EKS-MUM-00318
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00318
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IRE481.31.9E-144571832262
StatusReviewed
Ensembl ProteinENSMUSP00000001059
UniProt AccessionQ9EQY0; Q9D340;
Protein NameEndoribonuclease
Protein Synonyms/Alias Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; Ire1-alpha; IRE1a;
Gene NameErn1
Gene Synonyms/Alias Ern1; Ire1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000020715ENSMUSP00000001059ENSMUST00000001059
ENSMUSG00000020715ENSMUSP00000102413ENSMUST00000106801
ENSMUSG00000020715ENSMUSP00000102412ENSMUST00000106800
ENSMUSG00000020715ENSMUSP00000102411ENSMUST00000106799
OrganismMus musculus
Functional DescriptionSenses unfolded proteins in the lumen of the endoplasmicreticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Protein Length977
Protein Sequence
(FASTA)
MPARWLLLLL ALLLPPPGPG SFGRTSTVTL PETLLFVSTL DGSLHAVSKR TGSIKWTLKE 60
DPVLQVPTHV EEPAFLPDPN DGSLYTLGGK NNEGLTKLPF TIPELVQASP CRSSDGILYM 120
GKKQDIWYVI DLLTGEKQQT LSSAFADSLC PSTSLLYLGR TEYTITMYDT KTRELRWNAT 180
YFDYAASLPE DDVDYKMSHF VSNGDGLVVT VDSESGDVLW IQNYASPVVA FYVWQGEVLR 240
KVVHINVAVE TLRYLTFMSG EVGRITKWKY PFPKETEAKS KLTPTLYVGK YSTSLYASPS 300
MVHEGVAVVP RGSTLPLLEG PQTDGVTIGD KGECVITPST DLKFDPGLKG KSKLNYLRNY 360
WLLIGHHETP LSASTKMLER FPNNLPKHRE NVIPADSEKR SFEEVINIVG QTSDNTPTTV 420
SQDVEEKLAR APAKPEAPVD SMLKDMATII LSTFLLVGWV AFIITYPLSV HQQRQLQHQQ 480
FQKELEKIQL LQQQQLPFHP HGDLTQDPEF LDSSGPFSES SGTSSPSPSP RASNHSLHPS 540
SSASRAGTSP SLEQDDEDEE TRMVIVGKIS FCPKDVLGHG AEGTIVYKGM FDNRDVAVKR 600
ILPECFSFAD REVQLLRESD EHPNVIRYFC TEKDRQFQYI AIELCAATLQ EYVEQKDFAH 660
LGLEPITLLH QTTSGLAHLH SLNIVHRDLK PHNILLSMPN AHGRIKAMIS DFGLCKKLAV 720
GRHSFSRRSG VPGTEGWIAP EMLSEDCKDN PTYTVDIFSA GCVFYYVISE GNHPFGKSLQ 780
RQANILLGAC NLDCFHSDKH EDVIARELIE KMIAMDPQQR PSAKHVLKHP FFWSLEKQLQ 840
FFQDVSDRIE KEALDGPIVR QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSVRDL 900
LRAMRNKKHH YRELPVEVQE TLGSIPDDFV RYFTSRFPHL LSHTYQAMEL CRHERLFQTY 960
YWHEPTEPQP PVIPYAL 977
Nucleotide Sequence
(FASTA)
ATGCCGGCCC GGTGGCTGTT GCTCCTGCTG GCGCTGCTGC TACCGCCGCC CGGCCCCGGG 60
AGTTTTGGAA GAACCAGCAC AGTTACACTG CCTGAGACCT TGTTGTTTGT CTCGACCCTG 120
GATGGAAGCT TGCATGCTGT TAGCAAGAGG ACGGGCTCCA TCAAGTGGAC TTTAAAAGAA 180
GATCCAGTCC TGCAGGTCCC AACACACGTG GAAGAGCCGG CTTTCCTCCC AGATCCCAAT 240
GATGGCAGTC TGTACACACT TGGAGGCAAG AACAACGAAG GCCTGACGAA ACTTCCCTTT 300
ACCATCCCAG AATTGGTTCA GGCCTCCCCA TGCCGAAGTT CAGATGGAAT CCTCTACATG 360
GGTAAAAAGC AAGATATTTG GTATGTTATC GACCTCCTGA CTGGCGAGAA GCAGCAGACT 420
TTGTCATCGG CCTTTGCTGA TAGTCTCTGC CCATCAACTT CCCTTCTATA TCTTGGACGG 480
ACAGAATACA CCATCACCAT GTATGACACC AAGACCCGGG AGCTCCGCTG GAATGCCACC 540
TATTTTGACT ATGCAGCCTC ACTGCCGGAA GACGACGTGG ACTACAAGAT GTCCCACTTT 600
GTGTCCAATG GCGATGGACT GGTGGTAACT GTGGACAGTG AATCTGGGGA TGTCCTGTGG 660
ATCCAAAACT ATGCCTCTCC TGTGGTGGCC TTCTACGTCT GGCAGGGGGA GGTCCTGAGA 720
AAGGTGGTGC ACATCAACGT TGCTGTGGAG ACTCTACGCT ACTTGACCTT CATGTCTGGG 780
GAAGTGGGGC GCATCACCAA GTGGAAGTAT CCATTCCCCA AGGAGACAGA GGCCAAGAGC 840
