EKS-MUM-00509

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00509

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	583.3	1.3E-175	13	271	259

Status

Reviewed

Ensembl Protein

ENSMUSP00000099952

UniProt Accession

P11798; Q61284; Q6ZWN4;

Protein Name

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Protein Synonyms/Alias

CaM kinase II subunit alpha; CaMK-II subunit alpha;

Gene Name

Camk2a

Gene Synonyms/Alias

Camk2a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000024617	ENSMUSP00000099952	ENSMUST00000102888
ENSMUSG00000024617	ENSMUSP00000123480	ENSMUST00000137805
ENSMUSG00000024617	ENSMUSP00000048325	ENSMUST00000039904
ENSMUSG00000024617	ENSMUSP00000025519	ENSMUST00000025519
ENSMUSG00000024617	ENSMUSP00000110952	ENSMUST00000115297
ENSMUSG00000024617	ENSMUSP00000110950	ENSMUST00000115295

Organism

Mus musculus

Functional Description

CaM-kinase II (CAMK2) is a prominent kinase in thecentral nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Protein Length

478

Protein Sequence
(FASTA)

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 60

ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 120

EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 180

SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 240

TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 300

GAILTTMLAT RNFSGGKSGG NKKNDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA 360

ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH 420

LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH 478

Nucleotide Sequence
(FASTA)

ATGGCTACCA TCACCTGCAC CCGATTCACA GAAGAGTACC AGCTCTTTGA GGAACTGGGA 60

AAGGGAGCCT TCTCTGTGGT GCGCAGGTGT GTGAAGGTGC TGGCTGGTCA GGAGTATGCT 120

GCCAAGATTA TCAACACCAA GAAGCTTTCA GCCAGAGATC ACCAGAAGCT GGAGCGTGAG 180

GCCCGCATCT GCCGCTTGTT GAAGCACCCC AATATCGTCC GACTCCATGA CAGCATCTCC 240

GAGGAGGGGC ACCACTACCT TATCTTCGAT CTGGTTACTG GTGGGGAACT GTTTGAAGAC 300

ATTGTGGCCC GGGAGTATTA CAGTGAAGCT GATGCCAGCC ACTGTATCCA GCAGATCTTG 360

GAGGCTGTGC TACACTGTCA CCAGATGGGG GTGGTGCATC GTGACCTGAA GCCTGAGAAT 420

CTGTTGCTGG CCTCGAAGCT CAAGGGCGCT GCTGTGAAGC TGGCAGACTT TGGCCTGGCC 480

ATAGAGGTGG AGGGGGAGCA GCAGGCATGG TTTGGGTTCG CAGGGACACC TGGATACCTC 540

TCCCCAGAAG TGCTGAGGAA GGACCCGTAC GGGAAGCCCG TGGACCTGTG GGCCTGTGGC 600

GTCATCCTGT ATATCTTGCT GGTTGGGTAT CCCCCGTTCT GGGATGAAGA CCAGCATCGC 660

CTGTACCAGC AGATCAAAGC TGGTGCCTAT GATTTCCCAT CACCAGAATG GGACACCGTC 720

ACCCCAGAAG CCAAGGATCT GATCAATAAG ATGCTGACCA TCAACCCGTC CAAACGCATC 780

ACGGCCGCTG AGGCTCTCAA GCACCCATGG ATCTCGCACC GCTCCACCGT GGCCTCCTGC 840

ATGCACAGAC AGGAGACCGT GGACTGCCTG AAGAAGTTCA ATGCCAGGAG GAAACTGAAG 900

GGAGCCATCC TCACCACTAT GCTGGCCACC AGGAACTTCT CCGGAGGGAA GAGCGGAGGA 960

AACAAGAAGA ACGATGGTGT GAAGGAATCT TCTGAGAGCA CCAACACCAC CATTGAGGAC 1020

GAAGACACCA AAGTGCGCAA ACAGGAAATT ATCAAAGTGA CAGAGCAGCT GATCGAAGCC 1080

ATAAGCAATG GAGACTTTGA GTCCTACACG AAGATGTGCG ACCCTGGAAT GACAGCCTTT 1140

GAACCAGAGG CCCTGGGGAA CCTGGTGGAG GGCCTGGACT TTCATCGATT CTATTTTGAA 1200

AACCTGTGGT CCCGGAACAG CAAGCCCGTG CACACCACCA TCCTGAACCC TCACATCCAC 1260

CTGATGGGTG ACGAGTCAGC CTGCATCGCC TATATCCGCA TCACTCAGTA CCTGGATGCA 1320

GGCGGCATAC CCCGCACGGC CCAGTCAGAG GAGACCCGCG TCTGGCACCG CAGGGACGGC 1380

AAATGGCAGA TCGTCCACTT CCACAGATCT GGGGCGCCCT CCGTCCTGCC GCATTGA 1437

Domain Profile

S: 1     yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni  60

         yqlfeelgkgafsvvrrcvkv +gqeyaakiintkklsardhqklerearicrllkhpni

Q: 13    YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI  72

         9***********************************************************

S: 61    vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv  120

         vrlhdsiseeg+hyl+fdlvtggelfedivareyyseadashciqqile+vlh+hq+gvv

Q: 73    VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV  132

         ************************************************************

S: 121   hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk  180

         hrdlkpenlllask+kgaavkladfglaiev+g+qqawfgfagtpgylspevlrkdpygk

Q: 133   HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK  192

         ************************************************************

S: 181   pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml  240

         pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml

Q: 193   PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML  252

         ************************************************************

S: 241   tinpakritadealkhpwi  259

         tinp+krita+ealkhpwi

Q: 253   TINPSKRITAAEALKHPWI  271

         ******************8

Domain Sequence
(FASTA)

YQLFEELGKG AFSVVRRCVK VLAGQEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHPNI 60

VRLHDSISEE GHHYLIFDLV TGGELFEDIV AREYYSEADA SHCIQQILEA VLHCHQMGVV 120

HRDLKPENLL LASKLKGAAV KLADFGLAIE VEGEQQAWFG FAGTPGYLSP EVLRKDPYGK 180

PVDLWACGVI LYILLVGYPP FWDEDQHRLY QQIKAGAYDF PSPEWDTVTP EAKDLINKML 240

TINPSKRITA AEALKHPWI 259

Keyword

3D-structure; Alternative splicing; ATP-binding; Calmodulin-binding; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Synapse; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005954	; C:calcium- and calmodulin-dependent protein kinase complex
GO:0030054	; C:cell junction
GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0042734	; C:presynaptic membrane
GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006816	; P:calcium ion transport
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation
GO:0048168	; P:regulation of neuronal synaptic plasticity
GO:0046928	; P:regulation of neurotransmitter secretion

KEGG

mmu:12322

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013