EKS-MUM-00077

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00077

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/PIM	468.9	8.9E-141	122	374	253

Status

Unreviewed

Ensembl Protein

ENSMUSP00000024811

UniProt Accession

F6XDQ5;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase pim-1;

Gene Name

Pim1

Gene Synonyms/Alias

Pim1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000024014	ENSMUSP00000024811	ENSMUST00000024811

Organism

Mus musculus

Functional Description

Protein Length

397

Protein Sequence
(FASTA)

LGPAAPLALP PPALPDPAGE PARGQPRQRP QSSSDSPSAL RASRSQSRNA TRSLSPGRRL 60

SPSSLRRRCC SSRHRRRTDT LEVGMLLSKI NSLAHLRAAP CNDLHATKLA PGKEKEPLES 120

QYQVGPLLGS GGFGSVYSGI RVADNLPVAI KHVEKDRISD WGELPNGTRV PMEVVLLKKV 180

SSDFSGVIRL LDWFERPDSF VLILERPEPV QDLFDFITER GALQEDLARG FFWQVLEAVR 240

HCHNCGVLHR DIKDENILID LSRGEIKLID FGSGALLKDT VYTDFDGTRV YSPPEWIRYH 300

RYHGRSAAVW SLGILLYDMV CGDIPFEHDE EIIKGQVFFR QTVSSECQHL IKWCLSLRPS 360

DRPSFEEIRN HPWMQGDLLP QAASEIHLHS LSPGSSK 397

Nucleotide Sequence
(FASTA)

CTGGGTCCCG CAGCGCCTCT CGCCCTGCCG CCTCCCGCAC TGCCTGACCC AGCCGGCGAA 60

CCCGCCCGCG GCCAGCCCCG CCAGCGCCCT CAGTCGTCCT CCGACTCGCC CTCGGCCTTG 120

CGCGCCAGCC GCAGCCAGAG CCGCAACGCC ACCCGCAGTC TGAGTCCCGG CCGTCGGCTC 180

AGCCCCAGCT CGCTCCGCCG CCGCTGCTGC TCGTCCCGGC ACCGGCGCCG CACCGACACC 240

CTGGAGGTGG GGATGCTCCT GTCCAAGATC AACTCCCTGG CCCACCTGCG CGCCGCGCCC 300

TGCAACGACC TGCACGCCAC CAAGCTGGCG CCGGGCAAAG AGAAGGAGCC CCTGGAGTCG 360

CAGTACCAGG TGGGCCCGCT GTTGGGCAGC GGTGGCTTCG GCTCGGTCTA CTCTGGCATC 420

CGCGTCGCCG ACAACTTGCC GGTGGCCATT AAGCACGTGG AGAAGGACCG GATTTCCGAT 480

TGGGGAGAAC TGCCCAATGG CACCCGAGTG CCCATGGAAG TGGTCCTGTT GAAGAAGGTG 540

AGCTCGGACT TCTCGGGCGT CATTAGACTT CTGGACTGGT TCGAGAGGCC CGATAGTTTC 600

GTGCTGATCC TGGAGAGGCC CGAACCGGTG CAAGACCTCT TCGACTTTAT CACCGAACGA 660

GGAGCCCTAC AGGAGGACCT GGCCCGAGGA TTCTTCTGGC AGGTGCTGGA GGCCGTGCGG 720

CATTGCCACA ACTGCGGGGT TCTCCACCGC GACATCAAGG ACGAGAACAT CTTAATCGAC 780

CTGAGCCGCG GCGAAATCAA ACTCATCGAC TTCGGGTCGG GGGCGCTGCT CAAGGACACA 840

GTCTACACGG ACTTTGATGG GACCCGAGTG TACAGTCCTC CAGAGTGGAT TCGCTACCAT 900

CGCTACCACG GCAGGTCGGC AGCTGTCTGG TCCCTTGGGA TCCTGCTCTA TGACATGGTC 960

TGCGGAGATA TTCCGTTTGA GCACGATGAA GAGATCATCA AGGGCCAAGT GTTCTTCAGG 1020

CAAACTGTCT CTTCAGAGTG TCAGCACCTT ATTAAATGGT GCCTGTCCCT GAGACCATCA 1080

GATCGGCCCT CCTTTGAAGA AATCCGGAAC CATCCATGGA TGCAGGGTGA CCTCCTGCCC 1140

CAGGCAGCTT CTGAGATCCA TCTGCACAGT CTGTCACCGG GGTCCAGCAA GTAG 1194

Domain Profile

S: 1     ykvgallGkGGfGvvyagvrvadnlpvavkfvekervkewael.ngetvplevvllkkva  59

         y+vg+llG+GGfG+vy+g+rvadnlpva+k+vek+r+++w+el ng++vp+evvllkkv+

Q: 122   YQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELpNGTRVPMEVVLLKKVS  181

         9***********************************************************

S: 60    edvrGvirlldwferpegfllvlerpepaqdlfdfitekGaldedlarslfkqvlaavre  119

         +d++Gvirlldwferp++f+l+lerpep+qdlfdfite+Gal+edlar +f+qvl+avr+

Q: 182   SDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRH  241

         ************************************************************

S: 120   chskgvlhrdikdenllidlrrGevklidfGsgallkdtvytdfdGtrvysppewirkhr  179

         ch++gvlhrdikden+lidl+rGe+klidfGsgallkdtvytdfdGtrvysppewir+hr

Q: 242   CHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR  301

         ************************************************************

S: 180   ylgreatvwslGvllydlvcGdlpfekdeeilkgelkfraevskevkqlikkclalkpse  239

         y+gr+a+vwslG+llyd+vcGd+pfe+deei+kg+++fr++vs+e+++lik+cl+l+ps+

Q: 302   YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSD  361

         ************************************************************

S: 240   rpsleeiaahpwm  252

         rps+eei++hpwm

Q: 362   RPSFEEIRNHPWM  374

         ************9

Domain Sequence
(FASTA)

YQVGPLLGSG GFGSVYSGIR VADNLPVAIK HVEKDRISDW GELPNGTRVP MEVVLLKKVS 60

SDFSGVIRLL DWFERPDSFV LILERPEPVQ DLFDFITERG ALQEDLARGF FWQVLEAVRH 120

CHNCGVLHRD IKDENILIDL SRGEIKLIDF GSGALLKDTV YTDFDGTRVY SPPEWIRYHR 180

YHGRSAAVWS LGILLYDMVC GDIPFEHDEE IIKGQVFFRQ TVSSECQHLI KWCLSLRPSD 240

RPSFEEIRNH PWM 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0030145	; F:manganese ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008283	; P:cell proliferation
GO:0043066	; P:negative regulation of apoptotic process
GO:0043433	; P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0031659	; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013