EKS-MUM-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	437.1	4.8E-131	35	293	259

Status

Reviewed

Ensembl Protein

ENSMUSP00000027263

UniProt Accession

Q8BG48; Q3TNG7; Q8BLV9; Q923E7;

Protein Name

Serine/threonine-protein kinase 17B

Protein Synonyms/Alias

DAP kinase-related apoptosis-inducing protein kinase 2;

Gene Name

Stk17b

Gene Synonyms/Alias

Stk17b; Drak2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000026094	ENSMUSP00000027263	ENSMUST00000027263

Organism

Mus musculus

Functional Description

Acts as a positive regulator of apoptosis.Phosphorylates myosin light chains (By similarity).

Protein Length

372

Protein Sequence
(FASTA)

MSRRRFDCRS VSGLLTTTPQ TPIKTENFNN FYTLTPKELG RGKFAVVRQC ISKSTGQEYA 60

AKSLKKRRRG QDCRAEILHE IAVLELARSC PHVINLHEVY ENATEIILVL EYAAGGEIFN 120

LCLPELAEMV SENDVIRLIK QILEGVHYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF 180

GMSRKIGNAS ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN 240

QETYLNISQV NVDYSEEMFS SVSQLATDFI QSLLVKNPEK RPTAESCLSH SWLQQWDFGS 300

LFHPEETSGS SQIQDLTLRS SEEKTSKSSC NGSCGAREDK ENIPEDGSLV SKRFRFDDSL 360

PSPHELVPDL FC 372

Nucleotide Sequence
(FASTA)

ATGTCTCGGA GGAGATTCGA TTGCCGAAGT GTCTCAGGCT TGCTAACTAC AACCCCTCAA 60

ACGCCGATTA AAACAGAGAA TTTTAATAAT TTCTATACTC TTACCCCAAA AGAACTTGGG 120

AGAGGAAAAT TTGCTGTGGT TAGACAATGT ATATCAAAAT CAACTGGACA AGAGTATGCT 180

GCCAAATCCC TGAAAAAGAG GAGAAGAGGG CAGGATTGCC GGGCGGAAAT TCTGCATGAG 240

ATAGCTGTGC TGGAGCTGGC CAGGTCTTGT CCCCACGTGA TTAATCTGCA TGAGGTCTAC 300

GAAAATGCAA CGGAAATCAT TTTGGTGTTA GAATATGCTG CGGGTGGAGA AATTTTCAAC 360

CTGTGTTTAC CTGAGTTAGC CGAAATGGTA TCTGAAAATG ATGTTATCAG ACTCATTAAA 420

CAAATCCTTG AAGGAGTTCA TTATCTACAT CAGAATAACA TTGTTCACCT TGATTTAAAG 480

CCACAGAATA TACTTTTGAG CAGTATATAC CCACTCGGGG ACATAAAAAT TGTAGATTTT 540

GGAATGTCTC GAAAAATTGG GAATGCAAGT GAGCTTCGGG AAATCATGGG AACACCTGAA 600

TACTTAGCTC CAGAAATCCT CAACTATGAT CCCATTACCA CAGCAACAGA TATGTGGAAT 660

ATTGGCATAA TAGCGTATAT GTTGTTAACT CATACATCAC CATTTGTAGG AGAAGATAAT 720

CAAGAAACAT ATCTGAATAT TTCTCAAGTG AATGTAGATT ATTCAGAAGA AATGTTTTCA 780

TCAGTTTCAC AGCTGGCCAC AGACTTCATC CAGAGCCTTC TAGTAAAGAA CCCAGAGAAA 840

AGACCAACAG CAGAATCCTG CCTATCCCAC TCATGGCTGC AGCAGTGGGA CTTTGGAAGC 900

TTGTTTCATC CTGAGGAAAC TTCAGGCTCC TCTCAAATTC AGGATCTGAC TCTCAGGTCC 960

TCTGAAGAGA AGACCTCCAA GTCCTCCTGT AATGGGAGCT GTGGAGCCCG GGAGGACAAG 1020

GAGAACATCC CTGAAGATGG CAGCTTAGTT TCTAAAAGAT TTCGATTCGA TGACTCCTTG 1080

CCCAGCCCCC ATGAACTTGT TCCAGATTTG TTCTGTTAG 1119

Domain Profile

S: 3     tgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirse  62

         t kelg+Gkfavvr+c++kstG+eyaak lkkrr    r++++r+ei +e+avl+++rs+

Q: 35    TPKELGRGKFAVVRQCISKSTGQEYAAKSLKKRR----RGQDCRAEILHEIAVLELARSC  90

         679*******************************....**********************

S: 63    pnvinlhevyenksdvililelvaGGelfd..llaekeslseeeatellkqilegvkylh  120

         p+vinlhevyen++++il+le++aGGe+f+  l + +e++se+++++l+kqilegv+ylh

Q: 91    PHVINLHEVYENATEIILVLEYAAGGEIFNlcLPELAEMVSENDVIRLIKQILEGVHYLH  150

         ******************************877899************************

S: 121   skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny  180

         +++ivhldlkP+nill++ + p gdik++dfG+srki +++el+ei+GtPe++aPei+ny

Q: 151   QNNIVHLDLKPQNILLSSIY-PLGDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILNY  209

         ********************.***************************************

S: 181   eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf  240

         +p++++tdmw+iG+i+y+ll+++sPf+G+++qet+lnis+vn+d+see+fssvs+la+df

Q: 210   DPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDF  269

         ************************************************************

S: 241   irrllvkdpekrltieeclehswl  264

         i++llvk+pekr t+e+cl+hswl

Q: 270   IQSLLVKNPEKRPTAESCLSHSWL  293

         ***********************7

Domain Sequence
(FASTA)

TPKELGRGKF AVVRQCISKS TGQEYAAKSL KKRRRGQDCR AEILHEIAVL ELARSCPHVI 60

NLHEVYENAT EIILVLEYAA GGEIFNLCLP ELAEMVSEND VIRLIKQILE GVHYLHQNNI 120

VHLDLKPQNI LLSSIYPLGD IKIVDFGMSR KIGNASELRE IMGTPEYLAP EILNYDPITT 180

ATDMWNIGII AYMLLTHTSP FVGEDNQETY LNISQVNVDY SEEMFSSVSQ LATDFIQSLL 240

VKNPEKRPTA ESCLSHSWL 259

Keyword

Apoptosis; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005793	; C:endoplasmic reticulum-Golgi intermediate compartment
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

mmu:98267

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013