EKS-MUM-00032
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00032
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak343.72.0E-1028491120272
StatusUnreviewed
Ensembl ProteinENSMUSP00000025705
UniProt AccessionG5E852;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJak2
Gene Synonyms/Alias Jak2; mCG_9104;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000024789ENSMUSP00000025705ENSMUST00000025705
ENSMUSG00000024789ENSMUSP00000064394ENSMUST00000065796
OrganismMus musculus
Functional Description
Protein Length1132
Protein Sequence
(FASTA)
MGMACLTMTE MEATSTSPVH QNGDIPGSAN SVKQIEPVLQ VYLYHSLGQA EGEYLKFPSG 60
EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH DILYRIRFYF 120
PHWYCSGSSR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 180
MAVLDMMRIA KEKDQTPLAV YNSVSYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF 240
SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR 300
GKHKESETLT EQDVQLYCDF PDIIDVSIKQ ANQECSNESR IVTVHKQDGK VLEIELSSLK 360
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT 420
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSNLKDLLNC 480
YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGISDV QISPTLQRHN NVNQMVFHKI 540
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHKTEVLL KVLDKAHRNY SESFFEAASM 600
MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA 660
MHFLEEKSLI HGNVCAKNIL LIREEDRRTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL 780
ANLINNCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 840
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900
ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 960
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 1020
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE 1080
LLKSNGRLPR PEGCPDEIYV IMTECWNNNV SQRPSFRDLS LRVDQIRDSI AA 1132
Nucleotide Sequence
(FASTA)
ATGGGAATGG CCTGCCTTAC AATGACAGAA ATGGAGGCAA CCTCCACATC TCCTGTACAT 60
CAGAATGGTG ATATTCCTGG AAGTGCTAAT TCTGTGAAGC AGATAGAGCC AGTCCTTCAA 120
GTGTATCTGT ACCATTCTCT TGGGCAAGCT GAAGGAGAGT ATCTGAAGTT TCCAAGTGGA 180
GAGTATGTTG CAGAAGAAAT TTGTGTGGCT GCTTCTAAAG CTTGTGGTAT TACGCCTGTG 240
TATCATAATA TGTTTGCGTT AATGAGTGAA ACCGAAAGGA TCTGGTACCC ACCCAATCAT 300
GTCTTCCACA TAGACGAGTC AACCAGGCAT GACATACTCT ACAGGATAAG GTTCTACTTC 360
CCTCATTGGT ACTGTAGTGG CAGCAGCAGA ACCTACAGAT ACGGAGTGTC CCGTGGGGCT 420
GAAGCTCCTC TGCTTGATGA CTTTGTCATG TCTTACCTTT TTGCTCAGTG GCGGCATGAT 480
TTTGTTCACG GATGGATAAA AGTACCTGTG ACTCATGAAA CTCAGGAAGA GTGTCTTGGG 540
ATGGCGGTGT TAGACATGAT GAGAATAGCT AAGGAGAAAG ACCAGACTCC ACTGGCTGTC 600
TATAACTCTG TCAGCTACAA GACATTCTTA CCAAAGTGCG TTCGAGCGAA GATCCAAGAC 660
TATCACATTT TAACCCGGAA GCGAATCAGG TACAGATTTC GCAGATTCAT TCAGCAATTC 720
AGTCAATGTA AAGCCACTGC CAGGAACCTA AAACTTAAGT ATCTTATAAA CCTGGAAACC 780
CTGCAGTCTG CCTTCTACAC AGAACAGTTT GAAGTAAAAG AATCTGCAAG AGGTCCTTCA 840
GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA GTGGTCAAGA 900
GGGAAACATA AGGAAAGTGA GACACTGACA GAACAGGACG TACAGTTATA TTGTGATTTC 960
CCTGATATTA TTGATGTCAG TATTAAGCAA GCAAACCAGG AATGCTCAAA TGAAAGTAGA 1020
ATTGTAACTG TCCATAAACA AGATGGTAAA GTTTTGGAGA TAGAACTTAG CTCATTAAAA 1080
GAAGCCTTGT CATTCGTGTC ATTAATTGAC GGGTATTACA GACTAACTGC GGATGCGCAC 1140
CATTACCTCT GCAAAGAGGT GGCTCCCCCA GCTGTGCTCG AGAACATACA CAGCAACTGC 1200
CACGGCCCAA TATCAATGGA TTTTGCCATT AGCAAACTAA AGAAGGCGGG TAACCAGACT 1260
GGACTATATG TGCTACGATG CAGCCCTAAG GACTTCAACA AATACTTTCT GACCTTTGCT 1320
GTTGAGCGAG AAAATGTCAT TGAATATAAA CACTGTTTGA TTACGAAGAA TGAGAATGGA 1380
GAATACAACC TCAGCGGGAC TAAGAGGAAC TTCAGTAACC TTAAGGACCT TTTGAATTGC 1440
TACCAGATGG AAACTGTGCG CTCAGACAGT ATCATCTTCC AGTTTACCAA ATGCTGCCCC 1500
CCAAAGCCAA AAGATAAATC AAACCTTCTC GTCTTCAGAA CAAATGGTAT TTCTGATGTT 1560
CAGATCTCAC CAACATTACA GAGGCATAAT AATGTGAATC AAATGGTGTT TCACAAAATC 1620
AGGAATGAAG ATTTAATATT TAATGAAAGT CTTGGCCAAG GTACTTTTAC AAAAATTTTT 1680
AAAGGTGTAA GAAGAGAAGT TGGAGATTAT GGTCAACTGC ACAAAACGGA AGTTCTTTTG 1740
AAAGTCCTAG ATAAAGCACA TAGGAACTAT TCAGAGTCTT TCTTCGAAGC AGCAAGCATG 1800
ATGAGTCAGC TTTCTCACAA GCATTTGGTT TTGAATTATG GTGTCTGTGT CTGTGGAGAG 1860
GAGAACATTC TGGTTCAAGA ATTTGTAAAA TTTGGATCAC TGGATACATA CCTGAAGAAG 1920
AACAAAAATT CCATAAATAT ATTATGGAAA CTTGGAGTGG CTAAGCAGTT GGCATGGGCC 1980
ATGCATTTTC TAGAAGAAAA ATCCCTTATT CATGGGAATG TGTGTGCTAA AAATATCCTG 2040
CTTATCAGAG AAGAAGACAG GAGAACGGGG AACCCACCTT TCATCAAACT TAGTGATCCT 2100
GGCATTAGCA TTACAGTTCT ACCGAAGGAC ATTCTTCAGG AGAGAATACC ATGGGTACCT 2160
CCTGAATGCA TTGAGAATCC TAAAAATCTC AATCTGGCAA CAGACAAGTG GAGCTTCGGG 2220
ACCACTCTGT GGGAGATCTG CAGTGGAGGA GATAAGCCCC TGAGTGCTCT GGATTCTCAA 2280
AGAAAGCTGC AGTTCTATGA AGATAAGCAT CAGCTTCCTG CACCCAAGTG GACAGAGTTA 2340
GCAAACCTTA TAAATAATTG CATGGACTAT GAGCCAGATT TCAGGCCTGC TTTCAGAGCT 2400
GTCATCCGTG ATCTTAACAG CCTGTTTACT CCAGATTATG AACTACTAAC AGAAAATGAC 2460
ATGCTACCAA ACATGAGAAT AGGTGCCCTA GGGTTTTCTG GTGCTTTTGA AGACAGGGAC 2520
CCTACACAGT TTGAAGAGAG ACACTTGAAG TTTCTACAGC AGCTTGGCAA AGGTAACTTC 2580
GGGAGTGTGG AGATGTGCCG CTATGACCCG CTGCAGGACA ACACTGGCGA GGTGGTCGCT 2640
GTGAAGAAAC TCCAGCACAG CACTGAAGAG CACCTCCGAG ACTTTGAGAG GGAGATCGAG 2700
ATCCTGAAAT CCTTGCAGCA TGACAACATC GTCAAGTACA AGGGAGTGTG CTACAGTGCG 2760
GGTCGGCGCA ACCTAAGATT AATTATGGAA TATTTACCAT ATGGAAGTTT ACGAGACTAT 2820
CTCCAAAAAC ATAAAGAACG GATAGATCAC AAAAAACTTC TTCAATACAC ATCTCAGATA 2880
TGCAAGGGCA TGGAATATCT TGGTACAAAA AGGTATATCC ACAGGGACCT GGCAACAAGG 2940
AACATATTGG TGGAAAATGA GAACAGGGTT AAAATAGGAG ACTTCGGATT AACCAAAGTC 3000
TTGCCGCAGG ACAAAGAATA CTACAAAGTA AAGGAGCCAG GGGAAAGCCC CATATTCTGG 3060
TACGCACCTG AATCCTTGAC GGAGAGCAAG TTTTCTGTGG CCTCAGATGT GTGGAGCTTT 3120
GGAGTGGTTC TATACGAACT TTTCACATAC ATCGAGAAGA GTAAAAGTCC ACCCGTGGAA 3180
TTTATGCGAA TGATTGGCAA TGATAAACAA GGGCAAATGA TTGTGTTCCA TTTGATAGAG 3240
CTACTGAAGA GCAACGGAAG ATTGCCAAGG CCAGAAGGAT GCCCAGATGA GATTTATGTG 3300
ATCATGACAG AGTGCTGGAA CAACAATGTG AGCCAGCGTC CCTCCTTCAG GGACCTTTCC 3360
CTTCGGGTGG ATCAAATCCG GGACAGTATA GCTGCGTGA 3399
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+
Q: 849   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  908
         6899********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL+
Q: 909   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG  968
         **********999888********************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a
Q: 969   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1022
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224
         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el
Q: 1023  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpvefMRMIGNDkqgqmivfHLIEL  1081
         ********.****************************999999999899***********
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262
         l+++ rlp+p+ cp+e++++mt+c++++ sqrpsFr++ 
