EKS-MUM-00202

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00202

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	513.2	4.3E-154	4	284	281

Status

Reviewed

Ensembl Protein

ENSMUSP00000021792

UniProt Accession

Q04859; E9Q4B2; E9QAU5; E9QKR3; Q8CDL5;

Protein Name

Serine/threonine-protein kinase MAK

Protein Synonyms/Alias

Male germ cell-associated kinase; Protein kinase RCK;

Gene Name

Mak

Gene Synonyms/Alias

Mak; Rck;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000021363	ENSMUSP00000129615	ENSMUST00000165087
ENSMUSG00000021363	ENSMUSP00000021792	ENSMUST00000021792
ENSMUSG00000021363	ENSMUSP00000064750	ENSMUST00000070193

Organism

Mus musculus

Functional Description

Essential for the regulation of ciliary length andrequired for the long-term survival of photoreceptors. Could have an important function in sensory cells and in spermatogenesis. May participate in signaling pathways used in visual and olfactory sensory transduction. Phosphorylates FZR1 in a cell cycle- dependent manner. Plays a role in the transcriptional coactivation of AR (By similarity).

Protein Length

622

Protein Sequence
(FASTA)

MNRYTTMKQL GDGTYGSVLM GKSNESGELV AIKRMKRKFY SWDECMNLRE VKSLKKLNHA 60

NVIKLKEVIR ENDHLYFVFE YMKENLYQLM KDRNKLFPES VIRNIMYQIL QGLAFIHKHG 120

FFHRDMKPEN LLCMGPELVK IADFGLAREL RSQPPYTDYV STRWYRAPEV LLRSSVYSSP 180

IDVWAVGSIM AELYTFRPLF PGTSEVDEIF KICQVLGTPK KSDWPEGYQL ASSMNFRFPQ 240

CIPINLKTLI PNASSEAIQL MTEMLNWDPK KRPTASQALK HPYFQVGQVL GSSAHHLDTK 300

QTLHKQLQPL EPKPSSSERD PKPLPNILDQ PAGQPQPKQG HQPLQTIQPP QNTVTHPPPK 360

QQGHQKPPQT MFPSIIKTIP VNSVSTLGHK GARRRWGQTV FKSGDSCDDI EDDLGASHSK 420

KPSMEACKEK KKESPFRFPD SGLPVSNHFK GENRNLHASV SLKSDPNLST ASTAKQYYLK 480

QSRYLPGVNP KNVSLVAGGK DINSHSWNNQ LFPKSLGSMG ADLSFKRSNA AGNLGSYTTY 540

NQTGYMPSFL KKEVGSAGQR IQLAPLGASA SDYTWSTKTG RGQFSGRTYN PTAKNLNIVN 600

RTQPVPSVHG RTDWVAKYGG HR 622

Nucleotide Sequence
(FASTA)

ATGAACCGAT ACACAACCAT GAAGCAGCTG GGAGACGGCA CGTATGGGAG TGTACTGATG 60

GGCAAGAGCA ATGAGTCTGG GGAGCTGGTG GCAATCAAGA GGATGAAGAG AAAGTTCTAT 120

TCTTGGGATG AGTGTATGAA CTTGCGAGAA GTTAAGTCCC TGAAAAAACT CAATCACGCC 180

AATGTGATTA AACTAAAAGA AGTTATCAGA GAGAATGACC ATCTTTATTT TGTATTTGAA 240

TATATGAAAG AAAACCTCTA TCAGCTAATG AAAGACAGAA ACAAACTGTT CCCTGAGTCA 300

GTCATCAGAA ATATTATGTA TCAGATACTA CAGGGGCTGG CATTTATCCA TAAACACGGC 360

TTTTTTCACA GGGACATGAA ACCTGAGAAC TTGCTCTGCA TGGGCCCAGA GCTGGTGAAG 420

ATTGCTGATT TTGGACTTGC AAGAGAATTA AGATCACAGC CACCATATAC TGACTATGTG 480

TCTACCAGAT GGTACCGGGC TCCTGAAGTC TTACTAAGGT CTTCGGTGTA CAGCTCTCCC 540

ATTGACGTGT GGGCCGTGGG AAGTATAATG GCCGAGTTAT ATACATTTAG GCCGCTTTTC 600

CCAGGGACAA GTGAAGTTGA TGAGATCTTT AAAATCTGCC AAGTGTTAGG GACTCCCAAG 660

AAGAGTGACT GGCCGGAAGG ATACCAGCTT GCATCCTCCA TGAACTTCCG CTTTCCCCAG 720

TGCATTCCCA TCAACCTAAA AACTCTCATT CCCAATGCCA GTAGCGAGGC CATCCAGCTC 780

ATGACAGAGA TGCTGAACTG GGATCCAAAG AAGCGACCAA CAGCAAGCCA GGCACTGAAA 840

CACCCATATT TCCAAGTCGG TCAGGTACTG GGCTCTTCTG CACACCATCT GGATACAAAA 900

CAGACTTTAC ACAAGCAGCT GCAGCCTCTG GAGCCAAAGC CATCTTCCTC TGAACGGGAT 960

CCTAAGCCTT TGCCAAACAT ACTTGATCAG CCTGCCGGGC AGCCCCAGCC AAAACAGGGC 1020

CACCAACCAC TGCAGACCAT TCAGCCACCA CAGAACACAG TGACTCACCC ACCCCCAAAG 1080

CAGCAGGGTC ACCAGAAACC ACCACAAACC ATGTTTCCAA GTATCATCAA AACCATCCCA 1140

GTGAATTCAG TCAGCACCCT GGGCCATAAG GGAGCCCGGA GACGGTGGGG TCAGACAGTC 1200

TTCAAGTCTG GAGACAGCTG TGACGACATT GAGGACGACT TAGGAGCCTC CCACTCCAAG 1260

AAGCCAAGCA TGGAAGCCTG CAAGGAGAAG AAGAAGGAGT CTCCATTTCG GTTTCCAGAT 1320

TCAGGACTCC CAGTCTCCAA TCACTTTAAG GGGGAAAATA GGAATTTACA TGCATCTGTT 1380

TCCTTAAAAT CTGATCCAAA CTTGTCAACT GCTTCAACGG CTAAGCAGTA CTATTTGAAA 1440

CAATCAAGAT ACCTTCCAGG TGTGAACCCC AAGAATGTGT CTTTGGTAGC TGGAGGCAAG 1500

GATATAAATT CACACTCTTG GAATAATCAG CTATTTCCTA AGTCGCTGGG ATCCATGGGG 1560

GCGGACCTTT CCTTCAAGAG GAGTAACGCA GCAGGAAACC TTGGGAGCTA CACCACTTAC 1620

AACCAGACGG GATACATGCC TTCCTTTCTC AAGAAAGAAG TGGGATCAGC TGGCCAGAGG 1680

ATCCAATTGG CACCTTTAGG TGCGTCGGCT TCGGACTATA CCTGGAGCAC AAAAACTGGA 1740

CGAGGCCAGT TTTCGGGACG AACTTACAAC CCCACAGCCA AAAATCTCAA TATTGTGAAC 1800

CGCACACAGC CAGTCCCCTC GGTACACGGG AGGACAGACT GGGTGGCTAA GTATGGAGGC 1860

CACCGGTAG 1869

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         y+++k+lGdGt+g+vl++ks+++gelvaik+mkrkf+s++e++nlrevkslkkln h+n+

Q: 4     YTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANV  62

         99*****************************************************.****

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         iklkevi  rend+ly+v+e+m+enlyql+kdr+kl++es++++i+yqil+glafihkhg

Q: 63    IKLKEVI--RENDHLYFVFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG  120

         *******..***************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         ffhrd+kPen+l++g+elvk+adfGlare+rs++PytdyvstrwyraPevllrs+vyssp

Q: 121   FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP  180

         ************************************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +d+wavG+++ae++++rplfPG+se+d+ifki++vlGtPkk++w+e+y+las++n++fpq

Q: 181   IDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ  240

         ************************************************************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         +++++lktl++nas+ea++l++++l++dP++r+ta+qalk+pyf

Q: 241   CIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYF  284

         *******************************************9

Domain Sequence
(FASTA)

YTTMKQLGDG TYGSVLMGKS NESGELVAIK RMKRKFYSWD ECMNLREVKS LKKLNHANVI 60

KLKEVIREND HLYFVFEYMK ENLYQLMKDR NKLFPESVIR NIMYQILQGL AFIHKHGFFH 120

RDMKPENLLC MGPELVKIAD FGLARELRSQ PPYTDYVSTR WYRAPEVLLR SSVYSSPIDV 180

WAVGSIMAEL YTFRPLFPGT SEVDEIFKIC QVLGTPKKSD WPEGYQLASS MNFRFPQCIP 240

INLKTLIPNA SSEAIQLMTE MLNWDPKKRP TASQALKHPY F 281

Keyword

Alternative splicing; ATP-binding; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0030496	; C:midbody
GO:0072686	; C:mitotic spindle
GO:0005634	; C:nucleus
GO:0001917	; C:photoreceptor inner segment
GO:0001750	; C:photoreceptor outer segment
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0003713	; F:transcription coactivator activity
GO:0007049	; P:cell cycle
GO:0045494	; P:photoreceptor cell maintenance
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0006351	; P:transcription, DNA-dependent

KEGG

mmu:17152

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013