EKS-MUM-00425

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00425

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	323.9	2.4E-96	1224	1488	265

Status

Unreviewed

Ensembl Protein

ENSMUSP00000104890

UniProt Accession

F8VQ72;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 1;

Gene Name

Map3k1

Gene Synonyms/Alias

Map3k1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000021754	ENSMUSP00000117863	ENSMUST00000145055
ENSMUSG00000021754	ENSMUSP00000104890	ENSMUST00000109267

Organism

Mus musculus

Functional Description

Protein Length

1493

Protein Sequence
(FASTA)

MAAAAGDRAS SSGFPGAAAA SPEAGGGGGG GGALQGSGAP AAGAAGLLRE PGSAGRERAD 60

WRRRQLRKVR SVELDQLPEQ PLFLAAASPP CPSTSPSPEP ADAAAGASRF QPAAGPPPPG 120

AASRCGSHSA ELAAARDSGA RSPAGAEPPS AAAPSGREME NKETLKGLHK MEDRPEERMI 180

REKLKATCMP AWKHEWLERR NRRGPVVVKP IPIKGDGSEM NNLAAEPQGE GQAGSAAPAP 240

KGRRSPSPGS SPSGRSVKPE SPGVRRKRVS PVPFQSGRIT PPRRAPSPDG FSPYSPEETS 300

RRVNKVMRAR LYLLQQIGPN SFLIGGDSPD NKYRVFIGPQ NCSCGRGAFC IHLLFVMLRV 360

FQLEPSDPML WRKTLKNFEV ESLFQKYHSR RSSRIKAPSR NTIQKFVSRM SNCHTLSSSS 420

TSTSSSENSI KDEEEQMCPI CLLGMLDEES LTVCEDGCRN KLHHHCMSIW AEECRRNREP 480

LICPLCRSKW RSHDFYSHEL SSPVESPTSL RAVQQPSSPQ QPVAGSQRRN QESSFNLTHF 540

GTQQIPSAYK DLAEPWIQVF GMELVGCLFS RNWNVREMAL RRLSHDVSGA LLLANGESTG 600

NSGGGSGGSL SAGAASGSSQ PSISGDVVEA CCSVLSIVCA DPVYKVYVAA LKTLRAMLVY 660

TPCHSLAERI KLQRLLRPVV DTILVKCADA NSRTSQLSIS TVLELCKGQA GELAVGREIL 720

KAGSIGVGGV DYVLSCILGN QAESNNWQEL LGRLCLIDRL LLEFPAEFYP HIVSTDVSQA 780

EPVEIRYKKL LSLLTFALQS IDNSHSMVGK LSRRIYLSSA RMVTAVPAVF SKLVTMLNAS 840

GSTHFTRMRR RLMAIADEVE IAEVIQLGVE DTVDGHQDSL QVLAPASCLE NSSLEHTVHR 900

EKTGKGLSAT RLSASSEDIS DRLAGVSVGL PSSTTTEQPK PAVQTKGRPH SQCLNSSPLS 960

HAQLMFPAPS APCSSAPSVP DISKHRPQAF VPCKIPSASP QTQRKFSLQF QRNCSEHRDS 1020

DQLSPVFTQS RPPPSSNIHR PKPSRPVPGS TSKLGDATKS SMTLDLGSAS RCDDSFGGGG 1080

NSGNAVIPSE ETVFTPVEDK CRLDVNTELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE 1140

KAENDDTYKD DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII 1200

QQDTPETLPG HTKAKQPYRE DAEWLKGQQI GLGAFSSCYQ AQDVGTGTLM AVKQVTYVRN 1260

TSSEQEEVVE ALREEIRMMG HLNHPNIIRM LGATCEKSNY NLFIEWMAGG SVAHLLSKYG 1320

AFKESVVINY TEQLLRGLSY LHENQIIHRD VKGANLLIDS TGQRLRIADF GAAARLASKG 1380

TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA 1440

LIFKIASATT APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW 1493

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGGCGA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CGCGGCGGCG 60

AGTCCCGAGG CGGGCGGCGG CGGCGGAGGA GGAGGAGCTC TCCAGGGAAG CGGCGCGCCC 120

GCAGCGGGCG CGGCGGGGCT GCTGCGGGAG CCTGGCAGCG CGGGCCGCGA GCGCGCGGAC 180

TGGCGGCGGC GGCAGCTGCG CAAAGTGCGG AGTGTGGAGC TGGACCAGCT GCCGGAGCAG 240

CCGCTCTTCC TCGCCGCCGC CTCGCCGCCC TGCCCATCTA CTTCCCCGTC GCCGGAGCCC 300

GCGGACGCGG CTGCAGGAGC GAGTCGCTTC CAGCCCGCGG CGGGACCGCC ACCCCCGGGA 360

GCGGCGAGTC GCTGCGGCTC CCACTCTGCC GAGCTGGCGG CCGCGCGGGA CAGCGGCGCC 420

CGGAGCCCCG CGGGGGCCGA GCCGCCCTCT GCAGCGGCCC CCTCCGGTCG AGAGATGGAG 480

AATAAAGAAA CCCTCAAAGG ACTGCACAAG ATGGAGGATC GCCCGGAGGA GAGAATGATC 540

CGGGAGAAGC TCAAGGCGAC CTGTATGCCC GCCTGGAAGC ACGAGTGGTT GGAGAGGAGG 600

AACAGGAGAG GCCCTGTGGT GGTGAAGCCA ATCCCTATTA AAGGAGATGG ATCTGAAATG 660

AATAACTTGG CAGCTGAGCC CCAAGGAGAG GGCCAGGCAG GTTCCGCTGC ACCAGCCCCC 720

AAGGGCCGAC GAAGCCCATC TCCTGGCAGC TCTCCGTCAG GGCGCTCGGT GAAGCCGGAA 780

TCCCCAGGAG TGAGACGGAA ACGAGTGTCC CCGGTGCCTT TCCAGAGTGG CAGAATCACA 840

CCACCCCGAA GAGCCCCGTC ACCGGATGGC TTCTCCCCGT ACAGCCCAGA GGAGACGAGC 900

CGCCGCGTGA ACAAAGTGAT GAGAGCCAGG CTGTACCTGC TGCAGCAGAT AGGACCCAAC 960

TCTTTCCTGA TTGGAGGAGA CAGTCCAGAC AATAAATACC GGGTGTTTAT TGGGCCACAG 1020

AACTGCAGCT GTGGGCGTGG AGCATTCTGT ATTCACCTCT TGTTTGTCAT GCTCCGGGTG 1080

TTTCAGCTAG AACCCTCTGA CCCCATGTTA TGGAGAAAAA CTTTAAAAAA TTTCGAGGTT 1140

GAGAGTTTGT TCCAGAAATA CCACAGTAGG CGTAGCTCGA GAATCAAAGC TCCATCCCGG 1200

AACACCATCC AGAAGTTTGT GTCACGCATG TCAAATTGTC ACACACTGTC ATCGTCTAGC 1260

ACATCCACAT CTAGTTCAGA AAACAGCATC AAGGATGAAG AGGAGCAGAT GTGTCCCATC 1320

TGCTTGCTGG GCATGCTGGA TGAGGAGAGC CTGACTGTGT GTGAAGATGG CTGCAGGAAC 1380

AAGCTGCACC ACCATTGCAT GTCCATCTGG GCGGAAGAGT GTAGAAGAAA TAGAGAGCCT 1440

TTAATATGTC CCCTTTGTAG ATCTAAGTGG AGATCCCATG ACTTCTACAG CCATGAGTTA 1500

TCAAGCCCCG TGGAGTCCCC CACCTCCCTG CGAGCTGTCC AGCAGCCATC CTCCCCACAG 1560

CAGCCCGTGG CCGGATCACA GCGAAGGAAT CAGGAGAGCA GTTTTAACCT TACTCATTTT 1620

GGAACCCAGC AGATTCCTTC CGCTTACAAA GATTTGGCCG AGCCATGGAT TCAGGTGTTT 1680

GGAATGGAAC TCGTTGGCTG CTTATTCTCT AGAAACTGGA ACGTAAGGGA AATGGCCCTT 1740

AGGCGTCTTT CCCACGACGT TAGTGGGGCC CTGTTGTTGG CAAACGGGGA GAGCACTGGA 1800

AACTCTGGAG GCGGCAGTGG GGGCAGCTTA AGCGCGGGAG CGGCCAGCGG GTCCTCCCAG 1860

CCCAGCATCT CAGGGGATGT GGTGGAGGCG TGCTGCAGTG TCCTGTCTAT AGTCTGCGCT 1920

GACCCTGTCT ACAAAGTGTA CGTTGCTGCT TTAAAAACAT TGAGAGCCAT GCTGGTATAC 1980

