EKS-MUM-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUM-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trio	368.9	3.4E-110	1606	1859	254

Status

Reviewed

Ensembl Protein

ENSMUSP00000084361

UniProt Accession

Q62407; Q3TPH8; Q6P5V1; Q80TF7; Q80ZN0; Q8BZF4; Q9EQJ5;

Protein Name

Striated muscle-specific serine/threonine-protein kinase

Protein Synonyms/Alias

Aortic preferentially expressed protein 1; APEG-1;

Gene Name

Speg

Gene Synonyms/Alias

Speg; Apeg1, Kiaa1297;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000026207	ENSMUSP00000121825	ENSMUST00000132228
ENSMUSG00000026207	ENSMUSP00000113646	ENSMUST00000122266
ENSMUSG00000026207	ENSMUSP00000109217	ENSMUST00000113587
ENSMUSG00000026207	ENSMUSP00000119969	ENSMUST00000125306
ENSMUSG00000026207	ENSMUSP00000116953	ENSMUST00000148515
ENSMUSG00000026207	ENSMUSP00000084361	ENSMUST00000087122
ENSMUSG00000026207	ENSMUSP00000109219	ENSMUST00000113589
ENSMUSG00000026207	ENSMUSP00000109218	ENSMUST00000113588
ENSMUSG00000026207	ENSMUSP00000109220	ENSMUST00000113590

Organism

Mus musculus

Functional Description

Isoform 3 may have a role in regulating the growth anddifferentiation of arterial smooth muscle cells.

Protein Length

3262

Protein Sequence
(FASTA)

MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGD GAGAPVFLRP LKNAAVCAGS 60

DVRLRVVVSG TPQPSLSWFR DGQLLPPPAP EPSCLWLRSC GAQDAGVYSC SAQNERGQAS 120

CEAVLTVLEV RDSETAEDDI SDVPGTQRLE LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT 180

GTSEEQVSWW GSGQTVLEQE AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL 240

VGASWGSEDS LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LHREEPDLQP QPASDALRPR 300

PALPPPSKSA LLPPPSPRVG KRALPGPSTQ PPATPTSPHR RAQEPSLPED ITTTEEKRGK 360

KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA GSRILDKLQF FEERRRSLER 420

SDSPPAPLRP WVPLRKARSL EQPKSEGGAA WGTPEASQEE LRSPRGSVAE RRRLFQQKAA 480

SLDERTRQRS ATSDLELRFA QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL 540

FSRPSTPKTS RAVSPAATQP PPPSGAGKSG DEPGRPRSRG PVGRTEPGEG PQQEIKRRDQ 600

FPLTRSRAIQ ECRSPVPPYT ADPPESRTKA PSGRKREPPA QAVRFLPWAT PGVEDSVLPQ 660

TLEKNRAGPE AEKRLRRGPE EDGPWGPWDR RGTRSQGKGR RARPTSPELE SSDDSYVSAG 720

EEPLEAPVFE IPLQNMVVAP GADVLLKCII TANPPPQVSW KKDGSMLHSE GRLLIRAEGE 780

RHTLLLREAQ AADAGSYTAT ATNELGQATC ASSLAVRPGG STSPFSSPIT SDEEYLSPPE 840

EFPEPGETWP RTPTMKLSPS QDHDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE 900

PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV NEYGARQCEA 960

RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA DVEVDWLCRG RLLQPALLKC 1020

KMHFDGRKCK LLLTSVHEDD SGVYTCKLST AKDELTCSAR LTVRPSLAPL FTRLLEDVEV 1080

LEGRAARLDC KISGTPPPSV TWTHFGHPVN EGDNLRLQQD GGLHSLHIAR VGSEDEGLYE 1140

VSATNTHGQA HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ 1200

DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL VFPAVGPQHA 1260

GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPEVVAVT GRMVTLSWNP PRSLDMAIDP 1320

DSLTYTVQHQ VLGSDQWTAL VTGLREPAWA ATGLKKGIQH IFRVLSSSGK SSSKPSAPSE 1380

PVQLLEHGPP LEEAPAVLDK QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEARTG 1440

VYELSQPDDD QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SVTLELAEAP RFESIMEDVE 1500

VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVLL SAGSQDGGVY 1560

TCTARNLAGE VSCKAELSVL SAQTAMEVEG VGEDEEHRGR RLSDYYDIHQ EIGRGAFSYL 1620

RRVVERSSGL EFAAKFIPSQ AKPKASARRE ARLLARLQHG CVLYFHEAFE RRRGLVIVTE 1680

LCTEELLERM ARKPTVCESE TRTYMRQVLE GICYLHQSHV LHLDVKPENL LVWDGAGGEE 1740

QVRICDFGNA QELTPGEPQY CQYGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS 1800

PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA EETLEHPWFK 1860

TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE LLRAPPERVW VAMPRRQPPS 1920

GGLSSSSDSE EEELEELPSV PRPLQPEFSG SRVSLTDIPT EDEALGTPEA GAATPMDWQE 1980

QERTPSKDQE APSPEALPSP GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA 2040

ASVELPQRRS PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL 2100

GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA GAPLEIPVAR 2160

LGARRLQESP SLSALSETQP PSPARPSVPK LSITKSPEPS AVTSRDSPQP PEPQPVPEKV 2220

PEPKPEPVRA AKPAQPPLAL QMPTQPLTPY AQIMQSLQLS SPTLSPQDPA VPPSEPKPHA 2280

AVFARVASPP PGVSEKRVPS ARTPPVLAEK ARVPTVPPRP GSSLSGSIEN LESEAVFEAK 2340

FKRSRESPLS RGLRLLSRSR SEERGPFRGA EDDGIYRPSP AGTPLELVRR PERSRSVQDL 2400

RVAGEPGLVR RLSLSLSQKL RRTPPGQRHP AWESRSGDGE SSEGGSSARA SPVLAVRRRL 2460

SSTLERLSSR LQRSGSSEDS GGASGRSTPL FGRLRRATSE GESLRRLGVP HNQLGSQTGA 2520

TTPSAESLGS EASGTSGSSA PGESRSRHRW GLSRLRKDKG LSQPNLSSSV QEDLGHQYVP 2580

SESDFPPVFH IKLKDQVLLE GEAATLLCLP AACPAPRISW MKDKQSLRSE PSVVIVSCKD 2640

GRQLLSIPRA GKRHAGLYEC SATNVLGSIT SSCTVAVARI PGKLAPPEVP QTYHDTALVV 2700

WKPGDGRAPC TYTLERRVDG ESVWHPVSSG IPDCYYNVTQ LPVGVTVRFR VACSNRAGQG 2760

PFSNPSEKVF IRGTPDSPAQ PAAAPRDAPV TSGPTRAPPP DSPTSLAPTP ALAPPASQAS 2820

TLSPSTSSMS ANQALSSLKA VGPPPATPPR KHRGLLATQQ AEPSPPSIVV TPSEPRSFVP 2880

DTGTLTPTSS PQGVKPAPSS TSLYMVTSFV SAPPAPQAPA PEPPPEPTKV TVRSLSPAKE 2940

VVSSPTPEST TLRQGPPQKP YTFLEEKARG RFGVVRSCRE NATGRTFVAK IVPYAAEGKR 3000

RVLQEYEVLR TLHHERLMSL HEAYITPRYL VLIAESCGNR ELLCGLSDRF RYSEDDVATY 3060

VVQLLQGLDY LHGHHVLHLD IKPDNLLLAA DNALKIVDFG SAQPYNPQAL KPLGHRTGTL 3120

EFMAPEMVKG DPIGSATDIW GAGVLTYIML SGYSPFYEPD PQETEARIVG GRFDAFQLYP 3180

NTSQSATLFL RKVLSVHPWS RPSLQDCLAH PWLQDAYLMK LRRQTLTFTT NRLKEFLGEQ 3240

RRRRAEAATR HKVLLRSYPG SP 3262

Nucleotide Sequence
(FASTA)

ATGCAGAAAG CCCGGGGCAC GCGAGGCGAG GACGCCGGCA CGAGGGCACC TCCTAGCCCC 60

GGGGTGCCCC CGAAGAGAGC CAAGGTGGGG GCCGGCAGAG GGGTCCTCGT CACCGGGGAT 120

GGGGCCGGGG CGCCGGTCTT CCTGCGGCCC CTGAAGAACG CGGCGGTGTG TGCGGGCAGT 180

GATGTAAGGC TGCGGGTAGT AGTGAGCGGG ACACCCCAGC CTAGCCTCAG CTGGTTCCGG 240

GATGGGCAGC TCCTGCCTCC ACCGGCCCCA GAGCCCAGCT GCCTGTGGCT GCGGAGCTGC 300

GGGGCTCAGG ACGCCGGCGT GTACAGCTGC AGCGCCCAGA ATGAGCGGGG CCAGGCCTCC 360

TGTGAGGCAG TGCTCACAGT GCTGGAGGTC AGAGACTCGG AGACTGCCGA GGATGACATC 420

AGCGATGTGC CGGGGACCCA GCGCCTGGAG CTTCGGGATG ACAGGGCCTT CAGCACCCCC 480

ACGGGGGGCT CTGATACCCT GGTGGGTACC TCCCTGGACA CACCCCCGAC CTCCGTGACA 540

GGCACCTCAG AGGAGCAAGT GAGCTGGTGG GGCAGCGGGC AGACGGTCCT GGAGCAGGAA 600

GCGGGCAGCG GGGGTGGCAC CCGCCCCCTC CCAGGCAGCC CAAGGCAAGC ACAGACAACC 660

GGGGCCGGGC CACGGCACCT GGGGGTGGAG CCGCTGGTGC GGGCATCGCG AGCTAATCTG 720

GTGGGCGCAA GCTGGGGGTC AGAGGATAGC CTTTCGGTGG CCAGTGACCT CTATGGCAGC 780

GCGTTCAGTC TGTACAGAGG ACGGGCGCTC TCGATCCACG TCAGCATTCC TCCGAGTGGA 840

TTGCACAGAG AGGAGCCTGA CCTTCAGCCT CAGCCAGCCA GTGATGCCCT TCGTCCACGC 900

CCTGCCCTTC CACCTCCCTC CAAATCCGCT TTGCTTCCCC CACCATCTCC TCGGGTGGGA 960

AAGAGGGCTC TGCCAGGACC TAGTACCCAG CCCCCAGCTA CTCCCACTTC GCCCCATCGG 1020

CGTGCTCAGG AGCCCTCGCT GCCTGAGGAC ATCACCACCA CGGAAGAGAA GCGAGGGAAA 1080

AAGCCCAAGT CATCCGGGCC GTCGCTGGCG GGCACAGTGG AGTCCCGGCC CCAGACGCCA 1140

CTGAGCGAGG CTTCGGGTCG CCTGTCAGCA TTGGGCCGCT CGCCCCGGCT GGTGCGCGCG 1200

GGGTCCCGCA TCCTGGACAA GCTACAGTTC TTCGAAGAGC GGCGACGCAG CCTGGAGCGC 1260

AGCGACTCGC CGCCAGCGCC CCTGCGGCCC TGGGTGCCCC TGCGCAAGGC TCGCTCGCTG 1320

GAGCAGCCGA AGTCCGAGGG CGGTGCGGCG TGGGGCACAC CCGAGGCCTC GCAGGAGGAG 1380

CTGCGGTCAC CTCGGGGCAG TGTGGCAGAG CGGCGTCGCC TGTTCCAGCA AAAGGCGGCC 1440

TCGTTGGATG AACGCACGCG ACAACGCAGT GCAACCTCGG ACCTCGAACT CCGCTTCGCC 1500

CAGGAGCTGG GTCGCATCCG CCGATCTACG TCGCGGGAGG AGCTGGTGCG TTCGCACGAG 1560

TCCCTGCGTG CCACGCTGCA GCGCGCCCCA TCCCCTCGGG AGCCCGGCGA GCCCCCACTC 1620

TTCTCCCGGC CTTCCACACC CAAGACCTCA CGGGCTGTGA GCCCGGCTGC CACCCAGCCG 1680

CCGCCTCCTA GTGGTGCGGG CAAATCTGGG GACGAGCCTG GGAGGCCCCG AAGCAGAGGG 1740

CCGGTGGGCA GGACTGAACC GGGGGAAGGC CCGCAGCAGG AGATCAAGCG TCGGGACCAA 1800

TTCCCGCTAA CCAGGAGCAG AGCCATCCAG GAGTGCAGGA GCCCTGTGCC GCCCTACACC 1860

GCGGATCCCC CGGAGAGCAG GACAAAAGCC CCCTCCGGTC GCAAGCGGGA ACCCCCTGCT 1920

CAAGCGGTGC GCTTTCTGCC CTGGGCCACT CCGGGAGTGG AGGACTCTGT TCTGCCCCAA 1980

ACCTTGGAGA AGAATAGAGC GGGACCCGAG GCTGAGAAGA GGCTTCGCAG AGGACCTGAG 2040

GAGGATGGCC CCTGGGGGCC CTGGGACCGC AGAGGGACCC GCAGCCAAGG CAAAGGTCGC 2100

CGTGCTCGGC CTACTTCCCC CGAGCTCGAG TCCTCAGACG ACTCCTATGT GTCCGCTGGG 2160

GAAGAGCCCC TGGAGGCACC CGTGTTTGAG ATCCCTCTGC AGAATATGGT GGTGGCGCCA 2220

GGAGCTGACG TGCTACTTAA GTGTATCATC ACCGCCAACC CCCCACCCCA AGTGTCCTGG 2280

AAAAAGGATG GGTCCATGTT GCACAGCGAG GGTCGTCTTC TCATCCGGGC TGAAGGTGAA 2340

CGGCACACAC TGCTGCTCAG AGAGGCCCAG GCTGCCGATG CTGGGAGCTA CACAGCCACT 2400

GCCACCAACG AACTGGGCCA AGCTACCTGT GCTTCTTCAC TGGCTGTGAG ACCTGGCGGC 2460

TCCACATCCC CTTTCAGCAG CCCCATCACC TCTGATGAGG AGTACCTGAG CCCCCCAGAG 2520

GAGTTCCCAG AGCCTGGGGA GACCTGGCCC CGAACCCCTA CCATGAAGCT CAGTCCCAGC 2580

CAGGATCATG ATTCCTCCGA CTCTTCTTCC AAGGCACCCC CAACGTTCAA GGTCTCACTC 2640

ATGGACCAAT CGGTGAGAGA AGGTCAAGAT GTCATTATGA GCATCCGTGT GCAGGGAGAG 2700

CCCAAGCCTG TGGTTTCCTG GCTGAGGAAT CGACAGCCCG TGCGCCCAGA CCAGCGGCGC 2760

TTTGCAGAGG AGGCCGAGGG TGGGCTCTGC CGCTTGAGGA TCCTGGCTGC TGAACGGGGC 2820

GATGCTGGTT TCTACACATG CAAGGCGGTC AACGAATATG GCGCTCGGCA GTGCGAGGCC 2880

CGCCTGGAGG TCCGAGCACA CCCTGAAAGC CGGTCCCTGG CCGTGCTGGC CCCCCTGCAG 2940

GACGTGGACG TGGGGGCCGG GGAGATGGCG CTGTTTGAGT GCCTGGTGGC AGGTCCAGCT 3000

GACGTCGAGG TGGACTGGCT GTGCCGGGGC CGCCTGCTGC AGCCTGCGCT GCTCAAATGC 3060

AAGATGCATT TTGATGGCCG CAAGTGCAAG CTGCTGCTCA CCTCTGTGCA CGAGGACGAC 3120

AGTGGTGTCT ACACCTGCAA GCTGAGCACA GCCAAAGATG AACTGACCTG CAGTGCCCGG 3180

CTGACGGTTC GGCCGTCGCT GGCGCCTCTC TTCACCCGGT TGCTGGAAGA TGTGGAGGTG 3240

TTGGAAGGCC GTGCTGCCCG CTTGGATTGC AAGATCAGCG GTACCCCGCC TCCCTCCGTT 3300

ACCTGGACTC ATTTTGGCCA CCCCGTGAAT GAGGGTGACA ACTTGCGGCT TCAACAGGAT 3360

GGAGGTCTAC ACTCACTGCA CATTGCCCGG GTGGGCAGTG AGGACGAAGG ACTCTATGAA 3420

GTCAGTGCCA CCAACACTCA TGGCCAGGCC CACTGCTCCG CCCAGCTGTA TGTGGAGGAG 3480

CCTCGGACAG CTGCCTCTGG CCCCAGCTCG AAGCTGGAGA AGATGCCATC TATCCCTGAG 3540

GAGCCGGAGC ACGGAGATCT AGAGAGGCTG TCTATTCCTG ACTTCCTACG GCCACTGCAA 3600

GATCTGGAAG TGGGACTAGC TAAGGAGGCC ATGCTGGAGT GCCAAGTGAC CGGCCTGCCC 3660

TATCCCACCA TCAGCTGGTT CCACAATGGC CACCGCATTC AAAGCAGTGA CGACCGACGC 3720

ATGACACAGT ACAGGGACAT ACATCGCCTG GTGTTCCCAG CTGTGGGGCC TCAGCATGCT 3780

GGTGTCTATA AGAGTGTAAT CGCCAACAAG CTGGGCAAAG CGGCCTGCTA CGCCCATCTC 3840

TATGTCACAG ATGTGGTTCC AGGCCCTCCA GATGGTGCTC CGGAAGTAGT AGCTGTGACC 3900

GGAAGGATGG TCACACTATC GTGGAACCCA CCCAGGAGTC TGGACATGGC TATTGACCCA 3960

GATTCCCTAA CATACACTGT GCAGCACCAG GTGTTGGGCT CGGACCAGTG GACGGCACTG 4020

GTCACAGGCC TGCGGGAGCC TGCGTGGGCA GCCACAGGGC TGAAGAAGGG GATCCAGCAC 4080

ATCTTCCGGG TCCTCAGCTC CAGTGGCAAG AGCAGCAGCA AGCCCTCAGC ACCGTCGGAA 4140

CCCGTGCAGC TGCTAGAGCA TGGCCCACCC CTGGAAGAGG CGCCTGCTGT GCTGGACAAG 4200

CAGGACATTG TGTATGTGGT AGAGGGCCAG CCTGCCTGTG TCACCGTCAC TTTTAACCAT 4260

GTGGAGGCCC AGGTTGTCTG GAGGAGCTGC CGGGGAGCCC TCCTCGAGGC GCGCACAGGT 4320

GTGTATGAAC TGAGTCAGCC AGATGACGAC CAGTATTGTC TGCGGATCTG CCGGGTGAGC 4380

CGACGAGACC TGGGACCCCT TACTTGCAGT GCCCGAAACC GCCACGGCAC AAAGGCCTGC 4440

TCGGTCACCC TGGAGCTGGC AGAGGCACCT CGGTTTGAGT CTATCATGGA AGATGTGGAG 4500

GTGGGGCCTG GAGAAACCGC TCGCTTTGCT GTGGTAGTTG AGGGGAAACC ACTGCCAGAC 4560

ATCATGTGGT ACAAGGATGA GGTGCTGCTG GCCGAGAGCA ACCATGTGAG CTTCGTGTAT 4620

GAGGAGAACG AGTGTTCCCT AGTGCTGCTC AGCGCAGGAA GCCAGGATGG AGGCGTCTAT 4680

ACCTGTACCG CCCGGAACCT GGCAGGCGAA GTCTCCTGCA AGGCGGAGCT GTCTGTGCTT 4740

TCAGCTCAGA CAGCCATGGA GGTCGAGGGG GTCGGAGAGG ATGAGGAACA CCGAGGAAGA 4800

AGACTTAGCG ACTACTACGA CATCCACCAA GAGATTGGCA GGGGTGCCTT CTCCTACCTG 4860

CGGCGTGTAG TGGAGAGGAG CTCTGGCCTG GAGTTTGCAG CCAAGTTCAT CCCTAGCCAG 4920

GCTAAGCCTA AAGCATCAGC AAGACGCGAG GCGCGCTTGC TGGCCCGGCT CCAGCATGGC 4980

TGTGTGCTCT ACTTCCACGA AGCCTTTGAG AGGCGCAGGG GACTTGTCAT AGTCACGGAG 5040

CTCTGCACAG AAGAGCTTCT AGAGCGCATG GCCAGGAAGC CCACCGTGTG TGAGTCTGAG 5100

ACTCGGACCT ATATGCGTCA AGTGCTAGAG GGGATATGCT ATCTGCATCA GAGCCATGTG 5160

CTGCACCTGG ATGTCAAGCC GGAGAACCTG CTTGTGTGGG ATGGTGCAGG GGGTGAAGAG 5220

CAGGTGCGCA TCTGTGACTT CGGGAACGCC CAGGAACTCA CTCCGGGAGA GCCCCAGTAC 5280

TGTCAGTATG GCACGCCAGA GTTTGTAGCA CCTGAGATTG TCAACCAGAG CCCTGTGTCT 5340

GGAGTCACTG ACATCTGGCC CGTGGGCGTC GTTGCCTTTC TCTGTTTGAC GGGCATCTCC 5400

CCATTTGTTG GGGAGAATGA CCGGACAACA CTCATGAATA TCCGAAACTA CAACGTGGCA 5460

TTTGAGGAGA CTACGTTCCT GAGTCTGAGC AGGGAGGCCC GGGGCTTCCT CATCAAAGTG 5520

CTGGTGCAGG ATCGACTGAG ACCTACTGCA GAAGAGACAT TGGAACATCC TTGGTTCAAA 5580

ACAGAAGCAA AGGGTGCAGA GGTGAGCACA GATCACCTGA AGCTCTTCCT GTCACGGAGG 5640

AGGTGGCAGC GCTCTCAAAT CAGCTACAAG TGCCACCTGG TGCTGCGCCC CATTCCGGAA 5700

CTGCTACGGG CTCCCCCGGA GCGGGTGTGG GTGGCCATGC CTAGAAGACA ACCCCCGAGT 5760

GGGGGACTCT CATCCTCTTC AGACTCAGAA GAGGAAGAGT TGGAGGAACT TCCCTCAGTA 5820

