EKS-MUM-00520

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00520

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/CCK4	546.3	3.0E-164	788	1053	266

Status

Reviewed

Ensembl Protein

ENSMUSP00000043703

UniProt Accession

Q8BKG3; Q3V422; Q6W8S9; Q8CHK5; Q8K178;

Protein Name

Inactive tyrosine-protein kinase 7

Protein Synonyms/Alias

Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7;

Gene Name

Ptk7

Gene Synonyms/Alias

Ptk7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000023972	ENSMUSP00000043703	ENSMUST00000044442

Organism

Mus musculus

Functional Description

Inactive tyrosine kinase involved in Wnt signalingpathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Protein Length

1062

Protein Sequence
(FASTA)

MGARPLTLLR ALLLPLLAGA QAAIVFIKEP SSQDALQGRR ALLRCEVEAP DPVHVYWLLN 60

GVPVQDTERR FAQGSSLSFA AVDRLQDSGA FQCVARDNVT GEEVRSTNAS FNIKWIEAGP 120

VVLKHPASEA EIQPQTQVTL RCHIDGHPRP TYQWFRDGTP LSDDQSTHTV SSRERNLTLR 180

PASPEHSGLY SCCAHNAFGQ ACSSQNFTLS VADESFARVV LAPQDVVVAR NEEAMFHCQF 240

SAQPPPSLQW VFEDETPITN RSRPPHLRRA VVFANGSLLL TQVRPRNAGV YRCIGQGQRG 300

PPIVLEATLH LAEIEDMLPF EPRVFIAGDE ERVTCPAPQG LPTPSVWWEH AGVPLPAHGR 360

VHQKGLELVF VTIAESDTGV YTCHASNLAG QRRQDVNITV ATVPTWLRKP QDSQLEEGKP 420

GYLHCLTQAT PKPTVIWYRN QMLISEDSRF EVSKNGTLRI NSVEVYDGTL YRCVSSTPAG 480

SIEAQARVQV LEKLKFTPPP QPQQCMEFDK EATVPCSATG REKPTVKWVR ADGSSLPEWV 540

TDNAGTLHFA RVTRDDAGNY TCIASNEPQG QIRAHVQLTV AVFITFKVEP ERTTVYQGHT 600

ALLRCEAQGD PKPLIQWKGK DRILDPTKLG PRMHIFQNGS LVIHDVAPED SGSYTCIAGN 660

SCNIRHTEAP LLVVDKPVME DSEGPGSPPP YKMIQTIGLS VGAAVAYIIA VLGLMFYCKK 720

RCKAKRLQKQ PEGEEPEMEC LNGGPLQNGQ PSAEIQEEVA LTSLGSGPPA TNKRHSAGDR 780

MHFPRASLQP ITTLGKSEFG EVFLAKAQGV EEGATETLVL VKSLQSRDEQ QQLDFRREVE 840

MFGKLNHANV VRLLGLCREA EPHYMVLEYV DLGDLKQFLR ISKNKDEKLK SQPLSTKQKV 900

ALCSQVALGM EHLSNNRFVH KDLAARNCLI SAQRQVKVSA LGLSKDVYNS EYYHFRQAWV 960

PLRWMSPEAV LEGDFSTKSD VWAFGVLMWE VFTHGEMPHG GQADDEVLAD LQAGKARLPQ 1020

PEGCPSKLYR LMQRCWAPNP KDRPSFSEIA STLGDSPADS KQ 1062

Nucleotide Sequence
(FASTA)

ATGGGAGCCC GCCCGCTGAC TCTGCTCAGA GCCCTGCTTC TGCCGCTGCT GGCCGGTGCC 60

CAAGCCGCTA TCGTCTTTAT CAAGGAGCCG TCCTCCCAGG ATGCACTTCA AGGGCGCCGG 120

GCGCTGCTCC GTTGTGAAGT GGAGGCTCCG GACCCGGTGC ACGTGTACTG GCTGCTCAAT 180

GGGGTGCCTG TCCAGGACAC GGAGCGACGG TTTGCCCAGG GCAGCAGCCT GAGTTTCGCA 240

GCTGTGGACC GGCTCCAGGA TTCTGGTGCT TTCCAGTGTG TGGCTCGGGA TAACGTCACT 300

GGAGAGGAAG TCCGCAGTAC TAATGCCTCC TTCAACATCA AATGGATCGA AGCAGGTCCT 360

GTGGTCCTGA AGCACCCAGC CTCAGAAGCT GAGATCCAGC CCCAGACCCA GGTCACACTG 420

CGATGTCACA TTGACGGGCA CCCTCGGCCT ACCTACCAGT GGTTCCGAGA TGGGACCCCC 480

CTCTCTGATG ATCAGAGCAC CCACACCGTC AGCAGCAGGG AGAGGAACCT GACCCTACGG 540

CCAGCCAGTC CCGAACATAG TGGCCTCTAC TCCTGCTGTG CCCACAATGC CTTTGGCCAG 600

GCCTGCAGCA GCCAGAACTT CACCTTGAGT GTTGCAGATG AAAGCTTTGC CAGGGTGGTG 660

CTGGCACCTC AGGATGTTGT TGTAGCAAGG AACGAGGAGG CCATGTTCCA TTGCCAGTTT 720

TCAGCCCAGC CACCCCCGAG CCTGCAGTGG GTCTTTGAGG ACGAGACTCC CATCACTAAC 780

CGAAGCCGTC CCCCTCACCT CCGCAGAGCT GTGGTGTTTG CCAATGGCTC TCTGCTGCTG 840

ACCCAAGTCC GGCCACGGAA TGCAGGCGTC TACCGTTGCA TCGGTCAGGG ACAGAGGGGC 900

CCACCCATTG TCCTGGAAGC CACTCTCCAC CTGGCAGAGA TTGAAGACAT GCTGCCGTTT 960

GAACCACGGG TGTTCATAGC TGGTGATGAG GAACGAGTCA CCTGCCCAGC CCCCCAGGGC 1020

CTGCCTACAC CCAGTGTCTG GTGGGAGCAT GCTGGAGTCC CTCTTCCTGC CCATGGCAGG 1080

GTCCACCAGA AGGGCCTTGA GCTTGTGTTT GTCACCATCG CTGAGAGTGA TACTGGTGTC 1140

TACACCTGCC ATGCAAGCAA CCTGGCTGGT CAGCGGCGAC AGGATGTCAA TATCACAGTG 1200

GCCACTGTAC CCACATGGCT TAGGAAGCCC CAAGACAGCC AGCTGGAAGA GGGCAAGCCT 1260

GGCTACTTGC ACTGTCTGAC ACAGGCCACA CCCAAGCCCA CTGTGATCTG GTACAGGAAC 1320

CAGATGCTGA TCTCAGAGGA CTCGAGGTTC GAAGTTTCGA AGAATGGGAC CTTGCGCATC 1380

AATAGTGTGG AGGTGTATGA CGGGACATTG TACCGTTGCG TGAGCAGTAC CCCAGCCGGC 1440

AGCATCGAGG CCCAGGCCCG AGTCCAGGTG CTGGAAAAAC TCAAGTTCAC GCCACCACCG 1500

CAGCCACAGC AGTGCATGGA GTTTGATAAG GAGGCTACGG TGCCCTGCTC AGCCACTGGC 1560

CGGGAGAAGC CCACGGTTAA GTGGGTACGG GCAGATGGAA GTAGCCTCCC TGAATGGGTG 1620

ACAGACAATG CTGGAACCCT ACACTTTGCC CGAGTGACCC GAGATGATGC TGGCAACTAC 1680

ACTTGCATTG CATCCAACGA GCCACAGGGC CAGATCCGCG CTCATGTCCA GCTGACGGTG 1740

GCAGTTTTCA TCACCTTCAA AGTGGAACCT GAGCGTACAA CTGTGTACCA GGGCCACACA 1800

GCGCTGCTGC GGTGTGAGGC TCAGGGCGAC CCCAAGCCTC TCATTCAGTG GAAAGGCAAA 1860

GACCGGATCC TGGACCCTAC CAAGCTGGGA CCCAGGATGC ACATCTTCCA GAACGGTTCC 1920

CTGGTGATCC ATGACGTGGC CCCTGAGGAC TCAGGCTCCT ACACCTGCAT CGCTGGCAAC 1980

AGCTGTAACA TCAGGCACAC AGAGGCCCCG CTCTTAGTCG TGGACAAGCC AGTGATGGAA 2040

GACTCGGAGG GCCCAGGCAG CCCTCCCCCA TACAAGATGA TCCAGACCAT CGGGCTGTCG 2100

GTGGGCGCAG CGGTAGCCTA CATCATCGCG GTCCTGGGCC TCATGTTCTA CTGCAAGAAG 2160

CGGTGTAAAG CCAAGCGGCT GCAGAAACAG CCTGAGGGGG AGGAGCCAGA GATGGAGTGC 2220

CTCAATGGTG GGCCTTTGCA GAATGGTCAG CCATCAGCCG AGATCCAGGA AGAAGTGGCG 2280

TTGACCAGCT TGGGCTCTGG CCCCCCAGCC ACCAACAAGC GCCACAGCGC CGGTGATAGG 2340

ATGCATTTCC CGAGAGCCAG CCTGCAGCCT ATCACCACTC TGGGGAAAAG CGAGTTCGGG 2400

GAGGTGTTCC TGGCAAAGGC GCAGGGCGTA GAGGAAGGCG CGACGGAGAC CCTGGTCCTC 2460

GTGAAGAGCC TGCAGAGCAG GGACGAGCAA CAACAGCTGG ACTTCCGGAG AGAGGTGGAG 2520

ATGTTCGGGA AGTTGAACCA TGCCAACGTG GTGCGGCTTC TGGGGCTGTG CCGGGAGGCT 2580

GAGCCCCACT ACATGGTGCT GGAGTATGTG GACCTGGGAG ATCTCAAACA GTTCCTGAGG 2640

ATTTCCAAGA ACAAGGATGA AAAGTTGAAG TCACAGCCCC TCAGCACCAA ACAGAAGGTG 2700

GCCCTGTGTT CCCAGGTGGC CCTGGGCATG GAGCACCTGT CCAACAACCG CTTTGTGCAC 2760

AAGGACTTAG CGGCTCGCAA CTGCCTGATC AGTGCCCAGA GGCAGGTGAA GGTGTCCGCA 2820

CTGGGCCTGA GCAAGGATGT ATACAACAGT GAGTACTACC ACTTCCGCCA GGCCTGGGTA 2880

CCTCTGCGTT GGATGTCTCC AGAGGCTGTC CTGGAGGGTG ACTTCTCCAC TAAGTCTGAT 2940

GTCTGGGCCT TTGGTGTGCT CATGTGGGAA GTGTTCACTC ATGGAGAGAT GCCCCATGGT 3000

GGACAGGCAG ATGATGAGGT GCTGGCAGAC TTGCAGGCTG GCAAGGCTCG ACTCCCGCAG 3060

CCCGAAGGCT GCCCGTCTAA GCTCTACCGG CTGATGCAGC GCTGCTGGGC CCCGAACCCC 3120

AAGGACCGGC CCTCCTTCAG TGAGATCGCC AGCACCCTGG GAGACAGCCC TGCAGACAGC 3180

AAGCAGTGA 3189

Domain Profile

S: 1     lqelitlgksefgevflaklkgleegatetlvlvkslqkkdeqaqldfrrelellgklnh  60

         lq+++tlgksefgevflak++g+eegatetlvlvkslq++deq+qldfrre+e++gklnh

Q: 788   LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNH  847

         79**********************************************************

S: 61    anvvrllglcreaephymvleyvdlgdlkqflkiskakdeklksqplstkqkvalasqva  120

         anvvrllglcreaephymvleyvdlgdlkqfl+isk+kdeklksqplstkqkval+sqva

Q: 848   ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKDEKLKSQPLSTKQKVALCSQVA  907

         ************************************************************

S: 121   lgmealsrarfvhkdlaarnclisaerqvkvsalalskdvynseyykfrqalvplrwlsp  180

         lgme+ls++rfvhkdlaarnclisa+rqvkvsal+lskdvynseyy+frqa+vplrw+sp

Q: 908   LGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSP  967

         ************************************************************

S: 181   eaileddfstksdvfafgvlvwevftqaelpheeladdevladlqagklrlsqaeatpsk  240

         ea+le+dfstksdv+afgvl+wevft++e+ph+++addevladlqagk+rl+q+e++psk

Q: 968   EAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSK  1027

         ************************************************************

S: 241   lyrlllrcwasnpkdrpsfselasal  266

         lyrl++rcwa+npkdrpsfse+as+l

Q: 1028  LYRLMQRCWAPNPKDRPSFSEIASTL  1053

         ************************97

Domain Sequence
(FASTA)

LQPITTLGKS EFGEVFLAKA QGVEEGATET LVLVKSLQSR DEQQQLDFRR EVEMFGKLNH 60

ANVVRLLGLC REAEPHYMVL EYVDLGDLKQ FLRISKNKDE KLKSQPLSTK QKVALCSQVA 120

LGMEHLSNNR FVHKDLAARN CLISAQRQVK VSALGLSKDV YNSEYYHFRQ AWVPLRWMSP 180

EAVLEGDFST KSDVWAFGVL MWEVFTHGEM PHGGQADDEV LADLQAGKAR LPQPEGCPSK 240

LYRLMQRCWA PNPKDRPSFS EIASTL 266

Keyword

Cell adhesion; Cell junction; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0016021	; C:integral to membrane
GO:0016020	; C:membrane
GO:0016772	; F:transferase activity, transferring phosphorus-containing groups
GO:0031532	; P:actin cytoskeleton reorganization
GO:0003401	; P:axis elongation
GO:0060070	; P:canonical Wnt receptor signaling pathway
GO:0007155	; P:cell adhesion
GO:0016477	; P:cell migration
GO:0071300	; P:cellular response to retinoic acid
GO:0090103	; P:cochlea morphogenesis
GO:0060026	; P:convergent extension
GO:0045198	; P:establishment of epithelial cell apical/basal polarity
GO:0001736	; P:establishment of planar polarity
GO:0060484	; P:lung-associated mesenchyme development
GO:0001843	; P:neural tube closure
GO:0090179	; P:planar cell polarity pathway involved in neural tube closure
GO:0010976	; P:positive regulation of neuron projection development
GO:0042060	; P:wound healing

KEGG

mmu:71461

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 5.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 6.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 7.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; FALSE_NEG.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013