EKS-MUM-00528
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MUM-00528
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/FAM20CN/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinENSMUSP00000026972
UniProt AccessionQ5MJS3; Q4FJP0; Q571A3; Q6PKA8; Q8JZP7;
Protein NameExtracellular serine/threonine protein kinase Fam20C
Protein Synonyms/Alias Dentin matrix protein 4; DMP-4; Golgi-enriched fraction casein kinase; GEF-CK;
Gene NameFam20c
Gene Synonyms/Alias Fam20c; Dmp4, Kiaa4081;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMUSG00000025854ENSMUSP00000026972ENSMUST00000026972
ENSMUSG00000025854ENSMUSP00000124584ENSMUST00000160645
OrganismMus musculus
Functional DescriptionCalcium-binding kinase that phosphorylates the caseinsand several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif (By similarity).
Protein Length579
Protein Sequence
(FASTA)
MKMILVRRFR VLILVVFLLA CALHIAVDLL PKLDRRATRS SGEPGCSCAQ PAAEAAGPGW 60
AQARSRPGES AGGDAGWPNK HTLRILQDFS SDPASNLTSH SLEKLPSAAE PVDHAPRGQE 120
PRSPPPRDPA HRPLLRDPGP RPRVPPPGPS GDGSLLAKLF EHPLYQGAVP PLTEDDVLFN 180
VNSDIRFNPK AAENPDWPHE GAEGAEFLPT GEAAVNLYPN WLKFHIGINR YELYSRHNPA 240
IDALLRDLGS QKITSVAMKS GGTQLKLIMT FQNYGQALFK PMKQTREQET PPDFFYFSDY 300
ERHNAEIAAF HLDRILDFRR VPPVAGRMIN MTKEIRDVTR DKKLWRTFFV SPANNICFYG 360
ECSYYCSTEH ALCGRPDQIE GSLAAFLPDL SLAKRKTWRN PWRRSYHKRK KAEWEVDPDY 420
CEEVKQTPPY DSGHRILDIM DMTVFDFLMG NMDRHHYETF EKFGNETFII HLDNGRGFGK 480
YSHDELSILA PLHQCCRIRR STYLRLQLLA KEEHKLSLLM AESLQHDKVA PVLYQLHLEA 540
LDRRLRIVLQ AVRDCVEKDG LSSVVEDDLA TEHRASTER 579
Nucleotide Sequence
(FASTA)
ATGAAGATGA TACTGGTGCG CAGGTTTCGC GTGCTCATCC TGGTAGTATT CCTACTGGCT 60
TGCGCTTTGC ACATTGCTGT TGACCTGCTA CCCAAGCTGG ACCGACGCGC CACGCGATCC 120
TCCGGGGAGC CCGGTTGCTC CTGCGCTCAG CCGGCAGCAG AGGCAGCTGG TCCAGGCTGG 180
GCCCAGGCAA GGAGCAGACC GGGGGAGTCC GCCGGTGGCG ACGCAGGCTG GCCCAACAAA 240
CACACACTGC GCATCCTGCA AGACTTCAGC TCAGATCCAG CCTCTAACCT AACCTCCCAC 300
TCCTTGGAGA AGCTGCCTTC TGCAGCAGAG CCGGTGGATC ACGCTCCGCG GGGTCAGGAG 360
CCCCGTTCCC CGCCACCCCG TGACCCAGCG CATCGGCCGC TGCTTCGAGA CCCGGGGCCC 420
CGACCGCGGG TACCGCCCCC TGGCCCCAGC GGGGACGGAT CGCTCTTAGC CAAGTTGTTT 480
GAGCACCCTC TCTACCAGGG GGCTGTGCCT CCTCTGACAG AGGACGACGT CCTGTTTAAT 540
GTGAACAGCG ACATCAGGTT TAACCCCAAG GCAGCAGAGA ATCCTGACTG GCCGCATGAA 600
GGTGCTGAAG GCGCAGAATT CTTGCCCACT GGTGAGGCAG CTGTGAACCT CTATCCCAAC 660
TGGCTCAAAT TCCACATTGG CATCAACCGG TATGAGCTGT ACTCCAGACA CAACCCAGCC 720
ATCGATGCCT TACTGCGGGA CCTCGGCTCT CAGAAGATCA CCAGCGTCGC CATGAAGTCA 780
GGGGGCACGC AGCTGAAGCT CATCATGACC TTCCAGAATT ACGGGCAGGC GCTATTCAAA 840
CCCATGAAGC AGACGAGAGA GCAGGAGACG CCGCCTGACT TTTTTTATTT CTCTGACTAT 900
GAGAGGCACA ATGCGGAGAT CGCTGCCTTC CACCTGGACA GGATCCTGGA TTTCCGCAGA 960
GTCCCTCCAG TGGCTGGTAG GATGATCAAC ATGACCAAGG AGATCCGGGA TGTGACGCGG 1020
GATAAGAAGC TATGGAGAAC TTTCTTTGTG TCTCCAGCCA ACAACATCTG TTTCTACGGG 1080
GAGTGTTCCT ACTACTGTTC CACCGAGCAT GCCCTGTGTG GGAGGCCCGA CCAGATCGAA 1140
GGATCCCTGG CGGCCTTCCT GCCTGACCTG TCGCTGGCCA AGAGGAAGAC ATGGCGGAAC 1200
CCCTGGCGTC GTTCCTACCA CAAGCGAAAG AAGGCAGAGT GGGAAGTCGA CCCTGATTAC 1260
TGTGAGGAGG TGAAGCAGAC GCCACCCTAC GACAGTGGCC ACCGAATCCT GGACATCATG 1320
GATATGACCG TCTTTGATTT CCTCATGGGG AACATGGATC GGCATCACTA CGAGACCTTT 1380
GAGAAGTTCG GGAATGAGAC CTTCATCATC CACTTGGACA ACGGGCGCGG GTTTGGGAAA 1440
TACTCACACG ATGAGCTTTC CATTCTCGCT CCTCTTCATC AGTGCTGCAG GATCAGGAGG 1500
TCCACCTACC TGAGACTGCA GCTGCTGGCC AAAGAGGAAC ACAAACTGAG CCTGCTGATG 1560
GCCGAGTCCC TGCAGCATGA CAAGGTGGCA CCCGTGCTCT ACCAGCTGCA TCTGGAGGCC 1620
CTGGACCGGC GGTTGCGCAT AGTGCTGCAG GCTGTGCGAG ACTGTGTGGA GAAGGACGGG 1680
CTGAGCAGTG TGGTGGAGGA CGACCTAGCC ACTGAGCACA GAGCCTCCAC GGAGAGGTAG 1740
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
KeywordBiomineralization; Calcium; Complete proteome; Glycoprotein; Kinase; Manganese; Metal-binding; Reference proteome; Secreted; Serine/threonine-protein kinase; Signal; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00469
EKS-ANC-00488
EKS-BOT-00504
EKS-CAE-00441
EKS-CAJ-00513
EKS-CAF-00494
EKS-CAP-00530
EKS-DAR-00927
EKS-DRM-00236
EKS-EQC-00487
EKS-FEC-00482
EKS-GAM-00303
EKS-GAG-00413
EKS-HOS-00504
EKS-ICT-00476
EKS-LAC-00509
EKS-LOA-00504
EKS-MAM-00497
EKS-MEG-00402
EKS-MOD-00486
EKS-MUP-00491
EKS-NOL-00452
EKS-OCP-00145
EKS-ORN-00634
EKS-ORA-00431
EKS-ORC-00471
EKS-ORL-00579
EKS-OTG-00510
EKS-PES-00437
EKS-PTV-00193
EKS-RAN-00519
EKS-SAH-00470
EKS-TAG-00564
EKS-TAR-00625
EKS-TEN-00625
EKS-XET-00654
EKS-XIM-00621
Gene Ontology
GO:0005615; C:extracellular space
GO:0005509; F:calcium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0097187; P:dentinogenesis
GO:0070166; P:enamel mineralization
GO:0071895; P:odontoblast differentiation
GO:0036179; P:osteoclast maturation
GO:0030501; P:positive regulation of bone mineralization
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0051174; P:regulation of phosphorus metabolic process
GO:0001501; P:skeletal system development
KEGG
mmu:80752;
InterPros
IPR009581; DUF1193.
IPR024869; FAM20.
Pfam
PF06702; DUF1193; 1.
SMARTs
Prosites
Prints
Created Date20-Feb-2013