CCCCGCCCCC TGCAGCCTGA GTTCTCAGGT TCTCGGGTAT CCCTCACCGA CATCCCCACC 5880

GAAGATGAGG CTCTGGGGAC CCCGGAAGCT GGGGCTGCCA CCCCCATGGA CTGGCAAGAG 5940

CAGGAAAGGA CTCCCTCTAA GGACCAGGAG GCCCCCAGCC CTGAGGCACT CCCCTCTCCA 6000

GGCCAGGAGT CCCCTGATGG GCCTAGCCCC AGGCGGCCAG AGCTCCGCAG GGGTAGCTCT 6060

GCTGAGAGTG CCCTGCCCCG AGTCGGGTCG CGGGAACCGG GCCGGAGCTT GCACAAGGCA 6120

GCATCCGTGG AGCTGCCGCA GCGCAGGAGC CCCAGCCCGG GTGCCACCCG CCTGACTCGG 6180

GGAGGCCTGG GTGAGGGCGA GTATGCCCAG AGGCTGCAGG CCCTGCGTCA GCGGCTGCTG 6240

AGGGGAGGCC CCGAGGATGG CAAGGTCAGC GGCCTCAGGG GACCCCTGCT GGAGAGCCTG 6300

GGGGGCCGTG CACGGGATCC CAGGATGGCA AGGGCTGCCT CCAGCGAGGC TGCCCCCCAC 6360

CACCAGCCCC CTCCGGAGTC CCGGGGTCTG CAAAAGAGCA GCAGCTTCTC TCAGGGCGAG 6420

GCAGAGCCCC GGGGTCGGCA CCGCCGCGCG GGGGCACCCC TCGAAATCCC CGTGGCCAGA 6480

CTTGGGGCTC GCAGGCTGCA GGAGTCTCCC TCCTTATCTG CCCTTAGCGA GACCCAGCCA 6540

CCGAGCCCTG CGAGGCCCAG CGTCCCCAAA CTCAGTATCA CCAAGTCCCC GGAACCTTCC 6600

GCTGTCACAT CCAGAGACTC TCCCCAGCCC CCGGAACCTC AGCCTGTCCC AGAAAAGGTC 6660

CCTGAGCCCA AACCAGAACC AGTCCGAGCT GCAAAACCAG CACAACCCCC TTTGGCTCTG 6720

CAAATGCCAA CGCAGCCTCT CACCCCCTAT GCCCAGATCA TGCAGTCGCT CCAGCTGTCC 6780

AGTCCCACCC TGTCCCCACA GGACCCCGCT GTGCCTCCAT CAGAGCCCAA GCCCCACGCG 6840

GCTGTGTTTG CCAGGGTGGC TTCCCCACCA CCCGGAGTCT CTGAGAAGCG CGTGCCTTCG 6900

GCCAGAACTC CCCCAGTGCT AGCCGAGAAA GCCCGAGTCC CCACGGTGCC CCCCAGGCCA 6960

GGCAGCAGCC TCAGCGGCAG CATCGAAAAC CTTGAATCAG AGGCTGTGTT CGAGGCTAAG 7020

TTCAAACGCA GCCGCGAATC GCCACTGTCG CGGGGCCTGA GGCTACTGAG CCGCTCGCGC 7080

TCGGAGGAGC GCGGTCCCTT CCGTGGGGCG GAGGACGACG GCATATACCG GCCCAGTCCG 7140

GCAGGAACGC CGCTAGAGCT GGTGCGACGG CCCGAGCGCT CGCGCTCCGT GCAGGACCTC 7200

AGGGTAGCCG GAGAGCCGGG CCTTGTGCGT CGCCTTTCGC TGTCCCTGTC GCAGAAGCTG 7260

CGGCGGACAC CGCCGGGACA GCGACACCCT GCCTGGGAGT CCCGCAGCGG AGACGGGGAG 7320

AGCTCCGAGG GCGGCAGCTC AGCTCGGGCA TCCCCAGTGC TGGCGGTACG CAGGAGACTC 7380

AGCTCCACGC TGGAGCGTCT GTCCAGCCGT TTGCAGCGCA GCGGCAGCAG CGAGGACTCC 7440

GGGGGCGCCT CGGGTCGCAG CACGCCGCTG TTTGGACGGC TGCGCAGGGC TACTTCGGAA 7500

GGGGAGAGCC TGCGACGCCT CGGTGTTCCG CACAATCAGC TGGGCTCTCA GACTGGTGCC 7560

ACTACACCTT CCGCTGAGTC TCTGGGCTCA GAGGCCAGTG GCACATCGGG TTCTTCAGCT 7620

CCTGGAGAAA GCCGAAGCCG GCACCGGTGG GGCCTTTCCA GGCTGCGCAA GGACAAGGGA 7680

TTATCTCAGC CAAACCTCTC CTCCAGTGTC CAAGAGGACT TGGGTCACCA GTATGTGCCC 7740

AGTGAGTCAG ATTTCCCCCC AGTCTTCCAC ATCAAACTCA AGGACCAGGT GCTGTTGGAG 7800

