EKS-MUM-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/RIO	324.9	6.4E-97	252	480	229

Status

Reviewed

Ensembl Protein

ENSMUSP00000025270

UniProt Accession

Q9DBU3; Q3UI51; Q8CIC1;

Protein Name

Serine/threonine-protein kinase RIO3

Protein Synonyms/Alias

RIO kinase 3;

Gene Name

Riok3

Gene Synonyms/Alias

Riok3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000024404	ENSMUSP00000025270	ENSMUST00000025270

Organism

Mus musculus

Functional Description

Protein Length

519

Protein Sequence
(FASTA)

MDLVGVSSPE PGPAAAWGPS KCPWATPQNT VSCSLTEVMS EELAKELQLE EEAAAFPEVV 60

VAEGPFISGE NIDTSSDLML AQMLQMEFDR EYDAQLRREE KKFNGDSKVS ISFENYRKVH 120

PFEDSDSSED EVDWQDTRDD PYRPAKPIPT PKKGFIGKGK DITTKHDEVV CGRKNTARME 180

NFAPGFQVGD GIGMDLKLSN HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL 240

MYKMVNSGML ETITGCISTG KESVVFHAYG GSLEDEKEDG KAIPTECAIK VFKTTLNEFK 300

NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLTRMQ KAGIPCPTVV LLKKHILVMS 360

FIGHDQVPAP KLKEVKLSNE EMKDAYYQTL HLMQQLYNEC TLVHADLSEY NMLWHAGKVW 420

LIDVSQSVEP THPHGLEFLF RDCRNVSQFF QKGGVTEALN ERELFNAVSG LNISADNEAD 480

FLAEIEALEK MNEDHIQKNG RKAASFLKDD GSPPVLSAD 519

Nucleotide Sequence
(FASTA)

ATGGATCTGG TCGGAGTGTC TTCGCCTGAG CCAGGGCCCG CAGCAGCTTG GGGACCCAGT 60

AAGTGCCCAT GGGCTACCCC TCAAAACACA GTATCCTGTT CACTGACCGA GGTGATGAGT 120

GAGGAGCTGG CTAAAGAGCT GCAGTTGGAA GAAGAAGCGG CTGCTTTCCC TGAAGTTGTT 180

GTTGCTGAAG GACCATTCAT TTCTGGAGAA AACATTGACA CTTCCAGTGA CCTAATGCTG 240

GCTCAGATGC TACAGATGGA ATTTGACAGA GAATATGATG CACAGCTTAG GCGTGAGGAA 300

AAGAAGTTCA ATGGTGATAG CAAAGTTTCC ATTTCGTTTG AAAACTATCG CAAAGTTCAT 360

CCTTTTGAAG ACAGTGACAG CTCTGAAGAC GAGGTTGACT GGCAGGACAC TCGAGACGAT 420

CCCTACAGAC CAGCAAAGCC AATTCCTACT CCCAAAAAGG GTTTTATTGG AAAAGGAAAA 480

GACATCACCA CCAAGCATGA TGAAGTAGTA TGTGGAAGGA AGAACACAGC AAGAATGGAA 540

AATTTTGCCC CTGGCTTTCA GGTAGGGGAT GGAATTGGAA TGGATTTGAA ACTATCCAAC 600

CACGTTTTTA ATGCCTTAAA ACAACACGCC TACTCAGAAG AGCGTCGGAG TGCCCGTCTA 660

CACGAGAAGA AGGAACATTC TACCGCTGAA AAAGCAGTTG ATCCTAAGAC ACGCTTACTT 720

ATGTATAAAA TGGTCAACTC TGGAATGTTG GAGACAATCA CTGGCTGTAT TAGTACAGGA 780

AAGGAATCTG TTGTCTTTCA TGCATATGGA GGGAGCCTGG AGGATGAAAA GGAAGATGGT 840

AAAGCTATAC CAACAGAATG TGCCATCAAG GTATTTAAAA CAACCCTTAA TGAGTTTAAG 900

AATCGTGACA AGTACATTAA AGATGATTTC AGGTTTAAAG ATCGCTTCAG TAAACTAAAT 960

CCACGTAAGA TCATCCGCAT GTGGGCAGAG AAAGAAATGC ACAATCTTAC AAGAATGCAG 1020

AAGGCTGGAA TTCCTTGTCC AACAGTTGTA CTGCTTAAGA AGCACATTTT AGTTATGTCT 1080

TTCATTGGCC ATGATCAAGT TCCAGCCCCT AAATTAAAAG AAGTAAAGCT TAGTAATGAA 1140

GAAATGAAAG ATGCCTACTA TCAGACTCTT CATTTGATGC AGCAATTATA TAACGAATGT 1200

ACCCTTGTGC ATGCTGACCT CAGCGAGTAT AACATGTTGT GGCATGCTGG GAAGGTCTGG 1260

TTGATTGACG TCAGTCAGTC GGTAGAGCCA ACCCATCCTC ATGGCCTGGA GTTCTTATTC 1320

CGTGACTGTA GGAATGTTTC ACAGTTCTTC CAGAAAGGAG GAGTAACGGA AGCCCTCAAT 1380

GAACGGGAGC TGTTCAATGC TGTTTCTGGC CTGAACATCT CGGCAGACAA TGAAGCTGAT 1440

TTCTTAGCTG AGATAGAAGC TTTGGAGAAG ATGAATGAAG ATCACATTCA GAAGAACGGG 1500

AGGAAAGCAG CCTCGTTTCT GAAAGATGAT GGAAGCCCAC CTGTGCTGTC TGCCGACTAG 1560

Domain Profile

S: 2     svgntigvgkesdvykvsekngee...........raiKiyktsllvlknrdkYvdgefr  50

         +++++i++gkes v++++  + e+           +aiK++kt+l+++knrdkY++++fr

Q: 252   TITGCISTGKESVVFHAYGGSLEDekedgkaipteCAIKVFKTTLNEFKNRDKYIKDDFR  311

         79****************9999988999********************************

S: 51    fkksrskanprklsrlwAeKEfrnlkrlyekgvpvPepidlkrhvlvmeligrdgypapk  110

         fk+++sk nprk++r+wAeKE++nl+r++++g+p+P+++ lk+h+lvm++ig+d++papk

Q: 312   FKDRFSKLNPRKIIRMWAEKEMHNLTRMQKAGIPCPTVVLLKKHILVMSFIGHDQVPAPK  371

         ************************************************************

S: 111   lkdvklkeeeikelYsdllalivklynegrLvHaDlsEfnilleddklvliDvsqsveie  170

         lk+vkl++ee+k++Y+++l+l+++lyne++LvHaDlsE+n+l++++k++liDvsqsve++

Q: 372   LKEVKLSNEEMKDAYYQTLHLMQQLYNECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPT  431

         ************************************************************

S: 171   HpdaleflrrDvknvkefFkkklvydvlrerelfelvsasgltkekead  219

         Hp++lefl rD++nv++fF+k +v ++l+erelf++vs+ ++++++ead

Q: 432   HPHGLEFLFRDCRNVSQFFQKGGVTEALNERELFNAVSGLNISADNEAD  480

         **********************************************996

Domain Sequence
(FASTA)

TITGCISTGK ESVVFHAYGG SLEDEKEDGK AIPTECAIKV FKTTLNEFKN RDKYIKDDFR 60

FKDRFSKLNP RKIIRMWAEK EMHNLTRMQK AGIPCPTVVL LKKHILVMSF IGHDQVPAPK 120

LKEVKLSNEE MKDAYYQTLH LMQQLYNECT LVHADLSEYN MLWHAGKVWL IDVSQSVEPT 180

HPHGLEFLFR DCRNVSQFFQ KGGVTEALNE RELFNAVSGL NISADNEAD 229

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>