EKS-MUM-00420
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00420
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11364.59.3E-109356616261
StatusUnreviewed
Ensembl ProteinENSMUSP00000094326
UniProt AccessionG5E8L8;
Protein Name
Protein Synonyms/Alias Mitogen activated protein kinase kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2;
Gene NameMap3k2
Gene Synonyms/Alias Map3k2; mCG_127139;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000024383ENSMUSP00000094326ENSMUST00000096575
OrganismMus musculus
Functional Description
Protein Length619
Protein Sequence
(FASTA)
MDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKPSSPKK QNDVRVKFEH RGEKRILQVT 60
RPVKLEDLRS KSKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV 120
VNGSTQATNL EPSPSPEDLN NTPLGAERKK RLSVVGPPNR DRSSPPPGYI PDELHQIARN 180
GSFTSINSEG EFIPESMDQM LDPLSLSSPE NSGSGSCPSL DSPLDGESYP KSRMPRAQSY 240
PDNHQEFTDY DNPIFEKFGK GGTYPRRYHV SYHHQEYNDG RKTFPRARRT QGTSFRSPVS 300
FSPTDHSLST SSGSSVFTPE YDDSRIRRRG SDIDNPTLTV TDISPPSRSP RAPTNWRLGK 360
LLGQGAFGRV YLCYDVDTGR ELAVKQVQFN PESPETSKEV NALECEIQLL KNLLHERIVQ 420
YYGCLRDPQE KTLSIFMEYM PGGSIKDQLK AYGALTENVT RKYTRQILEG VHYLHSNMIV 480
HRDIKGANIL RDSTGNIKLG DFGASKRLQT ICLSGTGMKS VTGTPYWMSP EVISGEGYGR 540
KADIWSVACT VVEMLTEKPP WAEFEAMAAI FKIATQPTNP KLPPHVSDYT RDFLKRIFVE 600
AKLRPSAEEL LRHMFVHYH 619
Nucleotide Sequence
(FASTA)
ATGGATGATC AGCAAGCTTT GAATTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 60
AGTCGGCCAG CATTATCTTT ACAAGAAACC AGGAAAGCAA AACCTTCATC ACCAAAAAAA 120
CAGAATGATG TTCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGGATCCT GCAGGTTACT 180
AGACCAGTTA AACTAGAAGA CCTGAGATCT AAGTCTAAGA TCGCCTTTGG GCAGTCTATG 240
GATCTACACT ATACCAACAA TGAGTTGGTA ATTCCGTTAA CTACCCAAGA TGACTTGGAC 300
AAAGCTGTGG AACTGCTGGA TCGCAGTATT CACATGAAGA GTCTCAAGAT ATTACTTGTA 360
GTAAATGGGA GTACACAGGC TACTAATTTA GAACCATCAC CGTCACCAGA AGATTTGAAT 420
AATACACCAC TTGGTGCAGA GAGGAAAAAG CGGCTATCTG TAGTAGGTCC CCCTAATAGG 480
GATAGAAGTT CCCCTCCTCC AGGATACATT CCAGACGAGC TACACCAGAT TGCCCGGAAT 540
GGGTCATTCA CTAGCATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 600
CTGGATCCAT TGTCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGCTG TCCGTCACTT 660
GATAGTCCTT TGGATGGAGA AAGCTACCCA AAATCACGGA TGCCTAGGGC ACAGAGCTAC 720
CCAGATAATC ATCAGGAGTT TACAGACTAT GATAACCCCA TTTTTGAGAA ATTTGGAAAA 780
GGAGGAACAT ATCCAAGAAG GTACCACGTT TCCTATCATC ACCAGGAGTA TAATGACGGT 840
CGGAAGACTT TTCCAAGAGC TAGAAGGACC CAGGGCACCA GTTTCCGGTC TCCTGTGAGC 900
TTCAGTCCTA CTGATCACTC CTTAAGCACT AGTAGTGGAA GCAGTGTCTT TACCCCAGAG 960
TATGACGACA GTCGAATAAG AAGACGGGGG AGTGACATAG ACAATCCTAC TTTGACTGTC 1020
ACAGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ACTGGGCAAG 1080
CTGCTTGGCC AAGGAGCTTT TGGTAGGGTC TACCTCTGCT ATGATGTTGA TACCGGAAGA 1140
GAGCTGGCTG TTAAGCAAGT TCAGTTTAAC CCTGAGAGCC CAGAGACCAG CAAGGAAGTA 1200
AATGCACTTG AGTGTGAAAT TCAGTTGTTG AAAAACTTGT TGCATGAGCG AATTGTTCAG 1260
TATTATGGCT GTTTGAGGGA TCCTCAGGAG AAAACACTTT CCATCTTTAT GGAGTATATG 1320
CCAGGGGGTT CAATTAAGGA CCAACTAAAA GCCTACGGAG CTCTTACTGA GAACGTGACG 1380
AGGAAGTACA CCCGTCAGAT TCTGGAGGGG GTCCATTATT TGCATAGTAA TATGATTGTC 1440