Q: 1082  LKSNGRLPRPEgCPDEIYVIMTECWNNNVSQRPSFRDLS  1120
         ************************************985
Domain Sequence
(FASTA)
LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60
NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTS QICKGMEYLG 120
TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180
SKFSVASDVW SFGVVLYELF TYIEKSKSPP VEFMRMIGND KQGQMIVFHL IELLKSNGRL 240
PRPEGCPDEI YVIMTECWNN NVSQRPSFRD LS 272
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00026
EKS-ANC-00025
EKS-BOT-00031
EKS-CAJ-00030
EKS-CAF-00031
EKS-CAP-00032
EKS-CII-00224
EKS-DAR-00042
EKS-DRM-00011
EKS-EQC-00028
EKS-FEC-00028
EKS-GAM-00013
EKS-GAG-00025
EKS-GAA-00046
EKS-GOG-00030
EKS-HOS-00032
EKS-LAC-00033
EKS-LOA-00030
EKS-MAM-00031
EKS-MEG-00027
EKS-MOD-00030
EKS-MUP-00032
EKS-MYL-00032
EKS-NOL-00029
EKS-ORN-00046
EKS-ORA-00025
EKS-ORC-00031
EKS-ORL-00043
EKS-OTG-00031
EKS-PAT-00029
EKS-PES-00027
EKS-POA-00028
EKS-PTV-00030
EKS-RAN-00032
EKS-SAH-00029
EKS-SUS-00028
EKS-TAG-00028
EKS-TAR-00046
EKS-TEN-00052
EKS-XET-00030
EKS-XIM-00044
Gene Ontology
GO:0005901; C:caveola
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0005829; C:cytosol
GO:0016363; C:nuclear matrix
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0035401; F:histone kinase activity (H3-Y41 specific)
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0006915; P:apoptotic process
GO:0031103; P:axon regeneration
GO:0019221; P:cytokine-mediated signaling pathway
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0007186; P:G-protein coupled receptor signaling pathway
GO:0060396; P:growth hormone receptor signaling pathway
GO:0009755; P:hormone-mediated signaling pathway
GO:0060333; P:interferon-gamma-mediated signaling pathway
GO:0035722; P:interleukin-12-mediated signaling pathway
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0061180; P:mammary gland epithelium development
GO:0031959; P:mineralocorticoid receptor signaling pathway
GO:0030099; P:myeloid cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0022408; P:negative regulation of cell-cell adhesion
GO:0043392; P:negative regulation of DNA binding
GO:0045822; P:negative regulation of heart contraction
GO:0048008; P:platelet-derived growth factor receptor signaling pathway
GO:0043065; P:positive regulation of apoptotic process
GO:0050867; P:positive regulation of cell activation
GO:0045597; P:positive regulation of cell differentiation
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:0043388; P:positive regulation of DNA binding
GO:0050729; P:positive regulation of inflammatory response
GO:0032024; P:positive regulation of insulin secretion
GO:0032731; P:positive regulation of interleukin-1 beta production
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0033160; P:positive regulation of protein import into nucleus, translocation
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0046677; P:response to antibiotic
GO:0033194; P:response to hydroperoxide
GO:0007262; P:STAT protein import into nucleus
GO:0033209; P:tumor necrosis factor-mediated signaling pathway
GO:0007260; P:tyrosine phosphorylation of STAT protein
GO:0042508; P:tyrosine phosphorylation of Stat1 protein
GO:0042503; P:tyrosine phosphorylation of Stat3 protein
KEGG
mmu:16452;
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR01825; JANUSKINASE2.
PR00109; TYRKINASE.
Created Date20-Feb-2013