EKS-MUM-00168

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00168

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	473.5	4.0E-142	442	699	258

Status

Unreviewed

Ensembl Protein

ENSMUSP00000121722

UniProt Accession

E9QK39;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

Rps6ka6

Gene Synonyms/Alias

Rps6ka6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000025665	ENSMUSP00000121722	ENSMUST00000137712
ENSMUSG00000025665	ENSMUSP00000094073	ENSMUST00000096348
ENSMUSG00000025665	ENSMUSP00000118075	ENSMUST00000123213
ENSMUSG00000025665	ENSMUSP00000120611	ENSMUST00000132319
ENSMUSG00000025665	ENSMUSP00000121489	ENSMUST00000138645
ENSMUSG00000025665	ENSMUSP00000080694	ENSMUST00000082034
ENSMUSG00000025665	ENSMUSP00000121075	ENSMUST00000156639
ENSMUSG00000025665	ENSMUSP00000068483	ENSMUST00000065976
ENSMUSG00000025665	ENSMUSP00000109055	ENSMUST00000113428
ENSMUSG00000025665	ENSMUSP00000120004	ENSMUST00000123102
ENSMUSG00000025665	ENSMUSP00000117228	ENSMUST00000128819
ENSMUSG00000025665	ENSMUSP00000115975	ENSMUST00000123951

Organism

Mus musculus

Functional Description

Protein Length

760

Protein Sequence
(FASTA)

MLVLGPGSFF SRAPEAAMLP FAPVEDPWDQ EDMEVFGSTS SSEVNDLKMV DEPMEEGEPV 60

SCRREELVKE IPITQHVKEG YEKADPAQFD LLKVLGQGSF GKVFLVRKKT GPDAGQLYAM 120

KVLRKASLKV RDRVRTKMER DILVEVNHPF IVKLHYAFQT EGKLYLILDF LRGGDVFTRL 180

SKEVLFTEED VKFYLAELAL ALDHLHRLGI VYRDLKPENI LLDEIGHIKL TDFGLSKESV 240

DQEKKAYSFC GTVEYMAPEV VNRRGHSQSA DWWSYGVLMF EMLTGTLPFQ GKDRNETMNM 300

ILKAKLGMPQ FLSAEAQSLL RMLFKRNPAN RLGSEGVEEV KRHAFFASID WNKLYKREVQ 360

PPFRPASGKP DDTFCFDPEF TAKTPKDSPG LPASANAHQL FKGFSFVATS IAEEYKITPV 420

TSSNVLPIVQ INGNAAQFSE AYELKEDIGI GSYSVCKRCI HSASNVEFAV KIIDKNKRDP 480

SEEIEILMRY GQHPNIISLK EVFDDGKYVY LVTDLMKGGE LLDRILKKKC FSEQEASNVL 540

YVITKTVECL HSQGVVHRDL KPSNILYMDE SAHPDSIKIC DFGFAKQLRG ENGLLLTPCY 600

TANFVAPEVL TQQGYDAACD IWSLGVLLYT MLAGYTPFSN GPNDTPEEIL LRIGNGRFSL 660

SGGIWDNISR GAKDLLSHML HMDPHQRYTA EQVLKHPWIT QREQLPRHQP NSDEPPQEAV 720

AAPYSVLARN PNRHHPILEP VTASRLAQRR NMKKRTSTGL 760

Nucleotide Sequence
(FASTA)