CATAGAGATA TCAAAGGAGC AAATATCTTA AGGGATTCCA CAGGCAATAT CAAGTTAGGA 1500
GACTTTGGGG CTAGTAAACG GCTTCAGACC ATCTGTCTCT CAGGCACAGG AATGAAGTCT 1560
GTCACAGGCA CGCCATACTG GATGAGTCCT GAGGTCATCA GTGGAGAAGG CTATGGAAGA 1620
AAAGCAGACA TCTGGAGTGT AGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCACCT 1680
TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAGATCG CCACTCAGCC AACGAACCCA 1740
AAGCTGCCAC CTCATGTCTC AGACTATACT CGGGACTTCC TCAAACGGAT TTTTGTAGAG 1800
GCCAAACTTC GACCTTCAGC GGAGGAGCTC TTGCGGCACA TGTTTGTGCA TTATCACTAG 1860
Domain Profile
S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60
         w+ ++++g+G+fg+vy+++dvdtg+ lavK+v+++pe+ +++kev+al++Ei+llk+l H
Q: 356   WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLH  415
         78899*******************************************************
S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118
         e+iv+yyG+  + +e++l+if+Ey++gGs++++l++yg+l+e+v++kyt+qileg++yLH
Q: 416   ERIVQYYGClrDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH  475
         *********777899*********************************************
S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         +++ivHRDiKgaNil ds+g++kl+DFGaskrl++++ + + ++s+tGt+++m+PEvi++
Q: 476   SNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG  535
         **********************************************************99
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         +  gygrkaDiWs++c+v+emlt+k+P+ae+ e++a++fk++++ t+P++p ++s+ ++d
Q: 536   E--GYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD  592
         8..****************************.9***************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl++++ +++k rpsaeeLL+h+f+
Q: 593   FLKRIF-VEAKLRPSAEELLRHMFV  616
         ******.899*************96
Domain Sequence
(FASTA)
WRLGKLLGQG AFGRVYLCYD VDTGRELAVK QVQFNPESPE TSKEVNALEC EIQLLKNLLH 60
ERIVQYYGCL RDPQEKTLSI FMEYMPGGSI KDQLKAYGAL TENVTRKYTR QILEGVHYLH 120
SNMIVHRDIK GANILRDSTG NIKLGDFGAS KRLQTICLSG TGMKSVTGTP YWMSPEVISG 180
EGYGRKADIW SVACTVVEML TEKPPWAEFE AMAAIFKIAT QPTNPKLPPH VSDYTRDFLK 240
RIFVEAKLRP SAEELLRHMF V 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00360
EKS-ANC-00377
EKS-BOT-00388
EKS-CAF-00388
EKS-CAP-00419
EKS-DAR-00770
EKS-ECT-00002
EKS-EQC-00379
EKS-FEC-00375
EKS-GAG-00328
EKS-GAA-00476
EKS-GOG-00380
EKS-HOS-00396
EKS-ICT-00366
EKS-LAC-00403
EKS-LOA-00396
EKS-MAM-00392
EKS-MEG-00321
EKS-MOD-00375
EKS-MUP-00381
EKS-MYL-00385
EKS-NOL-00356
EKS-ORN-00499
EKS-ORC-00365
EKS-ORL-00459
EKS-OTG-00389
EKS-PAT-00367
EKS-PES-00345
EKS-PEM-00207
EKS-POA-00380
EKS-PTV-00104
EKS-RAN-00403
EKS-SAH-00358
EKS-SUS-00339
EKS-TAG-00459
EKS-TAR-00494
EKS-TEN-00493
EKS-VIP-00055
EKS-XET-00499
EKS-XIM-00490
Gene Ontology
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004672; F:protein kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0071260; P:cellular response to mechanical stimulus
GO:0000165; P:MAPK cascade
GO:0045893; P:positive regulation of transcription, DNA-dependent
KEGG
mmu:26405;
InterPros
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00564; PB1; 1.
PF00069; Pkinase; 1.
SMARTs
SM00666; PB1; 1.
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013