EPS-MUM-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	91.6	1.7E-25	52	334	283

Status

Reviewed

Ensembl Protein

ENSMUSP00000023050

UniProt Accession

Q8CF89; Q7TQJ5; Q80V65; Q8R0D1;

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1;

Gene Name

Tab1

Gene Synonyms/Alias

Tab1; Map3k7ip1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000022414	ENSMUSP00000023050	ENSMUST00000023050

Organism

Mus musculus

Functional Description

May be an important signaling intermediate between TGFBreceptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Protein Length

502

Protein Sequence
(FASTA)

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DNWLKFRSEN 60

NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA DVRRVLLQAF DVVERSFLES 120

IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKALER EISGGAMAVV AVLLNSKLYV 180

ANVGTNRALL CKSTVDGLQV TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST 240

RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300

GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK FCPRHEDMTL 360

LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK TSVTLSLVMP SQGQMVNGSH 420

SASTLDEATP TLTNQSPTLT LQSTNTHTQS SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV 480

DFAEFYRLWS VDHGEQSVMT AP 502

Nucleotide Sequence
(FASTA)

ATGGCGGCGC AGAGGAGGAG CCTGCTCCAG AGTGAGCAGC AGCCAAGCTG GACAGATGAC 60

CTGCCACTCT GTCACCTCTC TGGAGTTGGT TCAGCGTCCA ACCGCAGCTA CTCTGCTGAT 120

GGCAAGGGCA CTGAGAGCCA CCCTCCGGAG GACAACTGGC TTAAGTTCAG AAGTGAAAAT 180

AACTGCTTCC TGTACGGGGT CTTCAATGGC TATGATGGCA ACCGCGTGAC CAACTTTGTG 240

GCGCAGAGGC TTTCTGCAGA GCTCCTGCTG GGCCAGCTCA ACACTGAGCA CACTGAGGCT 300

GATGTGCGAC GGGTCCTGCT GCAGGCCTTT GATGTGGTGG AGAGGAGCTT CCTGGAGTCT 360

ATCGATGATG CCTTAGCTGA GAAAGCAAGC CTCCAGTCCC AGCTGCCGGA GGGTGTGCCC 420

CAGCACCAGC TGCCACCTCA GTACCAGAAG ATCCTTGAGA GACTCAAGGC ACTGGAGAGG 480

GAGATTTCGG GAGGAGCCAT GGCTGTCGTG GCAGTCCTTC TCAACAGCAA GCTCTACGTT 540

GCCAATGTCG GTACGAACAG GGCCCTTCTG TGCAAATCTA CAGTGGATGG GTTACAGGTT 600

ACACAGCTAA ACATGGACCA CACCACCGAG AACGAGGACG AGCTCTTTCG GCTTTCGCAA 660

CTGGGTTTAG ACGCAGGGAA GATCAAGCAG ATGGGCGTCA TCTGTGGACA GGAGAGCACC 720

AGGCGGATTG GGGATTACAA GGTCAAATAT GGCTACACCG ACATTGACCT GCTCAGCGCT 780

GCCAAGTCCA AACCCATCAT CGCAGAGCCG GAAATTCATG GCGCACAGCC TCTGGATGGC 840

GTGACGGGCT TCCTGGTGCT GATGTCAGAG GGGCTGTACA AGGCCCTGGA GGCAGCCCAT 900

GGGCCTGGGC AGGCCAACCA GGAGATTGCC GCGATGATTG ACACCGAGTT TGCCAAGCAG 960

ACCTCCCTGG ATGCGGTTGC CCAGGCTGTG GTAGACCGTG TAAAGCGGAT CCACAGTGAC 1020

ACCTTTGCCA GTGGTGGGGA GCGTGCCAAG TTCTGCCCAC GGCATGAAGA CATGACCCTG 1080

CTGGTGAGGA ACTTTGGCTA TCCATTGGGT GAAATGAGCC AGCCTACACC GACCCCTGCC 1140

CCAGGGGGCC GTGTGTACCC TGTTTCTGTG CCCTACTCAA GTGCCCAGAG CACCAGCAAG 1200

ACTAGTGTGA CTCTGTCCCT CGTCATGCCT TCTCAGGGCC AGATGGTCAA CGGCTCTCAC 1260

AGTGCCTCCA CTCTGGACGA AGCCACTCCC ACACTCACTA ACCAGAGCCC CACTCTGACC 1320

CTGCAGTCCA CCAACACGCA CACCCAGAGC AGCAGCTCCA GCTCTGACGG GGGCCTCTTC 1380

CGCTCCAGAC CGGCTCACTC ACTTCCACCC GGAGAGGATG GCCGTGTGGA GCCCTATGTG 1440

GACTTTGCTG AGTTCTACCG ACTCTGGAGC GTGGACCACG GCGAGCAGAG CGTGATGACG 1500

GCACCTTAG 1509

Domain Profile

S: 24    nflkspekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaF  83

         n lk +++++   ++gv++G  g++v++f++++l+  l     ++e +e++v+++l +aF

Q: 52    NWLKFRSENN-CFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNTEHTEADVRRVLLQAF  110

         4555555555.589********************97666555569***************

S: 84    lstdeel................................kvleeksldidk..sGstavv  109

           +++ +                                k+le+ +  +++   G+ avv

Q: 111   DVVERSFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLKALEREisGGAMAVV  170

         ***********************************999966666655555566999****

S: 110   alikdsklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvil  162

         a++ +sklyvanvG  ra+Lc++  +   + +l  dH++++edEl R+++ g   g++ +

Q: 171   AVLLNSKLYVANVGTNRALLCKSTvDglqVTQLNMDHTTENEDELFRLSQLGldaGKIKQ  230

         *********************97634666999999*****************97777776

S: 163   kdgaRvlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliL  207

              ++G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L

Q: 231   MG--VICG-QESTRRIGDYKVKygytdidllsaaksKPIIAEPEIHGAQPlDGVTGFLVL  287

         64..5555.69************************999*******98765155555****

S: 208   asDGlwdvvs........neeavslvrdvlekkeaeqeaakkLvkla  246

          s Gl++ ++        n+e+ +++     k+++++++a+ +v++

Q: 288   MSEGLYKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVDRV  334

         *******9863333333366666666666667788888888877765

Domain Sequence
(FASTA)

NWLKFRSENN CFLYGVFNGY DGNRVTNFVA QRLSAELLLG QLNTEHTEAD VRRVLLQAFD 60

VVERSFLESI DDALAEKASL QSQLPEGVPQ HQLPPQYQKI LERLKALERE ISGGAMAVVA 120

VLLNSKLYVA NVGTNRALLC KSTVDGLQVT QLNMDHTTEN EDELFRLSQL GLDAGKIKQM 180

GVICGQESTR RIGDYKVKYG YTDIDLLSAA KSKPIIAEPE IHGAQPLDGV TGFLVLMSEG 240

LYKALEAAHG PGQANQEIAA MIDTEFAKQT SLDAVAQAVV DRV 283

Keyword

Complete proteome; Phosphoprotein; Reference proteome; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0043234	; C:protein complex
GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

mmu:66513

;

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013