| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00042 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CK1/VRK | 440.2 | 5.7E-132 | 37 | 303 | 267 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000071922 |
| UniProt Accession | Q80X41; O88635; O88636; Q8C2P7; Q91YH9; |
| Protein Name | Serine/threonine-protein kinase VRK1 |
| Protein Synonyms/Alias | Serine/threonine-protein kinase 51PK; Vaccinia-related kinase 1; |
| Gene Name | Vrk1 |
| Gene Synonyms/Alias | Vrk1; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Serine/threonine kinase involved in Golgi disassemblyduring the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (By similarity). |
| Protein Length | 396 |
Protein Sequence
(FASTA) | | MPRVKAAQAG RPGPAKRRLA EQFAAGEVLT DMSRKEWKLG LPIGQGGFGC IYLADTNSSK 60 | | PVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD 120 | | KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA 180 | | SNLLLSHKNP DQVYLVDYGL AYRYCPDGVH KEYKEDPKRC HDGTLEFTSI DAHKGVAPSR 240 | | RGDLEILGYC MIQWLSGCLP WEDNLKDPNY VRDSKIRYRD NVAALMEKCF PEKNKPGEIA 300 | | KYMESVKLLE YTEKPLYQNL RDILLQGLKA IGSKDDGKLD FSAVENGSVK TRPASKKRKK 360 | | EAEESAVCAV EDMECSDTQV QEAAQTRSRT RKKAQK 396 |
|
Nucleotide Sequence
(FASTA) | | ATGCCCCGTG TAAAAGCAGC TCAGGCTGGA AGACCCGGAC CTGCGAAGAG GCGCCTCGCA 60 | | GAGCAGTTTG CCGCTGGAGA GGTCCTAACC GACATGTCTA GGAAGGAGTG GAAACTAGGA 120 | | TTGCCCATTG GCCAAGGTGG CTTTGGCTGC ATCTATCTGG CGGACACAAA TTCTTCCAAA 180 | | CCGGTTGGCA GTGACGCGCC CTGTGTTGTG AAAGTGGAAC CCAGTGACAA TGGACCTCTT 240 | | TTCACGGAAT TAAAGTTCTA CCAGAGGGCT GCTAAACCAG AGCAAATTCA GAAATGGATT 300 | | CGTACACATA AATTGAAGTA CCTTGGTGTT CCTAAGTATT GGGGATCTGG TCTACATGAT 360 | | AAAAATGGAA AAAGTTACAG GTTTATGATA ATGGACCGCT TTGGGAGTGA CCTTCAGAAA 420 | | ATATATGAAG CAAATGCCAA AAGGTTTTCT CGGAAAACTG TATTGCAGCT AAGCTTAAGA 480 | | ATTCTGGATA TCCTGGAGTA CATCCATGAG CATGAGTACG TGCACGGGGA CATCAAGGCC 540 | | TCCAACCTGC TCCTGAGTCA CAAGAACCCT GACCAGGTAT ATTTGGTAGA CTATGGCCTT 600 | | GCTTATCGGT ACTGCCCAGA TGGAGTTCAT AAAGAGTACA AGGAAGATCC CAAAAGGTGC 660 | | CATGACGGCA CCCTGGAGTT CACCAGCATC GACGCTCACA AAGGCGTGGC CCCATCAAGA 720 | | CGTGGTGATT TGGAAATACT TGGTTATTGC ATGATCCAGT GGCTCAGCGG CTGTCTTCCT 780 | | TGGGAAGATA ACTTGAAAGA TCCTAACTAC GTTAGGGATT CCAAAATTAG ATACAGAGAC 840 | | AACGTCGCAG CTTTGATGGA GAAATGCTTT CCTGAGAAAA ATAAGCCAGG TGAGATCGCT 900 | | AAGTACATGG AGTCTGTGAA ACTACTGGAA TACACCGAAA AACCTCTCTA TCAAAACCTA 960 | | CGTGATATCC TTTTACAAGG ACTAAAAGCT ATAGGAAGTA AAGACGACGG CAAACTGGAT 1020 | | TTTAGTGCTG TGGAGAACGG AAGTGTGAAG ACAAGACCAG CCTCAAAGAA GCGGAAGAAA 1080 | | GAAGCAGAAG AAAGCGCGGT GTGCGCTGTG GAGGACATGG AGTGCTCAGA CACACAGGTG 1140 | | CAAGAGGCCG CACAGACCCG TTCACGAACC AGAAAGAAAG CCCAGAAGTA A 1191 |
|
| Domain Profile | S: 1 wklgkkigkggfGeiyla..ltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqi 58 | wklg +ig+ggfG+iyla +++k +++da +vvkvep++nGpLf+elkfyqraak+eqi | Q: 37 WKLGLPIGQGGFGCIYLAdtNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI 96 | 9*****************98899999********************************** |
| S: 59 kkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlq 118 | +kw++++klk+lg+P++++sGlh+++g++yRf++++r+g+dLqk++e+n+kr+s+ktvlq | Q: 97 QKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ 156 | ************************************************************ |
| S: 119 lavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeyked 178 | l++r+ld+ley+He+eYvHgdikA+nlll++++++qvyLvdyGlayrycp+g+hkeyked | Q: 157 LSLRILDILEYIHEHEYVHGDIKASNLLLSHKNPDQVYLVDYGLAYRYCPDGVHKEYKED 216 | ************************************************************ |
| S: 179 krraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkake 238 | ++r+HdGtlefts+DaHkGvapsrR+DleiLgYc+++Wl+g+LPWe++lkdp++v+++k | Q: 217 PKRCHDGTLEFTSIDAHKGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRDSKI 276 | ************************************************************ |
| S: 239 kfldelpellkkllkkkssseelakyl 265 | ++ d++++l++k++++k++++e+aky+ | Q: 277 RYRDNVAALMEKCFPEKNKPGEIAKYM 303 | **************************8 |
|
Domain Sequence
(FASTA) | | WKLGLPIGQG GFGCIYLADT NSSKPVGSDA PCVVKVEPSD NGPLFTELKF YQRAAKPEQI 60 | | QKWIRTHKLK YLGVPKYWGS GLHDKNGKSY RFMIMDRFGS DLQKIYEANA KRFSRKTVLQ 120 | | LSLRILDILE YIHEHEYVHG DIKASNLLLS HKNPDQVYLV DYGLAYRYCP DGVHKEYKED 180 | | PKRCHDGTLE FTSIDAHKGV APSRRGDLEI LGYCMIQWLS GCLPWEDNLK DPNYVRDSKI 240 | | RYRDNVAALM EKCFPEKNKP GEIAKYM 267 |
|
| Keyword | Alternative splicing; ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |