EKS-MUM-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/RIO	278.6	8.9E-83	96	318	223

Status

Reviewed

Ensembl Protein

ENSMUSP00000024620

UniProt Accession

Q9CQS5; Q91XF3;

Protein Name

Serine/threonine-protein kinase RIO2

Protein Synonyms/Alias

RIO kinase 2;

Gene Name

Riok2

Gene Synonyms/Alias

Riok2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000023846	ENSMUSP00000024620	ENSMUST00000024620

Organism

Mus musculus

Functional Description

Protein Length

547

Protein Sequence
(FASTA)

MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPCSLIAS IASLKHGGCN KILRELVKHK 60

LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEAGQQL 120

ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID 180

YNRHAVIMEL INGYPLCQIH HVEDPASVYD EAMELIVKLG NHGLIHGDFN EFNLMLDKDD 240

HITMIDFPQM VSTSHPNAEW YFDRDVKCIR EFFMKRFSYE SELYPTFSDI RKEDSLDVEV 300

SASGYTKEMQ ADDELLHPVG PDDKITETEE DSDFTFSDEE MLEKAKVWRS ELEKEADPAD 360

ESGGSWCCSS TDSKQIKDGG LPEESAHVSS FEVTALSQAV EEMERQVLPH RSVTEFSEES 420

RRTENDGQPG QRSPAGSEDC DDEPPHLIAL SSVNREFRPF RDEESMSSVT RHRTRTLSVT 480

SAGSALSCST IPPELVKQKV KRQLTRQQKA AARRRLQKGE ANVFTKQRRE NMQNIKSSLE 540

AASFWGD 547

Nucleotide Sequence
(FASTA)