ACTCCTTGCC ACAGTCTGGC AGAAAGAATC AAACTTCAGA GACTCCTCCG GCCAGTTGTA 2040

GACACTATCC TTGTCAAGTG TGCAGATGCC AACAGCCGCA CGAGTCAGCT GTCCATATCT 2100

ACAGTGCTGG AACTCTGCAA GGGCCAAGCA GGAGAGCTGG CGGTTGGGAG AGAAATACTT 2160

AAAGCTGGGT CCATCGGGGT TGGTGGTGTC GATTACGTCT TAAGTTGTAT CCTTGGAAAC 2220

CAAGCTGAAT CAAACAACTG GCAAGAACTG CTGGGTCGCC TCTGTCTTAT AGACAGGTTG 2280

CTGTTGGAAT TTCCTGCTGA ATTCTATCCT CATATTGTCA GTACTGATGT CTCACAAGCT 2340

GAGCCTGTTG AAATCAGGTA CAAGAAGCTG CTCTCCCTCT TAACCTTTGC CTTGCAATCC 2400

ATTGACAATT CCCACTCGAT GGTTGGCAAG CTCTCTCGGA GGATATATCT GAGCTCTGCC 2460

AGGATGGTGA CCGCAGTGCC CGCTGTGTTT TCCAAGCTGG TAACCATGCT TAATGCTTCT 2520

GGCTCCACCC ACTTCACCAG GATGCGCCGG CGTCTGATGG CTATCGCGGA TGAGGTAGAA 2580

ATTGCCGAGG TCATCCAGCT GGGTGTGGAG GACACTGTGG ATGGGCATCA GGACAGCTTA 2640

CAGGTGCTGG CCCCCGCCAG CTGTCTAGAA AACAGCTCCC TTGAGCACAC AGTCCATAGA 2700

GAGAAAACTG GAAAAGGACT AAGTGCTACG AGACTGAGTG CCAGCTCGGA GGACATTTCT 2760

GACAGACTGG CCGGCGTCTC TGTAGGACTT CCCAGCTCAA CAACAACAGA ACAACCAAAG 2820

CCAGCGGTTC AAACAAAAGG CAGACCCCAC AGTCAGTGTT TGAACTCCTC CCCTTTGTCT 2880

CATGCTCAAT TAATGTTCCC AGCACCATCA GCCCCTTGTT CCTCTGCCCC GTCTGTCCCA 2940

GATATTTCTA AGCACAGACC CCAGGCATTT GTTCCCTGCA AAATACCTTC CGCATCTCCT 3000

CAGACACAGC GCAAGTTCTC TCTACAATTC CAGAGGAACT GCTCTGAACA CCGAGACTCA 3060

GACCAGCTCT CCCCAGTCTT CACTCAGTCA AGGCCCCCAC CCTCCAGTAA CATACACAGG 3120

CCAAAGCCAT CCCGACCCGT TCCGGGCAGT ACAAGCAAAC TAGGGGACGC CACAAAAAGT 3180

AGCATGACAC TTGATCTGGG CAGTGCTTCC AGGTGTGACG ACAGCTTTGG CGGCGGCGGC 3240

AACAGTGGCA ACGCCGTCAT ACCCAGCGAA GAGACAGTGT TCACGCCGGT GGAGGACAAG 3300

TGCAGGTTAG ATGTGAACAC CGAGCTCAAC TCCAGCATCG AGGACCTTCT TGAAGCATCC 3360

ATGCCTTCAA GTGACACGAC AGTCACTTTC AAGTCCGAAG TCGCCGTCCT CTCTCCGGAA 3420

AAGGCCGAAA ATGACGACAC CTACAAAGAC GACGTCAATC ATAATCAAAA GTGCAAAGAA 3480

AAGATGGAAG CTGAAGAGGA GGAGGCTTTA GCGATCGCCA TGGCGATGTC AGCGTCTCAG 3540

GATGCCCTCC CCATCGTCCC TCAGCTGCAG GTGGAAAATG GAGAAGATAT TATCATCATT 3600

CAGCAGGACA CACCAGAAAC TCTTCCAGGA CATACCAAAG CGAAACAGCC TTACAGAGAA 3660

GACGCTGAGT GGCTGAAAGG CCAGCAGATA GGCCTCGGAG CATTTTCTTC CTGTTACCAA 3720

GCACAGGATG TGGGGACTGG GACTTTAATG GCTGTGAAAC AGGTGACGTA CGTCAGAAAC 3780

ACATCCTCCG AGCAGGAGGA GGTGGTGGAA GCGTTGAGGG AAGAGATCCG GATGATGGGT 3840

