EKS-MUM-00167
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00167
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb491.99.6E-148415672258
StatusReviewed
Ensembl ProteinENSMUSP00000024575
UniProt AccessionQ9WUT3; Q9D2C0;
Protein NameRibosomal protein S6 kinase alpha-2
Protein Synonyms/Alias S6K-alpha-2; 90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Protein-tyrosine kinase Mpk-9; Ribosomal S6 kinase 3; RSK-3; pp90RSK3;
Gene NameRps6ka2
Gene Synonyms/Alias Rps6ka2; Mapkapk1c, Rsk3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000023809ENSMUSP00000024575ENSMUST00000024575
OrganismMus musculus
Functional DescriptionSerine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity).
Protein Length733
Protein Sequence
(FASTA)
MELSMKKFTV RRFFSVYLRK KSRSKSSSLS RLEEEGIVKE IDISNHVKEG FEKADPSQFE 60
LLKVLGQGSY GKVFLVRKVT GSDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF 120
IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHGLGI 180
IYRDLKPENI LLDEEGHIKI TDFGLSKEAT DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA 240
DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSAEAQSLL RALFKRNPCN 300
RLGAGVDGVE EIKRHPFFVT IDWNKLYRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS 360
PGVPPSANAH HLFRGFSFVA SSLVQEPSQQ DVPKAPIHPI VQQLHGNNIH FTDGYEIKED 420
IGVGSYSVCK RCVHKATDAE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK 480
YVYLVMELMR GGELLDRILR QRCFSEREAS DVLYTIARTM DYLHSQGVVH RDLKPSNILY 540
MDESGNPESI RICDFGFAKQ LRAENGLLMT PCYTANFVAP EVLKRQGYDA ACDVWSLGIL 600
LYTMLAGFTP FANGPDDTPE EILARIGSGK YALSGGNWDS ISDAAKDVVS KMLHVDPQQR 660
LTAVQVLKHP WIVNREYLSQ NQLSRQDVHL VKGAMAATYF ALNRTPQAPR LEPVLSSSLA 720
QRRGMKRLTS TRL 733
Nucleotide Sequence
(FASTA)
ATGGAGCTGA GCATGAAGAA GTTCACGGTG CGCAGGTTCT TCTCCGTGTA CCTGCGCAAG 60
AAGTCGCGCT CCAAGAGCTC CAGTCTGAGT CGCCTCGAGG AAGAAGGCAT TGTGAAGGAG 120
ATTGACATTA GCAACCATGT GAAGGAAGGC TTTGAGAAGG CAGACCCCTC CCAGTTCGAG 180
CTACTAAAGG TTTTAGGACA AGGGTCGTAT GGAAAGGTGT TCTTGGTGAG GAAGGTTACA 240
GGATCAGACG CTGGTCAGCT CTACGCCATG AAGGTCCTGA AGAAAGCCAC CTTGAAAGTG 300
CGAGACCGGG TCAGATCTAA GATGGAGAGA GACATCCTGG CAGAGGTGAA TCACCCTTTC 360
ATTGTCAAGC TGCATTATGC CTTTCAGACC GAAGGCAAGC TCTACCTGAT CCTGGACTTC 420
CTGCGGGGAG GTGACCTCTT CACCAGGCTT TCCAAAGAGG TGATGTTCAC GGAGGAGGAT 480
GTCAAGTTCT ACCTGGCTGA GCTGGCCTTG GCTCTAGACC ACCTCCATGG CCTGGGGATC 540
ATCTACAGGG ATCTGAAGCC AGAGAATATC CTCCTGGATG AAGAGGGACA CATTAAGATC 600
ACAGATTTTG GCTTGAGCAA GGAGGCCACC GACCATGACA AGAGAGCCTA TTCATTCTGT 660
GGGACTATTG AATACATGGC GCCCGAGGTG GTGAACCGGC GTGGACACAC ACAGAGTGCC 720
GACTGGTGGT CCTTCGGTGT GCTCATGTTC GAGATGCTCA CAGGGTCCCT GCCATTCCAG 780
GGGAAGGACA GGAAGGAAAC AATGGCCCTC ATCCTCAAAG CCAAGCTGGG TATGCCTCAG 840
TTCCTCAGTG CGGAGGCTCA GAGCCTGCTC AGGGCCCTTT TCAAGCGGAA CCCCTGCAAC 900
AGGCTAGGTG CTGGTGTTGA TGGAGTGGAG GAAATTAAAC GTCACCCGTT CTTTGTCACC 960
ATAGACTGGA ATAAGCTGTA CCGCAAGGAG ATCAAGCCAC CCTTCAAGCC AGCAGTGGGC 1020
AGGCCTGAGG ACACCTTCCA CTTTGACCCC GAGTTTACTG CAAGGACCCC CACAGATTCT 1080
CCTGGTGTCC CCCCAAGTGC AAACGCCCAC CACCTCTTCA GAGGATTCAG CTTTGTGGCC 1140
TCCAGCCTGG TCCAGGAGCC CTCACAGCAA GACGTGCCCA AGGCCCCCAT TCACCCAATT 1200
GTGCAGCAGC TACATGGGAA CAACATCCAC TTCACTGACG GCTATGAGAT CAAGGAGGAC 1260
ATCGGGGTGG GCTCCTACTC AGTGTGCAAG CGGTGTGTAC ACAAAGCCAC GGATGCTGAG 1320
TATGCTGTGA AGATCATCGA TAAGAGCAAA AGGGACCCCT CGGAGGAGAT TGAGATCCTC 1380
CTGCGCTATG GCCAGCACCC CAACATCATC ACCCTAAAAG ATGTCTATGA TGATGGCAAG 1440
TACGTCTACC TGGTGATGGA GCTCATGCGA GGCGGGGAGC TGCTGGACCG TATCCTCCGT 1500
CAGCGGTGCT TCTCAGAGCG TGAGGCCAGT GATGTGCTCT ATACCATCGC CAGGACCATG 1560
GACTACCTGC ACTCCCAAGG GGTTGTCCAT CGGGACCTGA AACCAAGTAA CATTCTGTAC 1620
ATGGATGAGT CTGGAAACCC CGAATCTATC CGCATCTGTG ACTTTGGGTT TGCCAAACAG 1680
CTTCGAGCGG AGAATGGGCT GCTCATGACC CCCTGCTATA CTGCAAACTT TGTAGCTCCC 1740
GAGGTCTTGA AGCGGCAAGG CTACGATGCA GCGTGTGATG TCTGGAGCTT GGGAATCCTG 1800
CTGTACACCA TGCTGGCTGG GTTCACTCCG TTTGCCAATG GCCCAGACGA TACCCCTGAG 1860
GAGATTCTGG CTAGGATCGG CAGTGGGAAG TACGCCCTTT CTGGGGGAAA CTGGGACTCC 1920
ATATCTGATG CAGCAAAAGA TGTCGTGTCC AAGATGCTCC ACGTGGACCC TCAGCAACGC 1980
CTAACAGCAG TTCAAGTGTT GAAGCACCCG TGGATCGTGA ACAGAGAGTA CCTATCCCAA 2040
AACCAGCTGA GCAGACAGGA TGTCCATCTA GTGAAGGGTG CCATGGCGGC CACCTACTTT 2100
GCTCTGAACA GGACCCCACA GGCACCGAGG CTAGAGCCTG TGCTCTCATC TAGCTTGGCC 2160
CAACGCAGAG GCATGAAGAG ACTCACGTCT ACCAGGTTGT AG 2202
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat+ e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 415   YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  474
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgkyvylv+el++GGelldri+++++fsereas++l+t++++++ylh+qGvvhrdlk
Q: 475   VYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLK  534
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 535   PSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDV  594
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 595   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  654
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+lkh+w+
Q: 655   VDPQQRLTAVQVLKHPWI  672
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDAEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKYVYL VMELMRGGEL LDRILRQRCF SEREASDVLY TIARTMDYLH SQGVVHRDLK 120
PSNILYMDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDV 180
WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPQQRLTAV QVLKHPWI 258
KeywordATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Tumor suppressor; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-DRM-00076
EKS-EQC-00163
EKS-GAG-00139
EKS-GAA-00191
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUP-00165
EKS-ORN-00201
EKS-ORC-00150
EKS-ORL-00188
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-TAR-00208
EKS-XET-00150
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
mmu:20112;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013