EKS-MUM-00484
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00484
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CK1/CK1490.72.1E-1479269261
StatusReviewed
Ensembl ProteinENSMUSP00000113096
UniProt AccessionQ9JMK2; Q8R389;
Protein NameCasein kinase I isoform epsilon
Protein Synonyms/Alias CKI-epsilon; CKIe;
Gene NameCsnk1e
Gene Synonyms/Alias Csnk1e;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000022433ENSMUSP00000122135ENSMUST00000135519
ENSMUSG00000022433ENSMUSP00000115637ENSMUST00000144790
ENSMUSG00000022433ENSMUSP00000113975ENSMUST00000120859
ENSMUSG00000022433ENSMUSP00000113341ENSMUST00000117786
ENSMUSG00000022433ENSMUSP00000116593ENSMUST00000156043
ENSMUSG00000022433ENSMUSP00000113096ENSMUST00000122044
OrganismMus musculus
Functional DescriptionCasein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.
Protein Length368
Protein Sequence
(FASTA)
MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ 60
GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240
CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASSS 300
QAQPRDNEAL APPCPRPWPC AGPAYSPTYW CPAPLGTQGP PDRPVEEEVE QLPPQRYWPV 360
VWTPGPQF 368
Nucleotide Sequence
(FASTA)
ATGGAGTTGC GTGTGGGAAA TAAGTATCGC CTGGGCCGAA AGATCGGCAG TGGCTCCTTT 60
GGAGACATCT ACCTGGGTGC CAACATTGCC TCTGGTGAGG AAGTAGCCAT CAAGCTCGAA 120
TGTGTGAAGA CGAAACATCC CCAGCTCCAC ATCGAGAGCA AGTTCTACAA GATGATGCAG 180
GGCGGAGTGG GGATCCCGTC CATCAAGTGG TGCGGGGCTG AGGGAGACTA TAACGTGATG 240
GTCATGGAGC TGCTGGGGCC CAGCCTGGAG GACCTCTTCA ACTTCTGTTC CCGGAAGTTC 300
AGCCTCAAGA CGGTGCTGTT GCTGGCCGAC CAGATGATCA GCCGCATCGA GTACATACAC 360
TCCAAGAACT TCATCCACCG GGATGTGAAG CCCGACAACT TCCTCATGGG CCTGGGGAAG 420
AAAGGCAACC TGGTGTACAT CATTGACTTC GGCCTGGCCA AGAAGTACCG CGATGCCCGC 480
ACACACCAGC ATATTCCCTA CCGGGAAAAC AAGAACCTGA CCGGCACTGC CCGCTATGCC 540
TCTATCAACA CCCACCTGGG CATTGAGCAA AGCCGTCGAG ATGACCTAGA GAGCTTGGGC 600
TATGTGCTCA TGTACTTCAA CCTGGGCTCC CTGCCCTGGC AGGGCCTCAA AGCAGCCACC 660
AAGCGTCAGA AGTACGAGCG GATTAGCGAG AAGAAGATGT CAACGCCAAT CGAGGTCCTC 720
TGCAAAGGCT ACCCCTCCGA GTTCTCAACA TACCTCAACT TCTGCCGCTC CCTGCGGTTC 780
GATGATAAGC CTGACTACTC CTACCTGCGC CAGCTCTTCC GAAATCTCTT TCACCGGCAG 840
GGTTTCTCCT ACGACTACGT CTTCGACTGG AACATGCTCA AATTCGGGGC TTCCTCGAGC 900
CAGGCTCAGC CCCGAGACAA CGAAGCTCTT GCGCCACCCT GCCCCCGCCC TTGGCCTTGC 960
GCTGGGCCCG CATACTCACC CACTTACTGG TGCCCGGCGC CCCTGGGCAC CCAAGGACCC 1020
CCAGATAGGC CGGTGGAGGA GGAGGTGGAA CAACTGCCCC CTCAAAGATA TTGGCCTGTG 1080
GTCTGGACTC CAGGGCCCCA GTTCTGA 1107
Domain Profile
S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60
         yr+++kiGsGsfGdiylg+n+asgeevaikle++k+k+pql++es++yk++qggvgiP++
Q: 9     YRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSI  68
         89**********************************************************
S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120
         +++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd
Q: 69    KWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD  128
         ************************************************************
S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180
         +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+
Q: 129   VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI  188
         ************************************************************
S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240
         eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef
Q: 189   EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF  248
         ************************************************************
S: 241   atylkyvrklkfeekPdyeyl  261
         +tyl+++r+l+f++kPdy+yl
Q: 249   STYLNFCRSLRFDDKPDYSYL  269
         *******************97
Domain Sequence
(FASTA)
YRLGRKIGSG SFGDIYLGAN IASGEEVAIK LECVKTKHPQ LHIESKFYKM MQGGVGIPSI 60
KWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120
VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180
EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240
STYLNFCRSL RFDDKPDYSY L 261
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Sus scrofa"; ?>
EKS-GAA-00551
EKS-HOS-00459
EKS-MAM-00451
EKS-MUP-00445
EKS-SUS-00400
Gene Ontology
GO:0005829; C:cytosol
GO:0005654; C:nucleoplasm
GO:0030529; C:ribonucleoprotein complex
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0034613; P:cellular protein localization
GO:0007623; P:circadian rhythm
GO:0030178; P:negative regulation of Wnt receptor signaling pathway
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016055; P:Wnt receptor signaling pathway
KEGG
mmu:27373;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013