EKS-MUM-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/PHK	530.3	2.2E-159	20	288	269

Status

Reviewed

Ensembl Protein

ENSMUSP00000026617

UniProt Accession

P07934;

Protein Name

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform

Protein Synonyms/Alias

Phosphorylase kinase subunit gamma-1;

Gene Name

Phkg1

Gene Synonyms/Alias

Phkg1; Phkg;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000025537	ENSMUSP00000026617	ENSMUST00000026617
ENSMUSG00000025537	ENSMUSP00000117510	ENSMUST00000140667
ENSMUSG00000025537	ENSMUSP00000122040	ENSMUST00000154932

Organism

Mus musculus

Functional Description

Phosphorylase b kinase catalyzes the phosphorylation ofserine in certain substrates, including troponin I.

Protein Length

388

Protein Sequence
(FASTA)

MTRDDALPDS HSAQTFYENY EPKEILGRGV SSVVRRCIHK PTCQEYAVKI IDITGGGSFS 60

SEEVQELREA TLKEVDILQK VSGHPNIIQL KDTYETNTFF FLVFDLMKRG ELFDYLTEKV 120

TLTEKETRKI MRALLEVICT LHKLNIVHRD LKPENILLDD NMNIKLTDFG FSCQLQPGEK 180

LREVCGTPSY LAPEIIQCSM DDGHPGYGKE VDMWSTGVIM YTLLAGSPPF WHRKQMLMLR 240

MIMDGKYQFG SPEWDDYSDT VKDLVSRFLV VQPQDRCSAE EALAHPFFQE YVVEEVRHFS 300

PRGKFKVICL TVLASVKIYY QYRRVKPVTR EIVIRDPYAL RPLRRLIDAY AFRIYGHWVK 360

KGQQQNRAAL FENTPKAVLL SLAEEEDF 388

Nucleotide Sequence
(FASTA)

ATGACCCGGG ATGACGCCCT CCCTGACTCG CATTCTGCAC AGACTTTCTA CGAGAACTAT 60

GAGCCCAAGG AGATCCTGGG CAGGGGAGTC AGCAGTGTGG TCAGGCGCTG CATCCACAAA 120

CCCACATGCC AGGAATACGC AGTGAAAATC ATTGACATCA CCGGAGGAGG AAGCTTTAGC 180

TCTGAGGAGG TACAGGAGCT TCGGGAAGCC ACCCTGAAGG AGGTGGACAT CCTGCAGAAG 240

GTCTCGGGAC ACCCCAACAT CATACAGCTG AAGGACACTT ACGAGACCAA CACTTTCTTC 300

TTCTTGGTAT TTGATCTGAT GAAGAGAGGG GAACTCTTTG ACTATCTCAC TGAGAAGGTC 360

ACCTTAACCG AGAAGGAAAC CAGAAAGATC ATGCGGGCCC TGCTGGAGGT GATCTGTACC 420

CTGCACAAAC TCAACATTGT CCATCGGGAC CTGAAGCCGG AGAATATCCT TTTGGATGAC 480

AACATGAATA TAAAGCTCAC AGACTTCGGG TTTTCCTGCC AGCTGCAGCC AGGAGAGAAG 540

CTCCGAGAGG TTTGTGGGAC TCCCAGTTAT CTGGCCCCTG AAATCATACA GTGCTCCATG 600

GACGACGGCC ATCCTGGCTA TGGGAAGGAG GTGGACATGT GGAGCACAGG CGTCATCATG 660

TACACTCTGC TGGCTGGCTC CCCGCCTTTC TGGCACCGGA AGCAAATGCT GATGTTGCGG 720

ATGATCATGG ACGGCAAATA CCAGTTTGGC TCACCAGAGT GGGATGACTA CTCTGACACA 780

GTGAAAGACT TGGTGTCTCG ATTCTTGGTG GTGCAACCTC AGGACCGCTG CTCGGCGGAA 840

GAGGCCTTGG CACACCCTTT CTTTCAGGAG TACGTAGTAG AAGAAGTACG GCACTTCAGC 900

CCCCGAGGGA AGTTCAAGGT GATCTGTCTA ACTGTGCTGG CATCAGTAAA GATCTACTAC 960

CAGTACCGTC GGGTGAAGCC GGTAACCAGG GAGATCGTCA TCCGAGACCC CTACGCCCTT 1020

CGGCCGCTGC GGAGGCTCAT TGACGCCTAT GCTTTCCGTA TCTACGGCCA CTGGGTGAAG 1080

AAAGGGCAAC AGCAGAACAG AGCCGCCCTC TTCGAGAACA CGCCCAAGGC TGTGCTCCTC 1140

TCCTTGGCTG AGGAGGAGGA CTTCTGA 1167

Domain Profile

S: 1     yepkeilGrGvssvvrrciekatgqefavkiidvs.aeklseeevkelreatlkeveilr  59

         yepkeilGrGvssvvrrci+k+t+qe+avkiid++ ++++s+eev+elreatlkev+il+

Q: 20    YEPKEILGRGVSSVVRRCIHKPTCQEYAVKIIDITgGGSFSSEEVQELREATLKEVDILQ  79

         9**********************************899**********************

S: 60    qvsGhpsiiklkdvyesssflflvfdlmkkGelfdyltekvtlseketrkimralleave  119

         +vsGhp+ii+lkd+ye+++f+flvfdlmk+Gelfdyltekvtl+eketrkimralle+++

Q: 80    KVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEKETRKIMRALLEVIC  139

         ************************************************************

S: 120   ylhaknivhrdlkpenillddneniklsdfGfstqleeGeklrelcGtpgylapeilkcs  179

         +lh+ nivhrdlkpenillddn+nikl+dfGfs+ql++Geklre+cGtp+ylapei++cs

Q: 140   TLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCS  199

         ************************************************************

S: 180   mdeeapGyskevdlwalGvilytllaGsppfwhrkqllmlrlimeGkyqftspewddise  239

         md+++pGy+kevd+w++Gvi+ytllaGsppfwhrkq+lmlr+im+Gkyqf+spewdd+s+

Q: 200   MDDGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSD  259

         ************************************************************

S: 240   evkdliskllvvdpekrltaeealahpff  268

         +vkdl+s++lvv+p++r++aeealahpff

Q: 260   TVKDLVSRFLVVQPQDRCSAEEALAHPFF  288

         ****************************8

Domain Sequence
(FASTA)

YEPKEILGRG VSSVVRRCIH KPTCQEYAVK IIDITGGGSF SSEEVQELRE ATLKEVDILQ 60

KVSGHPNIIQ LKDTYETNTF FFLVFDLMKR GELFDYLTEK VTLTEKETRK IMRALLEVIC 120

TLHKLNIVHR DLKPENILLD DNMNIKLTDF GFSCQLQPGE KLREVCGTPS YLAPEIIQCS 180

MDDGHPGYGK EVDMWSTGVI MYTLLAGSPP FWHRKQMLML RMIMDGKYQF GSPEWDDYSD 240

TVKDLVSRFL VVQPQDRCSA EEALAHPFF 269

Keyword

ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Kinase; Muscle protein; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005964	; C:phosphorylase kinase complex
GO:0005524	; F:ATP binding
GO:0004689	; F:phosphorylase kinase activity
GO:0005978	; P:glycogen biosynthetic process

KEGG

mmu:18682

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR002291	; Phosph_kin_gamma.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01049

; PHOSPHBKNASE.

Created Date

20-Feb-2013