EPS-MUM-00134

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00134

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	408.7	9.8E-123	80	280	201

Status

Reviewed

Ensembl Protein

ENSMUSP00000077532

UniProt Accession

P48455;

Protein Name

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Protein Synonyms/Alias

CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform;

Gene Name

Ppp3cc

Gene Synonyms/Alias

Ppp3cc; Calnc;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000022092	ENSMUSP00000077532	ENSMUST00000078434

Organism

Mus musculus

Functional Description

Calcium-dependent, calmodulin-stimulated proteinphosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Protein Length

513

Protein Sequence
(FASTA)

MSVRRPQFST TERVIKAVPF PPTRRLTLKE VFENGKPKMD LLKNHLVKEG RVEEEVALKI 60

INDGAAILKQ EKTMIEVEAP ITVCGDVHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY 120

FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTEYFTFKQ ECRIKYSEMV YDACMHTFDC 180

LPLAALLNQQ FLCVHGGMSP EITCLEDIRK LDRFSEPPAF GPVCDLLWSD PLEDYGSEKT 240

LEHYTHNTVR GCSYFFSYPA VCEFLQNNSL LSIIRAHEAQ DAGYRMYRKN QATGFPSLIT 300

IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM 360

LVNILNICSD EEMNVTDEEG ATTGRKEVIK NKIRAIGKMA RVFTVLREES ENVLTLKGLT 420

PTGTLPLGVL SGGKQTIETA KQEAAEEREA IRGFTIAHRI RSFEEARGLD RINERMPPRK 480

EASYHHDAGR MHSHSHPPHP QASRRTDHGK KAL 513

Nucleotide Sequence
(FASTA)

ATGTCCGTGA GGCGCCCTCA GTTCTCCACG ACCGAGCGCG TCATCAAAGC TGTCCCCTTT 60

CCTCCAACCC GACGGCTAAC TTTGAAGGAA GTTTTTGAGA ATGGGAAACC TAAAATGGAT 120

CTTTTGAAAA ACCATTTAGT AAAAGAAGGT CGGGTGGAAG AGGAGGTGGC CTTAAAGATC 180

ATCAATGATG GGGCTGCCAT CCTGAAGCAG GAGAAGACCA TGATAGAGGT GGAGGCTCCG 240

ATCACAGTGT GTGGTGATGT TCATGGACAA TTCTTTGACC TGATGAAGTT GTTTGAAGTT 300

GGGGGATCAC CTAGTAATAC TCGCTACCTC TTCCTGGGTG ACTATGTGGA CAGAGGCTAT 360

TTCAGTATAG AGTGTGTGCT GTATCTATGG AGCTTAAAGA TTAACCATCC TAAAACATTG 420

TTTCTGCTTC GAGGAAATCA TGAATGCAGG CATCTTACAG AGTACTTCAC CTTCAAACAG 480

GAATGTCGGA TCAAGTATTC AGAGATGGTG TACGATGCGT GCATGCACAC TTTCGACTGT 540

CTTCCTCTTG CTGCCCTCTT AAACCAGCAG TTTCTCTGTG TACATGGAGG AATGTCTCCT 600

GAAATTACTT GTTTAGAGGA CATTAGGAAA TTAGATAGGT TTTCTGAGCC TCCTGCTTTT 660

GGGCCAGTGT GTGACCTGCT GTGGTCTGAT CCCTTAGAGG ACTACGGCAG CGAGAAGACC 720

CTGGAGCACT ATACCCACAA CACTGTCCGA GGCTGCTCCT ACTTCTTCAG TTACCCTGCA 780

GTTTGTGAAT TTTTACAGAA CAACAGTTTA TTATCAATAA TCAGAGCCCA TGAAGCCCAG 840

GATGCGGGGT ACCGAATGTA TAGGAAGAAC CAAGCAACTG GCTTTCCGTC ACTTATTACG 900

ATTTTCTCTG CCCCTAATTA CCTAGATGTC TATAACAATA AAGCTGCAGT GTTGAAGTAT 960

GAAAACAATG TCATGAACAT CAGGCAGTTC AACTGTTCCC CACACCCCTA CTGGCTCCCA 1020

AACTTCATGG ATGTTTTCAC GTGGTCTTTG CCTTTTGTTG GAGAGAAAGT GACAGAGATG 1080

CTGGTCAATA TTCTCAACAT ATGCTCGGAT GAAGAAATGA ACGTAACCGA TGAAGAAGGA 1140

GCTACTACAG GTCGAAAAGA AGTCATCAAG AATAAAATCC GAGCCATTGG GAAAATGGCC 1200

CGGGTCTTTA CGGTTCTTCG GGAAGAGAGT GAGAATGTGC TGACCCTCAA GGGCCTCACT 1260

CCCACAGGCA CACTCCCACT GGGGGTCCTC TCTGGAGGAA AGCAGACCAT TGAGACTGCC 1320

AAACAAGAAG CCGCAGAGGA GCGGGAAGCC ATCAGAGGTT TTACAATTGC ACACAGGATC 1380

CGAAGTTTTG AAGAAGCCCG AGGTCTAGAC CGAATTAATG AGAGAATGCC ACCCCGAAAA 1440

GAGGCTTCAT ATCATCATGA TGCAGGGAGG ATGCACTCAC ACTCGCATCC GCCACACCCA 1500

CAGGCGTCAA GAAGGACCGA CCATGGAAAG AAAGCCCTGT AA 1542

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         p+tvcgd+hgqffdl+klfevggsp+ntrylflgdyvdrgyfsiecvlyl++lki++pkt

Q: 80    PITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKT  139

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         lfllrgnhecrhlteyftfkqe++ikyse vydac+++fd+lplaallnqqflcvhgg+s

Q: 140   LFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMS  199

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pe++ l+dirkldrf eppa+g++cdllwsdpled+g+ek+ e+++hn+vrgcsyf+sy+

Q: 200   PEITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYP  259

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         avceflq+n+llsiiraheaq

Q: 260   AVCEFLQNNSLLSIIRAHEAQ  280

         ********************8

Domain Sequence
(FASTA)

PITVCGDVHG QFFDLMKLFE VGGSPSNTRY LFLGDYVDRG YFSIECVLYL WSLKINHPKT 60

LFLLRGNHEC RHLTEYFTFK QECRIKYSEM VYDACMHTFD CLPLAALLNQ QFLCVHGGMS 120

PEITCLEDIR KLDRFSEPPA FGPVCDLLWS DPLEDYGSEK TLEHYTHNTV RGCSYFFSYP 180

AVCEFLQNNS LLSIIRAHEA Q 201

Keyword

Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>