ATGCTGGTGC TGGGGCCAGG CAGCTTCTTC TCGAGAGCCC CTGAAGCGGC GATGCTACCG 60

TTCGCCCCTG TGGAGGATCC CTGGGACCAA GAAGACATGG AGGTGTTCGG CAGCACGAGC 120

AGTAGCGAGG TAAATGATCT GAAAATGGTT GATGAGCCAA TGGAAGAGGG AGAGCCAGTT 180

TCTTGCCGGC GGGAAGAATT GGTTAAGGAG ATACCTATTA CACAGCATGT TAAAGAAGGA 240

TACGAGAAAG CAGATCCCGC ACAGTTTGAC TTGCTCAAGG TTCTTGGTCA GGGATCTTTT 300

GGAAAGGTTT TTCTTGTTAG AAAGAAGACT GGTCCTGATG CTGGGCAGCT CTATGCAATG 360

AAGGTGTTAA GAAAAGCTTC TTTGAAAGTT CGAGACCGAG TTCGCACAAA GATGGAGAGG 420

GATATCTTGG TGGAAGTAAA TCATCCCTTT ATCGTCAAAC TGCACTATGC TTTTCAGACT 480

GAAGGGAAGC TGTACTTAAT ATTGGATTTC CTCAGGGGAG GAGATGTCTT CACAAGATTA 540

TCCAAAGAGG TTCTTTTTAC AGAGGAAGAT GTGAAATTCT ACCTTGCAGA ATTGGCCCTG 600

GCTTTGGATC ATCTACATCG ATTAGGAATT GTTTATAGAG ACCTGAAACC AGAAAACATC 660

TTACTTGATG AAATAGGACA TATCAAGTTA ACAGATTTTG GGCTTAGCAA AGAGTCAGTG 720

GATCAAGAAA AGAAGGCCTA CTCATTTTGT GGTACTGTAG AATATATGGC CCCTGAAGTA 780

GTAAACAGAC GAGGCCATTC TCAGAGTGCT GATTGGTGGT CATATGGTGT ACTTATGTTT 840

GAAATGCTTA CTGGCACTTT GCCATTTCAA GGGAAAGACA GAAATGAGAC CATGAATATG 900

ATACTGAAAG CAAAACTTGG AATGCCCCAA TTCCTTAGTG CTGAAGCACA AAGTCTATTA 960

AGGATGTTAT TCAAAAGGAA TCCAGCAAAT AGATTGGGGT CAGAAGGAGT TGAAGAAGTC 1020

AAAAGACATG CTTTTTTTGC TTCCATTGAC TGGAATAAAC TATATAAAAG AGAAGTCCAG 1080

CCTCCTTTCA GACCTGCTTC TGGAAAACCG GATGATACCT TCTGTTTTGA TCCTGAATTT 1140

ACTGCCAAAA CACCTAAAGA TTCTCCTGGT TTGCCAGCCA GTGCAAACGC TCATCAACTC 1200

TTCAAAGGAT TCAGTTTTGT TGCGACTTCT ATTGCCGAAG AATATAAAAT CACTCCTGTT 1260

ACAAGTTCAA ATGTATTACC AATCGTTCAG ATAAATGGAA ATGCTGCTCA ATTTAGTGAA 1320

GCTTATGAAT TGAAAGAGGA TATTGGTATT GGTTCTTATT CTGTTTGCAA GCGATGCATA 1380

CACTCAGCTT CCAATGTGGA ATTTGCAGTC AAGATCATTG ATAAAAATAA GAGAGACCCC 1440

TCAGAAGAAA TTGAAATTTT GATGCGCTAT GGACAACATC CCAACATTAT CTCTTTAAAG 1500

GAGGTCTTTG ATGATGGGAA ATATGTTTAC CTTGTTACGG ACTTGATGAA AGGAGGAGAA 1560

CTTCTGGATC GGATTCTCAA AAAGAAATGT TTCTCAGAGC AGGAAGCTAG TAATGTGCTG 1620

TATGTAATAA CCAAGACAGT TGAATGCCTT CATTCTCAAG GAGTCGTTCA TCGTGATCTT 1680

AAGCCCAGTA ATATTTTATA TATGGATGAG TCAGCCCATC CAGATTCAAT CAAGATCTGT 1740

GATTTTGGGT TTGCAAAACA GCTTCGTGGA GAAAATGGAC TTCTGTTAAC TCCGTGCTAC 1800

ACCGCAAACT TTGTAGCACC TGAGGTTCTC ACTCAACAGG GATATGATGC TGCCTGTGAT 1860

ATTTGGAGCT TAGGAGTCCT TTTGTACACA ATGTTGGCTG GCTACACTCC ATTTTCCAAC 1920

GGCCCCAATG ATACTCCTGA GGAAATACTG CTGCGCATAG GCAACGGGAG GTTCTCTTTG 1980

AGTGGTGGAA TCTGGGACAA TATTTCACGT GGAGCAAAGG ATTTGCTTTC TCATATGCTT 2040

CACATGGACC CACATCAGCG TTATACTGCT GAGCAAGTAT TAAAGCACCC TTGGATAACC 2100

CAAAGAGAAC AACTGCCGCG CCATCAGCCA AACTCAGATG AGCCACCACA GGAAGCAGTG 2160

GCAGCACCAT ATTCTGTCTT GGCTCGGAAC CCAAACAGGC ATCATCCAAT CCTGGAGCCT 2220

GTTACTGCTT CACGTTTAGC TCAGAGGCGG AACATGAAAA AGCGAACATC AACTGGCTTG 2280

TAA 2283

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye+ked+G Gsysvckrc+h a+n efavkiidk+krd+seeieil+ry+qhpni++lk+

Q: 442   YELKEDIGIGSYSVCKRCIHSASNVEFAVKIIDKNKRDPSEEIEILMRYGQHPNIISLKE  501

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v+ddgkyvylv++l+kGGelldri+kkk+fse+eas++l++++k+ve lh+qGvvhrdlk

Q: 502   VFDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEASNVLYVITKTVECLHSQGVVHRDLK  561

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nily+des+ ++siki+dfGfak++r engll tpcyt+nfvapevl++qGyd+acd+

Q: 562   PSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDAACDI  621

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytmlaGy+pf+ngp+dt+eeil +i++G+fslsG+ wd++s  akdl+s++l+

Q: 622   WSLGVLLYTMLAGYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLH  681

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         +dp++r+++eq+lkh+w+

Q: 682   MDPHQRYTAEQVLKHPWI  699

         *****************8

Domain Sequence
(FASTA)

YELKEDIGIG SYSVCKRCIH SASNVEFAVK IIDKNKRDPS EEIEILMRYG QHPNIISLKE 60

VFDDGKYVYL VTDLMKGGEL LDRILKKKCF SEQEASNVLY VITKTVECLH SQGVVHRDLK 120

PSNILYMDES AHPDSIKICD FGFAKQLRGE NGLLLTPCYT ANFVAPEVLT QQGYDAACDI 180

WSLGVLLYTM LAGYTPFSNG PNDTPEEILL RIGNGRFSLS GGIWDNISRG AKDLLSHMLH 240

MDPHQRYTAE QVLKHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006978	; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007243	; P:intracellular protein kinase cascade

KEGG

mmu:67071

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013