EPS-MUM-00112

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00112

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PRL	161.3	9.8E-48	82	148	67

Status

Reviewed

Ensembl Protein

ENSMUSP00000027232

UniProt Accession

Q63739; O09097; O09154; Q3UFU9;

Protein Name

Protein tyrosine phosphatase type IVA 1

Protein Synonyms/Alias

Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1;

Gene Name

Ptp4a1

Gene Synonyms/Alias

Ptp4a1; Prl1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000026064	ENSMUSP00000110861	ENSMUST00000076587
ENSMUSG00000026064	ENSMUSP00000136128	ENSMUST00000178652
ENSMUSG00000026064	ENSMUSP00000027232	ENSMUST00000027232

Organism

Mus musculus

Functional Description

Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).

Protein Length

173

Protein Sequence
(FASTA)

MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK 60

EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI 120

EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ 173

Nucleotide Sequence
(FASTA)

ATGGCTCGAA TGAACCGCCC TGCTCCTGTG GAAGTCACAT ACAAGAACAT GCGATTTCTT 60

ATTACACACA ATCCAACCAA TGCGACCTTA AACAAATTTA TAGAGGAACT TAAGAAGTAT 120

GGAGTTACCA CAATAGTAAG AGTATGTGAA GCAACTTACG ACACTACTCT TGTGGAGAAA 180

GAAGGCATTC ATGTTCTTGA CTGGCCTTTT GATGATGGTG CACCACCATC CAACCAGATT 240

GTCGATGACT GGCTAAGTCT TGTGAAGATT AAGTTTCGTG AAGAACCTGG TTGCTGTATT 300

GCTGTCCATT GTGTCGCAGG CCTTGGCAGA GCTCCGGTGC TTGTTGCCCT AGCATTAATT 360

GAAGGTGGAA TGAAATATGA AGATGCAGTA CAATTCATAA GACAAAAGCG GCGTGGAGCT 420

TTTAACAGCA AGCAACTTTT GTATCTGGAG AAGTACCGTC CGAAAATGCG GCTCCGCTTC 480

AAGGATTCCA ATGGTCATAG AAACAACTGT TGTATTCAAT AA 522

Domain Profile

S: 1     ddwlslvkikfreepGsciavhcvaGlGrapvlvalaliesGmkyedavqfirqkrrGai  60

         ddwlslvkikfreepG+ciavhcvaGlGrapvlvalalie+GmkyedavqfirqkrrGa+

Q: 82    DDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAF  141

         8***********************************************************

S: 61    nskqlly  67

         nskqlly

Q: 142   NSKQLLY  148

         ******9

Domain Sequence
(FASTA)

DDWLSLVKIK FREEPGCCIA VHCVAGLGRA PVLVALALIE GGMKYEDAVQ FIRQKRRGAF 60

NSKQLLY 67

Keyword

Cell cycle; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Disulfide bond; Endoplasmic reticulum; Endosome; Hydrolase; Lipoprotein; Membrane; Methylation; Prenylation; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005769	; C:early endosome
GO:0005783	; C:endoplasmic reticulum
GO:0005768	; C:endosome
GO:0009898	; C:internal side of plasma membrane
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005819	; C:spindle
GO:0004727	; F:prenylated protein tyrosine phosphatase activity
GO:0007049	; P:cell cycle
GO:0007275	; P:multicellular organismal development
GO:0030335	; P:positive regulation of cell migration

KEGG

mmu:100044742	;
mmu:19243	;

InterPros

IPR000387	; Tyr/Dual-specificity_Pase.
IPR000242	; Tyr_Pase_rcpt/non-rcpt.

Pfam

PF00102

; Y_phosphatase; 1.

SMARTs

Prosites

PS00383	; TYR_PHOSPHATASE_1; FALSE_NEG.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50055	; TYR_PHOSPHATASE_PTP; FALSE_NEG.

Prints

Created Date

20-Feb-2013