EKS-MUM-00317
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00317
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR334.41.4E-99200501302
StatusReviewed
Ensembl ProteinENSMUSP00000023809
UniProt AccessionQ8K592; Q0VDQ4;
Protein NameAnti-Muellerian hormone type-2 receptor
Protein Synonyms/Alias Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII;
Gene NameAmhr2
Gene Synonyms/Alias Amhr2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000023047ENSMUSP00000123735ENSMUST00000162893
ENSMUSG00000023047ENSMUSP00000023809ENSMUST00000023809
OrganismMus musculus
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Protein Length568
Protein Sequence
(FASTA)
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP KGIRCLYSHC 60
CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP NPSSTLFTCS CGTDFCNANY 120
SHLPPSGNQG APGPQEPQAT PGGPVWMALL LLGMFLVLLL SSIILALLQR KACRVQGGSD 180
PEPGSGGDCS EELPELAELR FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER 240
AVYQLLGLQH DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM 300
ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL ALVLPGLAQP 360
PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA LQRADVYSLA LLLWEILSRC 420
SDLRPDHRPP PFQLAYEAEL GSNPSACELW ALAVEERKRP NIPSTWSCSA TDPRGLRELL 480
EDCWDADPEA RLTAECVQQR LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS 540
SCLLSVQQGP GSRSPDPVGD TVQVYVNE 568
Nucleotide Sequence
(FASTA)
ATGCTGGGGA CACTGGGGCT TTGGACACTG CTTCCTGCGG CAGCACAAGT ATCCCCAAAC 60
AGGAGGACCT GTGTGTTCTT TGAGGCTCCT GGAGTGCGGG GAAGCACAAA GACACTGGGG 120
GAAATGGTAG ATGCAGGACC AGGCCCCCCC AAGGGTATCC GCTGCCTCTA CAGCCATTGC 180
TGCTTTGGGA TCTGGAATCT TACCCATGGC CGGGCACAAG TGGAGATGCA AGGATGCCGA 240
GACAGTGATG AGCCAGGCTG TGAGTCCCTC CACTGTGACC CAGTCCCCAG AGCCCACCCG 300
AACCCCAGCT CCACACTCTT CACGTGTTCC TGTGGCACTG ACTTCTGCAA TGCCAATTAC 360
AGCCATCTGC CTCCTTCGGG AAACCAAGGG GCTCCTGGCC CCCAGGAGCC CCAGGCTACC 420
CCAGGTGGGC CCGTCTGGAT GGCACTGCTG CTCCTGGGAA TGTTTCTCGT GTTGTTGCTG 480
AGTAGCATCA TCTTGGCCCT GCTACAACGA AAGGCCTGCA GAGTGCAAGG TGGGTCAGAC 540
CCAGAGCCCG GCTCAGGCGG AGACTGCAGT GAGGAACTGC CAGAGCTGGC CGAGCTGCGT 600
TTCTCCCAGG TAATCCAGGA AGGAGGTCAT GCAGTCGTCT GGGCCGGGAG GCTTCAGGGT 660
GAGATGGTAG CCATCAAGGC CTTCCCCCCA AGGGCTGTGG CCCAGTTCCG AGCTGAGAGG 720
GCTGTGTACC AGCTGCTAGG CCTACAGCAT GACCATATCG TTCGCTTTAT CACTGCTGGC 780
CAGGGAGGCC CTGGCCCTCT GCCCTCTGGG CCTTTGCTGG TACTGGAACT GTACCCTAAG 840
GGCTCCTTAT GCCACTACTT GACTCAGTAC ACGAGCGACT GGGGAAGTTC CTTGAGGATG 900
GCTCTGTCCC TGGCAGAGGG CTTGGCTTTT CTCCACGAGG AGCGTTGGCA GGATGGCCAG 960
TACAAACCAG GTATCGCCCA CCGAGACCTG AGCAGCCAGA ATGTGCTCAT TCGGGAAGAT 1020
AGGTCATGCG CCATCGGGGA CCTGGGCCTT GCCTTGGTAC TCCCTGGTCT TGCTCAGCCC 1080
CCTGCCTTGG CCCCTACTCA ACCCCGAGGC CCCGCTGCCA TTTTGGAGGC TGGCACCCAG 1140
CGGTACATGG CTCCAGAGCT CTTGGACAAG ACTCTAGACT TGCAGGACTG GGGTACAGCT 1200
CTCCAGAGAG CGGATGTTTA CTCTCTGGCG CTACTACTGT GGGAGATCCT GAGCCGCTGT 1260
TCCGATTTGA GGCCTGACCA CAGACCACCA CCTTTCCAAT TGGCTTATGA GGCAGAACTG 1320
GGCAGCAATC CCAGTGCCTG TGAGCTCTGG GCCCTGGCAG TGGAGGAGAG GAAGCGCCCC 1380
AACATCCCAT CCACTTGGAG CTGCTCTGCC ACAGACCCTC GGGGGCTGAG GGAGCTCCTG 1440
GAAGATTGCT GGGACGCAGA CCCAGAAGCA CGGCTGACAG CTGAGTGTGT GCAGCAGCGC 1500
CTGGCAGCCC TGGCTTACCC TCACGGGGCG TCCTCTTTCC CAGAGAGTCC ACAGGGCTGC 1560
CCAGAGAACT GCCTTTCAGC TCCCGCCTCT GCCGTTTTCC CCTGTCGGCC TCAGCAGAGT 1620
TCTTGTCTCC TCAGTGTTCA GCAAGGCCCT GGCTCTAGGA GTCCCGATCC TGTAGGCGAC 1680
ACTGTTCAGG TGTATGTAAA TGAGTAG 1707
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
         +++++i++G ++ Vw+++l+ge+vA+K+f+ +  a++++E+++yq+  l+h++i++fi+a
Q: 200   RFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHDHIVRFITA  259
         6889********************************************************
S: 62    dk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
          +     + +  llv+e+++kgsL++yL+++t+d+ ++lr+alsla+Gla+LHee ++++
Q: 260   GQgGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEE-RWQD  318
         **88999************************************************.8999
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee........ldlaansqvG  172
         g++Kp iaHRDl+s+N+l+++d++c+i+DlGLal l   ++         +  aa+ ++G
Q: 319   GQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPpalaptqpRGPAAILEAG  378
         **********************************776665555888888888899*****
S: 173   tkRYmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfee  229
         t+RYmaPE+l+++l+l+d+  a++raDvYsl+L+lWE++sRc++  +d++ ++++l++e+
Q: 379   TQRYMAPELLDKTLDLQDWGtALQRADVYSLALLLWEILSRCSDlrPDHRPPPFQLAYEA  438
         *******************99***********************999*************
S: 230   vvgsdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvk  288
         ++gs+Ps+ e++++ ve+++rP+ip++w++++ + + l++lle+cWdadpeaRlta++v+
Q: 439   ELGSNPSACELWALAVEERKRPNIPSTWSCSAtDPRGLRELLEDCWDADPEARLTAECVQ  498
         *****************************998799*************************
S: 289   krl  291
         +rl
Q: 499   QRL  501
         986
Domain Sequence
(FASTA)
RFSQVIQEGG HAVVWAGRLQ GEMVAIKAFP PRAVAQFRAE RAVYQLLGLQ HDHIVRFITA 60
GQGGPGPLPS GPLLVLELYP KGSLCHYLTQ YTSDWGSSLR MALSLAEGLA FLHEERWQDG 120
QYKPGIAHRD LSSQNVLIRE DRSCAIGDLG LALVLPGLAQ PPALAPTQPR GPAAILEAGT 180
QRYMAPELLD KTLDLQDWGT ALQRADVYSL ALLLWEILSR CSDLRPDHRP PPFQLAYEAE 240
LGSNPSACEL WALAVEERKR PNIPSTWSCS ATDPRGLREL LEDCWDADPE ARLTAECVQQ 300
RL 302
KeywordATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00268
EKS-ANC-00275
EKS-BOT-00286
EKS-CAJ-00292
EKS-CAF-00292
EKS-CAP-00321
EKS-EQC-00278
EKS-FEC-00272
EKS-GOG-00285
EKS-HOS-00292
EKS-ICT-00271
EKS-LOA-00296
EKS-MAM-00288
EKS-MAE-00019
EKS-MIM-00022
EKS-MUP-00282
EKS-MYL-00288
EKS-NOL-00264
EKS-ORC-00268
EKS-OTG-00292
EKS-PAT-00271
EKS-POA-00278
EKS-PTV-00042
EKS-RAN-00302
EKS-SAH-00268
EKS-SUS-00251
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0042562; F:hormone binding
GO:0046872; F:metal ion binding
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0007548; P:sex differentiation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
mmu:110542;
InterPros
IPR000472; Activin_rcpt.
IPR015771; Anti-muellerian_hrmn_rcpt_II.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
Created Date20-Feb-2013