EKS-MUM-00473

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00473

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	480.0	4.6E-144	71	337	267

Status

Reviewed

Ensembl Protein

ENSMUSP00000025681

UniProt Accession

Q80UW5;

Protein Name

Serine/threonine-protein kinase MRCK gamma

Protein Synonyms/Alias

CDC42-binding protein kinase gamma; DMPK-like gamma; Myotonic dystrophy kinase-related CDC42-binding kinase gamma; MRCK gamma; Myotonic dystrophy protein kinase-like gamma; Myotonic dystrophy protein kinase-like alpha;

Gene Name

Cdc42bpg

Gene Synonyms/Alias

Cdc42bpg;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000024769	ENSMUSP00000025681	ENSMUST00000025681

Organism

Mus musculus

Functional Description

May act as a downstream effector of CDC42 incytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).

Protein Length

1551

Protein Sequence
(FASTA)

MEQRLRALEQ LVRGEAGGSP GLDGLLDLLL GVHQELSSAP LRRERNVAQF LSWASPFVTK 60

VKELRLQRDD FEILKVIGRG AFGEVAVVRQ RGSGQIFAMK MLHKWEMLKR AETACFREER 120

DVLVKGDSRW VTALHYAFQD EEYLYLVMDY YAGGDLLTLL SRFEDRLPPE LAQFYLAEMV 180

LAIHSLHQLG YVHRDVKPDN ILLDMNGHIR LADFGSCLRL NNNGMVDSSV AVGTPDYISP 240

EILQAMEEGK GHYGPQCDWW SLGVCAYELL FGETPFYAES LVETYGKIMN HEDHLQFPAD 300

VTDVPASAQD LIRQLLCRQE ERLGRGGLDD FRKHPFFEGV DWERLATSTA PYIPELRGPM 360

DTSNFDVDDD TLNRPETLPP SSHGAFSGHH LPFVGFTYTS GSPFDVQSSE LMAAPEGTPH 420

CVEQVKVELS HKCQEPLHGP LQPQELVRLQ KEVQVLQEKL AETLRDSKAS LSQTDGLHAR 480

SPAPNIQLQQ EKDRLQQELT EAQAALRVQD AELCQAQNRQ EEFLQRLWEA QEREAAAASQ 540

IQALNSQLEE AWVVRRELEG QVTTLSQEVT RLQGQCKQES SQAKTVHAAP ETNGIGSPEG 600

QSQEAQLRKE VAALREQLEH ACSQGISVGK EEVLCRLQEE NQRLSREQER LAGELELELQ 660

SKQRLEGERR ETESNWEAQI ADILSWVNDE KVSRGYLQAL ATKMAEELES LRNVGTQTLP 720

TRPLDHQWKA RRLQKMEASA RLELQSALEA EIRAKQSLQE QLTQVQEAQR QAERRLQEAE 780

KQSQALQQEV AELREELQAR GPGDARPSTS LIPLLSFWNT EKDSAKDPGN SGEGPRSGAE 840

AELRPEGRRS LRMGSVFPRV PAATTTPAEG PPAKPGSHTL RPRSFPSPTK CLRCTSLMLG 900

LGRQGLGCDT CGYFCHSACA SQAPPCPVPP ELLRTALGVH PETGTGTAYE GFLSVPRPSG 960

VRRGWQRVYA ALSDSRLLLF DAPDPRGSLA SGVLLQALDL RDPQFSATPV LAPDVIHAQS 1020

KDLPRIFRVT ASQLTVPPTT CTVLLLAENE GERERWLQVL GELQRLLLDA RPRPRPVYTL 1080

KEAYDNGLPL LPHALCAAVI DQERLALGTE EGLFVIHLHS NDIFQVGDCR RVQRLAVSSA 1140

AGLLAVLCGR GPSVRLFALD ELESAEVAGA KIPESRGCQA LVAGRILQAR TPVLCVAVKR 1200

QVLCYQLGPG PGPWQRRIRE LQAPAPVQSL GLLGDRLCVG AAGTFALYPL LNEAAPLALG 1260

TGLVAEELPA SRGGLGEALG AVELSLSELL LLFATAGVYV DSAGRKSRSH ELLWPAAPTG 1320

WGYTAPYLTV FSENALDVFD VRRAEWVQTV PLKKVRPLNP EGSLFLYGTE KVRLTYLRNP 1380

LAEKDEFDIP DLTDNSRRQL FRTKSKRRFF FRVSDELRQQ QRREMLKDPF VRSKFISPPT 1440

NFNHLVHVGP TEGRPNTRDG TRAQEQKSRG ARSSGPQRPH SFSEAFRRPV STGSDGLPGE 1500

TDPLVKRKPW TSLSSESVSC PQGSLSPAAS LIQVSERPRS LPPDPESESS P 1551

Nucleotide Sequence
(FASTA)

ATGGAGCAGC GGCTGCGTGC GCTGGAGCAG CTGGTACGGG GCGAAGCTGG TGGCAGCCCA 60

GGGCTCGACG GCCTCCTGGA TCTGCTGCTG GGGGTGCACC AAGAGCTCAG CAGCGCCCCC 120

CTGCGCCGGG AGCGTAACGT GGCGCAGTTT CTGAGCTGGG CCAGCCCCTT TGTAACAAAA 180

GTGAAAGAGC TGCGTCTACA GAGAGATGAC TTTGAGATCT TGAAGGTGAT TGGCAGAGGG 240

GCCTTTGGGG AGGTTGCCGT GGTGAGGCAG AGGGGCAGTG GCCAGATCTT TGCCATGAAG 300

ATGCTGCATA AGTGGGAGAT GCTGAAGAGG GCTGAGACGG CCTGTTTCCG GGAGGAGCGA 360

GATGTTCTAG TGAAGGGAGA CAGCCGCTGG GTGACTGCTC TGCACTACGC CTTCCAGGAT 420

GAAGAGTACC TGTACCTGGT GATGGACTAC TATGCTGGCG GGGACCTTCT CACGCTGCTG 480

AGCCGCTTTG AGGACCGCCT CCCACCTGAG CTGGCCCAGT TCTATCTGGC TGAGATGGTT 540

CTGGCCATCC ACTCACTGCA CCAGCTGGGC TATGTCCACA GGGATGTGAA GCCTGACAAC 600

ATCCTGCTGG ACATGAATGG CCACATCCGC CTGGCAGACT TTGGCTCCTG CCTGCGTCTC 660

AACAACAATG GCATGGTGGA TTCATCAGTC GCAGTTGGGA CCCCGGACTA CATCTCTCCT 720

GAGATCCTAC AGGCCATGGA GGAAGGCAAG GGCCACTACG GCCCACAGTG TGACTGGTGG 780

TCACTGGGAG TCTGCGCCTA TGAGCTGCTC TTTGGGGAAA CACCCTTTTA TGCAGAATCT 840

CTGGTAGAAA CCTACGGCAA GATCATGAAC CACGAGGACC ACCTCCAGTT CCCTGCTGAT 900

GTGACTGATG TGCCTGCTAG TGCCCAGGAC CTGATCCGAC AGCTGCTGTG CCGTCAGGAG 960

GAGCGGCTGG GCCGTGGTGG GCTGGACGAC TTCCGGAAGC ACCCCTTCTT TGAAGGGGTC 1020

GATTGGGAGA GGCTTGCAAC CAGCACAGCG CCATACATCC CTGAGCTTCG AGGGCCGATG 1080

GACACCTCCA ACTTCGACGT GGATGATGAT ACCCTCAACC GTCCAGAGAC GCTGCCACCA 1140

TCCTCCCATG GTGCCTTCTC AGGCCACCAC CTGCCATTTG TTGGCTTCAC TTACACCTCA 1200

GGCAGCCCCT TTGATGTGCA GAGCTCAGAG CTAATGGCTG CCCCAGAGGG GACGCCCCAC 1260

TGTGTGGAGC AGGTGAAAGT GGAGCTCAGC CACAAGTGTC AAGAGCCCCT GCATGGCCCA 1320

TTACAGCCCC AGGAGCTTGT GCGGCTTCAG AAGGAAGTAC AGGTTCTTCA GGAGAAACTG 1380

GCAGAGACAC TGAGGGACAG CAAGGCCTCC CTCTCACAAA CTGATGGCCT CCATGCTAGA 1440

AGCCCAGCCC CAAACATCCA ACTACAACAG GAGAAGGACC GCCTCCAGCA GGAGCTGACT 1500

GAAGCTCAGG CAGCATTGCG AGTGCAGGAT GCTGAGCTGT GCCAAGCGCA GAACCGGCAG 1560

GAAGAATTCC TGCAGAGGCT GTGGGAAGCC CAGGAGAGAG AGGCAGCTGC AGCCAGCCAG 1620

ATCCAGGCCC TGAACTCCCA GCTGGAGGAA GCCTGGGTTG TCCGGAGAGA GCTCGAAGGC 1680

CAGGTGACCA CCCTGAGTCA GGAGGTGACA CGGCTCCAGG GACAATGTAA ACAAGAATCT 1740

TCACAGGCCA AGACCGTCCA TGCAGCCCCT GAGACGAACG GCATAGGATC TCCTGAGGGT 1800

CAGTCTCAAG AGGCCCAGCT GAGGAAGGAA GTGGCGGCTC TGAGGGAGCA GCTGGAGCAT 1860

GCCTGCAGCC AAGGGATCAG TGTTGGGAAA GAGGAGGTTC TGTGCCGATT GCAGGAGGAA 1920

AACCAGCGGC TGAGCCGGGA GCAGGAACGG CTGGCAGGAG AGCTGGAACT GGAGCTACAG 1980

AGCAAGCAGC GTTTGGAGGG TGAACGGCGG GAGACTGAGA GCAACTGGGA GGCTCAGATC 2040

GCTGACATCC TCAGCTGGGT GAATGACGAG AAGGTCTCAA GAGGCTACCT GCAGGCCTTG 2100

GCTACTAAGA TGGCTGAGGA GCTGGAGTCC TTGAGGAATG TGGGCACGCA GACACTCCCT 2160

ACCCGGCCTC TGGATCACCA GTGGAAGGCT CGGAGGCTGC AGAAGATGGA GGCCTCAGCC 2220

CGGCTAGAGC TTCAGTCAGC ACTGGAAGCT GAGATCCGTG CCAAGCAGAG TCTGCAGGAG 2280

CAGCTGACGC AGGTGCAGGA GGCTCAGCGG CAGGCTGAAC GCCGCCTGCA GGAGGCTGAG 2340

AAGCAAAGTC AGGCCCTGCA GCAGGAGGTG GCTGAGCTCC GGGAGGAACT GCAAGCTCGA 2400

GGACCGGGGG ATGCCAGGCC TTCCACTTCC CTCATCCCTC TCCTGTCCTT CTGGAACACA 2460

GAGAAGGATT CTGCCAAGGA CCCTGGCAAT TCAGGAGAGG GTCCAAGGTC TGGAGCCGAA 2520

GCAGAGCTGA GGCCAGAGGG CCGCCGCAGT CTGCGCATGG GGAGTGTGTT CCCCAGGGTG 2580

CCCGCAGCCA CCACCACCCC TGCCGAAGGT CCTCCTGCTA AGCCCGGCTC ACACACCCTG 2640

CGTCCCCGGA GTTTTCCATC CCCTACCAAG TGTCTCCGCT GCACCTCGCT GATGCTGGGC 2700

CTGGGCCGCC AGGGCCTGGG CTGTGACACC TGTGGCTACT TCTGTCACTC AGCTTGTGCG 2760

TCACAAGCCC CACCTTGCCC TGTGCCCCCT GAACTCCTCC GCACAGCCTT GGGGGTGCAC 2820

CCCGAAACAG GCACAGGGAC TGCCTATGAG GGCTTCCTGT CGGTGCCGCG GCCCTCAGGT 2880

GTCCGTCGGG GCTGGCAGCG GGTGTACGCC GCTCTCAGTG ACTCCCGCCT GTTGTTGTTT 2940

GATGCTCCTG ACCCTCGAGG CAGCCTGGCC AGTGGGGTCC TCCTGCAGGC CTTGGATCTA 3000

AGGGACCCCC AGTTCTCAGC CACCCCTGTC TTGGCCCCAG ATGTCATTCA TGCCCAATCC 3060

AAGGACCTGC CACGTATCTT CAGGGTGACA GCCTCCCAGC TGACAGTGCC ACCAACCACA 3120

TGCACTGTGC TGCTGCTGGC AGAGAATGAG GGGGAGCGGG AGCGCTGGCT TCAGGTGCTG 3180

GGGGAGCTGC AGCGGCTGCT ACTGGATGCA CGTCCAAGGC CCCGACCGGT GTACACACTC 3240

AAGGAGGCCT ATGACAATGG GCTGCCACTG CTGCCTCATG CGCTCTGTGC TGCTGTCATT 3300

GACCAAGAGC GTCTTGCCCT GGGCACTGAG GAGGGGTTGT TTGTGATCCA TCTTCACAGC 3360

AATGACATCT TCCAGGTGGG AGACTGCCGC CGGGTGCAGC GGTTGGCTGT GAGCTCTGCG 3420

GCTGGCCTCC TGGCTGTGCT CTGTGGCCGT GGCCCCAGTG TGCGCCTCTT CGCCCTGGAC 3480

GAACTGGAGA GTGCTGAGGT GGCGGGTGCC AAGATCCCGG AATCCCGAGG CTGTCAGGCT 3540

TTGGTCGCTG GGCGCATCTT GCAGGCCCGG ACTCCAGTGC TCTGTGTGGC AGTCAAACGC 3600

CAAGTTCTCT GTTACCAGCT GGGCCCAGGA CCAGGGCCCT GGCAGCGCCG CATCCGAGAG 3660

CTGCAAGCAC CAGCTCCGGT GCAGAGCCTG GGCTTGCTGG GTGATCGGCT CTGTGTGGGC 3720

GCCGCAGGCA CCTTCGCTCT CTACCCGCTG CTCAATGAGG CTGCACCCTT AGCGCTGGGA 3780

ACTGGTCTGG TGGCCGAGGA GCTGCCTGCA TCCCGTGGGG GCCTAGGTGA GGCACTGGGT 3840

GCCGTGGAGC TCAGCCTCAG CGAGCTCCTG CTGCTCTTCG CCACTGCCGG CGTCTACGTG 3900