ATGGGGAAGG TGAATGTAGC CAAGCTTAGG TACATGAGCC GCGATGACTT CAGAGTTCTG 60

ACTGCGGTTG AAATGGGCAT GAAAAACCAT GAGATTGTTC CCTGCAGTTT GATTGCTTCT 120

ATAGCCAGCC TGAAACATGG TGGCTGTAAT AAGATTCTAA GAGAATTGGT GAAGCATAAA 180

CTTATAGCGT GGGAACGTAC TAAAACTGTG CAGGGCTATC GGTTGACAAA TGCTGGCTAT 240

GATTACCTAG CTCTGAAAAC GCTGTCTTCT AGACAGGTAG TTGAATCTGT TGGAAACCAG 300

ATGGGTGTGG GCAAAGAGTC AGACATTTAC ATTGTTGCCA ATGAAGCCGG GCAGCAGCTC 360

GCACTGAAGC TCCACAGACT CGGAAGAACT TCCTTTCGAA ATCTGAAAAA CAAGCGCGAT 420

TACCACAAGC ACAGGCACAA TGTTTCTTGG CTTTACTTAT CTCGGCTCTC GGCCATGAAG 480

GAATTTGCCT ATATGAAGGC ATTATATGAG AGGAAATTTC CAGTTCCAAA GCCAATTGAT 540

TATAATCGCC ATGCAGTGAT CATGGAGCTT ATTAATGGTT ATCCCCTATG TCAGATACAT 600

CATGTTGAAG ACCCTGCATC AGTATATGAT GAAGCTATGG AACTGATAGT CAAACTGGGA 660

AACCATGGAC TGATTCATGG AGATTTCAAT GAATTCAATC TCATGTTGGA CAAAGATGAC 720

CACATCACCA TGATTGATTT TCCGCAGATG GTTTCCACAT CCCACCCAAA TGCTGAATGG 780

TATTTTGACA GAGATGTTAA ATGCATTCGA GAATTCTTCA TGAAACGTTT TAGCTATGAA 840

AGTGAGCTCT ACCCAACCTT CAGTGATATC AGGAAGGAGG ATTCTCTTGA TGTTGAGGTC 900

TCTGCCAGTG GTTACACAAA GGAAATGCAA GCAGATGATG AACTGCTACA TCCAGTAGGC 960

CCAGATGATA AAATTACTGA AACAGAAGAG GACTCTGACT TCACGTTTTC TGATGAAGAA 1020

ATGTTAGAAA AAGCCAAAGT GTGGAGGTCA GAATTGGAAA AGGAAGCAGA CCCAGCAGAT 1080

GAATCAGGTG GATCCTGGTG CTGCTCGTCT ACAGACAGCA AACAAATAAA GGATGGCGGC 1140

TTACCAGAGG AGAGTGCTCA TGTGTCCAGT TTCGAAGTGA CGGCATTAAG CCAAGCTGTA 1200

GAAGAGATGG AAAGGCAGGT TCTTCCCCAC AGGTCGGTTA CTGAGTTCTC TGAGGAGAGC 1260

AGGAGAACTG AAAATGATGG GCAGCCAGGT CAGAGAAGCC CTGCTGGCTC TGAGGACTGT 1320

GACGATGAAC CCCCCCATCT GATTGCCTTG TCATCAGTGA ACAGGGAGTT CAGGCCTTTC 1380

AGAGACGAAG AGAGTATGAG TAGTGTTACT CGGCATAGAA CAAGAACATT GAGTGTTACG 1440

TCTGCGGGCA GTGCCCTAAG CTGTTCAACA ATCCCTCCAG AACTGGTGAA GCAGAAGGTG 1500

AAGCGTCAGC TGACAAGGCA GCAGAAGGCG GCTGCCAGAC GCCGGCTGCA GAAAGGAGAA 1560

GCCAATGTGT TTACCAAGCA GCGGAGGGAA AACATGCAGA ATATTAAATC GAGTTTGGAA 1620

GCAGCCAGCT TTTGGGGAGA CTAA 1644

Domain Profile

S: 2     svgntigvgkesdvykvsekngeeraiKiy...ktsllvlknrdkYvdgefrfkksrska  58

         svgn++gvgkesd+y v+++ g++ a+K++   +ts+++lkn+++Y       +k+r+++

Q: 96    SVGNQMGVGKESDIYIVANEAGQQLALKLHrlgRTSFRNLKNKRDY-------HKHRHNV  148

         79********************************************.......9******

S: 59    nprklsrlwAeKEfrnlkrlyekgvpvPepidlkrhvlvmeligrdgypapklkdvklke  118

         ++++lsrl+A+KEf+++k+lye+++pvP+pid++rh+++meli  +gyp+++++    +

Q: 149   SWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVIMELI--NGYPLCQIH----HV  202

         *******************************************..*********....9*

S: 119   eeikelYsdllalivklynegrLvHaDlsEfnill.eddklvliDvsqsveieHpdalef  177

         e+ +++Y+++++livkl n+g L+H+D++Efn++l +dd++++iD++q+v+++Hp+a+++

Q: 203   EDPASVYDEAMELIVKLGNHG-LIHGDFNEFNLMLdKDDHITMIDFPQMVSTSHPNAEWY  261

         *********************.*************899**********************

S: 178   lrrDvknvkefFkkklvy.........dvlrerelfelvsasgltkekeaddeilea  225

         ++rDvk+++efF+k+++y         d+++e++l+ +vsasg+tke++adde+l++

Q: 262   FDRDVKCIREFFMKRFSYeselyptfsDIRKEDSLDVEVSASGYTKEMQADDELLHP  318

         *****************************************************9986

Domain Sequence
(FASTA)

SVGNQMGVGK ESDIYIVANE AGQQLALKLH RLGRTSFRNL KNKRDYHKHR HNVSWLYLSR 60

LSAMKEFAYM KALYERKFPV PKPIDYNRHA VIMELINGYP LCQIHHVEDP ASVYDEAMEL 120

IVKLGNHGLI HGDFNEFNLM LDKDDHITMI DFPQMVSTSH PNAEWYFDRD VKCIREFFMK 180

RFSYESELYP TFSDIRKEDS LDVEVSASGY TKEMQADDEL LHP 223

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mmu:67045

;

InterPros

IPR011009	; Kinase-like_dom.
IPR018934	; RIO-like_kinase.
IPR015285	; RIO2_kinase_winged_hlx_N.
IPR018935	; RIO_kinase_CS.
IPR011991	; WHTH_trsnscrt_rep_DNA-bd.

Pfam

PF01163	; RIO1; 1.
PF09202	; Rio2_N; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; FALSE_NEG.
PS01245	; RIO1; 1.

Prints

Created Date

20-Feb-2013