AAGCTAACGC CTACTCTGTA TGTTGGGAAG TATTCCACCA GCCTCTATGC CTCTCCCTCA 900
ATGGTGCATG AGGGGGTTGC TGTCGTGCCT CGAGGCAGCA CTCTTCCTTT GCTGGAAGGC 960
CCCCAGACAG ATGGCGTCAC CATTGGAGAC AAAGGAGAGT GTGTGATCAC TCCCAGCACA 1020
GACCTCAAGT TTGACCCTGG ACTCAAAGGG AAGAGCAAGC TGAACTACTT GAGGAATTAC 1080
TGGCTTCTCA TAGGACACCA TGAAACTCCT CTGTCTGCAT CCACCAAGAT GCTGGAGAGA 1140
TTTCCTAACA ACCTGCCCAA ACATCGAGAA AATGTGATTC CTGCTGATTC AGAAAAAAGG 1200
AGCTTTGAGG AAGTTATCAA CATAGTTGGC CAGACTTCAG ACAACACACC GACCACCGTA 1260
TCTCAGGATG TGGAGGAGAA GCTCGCTCGC GCCCCTGCCA AGCCTGAGGC CCCCGTGGAC 1320
TCCATGCTCA AGGACATGGC TACCATTATC CTGAGCACCT TCCTGCTGGT TGGATGGGTG 1380
GCGTTCATCA TCACTTACCC CCTGAGCGTG CATCAGCAGC GTCAGCTCCA GCACCAACAG 1440
TTCCAGAAGG AGCTGGAGAA GATTCAGCTC CTGCAGCAGC AGCAGCTGCC CTTCCACCCA 1500
CACGGAGACC TTACCCAGGA CCCTGAGTTC CTGGATTCAT CTGGCCCCTT CTCAGAGAGC 1560
TCTGGCACCA GCAGCCCCAG CCCATCCCCC AGAGCCTCCA ACCACTCCCT CCACCCCAGC 1620
AGCTCTGCCT CCAGGGCCGG CACCAGCCCC TCTCTGGAGC AGGATGATGA GGATGAGGAA 1680
ACCAGAATGG TGATTGTTGG GAAAATTTCA TTCTGCCCCA AGGATGTCCT GGGTCATGGA 1740
GCTGAGGGCA CAATTGTATA CAAAGGTATG TTTGACAACC GAGATGTGGC CGTGAAGAGG 1800
ATCCTCCCTG AGTGTTTTAG CTTTGCCGAC CGTGAGGTCC AGCTGCTTCG AGAATCAGAC 1860
GAGCACCCAA ATGTGATCCG CTACTTTTGC ACAGAGAAGG ACCGGCAGTT CCAGTACATT 1920
GCTATCGAGC TGTGTGCAGC CACCCTACAA GAGTATGTGG AGCAGAAGGA CTTTGCCCAC 1980
CTTGGCCTCG AGCCCATCAC CCTGCTTCAT CAGACCACCT CAGGCCTGGC ACACCTGCAT 2040
TCTCTCAACA TTGTTCACAG AGACCTGAAG CCCCACAACA TTCTCCTCTC CATGCCCAAC 2100
GCACATGGCA GGATCAAGGC GATGATCTCT GACTTTGGCC TCTGCAAGAA GCTGGCAGTG 2160
GGCAGGCACA GTTTCAGCCG CCGTTCAGGG GTACCTGGCA CTGAAGGGTG GATCGCCCCA 2220
GAGATGCTGA GTGAAGACTG TAAGGACAAC CCTACCTACA CGGTGGACAT CTTTTCTGCA 2280
GGCTGTGTCT TTTACTATGT CATCTCTGAG GGCAACCATC CTTTTGGCAA ATCCTTGCAG 2340
CGGCAGGCCA ACATCCTCCT GGGCGCCTGC AACCTTGACT GTTTCCACTC AGACAAGCAT 2400
GAGGACGTCA TTGCTCGTGA ATTGATAGAG AAAATGATTG CTATGGATCC CCAGCAGCGT 2460
CCCTCTGCAA AGCACGTGCT GAAACACCCC TTCTTCTGGA GCCTGGAGAA GCAGCTCCAG 2520
TTTTTCCAGG ATGTAAGTGA CCGAATAGAA AAGGAGGCCT TGGACGGTCC AATCGTACGG 2580
CAGTTGGAGA GAGGCGGGAG AGCTGTGGTC AAGATGGACT GGCGGGAGAA CATCACTGTC 2640
CCCCTGCAGA CAGATCTGCG CAAATTCAGA ACCTACAAAG GTGGCTCTGT GAGAGACCTC 2700
CTCCGAGCCA TGAGAAACAA GAAACACCAC TACCGGGAGC TCCCCGTGGA GGTTCAGGAG 2760
ACGCTGGGCT CCATCCCGGA TGACTTTGTG CGCTACTTCA CTTCCCGCTT CCCCCACCTC 2820
CTCTCTCACA CCTACCAAGC CATGGAGCTG TGCAGACATG AGAGACTCTT TCAGACCTAC 2880
TACTGGCACG AGCCCACAGA ACCCCAGCCT CCAGTGATTC CATATGCCCT CTGA 2934
Domain Profile
S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60
         f+pkdvlG+GaeGt+v++G+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc
Q: 571   FCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  630
         79**********************************************************
S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120
         tekdrqf+yia+elcaa+lq+yve+kd++ + +lepi+ll+q++sGlahlhsl+ivhrdl
Q: 631   TEKDRQFQYIAIELCAATLQEYVEQKDFA-HLGLEPITLLHQTTSGLAHLHSLNIVHRDL  689
         *****************************.******************************
S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180
         kp+nil+s+p+a+g+++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++k+
Q: 690   KPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKD  749
         ************************************************************
S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240
         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g+++ld+++++k+e+via++li
Q: 750   NPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARELI  809
         ************************************************************
S: 241   skmidkdplkrpsakkvlkhplf  263
         +kmi++dp++rpsak+vlkhp+f
Q: 810   EKMIAMDPQQRPSAKHVLKHPFF  832
         **********************9
Domain Sequence
(FASTA)
FCPKDVLGHG AEGTIVYKGM FDNRDVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60
TEKDRQFQYI AIELCAATLQ EYVEQKDFAH LGLEPITLLH QTTSGLAHLH SLNIVHRDLK 120
PHNILLSMPN AHGRIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKDN 180
PTYTVDIFSA GCVFYYVISE GNHPFGKSLQ RQANILLGAC NLDCFHSDKH EDVIARELIE 240
KMIAMDPQQR PSAKHVLKHP FF 262
KeywordADP-ribosylation; Alternative splicing; Apoptosis; ATP-binding; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Kinase; Magnesium; Membrane; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Signal; Transcription; Transcription regulation; Transferase; Transmembrane; Transmembrane helix; Unfolded protein response.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00269
EKS-ANC-00277
EKS-BOT-00287
EKS-CAE-00246
EKS-CAJ-00294
EKS-CAF-00293
EKS-CAP-00322
EKS-CII-00169
EKS-CIS-00050
EKS-DAR-00632
EKS-DRM-00146
EKS-EQC-00279
EKS-FEC-00273
EKS-GAM-00181
EKS-GAG-00240
EKS-GAA-00355
EKS-GOG-00286
EKS-HOS-00293
EKS-ICT-00272
EKS-LAC-00301
EKS-MAM-00290
EKS-MEG-00229
EKS-MOD-00282
EKS-MUP-00283
EKS-MYL-00289
EKS-NOL-00265
EKS-ORN-00373
EKS-ORA-00253
EKS-ORC-00269
EKS-ORL-00345
EKS-OTG-00293
EKS-PAT-00272
EKS-PES-00256
EKS-POA-00279
EKS-RAN-00303
EKS-SAH-00269
EKS-SUS-00253
EKS-TAG-00301
EKS-TAR-00376
EKS-XET-00360
EKS-XIM-00366
EKS-SAC-00054
EKS-SCP-00051
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0030176; C:integral to endoplasmic reticulum membrane
GO:0005637; C:nuclear inner membrane
GO:0005524; F:ATP binding
GO:0004521; F:endoribonuclease activity
GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response
GO:0006915; P:apoptotic process
GO:0007050; P:cell cycle arrest
GO:0006917; P:induction of apoptosis
GO:0006397; P:mRNA processing
GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response
GO:0046777; P:protein autophosphorylation
GO:0006355; P:regulation of transcription, DNA-dependent
GO:0006351; P:transcription, DNA-dependent
KEGG
mmu:78943;
InterPros
IPR010513; KEN_RNase_activator.
IPR011009; Kinase-like_dom.
IPR018391; PQQ_beta_propeller_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR006567; PUG-dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF06479; Ribonuc_2-5A; 1.
SMARTs
SM00564; PQQ; 5.
SM00580; PUG; 1.
Prosites
PS51392; KEN; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013