EKS-MUM-00156
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00156
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/NDR513.05.5E-15489382294
StatusReviewed
Ensembl ProteinENSMUSP00000009138
UniProt AccessionQ91VJ4;
Protein NameSerine/threonine-protein kinase 38
Protein Synonyms/Alias NDR1 protein kinase; Nuclear Dbf2-related kinase 1;
Gene NameStk38
Gene Synonyms/Alias Stk38; Ndr1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000024006ENSMUSP00000113657ENSMUST00000119274
ENSMUSG00000024006ENSMUSP00000009138ENSMUST00000009138
OrganismMus musculus
Functional DescriptionNegative regulator of MAP3K1/2 signaling. ConvertsMAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
Protein Length465
Protein Sequence
(FASTA)
MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE 60
EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120
RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180
KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240
HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300
KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPVS EKAKGLILRF 360
CCEWEHRIGA PGVEEIKNNL FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK 420
PTVTTSSHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK 465
Nucleotide Sequence
(FASTA)
ATGGCAATGA CAGGATCAAC ACCTTGCTCA TCCATGAGTA ATCATACGAA GGAGAGGGTG 60
ACAATGACCA AAGTGACACT GGAGAATTTT TATAGCAACC TTATCGCTCA ACATGAAGAA 120
CGAGAAATGA GACAAAAGAA GTTAGAAAAG GTGATGGAAG AAGAAGGCCT GAAAGACGAA 180
GAGAAACGAC TCAGAAGATC CGCGCACGCT CGGAAGGAAA CAGAGTTTCT TCGATTAAAG 240
AGAACAAGGC TTGGACTGGA AGATTTTGAG TCTTTAAAAG TCATAGGCCG AGGAGCATTT 300
GGTGAGGTGC GGCTTGTTCA GAAGAAAGAC ACAGGGCATG TGTACGCAAT GAAAATCCTG 360
CGCAAAGCAG ACATGCTCGA GAAGGAGCAG GTTGGCCACA TTCGTGCGGA GCGTGACATT 420
CTAGTGGAGG CAGACAGTTT GTGGGTTGTG AAAATGTTCT ATAGTTTTCA GGATAAGCTA 480
AACCTCTACC TAATCATGGA GTTCCTGCCT GGAGGGGACA TGATGACTTT ATTGATGAAA 540
AAAGATACTC TGACAGAAGA GGAGACTCAG TTTTATATAG CAGAGACAGT ATTAGCCATA 600
GACTCCATTC ACCAGCTGGG ATTCATCCAC AGAGATATCA AGCCAGACAA CCTTCTCTTG 660
GACAGCAAGG GCCATGTGAA ACTTTCCGAC TTTGGCCTTT GCACAGGCCT GAAAAAAGCA 720
CACAGGACAG AATTTTATAG GAACCTGAAC CACAGCCTGC CCAGTGATTT CACTTTTCAG 780
AACATGAATT CCAAAAGGAA AGCAGAGACC TGGAAAAGAA ACAGACGCCA GCTAGCCTTC 840
TCTACAGTGG GCACTCCTGA CTACATTGCT CCAGAGGTGT TCATGCAGAC GGGTTACAAC 900
AAGCTCTGCG ATTGGTGGTC GCTCGGGGTA ATCATGTATG AGATGCTCAT CGGCTACCCA 960
CCATTCTGCT CCGAGACCCC ACAAGAGACA TACAAGAAAG TGATGAACTG GAAGGAAACT 1020
TTGACCTTTC CTCCAGAAGT TCCTGTCTCC GAGAAAGCCA AGGGCCTGAT TCTGAGGTTC 1080
TGCTGTGAAT GGGAACATAG AATCGGAGCC CCTGGAGTTG AAGAAATAAA AAATAATCTT 1140
TTTTTTGAAG GTGTTGACTG GGAACACATC AGGGAGAGAC CAGCTGCGAT ATCTATTGAA 1200
ATCAAGAGCA TCGATGATAC CTCAAACTTC GATGAATTTC CAGAGTCTGA TATTCTTAAG 1260
CCCACAGTGA CCACAAGTAG TCATCCTGAG ACGGACTACA AGAACAAAGA CTGGGTCTTC 1320
ATCAATTACA CATACAAGCG CTTCGAGGGC CTGACAGCCA GGGGGGCCAT ACCTTCGTAC 1380
ATGAAAGCAG CAAAATAG 1398
Domain Profile
S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60
         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w
Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148
         899*********************************************************
S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120
         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf
Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF  208
         ************************************************************
S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180
         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++
Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMNS  264
         *************************************************555....5555
S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236
         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++
Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324
         5544556*****************************************************
S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294
         etpqetykkv+nwketl+fp+ev++se+ak li r+++++e+r+g+ Gv+eik++ ff
Q: 325   ETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKNNLFF  382
         *******************************************************998
Domain Sequence
(FASTA)
FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60
VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYIAETVL AIDSIHQLGF 120
IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LNHSLPSDFT FQNMNSKRKA 180
ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240
ETYKKVMNWK ETLTFPPEVP VSEKAKGLIL RFCCEWEHRI GAPGVEEIKN NLFF 294
KeywordAcetylation; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00144
EKS-ANC-00144
EKS-BOT-00151
EKS-CAJ-00157
EKS-CAF-00159
EKS-CAP-00151
EKS-CHH-00019
EKS-CIS-00183
EKS-DAR-00437
EKS-DRM-00074
EKS-EQC-00149
EKS-FEC-00143
EKS-GAM-00079
EKS-GAG-00129
EKS-GAA-00179
EKS-HOS-00157
EKS-LAC-00160
EKS-LOA-00151
EKS-MAM-00149
EKS-MAE-00057
EKS-MEG-00119
EKS-MOD-00150
EKS-MUP-00156
EKS-MYL-00160
EKS-NOL-00144
EKS-ORN-00187
EKS-ORA-00132
EKS-ORC-00142
EKS-ORL-00176
EKS-OTG-00157
EKS-PAT-00142
EKS-PES-00135
EKS-POA-00148
EKS-PTV-00142
EKS-SAH-00146
EKS-SUS-00133
EKS-TAG-00179
EKS-TAR-00196
EKS-TEN-00190
EKS-TUT-00145
EKS-VIP-00073
EKS-XET-00140
EKS-XIM-00181
EKS-SCP-00052
Gene Ontology
GO:0005737; C:cytoplasm
GO:0070688; C:MLL5-L complex
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0043407; P:negative regulation of MAP kinase activity
KEGG
mmu:106504;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013