EKS-MUM-00353

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00353

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	335.3	6.3E-100	34	292	259

Status

Reviewed

Ensembl Protein

ENSMUSP00000026043

UniProt Accession

O54988; A2RRK4; Q80U65; Q8CAU2; Q8CDW2; Q9WU41;

Protein Name

STE20-like serine/threonine-protein kinase

Protein Synonyms/Alias

STE20-like kinase; mSLK; Etk4; STE20-related kinase SMAK; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2;

Gene Name

Slk

Gene Synonyms/Alias

Slk; Kiaa0204, Stk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000025060	ENSMUSP00000026043	ENSMUST00000026043
ENSMUSG00000025060	ENSMUSP00000049977	ENSMUST00000051691

Organism

Mus musculus

Functional Description

Mediates apoptosis and actin stress fiber dissolution.

Protein Length

1202

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSK WSSNFKDFLR KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV 300

RELIAEAKAE VTEEVEDGKE EDEEEEAENA LPIPANKRAS SDLSIASSEE DKLSQNACIL 360

ESVSERTEQS TSEDKFSNKI LNEKPTTDGP EKAVDEHASD VNLETGAELN DQTVGIHENG 420

REKKRPKLEN LPDTQDQQTV DVNSVSEENE NNRVTLETNT DCLKPEEDRN KENQETLESK 480

LIQSEEINDT HIQTMDLVSQ ETGEKEADFQ AVDNEVGLTK EETQEKLGKD GTAQKVITSD 540

RSSEVGTDEA LDDTQKAAEL SKAAQSGEGD EALAPTQTLA EKPTEGPEAG GAEEEPPGGE 600

RVEDKQPEQQ PAVCEAEGQL TSTSETTRAT LEQPETDEVE QVSESNSIEE LERLVVTGAE 660

ARALGSEGEA AATEVDLERK ENAQKVPVKA ESQAPAASQP SEPHPVLIPS ININSETTEN 720

KEEMGALPKP ETILPPEPEH EKGNDTDSGT GSTVENSSGD LNLSISSFLS KAKDSGSVSL 780

QETRRQKKTL KKTRKFIVDG VEVSVTTSKI VTDSDSKTEE LRFLRRQELR ELRLLQKEEQ 840

RAQQQLNGKL QQQREQIFRR FEQEMLSKKR QYDQEIENLE KQQKQTIERL EQEHTNRLRD 900

EAKRIKGEQE KELSKFQNVL KNRKKEEQEF VQKQQQELDG SLKKIIQQQK AELANIEREC 960

LNNKQQLMRA REAAIWELEE RHLQEKHQLL KQQLKDQYFM QRHQLLKRHE KETEQMQRYN 1020

QRLIEELKNR QTQERARLPK IQRSEAKTRM AMFKKSLRIN STATPDQDRE KIKQFAAQEE 1080

KRQKNERMAQ HQKHESQMRD LQLQCEANVR ELHQLQNEKC HLLVEHETQK LKELDEEHSQ 1140

ELKEWREKLR PRKKTLEEEF ARKLQEQEVF FKMTGESECL NPSAQSRISK FYPIPTLHST 1200

GS 1202

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAACAG 60

TACGAACACG TGAAGAGAGA CCTGAACCCC GAAGAGTTTT GGGAGATTAT TGGAGAACTG 120

GGCGACGGAG CCTTCGGGAA AGTCTATAAG GCCCAGAATA AAGAGACCAA TGTTTTAGCT 180

GCTGCAAAGG TGATTGACAC CAAATCTGAA GAAGAGCTTG AAGATTATAT GGTTGAGATT 240

GACATATTAG CATCTTGTGA TCACCCAAAC ATCGTCAAGC TTCTAGATGC CTTCTATTAC 300

GAGAACAACC TTTGGATCCT CATTGAATTC TGTGCAGGGG GAGCAGTGGA TGCTGTGATG 360

CTTGAACTTG AGAGACCATT AACTGAATCC CAAATCCAAG TAGTCTGCAA GCAGACATTA 420

GAGGCATTGA ATTACTTACA TGACAATAAA ATCATCCACC GAGATCTAAA AGCTGGCAAT 480

ATTCTCTTTA CCTTAGATGG AGACATTAAA TTAGCGGATT TTGGAGTATC AGCTAAAAAT 540

ACCAGGACAA TTCAAAGGAG GGATTCATTT ATTGGCACAC CATATTGGAT GGCTCCTGAA 600

GTAGTCATGT GTGAGACATC AAAGGACAGA CCTTATGACT ACAAAGCTGA TGTTTGGTCC 660

CTGGGTATTA CTTTAATAGA AATGGCTGAG ATAGAGCCAC CTCATCATGA GTTAAATCCA 720

ATGCGCGTGC TGCTGAAAAT TGCAAAATCT GAGCCCCCAA CATTAGCACA GCCATCAAAA 780

TGGTCTTCAA ATTTTAAGGA CTTTCTAAGG AAATGCTTGG AAAAGAATGT GGATGCGCGG 840

TGGACCACGT CTCAGCTGTT GCAGCATCCC TTTGTTACCG TTGATTCCAA CAAACCAGTC 900

CGAGAGTTGA TTGCTGAGGC AAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAGGAA 960

GAAGATGAGG AGGAGGAAGC AGAGAATGCT CTGCCAATAC CTGCAAATAA ACGTGCCTCC 1020

TCTGACCTCA GCATTGCCAG CTCTGAAGAA GATAAACTTT CACAAAATGC TTGTATTTTG 1080

GAATCTGTGT CAGAAAGAAC AGAACAAAGT ACTTCTGAGG ATAAATTTAG CAACAAAATT 1140

CTTAATGAGA AACCTACGAC TGACGGTCCT GAGAAGGCTG TGGATGAGCA TGCAAGTGAT 1200

GTGAACTTAG AAACTGGGGC TGAACTAAAT GACCAAACAG TAGGAATCCA TGAGAATGGG 1260

AGAGAGAAGA AAAGACCCAA GCTGGAAAAT CTGCCAGATA CACAAGACCA GCAAACTGTG 1320

GATGTTAATT CAGTCAGTGA AGAAAATGAG AATAATAGAG TAACTTTAGA AACGAACACT 1380

GATTGTCTGA AACCAGAGGA AGACAGAAAT AAAGAAAACC AAGAGACACT TGAGAGTAAA 1440

CTTATACAAT CTGAAGAAAT TAATGACACA CATATTCAAA CAATGGACTT AGTTTCTCAA 1500

GAGACTGGAG AAAAAGAAGC AGATTTTCAG GCAGTTGACA ATGAAGTTGG GCTTACAAAG 1560

GAAGAAACCC AAGAGAAATT AGGAAAAGAT GGTACAGCTC AAAAAGTTAT AACCAGTGAT 1620

AGAAGCAGTG AGGTGGGGAC AGACGAGGCT CTAGATGACA CTCAGAAGGC TGCTGAGCTC 1680

AGTAAGGCAG CACAGAGTGG GGAAGGGGAC GAAGCCCTGG CGCCTACCCA GACACTAGCA 1740

GAGAAGCCCA CAGAGGGCCC TGAGGCCGGT GGGGCTGAGG AAGAGCCTCC TGGTGGAGAG 1800

AGAGTTGAGG ATAAACAGCC AGAGCAGCAG CCTGCAGTGT GTGAAGCTGA GGGACAGTTA 1860

ACCAGCACGT CAGAGACCAC ACGGGCAACC CTGGAGCAAC CGGAGACGGA TGAAGTTGAG 1920

CAGGTCAGCG AGTCCAATAG CATTGAGGAG CTAGAGAGAC TTGTAGTTAC TGGTGCTGAG 1980

GCACGGGCTC TCGGGAGTGA AGGTGAGGCA GCTGCTACTG AGGTAGATTT GGAGAGAAAA 2040

GAAAACGCAC AGAAAGTGCC CGTTAAAGCA GAGTCCCAAG CTCCTGCAGC ATCGCAGCCC 2100

AGCGAGCCTC ACCCTGTCTT AATACCCAGT ATTAATATTA ATTCTGAAAC CACAGAAAAT 2160

AAAGAAGAAA TGGGTGCTTT GCCAAAACCT GAAACCATAC TGCCACCAGA GCCTGAACAT 2220

GAAAAGGGAA ATGACACCGA CTCAGGGACT GGGTCCACTG TGGAGAATAG CAGTGGTGAC 2280

CTGAACTTGT CCATCTCTAG CTTCCTAAGC AAAGCTAAGG ACAGCGGCTC AGTGTCTCTG 2340

CAGGAGACAA GAAGACAGAA GAAAACATTG AAGAAAACAC GCAAGTTTAT TGTCGATGGT 2400

GTAGAAGTGA GTGTGACGAC ATCGAAGATA GTTACAGACA GCGACTCCAA AACGGAGGAA 2460

CTGCGCTTTC TCAGGCGTCA GGAACTTCGG GAGCTGAGGC TTCTTCAGAA GGAGGAGCAG 2520

CGAGCCCAGC AGCAGCTCAA TGGGAAACTG CAGCAGCAGC GGGAGCAGAT CTTCAGGCGC 2580

TTTGAGCAGG AGATGCTGAG TAAGAAGCGA CAATATGACC AAGAAATTGA GAATTTAGAG 2640

AAGCAGCAGA AACAGACAAT TGAACGGCTA GAACAAGAGC ACACTAACCG CCTGAGAGAC 2700

GAAGCCAAGC GCATCAAAGG AGAGCAGGAG AAGGAGCTGT CCAAGTTCCA GAATGTGCTG 2760

AAAAACCGCA AGAAGGAGGA ACAAGAATTT GTTCAGAAGC AACAACAAGA GTTAGATGGT 2820

TCTCTGAAAA AGATTATCCA GCAGCAGAAG GCAGAGTTGG CCAATATTGA GAGAGAATGC 2880

CTGAATAACA AGCAGCAGCT CATGAGAGCT CGAGAAGCCG CAATTTGGGA GCTTGAAGAG 2940

CGACATTTAC AAGAGAAGCA CCAGCTGCTT AAACAGCAGC TTAAAGATCA GTATTTCATG 3000

CAGAGACATC AGCTGCTAAA ACGCCATGAG AAGGAAACAG AACAAATGCA GCGCTACAAT 3060

CAACGACTTA TTGAAGAACT GAAAAACAGA CAGACTCAGG AACGAGCGAG ACTGCCCAAG 3120

ATTCAAAGAA GTGAAGCCAA GACACGAATG GCCATGTTTA AAAAAAGTTT GAGGATCAAC 3180

TCAACAGCCA CACCAGACCA GGACCGTGAA AAAATTAAAC AGTTTGCTGC ACAAGAAGAA 3240

AAGAGACAGA AAAATGAGAG AATGGCTCAG CATCAAAAAC ATGAGAGCCA AATGCGGGAT 3300

CTTCAGTTGC AGTGTGAAGC CAATGTTCGG GAACTGCACC AGCTGCAGAA TGAAAAATGC 3360

CACCTGTTGG TTGAACATGA GACTCAGAAG CTGAAGGAGT TGGATGAGGA GCACAGCCAA 3420

GAGCTGAAGG AGTGGAGAGA GAAGCTGAGA CCCAGGAAGA AGACACTGGA AGAAGAGTTT 3480

GCCAGGAAAC TGCAGGAACA GGAAGTGTTC TTTAAAATGA CTGGGGAGTC CGAATGTCTT 3540

AATCCATCAG CACAGAGCCG GATCTCTAAA TTCTACCCTA TTCCCACCTT ACATTCCACT 3600

GGGTCATAG 3609

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLEALNYLHDNKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+ae epP+++l+p+++llki+k+epp+l +++k+s++fk+f++kc

Q: 213   DYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDARWTTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVYKAQN KETNVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLEAL NYLHDNKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAEIEP PHHELNPMRV LLKIAKSEPP TLAQPSKWSS NFKDFLRKCL 240

EKNVDARWTT SQLLQHPFV 259

Keyword

Alternative splicing; Apoptosis; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0042803	; F:protein homodimerization activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0046777	; P:protein autophosphorylation

KEGG

mmu:20874

;

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013