GGGGAAGCAG CCACCCTGCT CTGCCTACCC GCAGCCTGCC CAGCACCCCG CATCTCCTGG 7860

ATGAAAGATA AGCAGTCCCT GCGTTCAGAG CCCTCAGTGG TCATTGTGTC CTGCAAAGAT 7920

GGACGGCAGC TGCTGAGCAT ACCCCGGGCC GGCAAGCGGC ATGCTGGGCT CTATGAGTGC 7980

TCAGCCACCA ATGTCCTGGG CAGCATTACC AGCTCCTGTA CTGTGGCCGT GGCCCGCATT 8040

CCAGGGAAGC TAGCTCCTCC AGAGGTGCCC CAGACCTACC ATGACACAGC ACTAGTAGTG 8100

TGGAAGCCAG GAGACGGTCG GGCACCTTGC ACATACACTC TGGAGCGGCG GGTGGATGGG 8160

GAATCTGTCT GGCACCCTGT GAGCTCAGGC ATCCCCGACT GTTATTACAA TGTGACTCAG 8220

CTGCCTGTCG GCGTGACCGT GCGGTTCCGT GTGGCCTGTT CCAATCGTGC TGGGCAGGGG 8280

CCCTTCAGCA ACCCTTCTGA GAAGGTCTTC ATCCGAGGCA CTCCAGATTC TCCTGCTCAG 8340

CCAGCTGCTG CTCCCCGAGA TGCCCCTGTT ACCTCAGGGC CAACCAGGGC CCCACCGCCT 8400

GACTCTCCTA CCTCACTGGC CCCCACCCCC GCTCTTGCGC CCCCAGCCTC CCAGGCATCC 8460

ACTCTCAGCC CCTCAACTTC CTCCATGTCT GCCAACCAGG CCTTGTCCTC ACTCAAGGCT 8520

GTGGGTCCAC CACCCGCAAC CCCTCCACGA AAGCACAGGG GCCTTCTGGC CACCCAGCAA 8580

GCAGAGCCAT CCCCACCCAG TATCGTGGTC ACCCCAAGTG AACCCAGGTC TTTTGTCCCT 8640

GACACTGGAA CCCTGACCCC AACCTCTAGT CCTCAAGGGG TTAAACCAGC ACCTTCCTCA 8700

ACTTCCTTGT ATATGGTGAC TTCCTTCGTG TCTGCACCTC CAGCCCCCCA GGCCCCAGCC 8760

CCTGAGCCCC CTCCTGAGCC CACCAAGGTG ACTGTGCGGA GCCTCAGCCC AGCCAAGGAG 8820

GTGGTCAGCT CCCCAACTCC TGAGAGCACC ACTCTTCGGC AGGGTCCCCC TCAGAAACCC 8880

TACACCTTCC TGGAGGAGAA GGCCAGGGGC CGCTTTGGCG TTGTGCGGTC ATGCCGGGAG 8940

AATGCTACGG GCCGAACGTT TGTCGCCAAG ATCGTGCCGT ACGCCGCGGA GGGCAAGCGA 9000

CGCGTGCTGC AGGAATACGA GGTGCTTCGG ACGCTGCACC ACGAGCGGCT CATGTCCCTG 9060

CACGAGGCCT ACATCACCCC TCGGTACCTC GTGCTTATCG CTGAGAGCTG TGGCAACCGG 9120

GAACTCCTCT GTGGGCTCAG CGACAGATTC CGGTATTCAG AAGATGACGT GGCCACCTAT 9180

GTGGTGCAGC TGCTACAAGG CCTGGACTAC CTCCACGGCC ACCACGTGCT ACACCTGGAC 9240

ATCAAGCCGG ACAATCTACT GTTGGCCGCT GACAATGCCC TTAAAATTGT GGACTTCGGC 9300

AGTGCTCAGC CCTATAACCC TCAGGCCCTG AAGCCACTTG GCCACCGCAC AGGCACTCTG 9360

GAGTTCATGG CTCCTGAGAT GGTGAAGGGA GACCCCATTG GCTCTGCCAC GGACATCTGG 9420

GGAGCGGGTG TGCTCACCTA CATCATGCTT AGTGGGTACT CCCCATTCTA TGAGCCAGAC 9480

CCCCAGGAAA CAGAGGCTCG GATTGTTGGG GGTCGCTTTG ATGCCTTCCA GTTGTATCCT 9540

AACACATCCC AGAGTGCCAC CCTCTTCTTG AGAAAGGTCC TCTCAGTACA TCCCTGGAGC 9600

CGGCCCTCTC TGCAGGACTG CTTGGCCCAC CCATGGCTGC AAGATGCCTA CCTGATGAAG 9660

CTGCGCCGCC AGACACTCAC CTTCACCACC AACCGGCTCA AGGAATTCCT GGGCGAGCAG 9720

CGGCGACGTC GGGCTGAGGC TGCTACCCGT CACAAGGTGC TGCTCCGCTC CTACCCTGGC 9780

AGCCCCTAG 9789

Domain Profile

S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60

         y++++eigRG+Fs++++v+e++++ ++aakf+p++ak ka+++rEa++L+rLqH +++++

Q: 1606  YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHGCVLYF  1665

         99**********************************************************

S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120

         h+a+e++r lv+++Elc+ eeLL+r+a+k +++Ese+++y+rq+le+++YLH+s+vlHLD

Q: 1666  HEAFERRRGLVIVTELCT-EELLERMARKPTVCESETRTYMRQVLEGICYLHQSHVLHLD  1724

         ******************.9****************************************

S: 121   ikpenllv..laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatD  178

         +kpenllv   a  ee+v+i+D+gnAqeltp epq++++gtpEfvaPEi++++pvs +tD

Q: 1725  VKPENLLVwdGAGGEEQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTD  1784

         ********988999**********************************************

S: 179   iWavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqed  238

         iW+vGv+a+++L+g+sPf++e++r+tl+ni++++v+f+e++f +ls+eA+ Fl+kvL++d

Q: 1785  IWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD  1844

         ************************************************************

S: 239   prkRPsaaecLqhpWl  254

          r RP+a+e+L+hpW+

Q: 1845  -RLRPTAEETLEHPWF  1859

         .**************8

Domain Sequence
(FASTA)

YDIHQEIGRG AFSYLRRVVE RSSGLEFAAK FIPSQAKPKA SARREARLLA RLQHGCVLYF 60

HEAFERRRGL VIVTELCTEE LLERMARKPT VCESETRTYM RQVLEGICYL HQSHVLHLDV 120

KPENLLVWDG AGGEEQVRIC DFGNAQELTP GEPQYCQYGT PEFVAPEIVN QSPVSGVTDI 180

WPVGVVAFLC LTGISPFVGE NDRTTLMNIR NYNVAFEETT FLSLSREARG FLIKVLVQDR 240

LRPTAEETLE HPWF 254

Keyword

Alternative promoter usage; Alternative splicing; ATP-binding; Complete proteome; Differentiation; Disulfide bond; Immunoglobulin domain; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030154	; P:cell differentiation

KEGG

mmu:11790

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR015726	; Ser/Thr_kin_striated_muscle-sp.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07679	; I-set; 8.
PF00069	; Pkinase; 2.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 4.
SM00408	; IGc2; 5.
SM00220	; S_TKc; 2.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 8.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013