EPS-MUM-00005
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-MUM-00005
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/aDSP184.72.1E-5421159139
StatusReviewed
Ensembl ProteinENSMUSP00000026018
UniProt AccessionQ9D9D8;
Protein NameDual specificity phosphatase 21
Protein Synonyms/Alias
Gene NameDusp21
Gene Synonyms/Alias Dusp21;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000025043ENSMUSP00000026018ENSMUST00000026018
OrganismMus musculus
Functional DescriptionCan dephosphorylate single and diphosphorylatedsynthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine (By similarity).
Protein Length189
Protein Sequence
(FASTA)
MTTASCIFPS QATQQDNIYG LSQITASLFI SNSAVANDKL TLSNNHITTI INVSAEVVNT 60
FFEDIQYVQV PVSDAPNSYL YDFFDPIADH IHGVEMRNGR TLLHCAAGVS RSATLCLAYL 120
MKYHNMTLLD AHTWTKTCRP IIRPNNGFWE QLIHYEFKLF SRNTVRMIYS PIGLIPNIYE 180
KEAYLMELM 189
Nucleotide Sequence
(FASTA)
ATGACAACAG CATCTTGTAT CTTTCCGTCT CAAGCTACCC AACAGGATAA CATCTATGGT 60
CTCTCTCAAA TAACTGCCAG TCTTTTTATC AGTAACTCTG CGGTAGCTAA CGACAAACTC 120
ACCTTGTCCA ACAACCATAT CACCACGATC ATCAATGTCT CTGCAGAAGT AGTGAATACG 180
TTCTTTGAAG ACATTCAGTA CGTGCAAGTG CCGGTGAGCG ATGCTCCTAA TTCTTACCTC 240
TATGACTTTT TCGACCCCAT AGCTGATCAC ATCCACGGTG TGGAAATGAG AAATGGCCGC 300
ACGCTGTTGC ACTGTGCCGC AGGAGTGAGC CGCTCAGCAA CTCTCTGCCT TGCCTATCTC 360
ATGAAATACC ACAATATGAC CCTGCTGGAT GCACACACAT GGACCAAGAC CTGCCGCCCC 420
ATCATCCGTC CCAACAATGG CTTTTGGGAA CAACTGATTC ATTACGAGTT CAAGCTGTTT 480
AGTAGGAATA CCGTTCGCAT GATCTACTCT CCTATAGGTC TGATTCCTAA CATCTATGAA 540
AAGGAGGCCT ATTTAATGGA GCTAATGTAA 570
Domain Profile
S: 2     vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd  61
         +++i+++l+++++a+a+d+++Ls+++it++in+s++v++       ++ ++i+y+++pv+
Q: 21    LSQITASLFISNSAVANDKLTLSNNHITTIINVSAEVVN-------TFFEDIQYVQVPVS  73
         689************************************.......899***********
S: 62    DsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAie  121
         D+++++l+++fd++a++i+ +++++g++l+HCaaGvsRSatl+laYLmk+++++l dA++
Q: 74    DAPNSYLYDFFDPIADHIHGVEMRNGRTLLHCAAGVSRSATLCLAYLMKYHNMTLLDAHT  133
         ************************************************************
S: 122   avkrkrpsiepnegfleQLlelekkl  147
         ++k++rp+i+pn+gf+eQL+++e kl
Q: 134   WTKTCRPIIRPNNGFWEQLIHYEFKL  159
         ***********************998
Domain Sequence
(FASTA)
LSQITASLFI SNSAVANDKL TLSNNHITTI INVSAEVVNT FFEDIQYVQV PVSDAPNSYL 60
YDFFDPIADH IHGVEMRNGR TLLHCAAGVS RSATLCLAYL MKYHNMTLLD AHTWTKTCRP 120
IIRPNNGFWE QLIHYEFKL 139
KeywordComplete proteome; Cytoplasm; Hydrolase; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleus; Protein phosphatase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Mustela putorius furo"; ?>Rattus norvegicus"; ?>Vicugna pacos"; ?>
EPS-AIM-00011
EPS-BOT-00006
EPS-CAF-00011
EPS-FEC-00012
EPS-HOS-00007
EPS-ICT-00005
EPS-MUP-00005
EPS-RAN-00006
EPS-VIP-00003
Gene Ontology
GO:0019898; C:extrinsic to membrane
GO:0005743; C:mitochondrial inner membrane
GO:0005758; C:mitochondrial intermembrane space
GO:0005634; C:nucleus
GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0035335; P:peptidyl-tyrosine dephosphorylation
GO:0006612; P:protein targeting to membrane
GO:0006626; P:protein targeting to mitochondrion
KEGG
mmu:73547;
InterPros
IPR020417; Atypical_DUSP.
IPR020420; Atypical_DUSP_famB.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR020422; Dual-sp_phosphatase_subgr_cat.
IPR024950; DUSP.
IPR000387; Tyr/Dual-specificity_Pase.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
SMARTs
SM00195; DSPc; 1.
Prosites
PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
PS50054; TYR_PHOSPHATASE_DUAL; 1.
Prints
PR01908; ADSPHPHTASE.
PR01910; ADSPHPHTASEB.
Created Date20-Feb-2013