EKS-MUM-00209

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00209

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	529.0	5.0E-159	4	287	284

Status

Reviewed

Ensembl Protein

ENSMUSP00000021377

UniProt Accession

Q8CEQ0;

Protein Name

Cyclin-dependent kinase-like 1

Protein Synonyms/Alias

Gene Name

Cdkl1

Gene Synonyms/Alias

Cdkl1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000020990	ENSMUSP00000021377	ENSMUST00000021377

Organism

Mus musculus

Functional Description

Protein Length

352

Protein Sequence
(FASTA)

MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKRFLETED DPVIKKIALR EIRMLKQLKH 60

PNLVNLLEVF RRKRRLHLVF EYCDHTVLHE LDRYQRGVPE PLVKNITWQT LQAVNFCHKH 120

NCIHRDVKPE NILITKQSAI KLCDFGFARL LTGPGDYYTD YVATRWYRSP ELLVGDTQYG 180

PPVDVWAIGC VFAELLSGVP LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS MNQYFSGVKI 240

PDPEDMETLE LKFPNISYSA LGFLKGCLHM DPAERLTCEQ LLQHPYFDSI REVGELTRQH 300

DKPARKTLRQ SRKHLTGLQY LPQLTSSRIL PALDNKKYHC STKRFNYHFP NI 352

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAAAAAAT TGGAAAGATT GGAGAAGGCT CCTATGGGGT AGTGTTCAAG 60

TGCAGAAACA GGGACACGGG TCAGATCGTG GCCATCAAGA GGTTTCTGGA AACCGAAGAT 120

GACCCTGTCA TAAAGAAAAT CGCCCTTCGA GAAATCCGCA TGCTCAAGCA ACTCAAGCAC 180

CCCAACCTGG TCAACCTCCT GGAAGTCTTC CGGAGGAAGC GGAGGCTTCA CCTGGTGTTC 240

GAGTACTGCG ACCACACGGT GCTTCACGAG CTGGATCGGT ATCAGAGGGG GGTACCAGAG 300

CCTCTCGTGA AGAACATAAC TTGGCAGACA CTGCAGGCTG TAAATTTCTG CCATAAACAT 360

AACTGCATAC ACAGAGACGT GAAGCCGGAA AATATTCTCA TCACCAAACA GTCAGCCATT 420

AAGCTCTGTG ACTTTGGGTT CGCACGGCTT CTCACTGGAC CAGGTGACTA CTACACGGAC 480

TACGTGGCCA CCCGGTGGTA CCGCTCACCC GAGCTGCTAG TGGGAGACAC GCAGTATGGT 540

CCCCCTGTAG ATGTCTGGGC AATTGGCTGT GTGTTTGCTG AGTTACTGTC CGGAGTGCCT 600

CTATGGCCAG GAAAATCTGA CGTGGATCAG CTCTACCTGA TAAGGAAAAC CCTGGGGGAC 660

CTCATTCCCA GGCACCAGCA AGTATTTAGC ATGAATCAAT ACTTCAGTGG GGTGAAAATT 720

CCAGACCCTG AAGACATGGA AACACTTGAG TTGAAATTTC CAAACATCTC CTACTCTGCA 780

CTGGGCTTCT TAAAGGGCTG CCTCCACATG GATCCTGCTG AGAGGCTGAC ATGCGAACAG 840

CTGTTGCAGC ATCCATATTT TGACAGCATT CGAGAAGTTG GGGAGTTGAC GAGACAACAT 900

GACAAACCAG CGAGGAAGAC TCTGAGGCAG AGTAGAAAGC ACTTGACTGG GCTGCAGTAC 960

CTACCTCAGC TAACCAGCAG CCGCATCCTT CCAGCTTTGG ACAATAAGAA GTACCACTGT 1020

AGTACCAAGA GATTTAACTA CCATTTTCCA AATATTTAA 1059

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yek+gk+GeGsyGvv+kcrn+dtgqivaik+fle+edd+++kkialrei++lkqlkh+nl

Q: 4     YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllevfrrk++l+lvfey+d+tvl+el+ry++Gv+e lvk+i++q+l+a++fchk+n+i

Q: 64    VNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCI  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k++ +klcdfGfarll++pgd+ytdyvatrwyr+pellvgdt+yG++v

Q: 124   HRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGc++aell+G pl+pgksdvdqly+irktlG+liprhq++fs+n++f+Gvk+p++

Q: 184   DVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDP  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ed+e+le k+p++++++l +lk+cl++dpaerl+ce+ll+h+yf

Q: 244   EDMETLELKFPNISYSALGFLKGCLHMDPAERLTCEQLLQHPYF  287

         *******************************************9

Domain Sequence
(FASTA)

YEKIGKIGEG SYGVVFKCRN RDTGQIVAIK RFLETEDDPV IKKIALREIR MLKQLKHPNL 60

VNLLEVFRRK RRLHLVFEYC DHTVLHELDR YQRGVPEPLV KNITWQTLQA VNFCHKHNCI 120

HRDVKPENIL ITKQSAIKLC DFGFARLLTG PGDYYTDYVA TRWYRSPELL VGDTQYGPPV 180

DVWAIGCVFA ELLSGVPLWP GKSDVDQLYL IRKTLGDLIP RHQQVFSMNQ YFSGVKIPDP 240

EDMETLELKF PNISYSALGF LKGCLHMDPA ERLTCEQLLQ HPYF 284

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle
GO:0007507	; P:heart development

KEGG

mmu:71091

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013