EKS-MUM-00507

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00507

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	587.6	6.5E-177	14	272	259

Status

Reviewed

Ensembl Protein

ENSMUSP00000098398

UniProt Accession

Q923T9; Q3U3H3; Q8VED3;

Protein Name

Calcium/calmodulin-dependent protein kinase type II subunit gamma

Protein Synonyms/Alias

CaM kinase II subunit gamma; CaMK-II subunit gamma;

Gene Name

Camk2g

Gene Synonyms/Alias

Camk2g;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000021820	ENSMUSP00000071720	ENSMUST00000071816
ENSMUSG00000021820	ENSMUSP00000079298	ENSMUST00000080440
ENSMUSG00000021820	ENSMUSP00000098398	ENSMUST00000100837

Organism

Mus musculus

Functional Description

Calcium/calmodulin-dependent protein kinase thatfunctions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity).

Protein Length

495

Protein Sequence
(FASTA)

MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 60

EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 120

LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 180

LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 240

VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 300

KGAILTTMLV SRNFSAAKSL LNKKSDGGVK EPQTTVVHNA TDGIKGSTES CNTTTEDEDL 360

KVRKQEIIKI TEQLIEAINN GDFEAYTKIC DPGLTSFEPE ALGNLVEGMD FHKFYFENLL 420

SKNSKPIHTT ILNPHVHVIG EDAACIAYIR LTQYIDGQGR PRTSQSEETR VWHRRDGKWL 480

NVHYHCSGAP AAPLQ 495

Nucleotide Sequence
(FASTA)

ATGGCCACCA CCGCCACCTG CACCCGCTTC ACCGACGACT ACCAGCTTTT CGAGGAGCTC 60

GGCAAGGGTG CCTTCTCAGT GGTCCGGAGG TGTGTAAAGA AAACATCTAC GCAGGAATAT 120

GCTGCAAAAA TCATCAATAC CAAGAAGTTG TCCGCCCGAG ATCATCAGAA ACTAGAACGA 180

GAGGCCCGGA TATGCCGACT TCTGAAACAT CCAAACATTG TGCGTCTCCA TGACAGTATT 240

TCTGAAGAAG GGTTTCACTA CCTCGTGTTT GACCTTGTTA CCGGAGGGGA GTTGTTTGAA 300

GACATTGTGG CCAGAGAGTA CTACAGTGAA GCTGATGCCA GCCACTGTAT ACATCAGATC 360

CTGGAGAGTG TTAACCACAT CCACCAGCAT GACATCGTCC ACCGGGATCT GAAGCCTGAG 420

AACTTGCTGC TGGCGAGTAA ATGCAAGGGT GCTGCGGTCA AGCTAGCTGA TTTTGGCCTG 480

GCCATCGAAG TACAGGGAGA GCAGCAGGCT TGGTTTGGTT TTGCCGGCAC CCCAGGTTAC 540

TTGTCCCCTG AGGTCTTGAG GAAAGATCCC TATGGAAAAC CTGTGGACAT CTGGGCCTGC 600

GGGGTCATCC TGTATATCCT CCTGGTGGGC TACCCTCCCT TCTGGGATGA GGATCAGCAC 660

AAGCTGTATC AGCAGATCAA AGCTGGAGCC TACGATTTCC CATCACCAGA ATGGGACACA 720

GTCACTCCTG AAGCTAAGAA CTTGATCAAC CAGATGCTGA CCATAAACCC TGCAAAGCGC 780

ATCACGGCCG ACCAGGCTCT CAAGCACCCA TGGGTCTGTC AACGGTCTAC GGTGGCATCC 840

ATGATGCATC GCCAAGAGAC GGTAGAGTGC TTACGCAAAT TCAACGCCCG GAGAAAACTG 900

AAGGGTGCCA TCCTCACAAC CATGCTTGTC TCCAGGAACT TTTCAGCTGC CAAAAGCCTA 960

TTGAACAAGA AGTCAGATGG CGGTGTCAAG GAACCACAAA CCACCGTGGT ACATAATGCT 1020

ACAGATGGGA TCAAGGGCTC CACAGAGAGC TGTAACACCA CTACAGAAGA CGAAGATCTC 1080

AAAGTGAGAA AACAAGAAAT CATTAAGATC ACAGAACAAC TGATCGAAGC CATCAACAAT 1140

GGGGACTTTG AGGCCTACAC GAAGATTTGT GACCCGGGCC TCACATCCTT TGAGCCAGAA 1200

GCCCTTGGTA ACCTCGTGGA AGGAATGGAT TTCCATAAGT TTTACTTTGA GAATCTCCTG 1260

TCCAAGAACA GCAAGCCTAT CCACACCACC ATCCTAAACC CTCACGTCCA CGTGATTGGG 1320

GAGGACGCAG CTTGCATCGC CTATATCCGG CTCACTCAGT ACATCGACGG GCAGGGTCGG 1380

CCTCGCACCA GTCAGTCAGA GGAGACCCGG GTGTGGCACC GCCGGGATGG CAAGTGGCTC 1440

AATGTCCACT ATCACTGCTC AGGGGCCCCT GCCGCACCGC TACAGTGA 1488

Domain Profile

S: 1     yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni  60

         yqlfeelgkgafsvvrrcvk+t++qeyaakiintkklsardhqklerearicrllkhpni

Q: 14    YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI  73

         9***********************************************************

S: 61    vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv  120

         vrlhdsiseegfhylvfdlvtggelfedivareyyseadashci+qilesv+hihq+++v

Q: 74    VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV  133

         ************************************************************

S: 121   hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk  180

         hrdlkpenlllask+kgaavkladfglaievqg+qqawfgfagtpgylspevlrkdpygk

Q: 134   HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGK  193

         ************************************************************

S: 181   pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml  240

         pvd+wacgvilyillvgyppfwdedqh+lyqqikagaydfpspewdtvtpeak+lin+ml

Q: 194   PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML  253

         ************************************************************

S: 241   tinpakritadealkhpwi  259

         tinpakritad+alkhpw+

Q: 254   TINPAKRITADQALKHPWV  272

         ******************8

Domain Sequence
(FASTA)

YQLFEELGKG AFSVVRRCVK KTSTQEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHPNI 60

VRLHDSISEE GFHYLVFDLV TGGELFEDIV AREYYSEADA SHCIHQILES VNHIHQHDIV 120

HRDLKPENLL LASKCKGAAV KLADFGLAIE VQGEQQAWFG FAGTPGYLSP EVLRKDPYGK 180

PVDIWACGVI LYILLVGYPP FWDEDQHKLY QQIKAGAYDF PSPEWDTVTP EAKNLINQML 240

TINPAKRITA DQALKHPWV 259

Keyword

Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0033017	; C:sarcoplasmic reticulum membrane
GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006816	; P:calcium ion transport
GO:0030154	; P:cell differentiation
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0007399	; P:nervous system development
GO:0046777	; P:protein autophosphorylation
GO:0001666	; P:response to hypoxia
GO:0006979	; P:response to oxidative stress

KEGG

mmu:12325

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013