GATAGTGCTG GCCGCAAGTC ACGAAGCCAC GAGCTGCTGT GGCCAGCTGC ACCCACTGGC 3960

TGGGGTTACA CAGCACCCTA CCTAACAGTG TTCAGTGAAA ACGCCCTTGA TGTGTTTGAC 4020

GTGAGGAGAG CAGAATGGGT ACAGACTGTG CCGCTCAAGA AGGTGAGACC CCTGAATCCA 4080

GAAGGCTCCT TGTTCCTTTA TGGCACCGAG AAGGTCCGCC TGACCTACCT CAGGAATCCA 4140

TTGGCAGAGA AGGACGAGTT TGACATTCCC GACCTCACGG ACAACAGCCG GCGCCAGCTG 4200

TTCCGCACCA AGAGCAAGCG CCGTTTCTTC TTCCGGGTGT CTGATGAGCT GCGACAGCAG 4260

CAGCGCAGGG AGATGCTGAA GGACCCTTTT GTGCGCTCCA AGTTCATCTC GCCGCCCACC 4320

AACTTCAACC ACCTGGTGCA CGTGGGCCCT ACGGAGGGAA GGCCCAACAC CAGGGATGGG 4380

ACCCGGGCTC AGGAACAGAA GAGCAGAGGT GCCCGCAGCT CCGGGCCGCA GCGGCCCCAC 4440

AGCTTCTCAG AGGCATTTCG GCGGCCAGTG TCCACGGGCA GTGATGGTCT CCCTGGAGAA 4500

ACAGACCCAT TAGTGAAGAG GAAACCTTGG ACATCTCTGT CCAGCGAATC AGTGTCCTGC 4560

CCCCAGGGGT CCCTGAGCCC TGCAGCATCC CTGATACAGG TCTCAGAACG GCCCCGAAGT 4620

CTCCCTCCAG ATCCTGAGTC AGAGAGCTCC CCCTGA 4656

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavvr++ +++++amk+l+k+e+lkrae+a+freerdvlvk+ds+w

Q: 71    FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRW  130

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +++l+yafqde+ylylvm+y++GGdlltlls++ed+lp ela+fylae+vla++s+h+lg

Q: 131   VTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLG  190

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrd+kpdnilld++Ghi+ladfGscl+ln++g+v+ssvavGtpdyispe+l+a+eegk

Q: 191   YVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGK  250

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg++cdwwslGv++yell+getpfyaeslvety+ki+nh+++l+fp+d+ +v+++a+d

Q: 251   GHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPADVtDVPASAQD  310

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++ll+++eerlgr g++d++khpff

Q: 311   LIRQLLCRQEERLGRGGLDDFRKHPFF  337

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVRQ RGSGQIFAMK MLHKWEMLKR AETACFREER DVLVKGDSRW 60

VTALHYAFQD EEYLYLVMDY YAGGDLLTLL SRFEDRLPPE LAQFYLAEMV LAIHSLHQLG 120

YVHRDVKPDN ILLDMNGHIR LADFGSCLRL NNNGMVDSSV AVGTPDYISP EILQAMEEGK 180

GHYGPQCDWW SLGVCAYELL FGETPFYAES LVETYGKIMN HEDHLQFPAD VTDVPASAQD 240

LIRQLLCRQE ERLGRGGLDD FRKHPFF 267

Keyword

ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0031252	; C:cell leading edge
GO:0005813	; C:centrosome
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

mmu:240505

;

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013