| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00383 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/NEK | 348.8 | 5.0E-104 | 34 | 289 | 256 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000027642 |
| UniProt Accession | Q9ES74; Q3UEV7; |
| Protein Name | Serine/threonine-protein kinase Nek7 |
| Protein Synonyms/Alias | Never in mitosis A-related kinase 7; NimA-related protein kinase 7; |
| Gene Name | Nek7 |
| Gene Synonyms/Alias | Nek7; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Protein kinase which plays an important role in mitoticcell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. |
| Protein Length | 302 |
Protein Sequence
(FASTA) | | MDEQSQGMQG PPVTQFQPQK ALRPDMGYNT LANFRIEKKI GRGQFSEVYR ASCLLDGVPV 60 | | ALKKVQIFDL MDAKARADCI KEIDLLKQLN HPNVIKYYAS FIEDNELNIV LELADAGDLS 120 | | RMIKHFKKQK RLIPERTVWK YFVQLCSALD HMHSRRVMHR DIKPANVFIT ATGVVKLGDL 180 | | GLGRFFSSKT TAAHSLVGTP YYMSPERIHE NGYNFKSDIW SLGCLLYEMA ALQSPFYGDK 240 | | MNLYSLCKKI EQCDYPPLPS DHYSEELRQL VNICINPDPE KRPDIAYVYD VAKRMHACTA 300 | | ST 302 |
|
Nucleotide Sequence
(FASTA) | | ATGGATGAAC AATCACAAGG AATGCAAGGG CCGCCCGTTA CTCAGTTCCA GCCACAGAAG 60 | | GCATTACGGC CAGATATGGG CTATAATACT TTAGCCAACT TCCGAATAGA AAAGAAAATT 120 | | GGTCGTGGAC AATTTAGTGA AGTTTATAGA GCATCCTGTC TCTTGGATGG AGTGCCGGTA 180 | | GCGTTAAAAA AAGTACAGAT ATTTGATTTA ATGGATGCCA AAGCACGTGC TGATTGTATC 240 | | AAAGAAATAG ACCTCCTTAA GCAACTCAAC CATCCAAATG TAATTAAATA CTATGCATCA 300 | | TTCATTGAGG ATAATGAGCT GAACATAGTT TTGGAGTTAG CAGATGCTGG TGACCTCTCC 360 | | AGAATGATAA AGCACTTTAA GAAACAAAAG AGGCTAATCC CTGAGAGAAC CGTTTGGAAA 420 | | TACTTCGTTC AGCTCTGCAG TGCACTGGAC CACATGCATT CTCGAAGAGT CATGCACAGA 480 | | GATATAAAAC CAGCTAATGT GTTCATTACA GCCACTGGGG TAGTAAAACT CGGAGACCTT 540 | | GGGCTTGGTC GGTTTTTCAG CTCCAAAACC ACAGCTGCAC ATTCTTTAGT GGGTACACCT 600 | | TACTACATGT CTCCAGAGAG AATACATGAA AATGGATACA ACTTCAAGTC TGACATCTGG 660 | | TCTCTTGGCT GTCTGCTATA TGAGATGGCT GCACTGCAGA GTCCTTTCTA CGGCGACAAG 720 | | ATGAACTTGT ATTCTCTGTG TAAGAAGATA GAGCAGTGTG ACTACCCGCC TCTCCCGTCA 780 | | GATCACTATT CGGAGGAGCT ACGACAGCTA GTTAATATAT GCATCAACCC AGATCCAGAG 840 | | AAGCGACCCG ACATCGCCTA TGTTTATGAT GTGGCAAAGA GGATGCATGC ATGTACCGCA 900 | | AGCACCTAA 909 |
|
| Domain Profile | S: 1 yevlkkiGrGsfgevlkvrkksdkkllvlKeikleel.dekerqklvkevsllkqlkHpn 59 | +++ kkiGrG+f+ev+++++ d+ ++lK++++ +l d+k+r +++ke++llkql+Hpn | Q: 34 FRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLmDAKARADCIKEIDLLKQLNHPN 93 | 57889*****************************997699******************** |
| S: 60 iveyyesfeeneelyivmeyceggdLsqlikeqkekkklleEktvlkilvqlllalkklH 119 | +++yy+sf+e++el+iv+e++++gdLs++ik++k++k+l++E+tv+k++vql++al+++H | Q: 94 VIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMH 153 | ************************************************************ |
| S: 120 ekkilHRDlkpaNifltkkevvklgDfGlaklleskielaktlvGtpyYlsPEvleekpY 179 | +++++HRD+kpaN+f+t+++vvklgD+Gl+++++sk+++a++lvGtpyY+sPE ++e++Y | Q: 154 SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGY 213 | ************************************************************ |
| S: 180 neksDiWslgCvlyelcaLkkpFeak..nllelvlkivegklepvpe.kyseelkelies 236 | n ksDiWslgC+lye++aL++pF+++ nl++l++ki++++++p+p+ +yseel++l++ | Q: 214 NFKSDIWSLGCLLYEMAALQSPFYGDkmNLYSLCKKIEQCDYPPLPSdHYSEELRQLVNI 273 | *************************978999***************99************ |
| S: 237 llkvdpekrpsveeil 252 | ++++dpekrp+++ + | Q: 274 CINPDPEKRPDIAYVY 289 | ************9876 |
|
Domain Sequence
(FASTA) | | FRIEKKIGRG QFSEVYRASC LLDGVPVALK KVQIFDLMDA KARADCIKEI DLLKQLNHPN 60 | | VIKYYASFIE DNELNIVLEL ADAGDLSRMI KHFKKQKRLI PERTVWKYFV QLCSALDHMH 120 | | SRRVMHRDIK PANVFITATG VVKLGDLGLG RFFSSKTTAA HSLVGTPYYM SPERIHENGY 180 | | NFKSDIWSLG CLLYEMAALQ SPFYGDKMNL YSLCKKIEQC DYPPLPSDHY SEELRQLVNI 240 | | CINPDPEKRP DIAYVY 256 |
|
| Keyword | Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |