| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00121 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/NAK | 330.8 | 1.6E-98 | 22 | 290 | 269 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000027401 |
| UniProt Accession | O88697; Q3UEG5; Q9JMJ0; Q9JMJ1; Q9QX00; |
| Protein Name | Serine/threonine-protein kinase 16 |
| Protein Synonyms/Alias | Embryo-derived protein kinase; Edpk; Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK; Protein kinase Krct; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16; |
| Gene Name | Stk16 |
| Gene Synonyms/Alias | Stk16; Edpk, Krct, Mpsk1, Pkl12, Tsf1; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Membrane-associated protein kinase that phosphorylateson serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. |
| Protein Length | 305 |
Protein Sequence
(FASTA) | | MGHALCVCSR GTVIIDNKRY LFVQKLGEGG FSYVDLVEGL HDGHFYALKR ILCHEQQDQE 60 | | EAQREAEMHR LFQHPNILRL MAYSLKERGA KHEAWLLLPF FKKGTLWNEI ERLKDQGSFL 120 | | TEDQILPLLL GISRGLEAIH AKGYAHRDLK PTNILLGDEG QPVLMDLGSM NQACIQVEGS 180 | | RQALALQDWA AQRCTISYRA PELFSVQSHC VIDERTDVWS LGCVLYAMMF GEGPYDMVFQ 240 | | KGDSVALAVQ NELSIPQSPR HSSALRQLLS SMMTVDPQQR PHIPVLLSQL EALQPPAPGQ 300 | | HTTQI 305 |
|
Nucleotide Sequence
(FASTA) | | ATGGGCCACG CACTGTGTGT CTGCTCCCGG GGAACTGTCA TCATTGACAA TAAGCGTTAC 60 | | CTCTTCGTCC AGAAATTGGG GGAAGGTGGA TTCAGCTATG TGGACCTAGT GGAGGGCTTG 120 | | CATGATGGAC ACTTCTACGC CCTGAAGCGG ATCCTGTGCC ATGAGCAGCA AGACCAGGAA 180 | | GAAGCCCAAC GAGAGGCAGA GATGCATCGC CTCTTCCAGC ATCCCAACAT CCTTCGCCTC 240 | | ATGGCTTACT CTCTGAAAGA ACGAGGTGCT AAGCATGAAG CCTGGCTGCT GCTGCCCTTC 300 | | TTCAAGAAAG GTACACTGTG GAATGAGATA GAAAGGCTGA AGGACCAAGG CAGCTTCCTG 360 | | ACTGAAGACC AGATCCTGCC GCTGTTGCTG GGTATCAGCA GAGGCCTTGA GGCTATTCAT 420 | | GCCAAAGGTT ATGCACACAG GGACCTGAAG CCCACCAATA TTTTGCTTGG TGATGAGGGG 480 | | CAGCCAGTTT TAATGGACTT GGGTTCTATG AATCAAGCAT GCATTCAAGT GGAGGGCTCT 540 | | CGCCAGGCAC TAGCTCTTCA GGACTGGGCA GCTCAGCGGT GCACCATCTC CTACCGGGCA 600 | | CCTGAACTTT TTTCTGTGCA AAGCCACTGT GTCATCGATG AGCGGACTGA TGTCTGGTCC 660 | | CTAGGCTGTG TGCTTTATGC CATGATGTTT GGGGAAGGCC CTTACGATAT GGTGTTCCAG 720 | | AAGGGTGACA GTGTGGCCCT TGCTGTGCAG AATGAACTCA GCATCCCACA AAGCCCCAGG 780 | | CATTCTTCAG CATTGCGACA GCTATTGTCT TCTATGATGA CTGTGGACCC CCAGCAGAGG 840 | | CCTCACATCC CTGTCCTCCT CAGTCAGTTG GAGGCATTGC AGCCACCAGC TCCTGGCCAG 900 | | CACACCACCC AAATCTGA 918 |
|
| Domain Profile | S: 3 iekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivkl 62 | + ++l+eGGf++v+l+e++++g+ yalKril++e++d+ee++rE+e+++ ++ h+ni++l | Q: 22 FVQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDQEEAQREAEMHRLFQ-HPNILRL 80 | 6799************************************************.******* |
| S: 63 vdssvkeekdngskevlllleyckkgslvdllnkrlekge.lseaeilkilldvtravaa 121 | +++s+ke+ + ++e++lll+++kkg+l++ +++ +++g+ l+e++il +ll+++r+++a | Q: 81 MAYSLKERGA--KHEAWLLLPFFKKGTLWNEIERLKDQGSfLTEDQILPLLLGISRGLEA 138 | ********99..9*********************************************** |
| S: 122 lHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeieknttl 181 | +H +++++HRDlk++Nill deg++vl+DlGS+++a+++ve+++++ alq+++++++t+ | Q: 139 IH--AKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIQVEGSRQALALQDWAAQRCTI 196 | **..99****************************************************** |
| S: 182 syrsPElidlysnlvideksDiWaLGcllYklcffesPf......eesvklailngkysi 235 | syr+PEl++++s++vide++D+W+LGc+lY+++f+e P+ ++sv+la++n ++si | Q: 197 SYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYdmvfqkGDSVALAVQN-ELSI 255 | *******************************************************.**** |
| S: 236 PensryseklkslikkmlevdpeeRptiaqvlell 270 | P+++r+s++l++l+++m++vdp++Rp+i +l++l | Q: 256 PQSPRHSSALRQLLSSMMTVDPQQRPHIPVLLSQL 290 | *****************************999875 |
|
Domain Sequence
(FASTA) | | FVQKLGEGGF SYVDLVEGLH DGHFYALKRI LCHEQQDQEE AQREAEMHRL FQHPNILRLM 60 | | AYSLKERGAK HEAWLLLPFF KKGTLWNEIE RLKDQGSFLT EDQILPLLLG ISRGLEAIHA 120 | | KGYAHRDLKP TNILLGDEGQ PVLMDLGSMN QACIQVEGSR QALALQDWAA QRCTISYRAP 180 | | ELFSVQSHCV IDERTDVWSL GCVLYAMMFG EGPYDMVFQK GDSVALAVQN ELSIPQSPRH 240 | | SSALRQLLSS MMTVDPQQRP HIPVLLSQL 269 |
|
| Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |