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP 240

QVQHPKTARK KYPKLNGLLA DIVHACLQID PAERTSSTDL LRHDYFTRDG FIEKKWTETK 300

GPRSSKSESL RPKGAKEMSQ TRRSQSMKAT TASRAQLMTH SPHHWTRSLL SWN 353

Nucleotide Sequence
(FASTA)

ATGGAGATGT ATGAAACCCT TGGAAAAGTG GGAGAGGGAA GTTATGGAAC GGTCATGAAA 60

TGCAAACATA AGGACACTGG GCGAATAGTG GCCATTAAGA TTTTCTATGA GAAACCAGAA 120

AAATCTGTCA ACAAAATTGC AACGAGAGAA ATAAAGTTTC TAAAGCAATT TCGGCATGAA 180

AACCTGGTCA ATTTGATTGA AGTTTTTAGA CAAAAGAAGA AAATTCATTT GGTATTTGAG 240

TTTATTGACC ACACGGTCTT AGATGAGCTG CAGCACTACT GTCACGGACT AGAGAGTAAG 300

CGGCTGAGAA AGTACCTCTT CCAGATCCTT CGCGCCATTG AGTACCTGCA TAATAATAAT 360

ATTATCCATC GAGATATAAA GCCTGAGAAT ATTTTAGTCT CCCAGTCAGG AATTACGAAG 420

CTGTGTGATT TTGGGTTTGC GAGGACACTA GCAGCTCCTG GAGACGTTTA CACAGACTAC 480

GTGGCCACAC GCTGGTACAG AGCTCCAGAG CTGGTGTTGA AAGACACCTC CTACGGAAAG 540

CCAGTGGACA TCTGGGCTTT GGGCTGTATG ATCATTGAAA TGGCCACTGG CCATCCCTTC 600

CTTCCTAGCA GTTCCGATTT GGATTTGCTC CACAAGATTG TTTTAAAAGT AGGCAACCTG 660

ACCCCGCACC TGCACAATAT CTTTTCCAAG AGTCCCATCT TTGCTGGGGT GGTTCTTCCT 720

CAAGTTCAAC ACCCAAAAAC CGCAAGAAAG AAATACCCCA AGCTCAATGG ATTGCTGGCA 780

GATATAGTTC ATGCTTGTTT ACAAATTGAT CCTGCTGAGA GGACATCATC TACTGATCTT 840

TTGCGTCACG ATTACTTTAC TAGAGATGGA TTTATTGAGA AGAAGTGGAC AGAGACAAAA 900

GGGCCAAGGA GCTCAAAGTC AGAGTCATTA AGGCCAAAGG GGGCAAAGGA GATGTCCCAG 960

ACCAGAAGAA GCCAGAGTAT GAAGGCGACC ACCGCCAGCA GGGCACAGCT GATGACACAC 1020

AGCCCTCATC ACTGGACAAG AAGCCTTCTG TCTTGGAACT GA 1062

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lgkvGeGsyG+v+kc++kdtg+ivaik f+e+++ k+v+kia+reik+lkq++henl

Q: 4     YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPE-KSVNKIATREIKFLKQFRHENL  62

         9***********************************9.9*********************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfr+kkk++lvfe++d+tvldel++y++G+e+++++k+l+qil+aie++h+nnii

Q: 63    VNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNII  122

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sg++klcdfGfar+laapgdvytdyvatrwyrapel+++dt+yGk+v

Q: 123   HRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPV  182

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+wa+Gc+++e++tG+p++p++sd+d l+ki+ ++G+l+p+ ++ifsk+++faGv+lp+v

Q: 183   DIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQV  242

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++++++kkypkln +l+d++++cl++dpaer+s+++ll+h+yf

Q: 243   QHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRHDYF  286

         *******************************************9

Domain Sequence
(FASTA)

YETLGKVGEG SYGTVMKCKH KDTGRIVAIK IFYEKPEKSV NKIATREIKF LKQFRHENLV 60

NLIEVFRQKK KIHLVFEFID HTVLDELQHY CHGLESKRLR KYLFQILRAI EYLHNNNIIH 120

RDIKPENILV SQSGITKLCD FGFARTLAAP GDVYTDYVAT RWYRAPELVL KDTSYGKPVD 180

IWALGCMIIE MATGHPFLPS SSDLDLLHKI VLKVGNLTPH LHNIFSKSPI FAGVVLPQVQ 240

HPKTARKKYP KLNGLLADIV HACLQIDPAE RTSSTDLLRH DYF 283

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

mmu:213084

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013