EKS-MUM-00434
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00434
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR604.41.7E-181604962359
StatusUnreviewed
Ensembl ProteinENSMUSP00000110929
UniProt AccessionE9QN12;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePdgfrb
Gene Synonyms/Alias Pdgfrb;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000024620ENSMUSP00000110929ENSMUST00000115274
ENSMUSG00000024620ENSMUSP00000025522ENSMUST00000025522
OrganismMus musculus
Functional Description
Protein Length1103
Protein Sequence
(FASTA)
MEDTMGLPGV IPALVLRGQL LLSVLWLLGP QTSRGLVITP PGPEFVLNIS STFVLTCSGS 60
APVMWEQMSQ VPWQEAAMNQ DGTFSSVLTL TNVTGGDTGE YFCVYNNSLG PELSERKRIY 120
IFVPDPTMGF LPMDSEDLFI FVTDVTETTI PCRVTDPQLE VTLHEKKVDI PLHVPYDHQR 180
GFTGTFEDKT YICKTTIGDR EVDSDTYYVY SLQVSSINVS VNAVQTVVRQ GESITIRCIV 240
MGNDVVNFQW TYPRMKSGRL VEPVTDYLFG VPSRIGSILH IPTAELSDSG TYTCNVSVSV 300
NDHGDEKAIN ISVIENGYVR LLETLGDVEI AELHRSRTLR VVFEAYPMPS VLWLKDNRTL 360
GDSGAGELVL STRNMSETRY VSELILVRVK VSEAGYYTMR AFHEDDEVQL SFKLQVNVPV 420
RVLELSESHP ANGEQTIRCR GRGMPQPNVT WSTCRDLKSR CPRKLSPTPL GNSSKEESQL 480
ETNVTFWEED QEYEVVSTLR LRHVDQPLSV RCMLQNSMGG DSQEVTVVPH SLPFKVVVIS 540
AILALVVLTV ISLIILIMLW QKKPRYEIRW KVIESVSSDG HEYIYVDPVQ LPYDSTWELP 600
RDQLVLGRTL GSGAFGQVVE ATAHGLSHSQ ATMKVAVKML KSTARSSEKQ ALMSELKIMS 660
HLGPHLNVVN LLGACTKGGP IYIITEYCRY GDLVDYLHRN KHTFLQRHSN KHCPPSAELY 720
SNALPVGFSL PSHLNLTGES DGGYMDMSKD ESIDYVPMLD MKGDIKYADI ESPSYMAPYD 780
NYVPSAPERT YRATLINDSP VLSYTDLVGF SYQVANGMDF LASKNCVHRD LAARNVLICE 840
GKLVKICDFG LARDIMRDSN YISKGSTFLP LKWMAPESIF NSLYTTLSDV WSFGILLWEI 900
FTLGGTPYPE LPMNDQFYNA IKRGYRMAQP AHASDEIYEI MQKCWEEKFE TRPPFSQLVL 960
LLERLLGEGY KKKYQQVDEE FLRSDHPAIL RSQARFPGIH SLRSPLDTSS VLYTAVQPNE 1020
SDNDYIIPLP DPKPDVADEG LPEGSPSLAS STLNEVNTSS TISCDSPLEL QEEPQQAEPE 1080
AQLEQPQDSG CPGPLAEAED SFL 1103
Nucleotide Sequence
(FASTA)
ATGGAGGACA CCATGGGGCT TCCAGGAGTG ATACCAGCTT TAGTCCTCAG AGGCCAGTTG 60
TTGCTGTCCG TGTTATGGCT CCTGGGACCG CAGACCTCCC GGGGCCTAGT CATCACGCCC 120
CCTGGGCCAG AGTTTGTTCT CAACATCTCC AGCACCTTTG TTCTGACCTG CTCGGGCTCA 180
GCTCCGGTGA TGTGGGAACA GATGTCCCAG GTGCCCTGGC AAGAAGCGGC CATGAATCAG 240
GACGGCACCT TCTCCAGTGT GCTGACACTG ACCAATGTCA CTGGGGGAGA CACTGGGGAA 300
TACTTTTGTG TCTACAACAA CTCACTAGGG CCGGAGCTCA GTGAGAGGAA GCGTATCTAT 360
ATCTTTGTGC CAGATCCCAC CATGGGCTTC CTCCCTATGG ACTCCGAGGA CCTGTTCATT 420
TTTGTCACGG ATGTCACTGA GACGACAATT CCGTGCCGAG TGACAGACCC CCAGCTGGAG 480
GTGACGCTAC ATGAGAAGAA AGTGGATATC CCCCTACACG TACCCTACGA CCACCAGCGA 540
GGTTTCACTG GTACTTTTGA GGACAAGACT TACATTTGCA AAACCACCAT TGGGGACAGG 600
GAAGTGGACT CCGATACTTA CTACGTCTAC AGCCTCCAGG TGTCATCCAT CAACGTCTCT 660
GTGAATGCCG TGCAGACTGT GGTCCGCCAG GGCGAGAGCA TCACCATCCG GTGCATTGTG 720
ATGGGCAATG ATGTGGTGAA CTTCCAATGG ACGTACCCCC GCATGAAGAG TGGGCGGCTG 780
GTGGAGCCAG TGACAGACTA CCTCTTTGGA GTGCCCTCCC GCATTGGCTC CATCCTGCAT 840
ATCCCCACGG CTGAGCTGAG TGATTCGGGC ACCTATACTT GCAACGTGTC AGTGAGTGTG 900
AACGACCATG GCGATGAGAA AGCCATCAAC ATCTCTGTGA TCGAGAATGG CTACGTGCGG 960
CTGCTGGAGA CACTGGGAGA TGTAGAAATT GCTGAGCTGC ACCGGAGTCG GACGCTGCGG 1020
GTGGTGTTCG AGGCTTATCC GATGCCTTCT GTCCTGTGGC TCAAGGACAA CCGTACCTTG 1080
GGTGACTCCG GCGCTGGCGA GTTAGTTTTG TCTACTCGCA ACATGTCTGA GACCCGGTAC 1140
GTGTCAGAAC TGATCCTGGT ACGTGTGAAG GTGTCAGAAG CGGGCTACTA TACTATGCGA 1200
GCCTTCCACG AGGACGATGA GGTCCAGCTC TCCTTCAAGC TGCAGGTCAA TGTCCCCGTC 1260
CGTGTGCTGG AGCTGAGTGA GAGTCACCCT GCCAATGGGG AGCAGACAAT CCGCTGTCGT 1320
GGCCGGGGCA TGCCTCAGCC AAATGTCACC TGGTCTACCT GCAGAGACCT CAAAAGTAGG 1380
TGTCCACGAA AACTGTCACC CACACCCTTG GGGAATAGTT CCAAGGAGGA GAGCCAGCTA 1440
GAAACGAATG TGACTTTCTG GGAGGAAGAT CAGGAATACG AGGTGGTGAG CACACTGCGC 1500
CTGCGCCACG TGGATCAGCC ACTGTCCGTA CGCTGCATGC TGCAGAACTC CATGGGTGGA 1560
GATTCGCAGG AGGTCACCGT GGTCCCACAT TCCTTGCCCT TCAAAGTGGT GGTGATCTCA 1620
GCCATCCTGG CCTTAGTGGT CCTTACCGTC ATCTCTCTCA TCATCCTCAT CATGCTGTGG 1680
CAGAAGAAGC CACGCTATGA GATCCGATGG AAGGTCATTG AGTCTGTGAG CTCTGACGGT 1740
CATGAGTACA TCTACGTGGA CCCTGTGCAG TTGCCTTACG ACTCCACCTG GGAGCTGCCA 1800
CGGGACCAGC TTGTTCTGGG ACGCACTCTT GGCTCTGGGG CTTTCGGACA GGTGGTGGAG 1860
GCCACAGCTC ACGGTCTGAG CCATTCGCAG GCCACCATGA AAGTGGCTGT CAAGATGCTG 1920
AAATCGACAG CCAGAAGTAG CGAGAAGCAA GCCTTAATGT CCGAGCTGAA GATTATGAGT 1980
CATCTTGGAC CCCACCTGAA CGTGGTCAAC CTGCTGGGGG CCTGCACCAA AGGAGGGCCC 2040
ATCTACATCA TCACGGAATA CTGCCGATAC GGTGATCTGG TGGACTACCT GCACCGGAAC 2100
AAACACACCT TCTTGCAGCG ACACTCCAAC AAGCATTGTC CGCCCAGTGC TGAGCTCTAC 2160
AGCAACGCCC TGCCAGTGGG GTTCTCCCTA CCCAGCCACT TGAACCTGAC TGGGGAGAGT 2220
GACGGTGGCT ACATGGATAT GAGCAAGGAT GAATCTATAG ATTACGTGCC CATGTTGGAC 2280
ATGAAAGGAG ACATCAAATA CGCAGACATT GAGTCCCCCA GCTACATGGC CCCTTATGAT 2340
AACTATGTCC CATCTGCCCC TGAAAGGACC TATCGCGCCA CCTTAATCAA CGACTCACCA 2400
GTGCTCAGCT ACACAGACCT CGTGGGCTTC AGCTACCAAG TGGCCAACGG CATGGACTTC 2460
TTAGCCTCTA AGAACTGTGT TCACCGAGAC TTGGCGGCCA GGAATGTGCT CATCTGCGAG 2520
GGCAAGCTGG TCAAGATCTG TGACTTCGGC CTGGCTCGAG ACATCATGAG GGACTCAAAC 2580
TACATCTCCA AAGGCAGCAC CTTCCTGCCT CTGAAGTGGA TGGCCCCAGA GAGCATCTTC 2640
AACAGCCTCT ACACCACTTT GAGTGATGTC TGGTCTTTTG GGATCCTACT CTGGGAGATC 2700
TTCACACTGG GTGGCACCCC TTACCCAGAG CTGCCCATGA ACGACCAGTT CTACAATGCC 2760
ATCAAGAGGG GCTACCGCAT GGCCCAGCCT GCTCATGCCT CCGACGAGAT CTATGAGATC 2820
ATGCAGAAAT GCTGGGAAGA AAAGTTTGAG ACTCGACCCC CCTTCTCCCA GCTGGTGCTG 2880
CTCCTGGAGA GGCTTCTGGG TGAAGGCTAT AAAAAGAAGT ACCAGCAGGT AGATGAGGAG 2940
TTCCTGAGGA GTGACCATCC TGCCATCCTG AGGTCCCAAG CCCGCTTTCC GGGGATCCAC 3000
AGCCTCCGAT CCCCTCTGGA CACCAGCTCT GTTCTCTACA CTGCCGTGCA GCCCAATGAG 3060
AGTGACAATG ACTACATCAT CCCCTTACCT GACCCCAAGC CTGACGTTGC TGATGAAGGT 3120
CTCCCAGAGG GGTCCCCCAG CCTTGCCAGT TCCACCTTGA ATGAAGTCAA CACTTCCTCC 3180
ACCATCTCCT GCGACAGTCC CCTGGAGCTC CAAGAAGAGC CACAGCAAGC AGAGCCTGAG 3240
GCACAACTGG AGCAGCCACA GGATTCAGGC TGCCCAGGAC CTCTGGCTGA AGCAGAGGAC 3300
AGCTTCCTGT AG 3312
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 604   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  663
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++++k++++++el+s+a
Q: 664   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNA  723
         ************************************************************
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
         l+++ sl s+ +l+ es++ y+d++kd                ++d++s ++++++++++
Q: 724   LPVGFSLPSHLNLTGESDGGYMDMSKDesidyvpmldmkgdikYADIESPSYMAPYDNYV  783
         ************************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          sa er+++a+l+++ s vl+++dl+ fsyqva+Gm+flaskncvhrdlaarnvl++eGk
Q: 784   PSAPERTYRATLIND-SPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGK  842
         *************98.9*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 843   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  902
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e+rp+f+qlv ll
Q: 903   LGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLL  962
         ********************************************************9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQRHSNKHC PPSAELYSNA 120
LPVGFSLPSH LNLTGESDGG YMDMSKDESI DYVPMLDMKG DIKYADIESP SYMAPYDNYV 180
PSAPERTYRA TLINDSPVLS YTDLVGFSYQ VANGMDFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NDQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFETRP PFSQLVLLL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0016301; F:kinase activity
GO:0004871; F:signal transducer activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0001701; P:in utero embryonic development
GO:0001822; P:kidney development
GO:0006807; P:nitrogen compound metabolic process
GO:0048008; P:platelet-derived growth factor receptor signaling pathway
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705; P:skeletal system morphogenesis
GO:0048745; P:smooth muscle tissue development
GO:0001894; P:tissue homeostasis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013