CACCTCAACC ATCCAAACAT CATCCGGATG CTGGGGGCCA CGTGCGAGAA GAGCAACTAC 3900

AACCTCTTCA TTGAGTGGAT GGCGGGAGGA TCTGTGGCTC ACCTCTTGAG TAAATACGGA 3960

GCTTTCAAGG AGTCAGTCGT CATTAACTAC ACTGAGCAGT TACTCCGTGG CCTTTCCTAT 4020

CTCCACGAGA ACCAGATCAT TCACAGAGAC GTCAAAGGTG CCAACCTGCT CATTGACAGC 4080

ACCGGTCAGA GGCTGAGAAT TGCAGACTTT GGAGCTGCTG CCAGGTTGGC ATCAAAAGGA 4140

ACCGGTGCAG GAGAGTTCCA GGGACAGTTA CTGGGGACAA TTGCATTCAT GGCGCCTGAG 4200

GTCCTAAGAG GTCAGCAGTA TGGTAGGAGC TGTGATGTAT GGAGTGTTGG CTGCGCCATT 4260

ATAGAAATGG CTTGTGCAAA ACCACCTTGG AATGCAGAAA AACACTCCAA TCATCTCGCC 4320

TTGATATTTA AGATTGCTAG CGCAACTACT GCACCGTCCA TCCCGTCACA CCTGTCCCCG 4380

GGTCTGCGCG ACGTGGCGCT GCGCTGCTTA GAACTTCAGC CTCAGGACCG GCCTCCGTCC 4440

AGAGAGCTGC TGAAACATCC GGTCTTCCGT ACCACGTGGT AG 4482

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++ +l+

Q: 1224  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMGHLN  1283

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1284  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1343

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1344  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1403

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1404  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1461

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1462  LRDVALRCLELQPQDRPPSRELLKHPV  1488

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMGHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004706	; F:JUN kinase kinase kinase activity
GO:0046625	; F:sphingolipid binding
GO:0004842	; F:ubiquitin-protein ligase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0032232	; P:negative regulation of actin filament bundle assembly
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0043065	; P:positive regulation of apoptotic process
GO:0050434	; P:positive regulation of viral transcription
GO:0046777	; P:protein autophosphorylation
GO:0051259	; P:protein oligomerization
GO:0000209	; P:protein polyubiquitination
GO:0042787	; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334	; P:regulation of cell migration
GO:0006970	; P:response to osmotic stress
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

mmu:26401

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013