| Tag | Content |
|---|
| EKPD ID | EKS-MUM-00308 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TKL/STKR | 453.8 | 5.8E-136 | 65 | 352 | 288 |
|
| Status | Reviewed |
| Ensembl Protein | ENSMUSP00000097663 |
| UniProt Accession | Q8K348; A2AJR4; |
| Protein Name | Activin receptor type-1C |
| Protein Synonyms/Alias | Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7; |
| Gene Name | Acvr1c |
| Gene Synonyms/Alias | Acvr1c; Alk7; |
| Ensembl Information | |
| Organism | Mus musculus |
| Functional Description | Serine/threonine protein kinase which forms a receptorcomplex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
| Protein Length | 363 |
Protein Sequence
(FASTA) | | MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TGLPLLVQRT 60 | | IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL 120 | | GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA SGLAHLHMEI 180 | | VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS IMNTIDIPQN PKVGTKRYMA 240 | | PEMLDDTMNL SIFESFKRAD IYSVGLVYWE IARRCSVGGV VEEYQLPYYD MVPSDPSIEE 300 | | MRKVVCDQKL RPNLPNQWQS CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED 360 | | CKA 363 |
|
Nucleotide Sequence
(FASTA) | | ATGCTAACCA ACGGGAAAGA GCAGGTGATC AAATCGTGTG TGTCCCTCCC GGAACTAAAT 60 | | GCTCAGGTCT TCTGTCACAG TTCCAACAAC GTGACCAAAA CCGAATGTTG CTTCACAGAC 120 | | TTCTGCAACA ATATCACACT GCACCTTCCC ACAGGTCTGC CTCTCTTGGT TCAAAGAACA 180 | | ATCGCAAGGA CAATTGTACT TCAAGAAATC GTAGGAAAAG GTCGGTTTGG GGAAGTGTGG 240 | | CACGGAAGAT GGTGTGGAGA AGATGTGGCT GTGAAAATAT TCTCCTCCAG GGATGAGAGA 300 | | TCTTGGTTCC GTGAGGCGGA AATTTATCAG ACGGTGATGC TGAGACACGA GAACATCCTC 360 | | GGTTTCATCG CAGCTGACAA CAAAGATAAT GGAACTTGGA CACAACTCTG GCTTGTGTCA 420 | | GAGTATCACG AGCAGGGCTC CTTGTATGAC TATTTGAACA GAAACATAGT GACTGTGGCT 480 | | GGAATGGTCA AGCTGGCGCT TTCCATAGCG AGTGGTCTGG CTCACCTGCA CATGGAGATC 540 | | GTGGGTACTC AAGGTAAGCC TGCTATTGCT CACCGAGATA TAAAGTCAAA GAATATCCTA 600 | | GTCAAAAAAT GTGACACTTG TGCCATAGCT GACTTAGGGC TGGCTGTGAA GCACGATTCT 660 | | ATCATGAACA CTATAGACAT ACCCCAGAAT CCTAAAGTGG GAACCAAGAG GTACATGGCT 720 | | CCCGAAATGC TTGATGATAC AATGAACCTG AGCATCTTTG AGTCCTTCAA GCGAGCTGAC 780 | | ATCTATTCGG TGGGGCTGGT TTACTGGGAA ATAGCTCGAA GGTGTTCAGT TGGAGGAGTT 840 | | GTTGAGGAGT ACCAGTTGCC TTACTATGAC ATGGTGCCTT CAGATCCTTC GATAGAAGAA 900 | | ATGAGGAAGG TTGTCTGTGA TCAGAAACTC CGACCAAATC TCCCAAACCA GTGGCAAAGC 960 | | TGTGAAGCGC TGCGGGTCAT GGGAAGAATA ATGCGTGAGT GCTGGTACGC CAACGGGGCA 1020 | | GCACGCCTGA CAGCCCTGCG CGTGAAGAAG ACCATCTCCC AGCTGTGTGT CAAGGAAGAC 1080 | | TGTAAAGCTT AG 1092 |
|
| Domain Profile | S: 1 lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia 60 | + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia | Q: 65 IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA 124 | 5789******************************************************** |
| S: 61 adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk 120 | ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v +++lals+asGlahLH+eivgt+ | Q: 125 ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQ 184 | ************************************************************ |
| S: 121 gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE 180 | g KpaiaHRD+kskNilvkk tc+iaDlGLa+k+++ +++d+ +n +vGtkRYmaPE | Q: 185 G--KPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPE 242 | *..********************************************************* |
| S: 181 vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem 240 | +l++++nl+ fe+fkraD+Ys+gLv+WE+a+Rc+ +++veey+lp++++v+sdPs+eem | Q: 243 MLDDTMNLSIFESFKRADIYSVGLVYWEIARRCSV-GGVVEEYQLPYYDMVPSDPSIEEM 301 | **********************************9.************************ |
| S: 241 kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl 291 | ++vv+++klrP++p++w+++eal+++ ++++ecW+a+++aRltalrvkk++ | Q: 302 RKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTI 352 | ************************************************986 |
|
Domain Sequence
(FASTA) | | IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60 | | ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMVK LALSIASGLA HLHMEIVGTQ 120 | | GKPAIAHRDI KSKNILVKKC DTCAIADLGL AVKHDSIMNT IDIPQNPKVG TKRYMAPEML 180 | | DDTMNLSIFE SFKRADIYSV GLVYWEIARR CSVGGVVEEY QLPYYDMVPS DPSIEEMRKV 240 | | VCDQKLRPNL PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRVKKTI 288 |
|
| Keyword | Apoptosis; ATP-binding; Complete proteome; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |